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Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus.
BACKGROUND:Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was…
Position: 2403 (25 views)
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy.
To evaluate the presence of viruses and bacteria in middle ear and adenoids of patients with and without otitis media with effusion (OME).Adenoid samples and middle ear washes (MEW) were obtained from children with OME associated with adenoid…
Position: 12407 (15 views)
HTCC: Broad Range Inhibitor of Coronavirus Entry.
To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and…
Position: 13981 (14 views)
Single primer isothermal amplification (SPIA) combined with next generation sequencing provides complete bovine coronavirus genome coverage and higher sequence depth compared to sequence-independent single primer amplification (SISPA).
Coronaviruses are of major importance for both animal and human health. With the emergence of novel coronaviruses such as SARS and MERS, the need for fast genome characterisation is ever so important. Further, in order to understand the influence of…
Position: 3309 (23 views)
Contrasting phylogeographic patterns and demographic history in closely related species of Daphnia longispina group (Crustacea: Cladocera) with focus on North-Eastern Eurasia.
Species with large geographic distributions present a challenge for phylogeographic studies due to the logistic difficulties of obtaining adequate samples. Daphnia O.F. Müller (Anomopoda: Daphniidae) is a model genus for evolutionary biology and…
Position: 2806 (24 views)
An evaluation of emergency guidelines issued by the World Health Organization in response to four infectious disease outbreaks.
BACKGROUND:The production of high-quality guidelines in response to public health emergencies poses challenges for the World Health Organization (WHO). The urgent need for guidance and the paucity of structured scientific data on emerging diseases…
Position: 820 (34 views)
Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong.
The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak…
Position: 747 (35 views)
Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis.
Patients with neurodegenerative diseases such as multiple sclerosis, Parkinson's, and Alzheimer's often present with lower urinary tract symptoms (LUTS, urinary frequency, urgency, nocturia and retention) resulting from damage to the peripheral and…
Position: 3956 (22 views)
Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes.
Splice-switching antisense oligonucleotides (SSOs) offer great potential for RNA-targeting therapies, and two SSO drugs have been recently approved for treating Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA). Despite promising…
Position: 7894 (18 views)
Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses.
The severity of respiratory viral infections is partially determined by the cellular response mounted by infected lung epithelial cells. Disease prevention and treatment is dependent on our understanding of the shared and unique responses elicited by…
Position: 9304 (17 views)