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Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation.
Similar to eukaryotic mRNA, the positive-strand coronavirus genome of ~30 kilobases is 5'-capped and 3'-polyadenylated. It has been demonstrated that the length of the coronaviral poly(A) tail is not static but regulated during infection; however,…
Position: 3961 (22 views)
Antiviral Action of Tryptanthrin Isolated from <i>Strobilanthes cusia</i> Leaf against Human Coronavirus NL63
Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. The methanol extract of S. cusia leaf contains chemical components such as β-sitosterol, indirubin, tryptanthrin, betulin,…
Position: 5603 (20 views)
A Novel Range Compression Algorithm for Resolution Enhancement in GNSS-SARs
In this paper, a novel range compression algorithm for enhancing range resolutions of a passive Global Navigation Satellite System-based Synthetic Aperture Radar (GNSS-SAR) is proposed. In the proposed algorithm, within each azimuth bin, firstly…
Position: 12417 (15 views)
Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study
Abstract Background Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival…
Position: 10766 (16 views)
How Did Chinese Government Implement Unconventional Measures Against COVID-19 Pneumonia
Xiang Yu,1 Na Li2,3 1School of Public Affairs, Fujian Jiangxia University, Fuzhou, Fujian Province, People’s Republic of China; 2School of Law, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Research Academy of…
Position: 9315 (17 views)
How Did Chinese Government Implement Unconventional Measures Against COVID-19 Pneumonia
Xiang Yu,1 Na Li2,3 1School of Public Affairs, Fujian Jiangxia University, Fuzhou, Fujian Province, People’s Republic of China; 2School of Law, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Research Academy of…
Position: 17024 (12 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1; peer review: 2 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 7903 (18 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1; peer review: 2 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 17024 (12 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 1; peer review: 2 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 7903 (18 views)
