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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Perfil epidemiológico dos casos de gripe A na região sul de Santa Catarina, Brasil, na epidemia de 2009 Epidemiological profile of pandemic influenza A cases in the south of Santa Catarina state, Brazil, in 2009</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Fabiana Schuelter-Trevisol, Daisson José Trevisol, Estevão José Muller Uliano, Marina Constante Dutra, Janete Zandomênico</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>OBJETIVO: Descrever o perfil epidemiológico dos casos de gripe A (H1N1) ocorridos em 14 municípios de Santa Catarina, Brasil, em 2009. MÉTODOS: O presente estudo transversal enfocou os casos suspeitos de infecção pelo H1N1 notificados à 20ª Gerência de Saúde do Estado de Santa Catarina durante os meses da epidemia, de julho a setembro de 2009. Os dados foram coletados a partir das fichas do Sistema de Informação de Agravos de Notificação (SINAN) por técnicos da vigilância epidemiológica. A definição de caso de H1N1 foi feita mediante confirmação laboratorial (RT-PCR positivo) ou perfil epidemiológico positivo de síndrome respiratória aguda grave. RESULTADOS: Foram notificados 1 149 casos suspeitos de gripe A no período, sendo 560 (48,6%) confirmados, resultando em uma taxa de incidência de 241,9/100 000 habitantes. A média de idade dos casos confirmados foi de 29,5 ± 17,1 anos, vs. 32,2 ± 20 anos entre os descartados (P = 0,03). Do total de casos confirmados, 37,1% indivíduos ficaram hospitalizados, com taxa de incidência hospitalar de 89,9/100 000 habitantes e taxa de letalidade de 5,6/100 000 habitantes. Ser jovem, com 30 anos ou menos de idade, ter sinais e sintomas de febre, tosse e dispneia, e ocorrência de óbito foram fatores independentes associados à infecção pela influenza pandêmica (P &lt; 0,05). Nenhuma comorbidade apresentou associação com os casos confirmados de gripe A. CONCLUSÕES: A amostra estudada diferiu do perfil nacional de casos de gripe A no Brasil pela ausência de comorbidade associada, porém aproximou-se do perfil nacional pelo acometimento principalmente de jovens e pela associação significativa com febre, tosse e dispneia. É preciso considerar a ampliação da campanha anual de vacinação, hoje dirigida a grupos de risco, para toda a população.OBJECTIVE: To describe the epidemiological features of influenza A (H1N1) cases in 14 municipalities of Santa Catarina, Brazil, during the 2009 pandemic. METHOD: This cross-sectional study focused on suspected cases of H1N1 reported to the 20th Santa Catarina State Health Administration during the 2009 pandemic between July to September. Data were collected by epidemiological surveillance officers from the Brazilian communicable diseases information system SINAN. H1N1 cases were confirmed by laboratory testing (positive RT-PCR) or signs and symptoms characteristic of severe acute respiratory syndrome. RESULTS: During the pandemic period, 1 149 suspected cases of influenza A were notified, of which 560 (48.6%) were confirmed. That translated into an incidence of 241.9/100 000 population. Mean age for confirmed cases was 29.5 ± 17.1 years, vs. 32.2 ± 20 years for those ruled out (P = 0.03). Of the total confirmed cases, 37.1% were hospitalized, with a hospital incidence rate of 89.9/100 000 people and lethality rate of 5.6/100 000 population. Age &lt; 30 years, symptoms of fever, cough and dyspnea, and death were independently associated with influenza A infection (P &lt; 0.05). There were no associations between confirmed cases and any comorbidities. CONCLUSION: The studied sample differed from the national profile of influenza A cases in Brazil by the absence of associated comorbidities. However, it was similar to the national profile in terms of the young age of cases and the significant association with fever, cough, and dyspnea. An extension of the annual immunization campaign (currently focused on risk groups) to the overall population should be considered.</text>
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                <text>2012</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>influenza, Brasil, Epidemiology, human, epidemiología, Brazil, Influenza A virus, H1N1 subtype, vírus da influenza A subtipo H1N1, Influenza Humana</text>
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                <text>DOI: </text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Revista Panamericana de Salud Pública</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Pan American Health Organization</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Arctic medicine. Tropical medicine, Public aspects of medicine, Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Molecular Characterization of the Porcine Group A Rotavirus NSP2 and NSP5/6 Genes from São Paulo State, Brazil, in 2011/12</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27329">
                <text>Fabio Gregori, Laila Andreia Rodrigues Beserra, Bruna Rocha Passos Barbosa, Nara Thiers Cacciatori Galleti Bernardes</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Rotaviruses are responsible for the acute diarrhea in various mammalian and avian species. The nonstructural proteins NSP2 and NSP5 are involved in the rotavirus replication and the formation of viroplasm, cytoplasmic inclusion bodies within which new viral particles morphogenesis and viral RNA replication occur. There are few studies on the genetic diversity of those proteins; thus this study aims at characterizing the diversity of rotavirus based on NSP2 and NSP5 genes in rotaviruses circulating in Brazilian pig farms. For this purpose, 63 fecal samples from pig farms located in six different cities in the São Paulo State, Brazil, were screened by nested RT-PCR. Seven strains had the partial nucleotide sequencing for NSP2, whereas in six, the total sequencing for NSP5. All were characterized as genotype H1 and N1. The nucleotide identity of NSP2 genes ranged from 100% to 86.4% and the amino acid identity from 100% to 91.5%. For NSP5, the nucleotide identity was from 100% to 95.1% and the amino acid identity from 100% to 97.4%. It is concluded that the genotypes of the strains circulating in the region of study are in agreement with those reported in the literature for swine and that there is the possibility of interaction between human and animal rotaviruses.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2013</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="27332">
                <text>DOI: 10.1155/2013/241686</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="27333">
                <text>The Scientific World Journal</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27334">
                <text>Hindawi Limited</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="27335">
                <text>Technology, Science, Medicine</text>
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          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27337">
                <text>Antonios Papadopoulos, Foula Vassilara, Aikaterini Spyridaki, George Pothitos, Athanassia Deliveliotou</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="27338">
                <text>Human coronavirus 229E (HCoV-229E) is one of the first coronavirus strains being described. It is linked to common cold symptoms in healthy adults. Younger children and the elderly are considered vulnerable to developing lower respiratory tract infections (LRTIs). In particular, immunocompromised patients have been reported with severe and life-threatening LRTIs attributed to HCoV-229E. We report for the first time a case of LRTI and acute respiratory distress syndrome developed in a healthy adult with no comorbidities and HCoV-229E strain identified as the only causative agent. A 45-year-old female with a clear medical history presented with fever, cough, and headache. Respiratory tract infection was diagnosed, and empirical antibiotics were started. Within two days, she developed bilateral pleural effusions, diffuse consolidations, and ground glass opacities involving all lung fields. She needed immediate oxygen supply, while ABGs deteriorated and chest imaging and PaO2/FiO2 indicated ARDS. Early administration of systemic corticosteroids led to gradual clinical improvement. Multiplex PCR from nasal secretions was positive only for HCoV-229E and negative for multiple other pathogens. It remains to be elucidated how an immunocompetent adult developed a life-threatening LRTI caused by a “benign considered” coronavirus strain, the HCoV-229E.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2018</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="27340">
                <text>DOI: 10.1155/2018/6796839</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="27341">
                <text>Case Reports in Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27342">
                <text>Hindawi Limited</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="27343">
                <text>Infectious and parasitic diseases</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="27344">
                <text>The Current Viral agents; ZIKA, CHIKUNGUNYA, EBOLA, ENTEROVIRUS D68, MERS CoV, Influenza</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27345">
                <text>Mustafa ALTINDİŞ, Ferhat Gürkan  Aslan</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>In this review was mentioned briefly cover of current viral agents that not only to restricted regions of the world but also for our region began to increase of the importance and threaten the health; Zika, Chikungunya, Ebola, Enterovirus d68, MERS and Influenzavirus.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2016</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Zika, Influenza virus, Ebola, Chikungunya, MERS-CoV, enterovirus-D68</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.30934/kusbed.358635</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Kocaeli Üniversitesi Sağlık Bilimleri Dergisi</text>
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                <text>Kocaeli University</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine (General), Medicine</text>
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                <text>Learning from Mistakes</text>
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                <text>LE Nicolle</text>
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                <text>In the present issue of the Journal, Patrick and his colleagues (pages 330-336) describe an episode in the summer of 2003, immediately following the severe acute respiratory syndrome (SARS) epidemic, when an outbreak of respiratory illness occurred in a long-term care facility in Vancouver, and was initially reported by the National Microbiology Laboratory (NML) to be SARS. The local laboratories did not support the diagnosis and, subsequently, the NML diagnosis was acknowledged to be incorrect. The misdiagnosis, however, had an immediate negative impact by suggesting that SARS continued to be transmitted in Canada, raising the spectre of social and economic impacts recently experienced by Toronto. The episode also had a longer term negative impact on national and international perceptions of the reliability of the Canadian laboratory. Thus, a critical review of this episode to understand what happened and to avoid future errors is appropriate. Dr Patrick and his coauthors, including those from the NML, are to be congratulated for presenting this information to the Canadian infectious diseases and public health communities.</text>
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                <text>2006</text>
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                <text>DOI: 10.1155/2006/953706</text>
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                <text>Canadian Journal of Infectious Diseases and Medical Microbiology</text>
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                <text>Hindawi Limited</text>
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                <text>Infectious and parasitic diseases, Microbiology</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS)</text>
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            <description>An account of the resource</description>
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                <text>Severe acute respiratory syndrome (SARS) is frequently complicated with acute respiratory failure. In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. Most SARS patients would require high flow oxygen supplementation, 20&amp;#8211;30% required intensive care unit (ICU) or high dependency care, and 13&amp;#8211;26% developed acute respiratory distress syndrome (ARDS). In some of these patients, the clinical course can progress relentlessly to septic shock and/or multiple organ dysfunction syndrome (MODS). The management of critically ill SARS patients requires timely institution of pharmacotherapy where applicable and supportive treatment (oxygen therapy, noninvasive and invasive ventilation). Superimposed bacterial and other opportunistic infections are common, especially in those treated with mechanical ventilation. Subcutaneous emphysema, pneumothoraces and pneumomediastinum may arise spontaneously or as a result of positive ventilatory assistance. Older age is a consistently a poor prognostic factor. Appropriate use of personal protection equipment and adherence to infection control measures is mandatory for effective infection control. Much of the knowledge about the clinical aspects of SARS is based on retrospective observational data and randomized-controlled trials are required for confirmation. Physicians and scientists all over the world should collaborate to study this condition which may potentially threaten human existence.</text>
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                <text>2004</text>
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            <description>The topic of the resource</description>
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                <text>Management, Critically ill patients, severe acute respiratory syndrome, SARS, Treatment and control</text>
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                <text>DOI: </text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="27366">
                <text>International Journal of Medical Sciences</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Ivyspring International Publisher</text>
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                <text>Medicine</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Development of a Conventional RT-PCR Assay for Rapid Detection of Porcine Deltacoronavirus with the Same Detection Limit as a SYBR Green-Based Real-Time RT-PCR Assay</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27370">
                <text>Lei Ma, Jingyun Ma, Feng Cong, Ren Huang, Pengju Guo, Fanwen Zeng, Bihong Huang</text>
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            <description>An account of the resource</description>
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                <text>Porcine deltacoronavirus (PDCoV) is a newly discovered coronavirus, which belongs to the family Coronaviridae. It causes watery diarrhea, vomiting, and dehydration in newborn piglets. A sensitive RT-PCR method is urgently required to detect PDCoV infection. In this study, we developed and evaluated a conventional RT-PCR assay and a SYBR green-based real-time RT-PCR assay that targeted the PDCoV n gene. Both assays are specific and have the same limit of detection at 2 × 101 copies of RNA molecules per reaction. Eighty-four clinical samples were subjected to both conventional RT-PCR and real-time RT-PCR, and the same positive rate (41.7%) was achieved, which was much higher than the positive rate (26.2%) using a previously described one-step RT-PCR technique. In summary, a conventional RT-PCR technique was successfully established for the detection of PDCoV with the same detection limit as a SYBR green-based real-time RT-PCR assay.</text>
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                <text>2018</text>
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              <elementText elementTextId="27373">
                <text>DOI: 10.1155/2018/5035139</text>
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          <element elementId="48">
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            <description>A related resource from which the described resource is derived</description>
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                <text>BioMed Research International</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Hindawi Limited</text>
              </elementText>
            </elementTextContainer>
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                <text>Medicine</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="27377">
                <text>Intrahost Diversity of Feline Coronavirus: A Consensus between the Circulating Virulent/Avirulent Strains and the Internal Mutation Hypotheses?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27378">
                <text>Paulo E. Brandão, Leonardo J. Richtzenhain, Paulo Maiorka, Juliana M. Guerra, Karen M. Asano, Aline S. Hora, Ramon G. Mesquita</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="27379">
                <text>To evaluate the most controversial issue concerning current feline coronavirus (FCoV) virology, the coexisting hypotheses of the intrahost and interhost origins of feline infectious peritonitis virus (FIPV) in regard to the pathogenesis of feline infectious peritonitis (FIP), this study aimed to assess the molecular diversity of the membrane gene FCoVs in 190 samples from 10 cats with signs of FIP and in 5 faecal samples from cats without signs of FIP. All samples from the non-FIP cats and 25.26% of the samples from the FIP cats were positive for the FCoV membrane (M) gene. Mutations in this gene consisted of SNP changes randomly scattered among the sequences; few mutations resulted in amino acid changes.  No geographic pattern was observed. Of the cats without FIP that harboured FECoV, the amino acid sequence identities for the M gene were 100% among cats (Cats 1–3) from the same cattery, and the overall sequence identity for the M gene was ≥91%. In one cat, two different lineages of FCoV, one enteric and one systemic, were found that segregated apart in the M gene tree. In conclusion, the in vivo mutation transition hypothesis and the circulating high virulent-low virulent FCoV hypothesis have been found to be plausible according to the results obtained from sequencing the M gene.</text>
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                <text>2013</text>
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              <elementText elementTextId="27381">
                <text>DOI: 10.1155/2013/572325</text>
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                <text>The Scientific World Journal</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Hindawi Limited</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Technology, Science, Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Early Cardiac Allograft Vasculopathy: Are the Viruses to Blame?</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27386">
                <text>John Hamilton, Ashim Aggarwal, Joseph Pyle, Geetha Bhat</text>
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            <description>An account of the resource</description>
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                <text>This paper describes a case of early (7 months after transplant) cardiac allograft vasculopathy. This-43-year-old (CMV positive, EBV negative) female patient underwent an orthotopic heart transplant with a (CMV negative, EBV positive) donor heart. She had a history of herpes zoster infection and postherpetic neuralgia in the past. The patient’s panel reactive antibodies had been almost undetectable on routine surveillance testing, and her surveillance endomyocardial biopsies apart from a few episodes of mild-to-moderate acute cellular rejection (treated adequately with steroids) never showed any evidence of humoral rejection. The postoperative course was complicated by multiple admissions for upper respiratory symptoms, and the patient tested positive for entero, rhino, and coronaviruses serologies. During her last admission (seven months postoperatively) the patient developed mild left ventricular dysfunction with an ejection fraction of 40%. The patient’s endomyocardial biopsy done at that time revealed concentric intimal proliferation and inflammation resulting in near-total luminal occlusion in the epicardial and the intramyocardial coronary vessels, suggestive of graft vasculopathy with no evidence of rejection, and the patient had a fatal ventricular arrhythmia.</text>
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                <text>2012</text>
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              <elementText elementTextId="27389">
                <text>DOI: 10.1155/2012/734074</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="27390">
                <text>Case Reports in Medicine</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27391">
                <text>Hindawi Limited</text>
              </elementText>
            </elementTextContainer>
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                <text>Medicine</text>
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