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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Lucky China: Efficient Prevention from Middle East Respiratory Syndrome and its Beyond</text>
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                <text>Ran Li, Zhancheng Gao, Yali Zheng</text>
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                <text>2015</text>
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                <text>China; Middle East Respiratory Syndrome; Prevention</text>
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            <name>Identifier</name>
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                <text>DOI: 10.4103/0366-6999.167292</text>
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                <text>Chinese Medical Journal</text>
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                <text>Wolters Kluwer</text>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>Available Evidence of Association between Zika Virus and Microcephaly</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Jing Wu, Jun-tao Ma, Yifei Hu, Dayong Huang, Yinghua Ma</text>
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                <text>Objective: To clarify the possible association between the Zika virus (ZIKV) and microcephaly and understand where we are in terms of research and the debate on the causation between mild maternal clinical features and severe fetal microcephaly. Data Sources: We did a comprehensive literature review with the keywords “zika” and/or “microcephaly” from inception to May 27, 2016, with PubMed. Study Selection: Studies were included and analyzed if they met all of the following criteria: “probable or confirmed infant microcephaly” and “probable or confirmed ZIKV infection among mothers or infants”. Results: We emphasize the diagnosis of ZIKV infection, including maternal clinical manifestations, maternal and fetal laboratory confirmation, and possible autopsy if need. Other confounders that may lead to microcephaly should be excluded from the study. We presented the results from clinical manifestations of ZIKV infection, testing methods evolving but the mechanism of microcephaly uncertain, flexible definition challenging the diagnosis of microcephaly, and limited causal reference on pregnant women. We made analog comparison of severe acute respiratory syndrome and chikungunya virus in terms of DNA mutation and global movement to provide further research recommendation. The chance of catch-up growth may decrease the number of pervious “diagnosed” microcephaly. Conclusions: There are some evidence available through mice models and direct isolation of ZIKV in affected pregnancies on kindly causal relationship but not convincible enough. We analyzed and presented the weakness or limitation of published reports with the desire to shed light to further study directions.</text>
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                <text>2016</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Microcephaly; Pregnant Woman; Zika Virus</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.4103/0366-6999.190672</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="27414">
                <text>Chinese Medical Journal</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27415">
                <text>Wolters Kluwer</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>SARS-CoV Sampling from 3 Portals</text>
              </elementText>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27418">
                <text>Tommy R. Tong</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2005</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27420">
                <text>Saliva, Conjunctiva, Letter, SARS, tear, SARS-CoV</text>
              </elementText>
            </elementTextContainer>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="27421">
                <text>DOI: 10.3201/eid1101.040645</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="27422">
                <text>Emerging Infectious Diseases</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="27424">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
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          </elementContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27425">
                <text>Coronavirus-positive Nasopharyngeal Aspirate as Predictor for Severe Acute Respiratory Syndrome Mortality</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27426">
                <text>Wilina Lim, Wai-Cho Yu, Owen Tak-yin Tsang, Sik To Lai, Tai-Nin Chau, Kin-Wing Choi, Eugene Yuk-Keung Tso, Ming-Chi Chiu, Wing-Lok Tong, Po-Oi Lee, Bosco Hoi Shiu Lam, Tak-Keung Ng, Jak-Yiu Lai</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Severe acute respiratory syndrome (SARS) has caused a major epidemic worldwide. A novel coronavirus is deemed to be the causative agent. Early diagnosis can be made with reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal aspirate samples. We compared symptoms of 156 SARS-positive and 62 SARS-negative patients in Hong Kong; SARS was confirmed by RT-PCR. The RT-PCR–positive patients had significantly more shortness of breath, a lower lymphocyte count, and a lower lactate dehydrogenase level; they were also more likely to have bilateral and multifocal chest radiograph involvement, to be admitted to intensive care, to need mechanical ventilation, and to have higher mortality rates. By multivariate analysis, positive RT-PCR on nasopharyngeal aspirate samples was an independent predictor of death within 30 days.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="27428">
                <text>2003</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27429">
                <text>China, Hong Kong, severe acute respiratory syndrome, Coronavirus infection, SARS virus</text>
              </elementText>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="27430">
                <text>DOI: 10.3201/eid0911.030400</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="27431">
                <text>Emerging Infectious Diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="27432">
                <text>Centers for Disease Control and Prevention</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="27433">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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  <item itemId="2923" public="1" featured="0">
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="27434">
                <text>TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.</text>
              </elementText>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27435">
                <text>Wenhui Li, Gordon J. Freeman, Rosemarie H DeKruyff, Michael Farzan, Asim A. Ahmed, Hyeryun Choe, Stephanie Jemielity, Jinyize J Wang, Ying Kai Chan, Sheena Monahan, Xia Bu, Dale T Umetsu</text>
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                <text>Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue virus. Here we show that TIM1 promotes infection of retroviruses and virus-like particles (VLPs) pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, New World arenavirus and alphavirus families. TIM1 also robustly enhanced the infection of replication-competent viruses from the same families, including dengue, Tacaribe, Sindbis and Ross River viruses. All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments. In addition, other PS-binding proteins, such as Axl and TIM4, promoted infection similarly to TIM1. Finally, the blocking of PS receptors on macrophages inhibited the entry of Ebola VLPs, suggesting that PS receptors can contribute to infection in physiologically relevant cells. Notably, infection mediated by the entry proteins of Lassa fever virus, influenza A virus and SARS coronavirus was largely unaffected by TIM1 expression. Taken together our data show that TIM1 and related PS-binding proteins promote infection of diverse families of enveloped viruses, and may therefore be useful targets for broad-spectrum antiviral therapies.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2013</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="27438">
                <text>DOI: 10.1371/journal.ppat.1003232</text>
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                <text>Infection with MERS-CoV causes lethal pneumonia in the common marmoset.</text>
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                <text>Jiang ZHU, Tingting Liu, Heinz Feldmann, Darryl Falzarano, Emmie de Wit, Friederike Feldmann, Elaine Haddock, Dana P. Scott, Neeltje van Doremalen, Vincent J. Munster, Atsushi Okumura, Michael G. Katze, Angela L. Rasmussen, Rachel LaCasse, Jason S. McLellan, Matthew J Thomas, Xinxia Peng, Lee Nagy</text>
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                <text>The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction between the MERS-CoV spike glycoprotein and its receptor dipeptidyl peptidase 4 predicted comparable interaction energies in common marmosets and humans. The suitability of the marmoset as a MERS-CoV model was tested by inoculation via combined intratracheal, intranasal, oral and ocular routes. Most of the marmosets developed a progressive severe pneumonia leading to euthanasia of some animals. Extensive lesions were evident in the lungs of all animals necropsied at different time points post inoculation. Some animals were also viremic; high viral loads were detected in the lungs of all infected animals, and total RNAseq demonstrated the induction of immune and inflammatory pathways. This is the first description of a severe, partially lethal, disease model of MERS-CoV, and as such will have a major impact on the ability to assess the efficacy of vaccines and treatment strategies as well as allowing more detailed pathogenesis studies.</text>
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                <text>DOI: 10.1371/journal.ppat.1004250</text>
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                <text>Biology (General), Immunologic diseases. Allergy</text>
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                <text>Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity.</text>
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                <text>Mark R. Denison, Everett Clinton Smith</text>
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                <text>DOI: 10.1371/journal.ppat.1003760</text>
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                <text>Biology (General), Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Paramyxo- and Coronaviruses in Rwandan Bats</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27458">
                <text>Wanda Markotter, Louis Nel, Janusz Paweska, Julius Nziza, Jacqueline Weyer, Petrus Jansen van Vuren, Alan Kemp, Marinda Mortlock, Antoine Mudakikwa, Marike Geldenhuys</text>
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                <text>A high diversity of corona- and paramyxoviruses have been detected in different bat species at study sites worldwide, including Africa, however no biosurveillance studies from Rwanda have been reported. In this study, samples from bats collected from caves in Ruhengeri, Rwanda, were tested for the presence of corona- and paramyxoviral RNA using reverse transcription PCR assays. Positive results were further characterized by DNA sequencing and phylogenetic analysis. In addition to morphological identification of bat species, we also did molecular confirmation of species identities, contributing to the known genetic database available for African bat species. We detected a novel Betacoronavirus in two Geoffroy&amp;#8217;s horseshoe bats (Rhinolophus clivosus) bats. We also detected several different paramyxoviral species from various insectivorous bats. One of these viral species was found to be homologous to the genomes of viruses belonging to the Jeilongvirus genus. Additionally, a Henipavirus-related sequence was detected in an Egyptian rousette fruit bat (Rousettus aegyptiacus). These results expand on the known diversity of corona- and paramyxoviruses and their geographical distribution in Africa.</text>
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                <text>2019</text>
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                <text>Surveillance, Rwanda, coronavirus, barcoding, caves, bat, Paramyxovirus, Henipavirus, jeilongvirus</text>
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                <text>DOI: 10.3390/tropicalmed4030099</text>
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                <text>Tropical Medicine and Infectious Disease</text>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Knowledge and practices of dentists regarding MERS-CoV: A cross-sectional survey in Saudi Arabia</text>
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                <text>Faraz A Farooqi, Balgis O. Gaffar, Asim A. Al-Ansari, Adel S Alagl, Maha El Tantawi, Khalid M. Almas</text>
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                <text>Objectives: To assess virus knowledge among dentistsin Saudi Arabia and to identify factors associated withrecommended management practices of patients.Method: A structured questionnaire was distributed todentists in major Saudi cities between September 2016and December 2017. The questionnaire investigatedparticipants’ knowledge about Middle EastRespiratory Syndrome Coronavirus (MERS-CoV)transmission, consequences, patient identificationand history taking practices. Data was collectedusing paper-based questionnaires or an online linksent to dentists registered with Saudi Dental Societynationwide. The analysis was carried using StatisticalPackage for Social Sciences for Windows, version 22.0(IBM Corp., Armonk, NY, USA) logistic regression,odds ratio and confidence intervals to identify therelationship between variables.Results: A total of 423 dentists responded the paper-basedquestionnaire. Overall the knowledge was goodwith gaps in history taking practices. Best managementpractices of MERS-CoV patients were significantlyhigher among dentists with better knowledge of virustransmission (odd ration [OR]=1.16, p</text>
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                <text>dentist, Saudi Arabia, Middle East respiratory syndrome coronavirus</text>
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                <text>DOI: 10.15537/smj.2019.7.24304</text>
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                <text>Saudi Medical Journal</text>
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                <text>Ministry of Defence and Aviation</text>
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                <text>Medicine</text>
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                <text>Metagenomic analysis of the ferret fecal viral flora.</text>
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                <text>Albert D.M.E. Osterhaus, Bart L. Haagmans, V. Stalin Raj, Saskia L. Smits, Koert J. Stittelaar, Rogier Bodewes, Claudia M.E. Schapendonk, Minoushka D Oduber, Lisette Provacia</text>
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                <text>Ferrets are widely used as a small animal model for a number of viral infections, including influenza A virus and SARS coronavirus. To further analyze the microbiological status of ferrets, their fecal viral flora was studied using a metagenomics approach. Novel viruses from the families Picorna-, Papilloma-, and Anelloviridae as well as known viruses from the families Astro-, Corona-, Parvo-, and Hepeviridae were identified in different ferret cohorts. Ferret kobu- and hepatitis E virus were mainly present in human household ferrets, whereas coronaviruses were found both in household as well as farm ferrets. Our studies illuminate the viral diversity found in ferrets and provide tools to prescreen for newly identified viruses that potentially could influence disease outcome of experimental virus infections in ferrets.</text>
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            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27478">
                <text>2013</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="27479">
                <text>DOI: 10.1371/journal.pone.0071595</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="27480">
                <text>PLoS ONE</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="27481">
                <text>Public Library of Science (PLoS)</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="27482">
                <text>Science, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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