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                <text>Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection</text>
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                <text>Lei Zhang, Lihong He, Xun Li, Junfeng Li, Longfei Ren, Yong-Na Wu</text>
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                <text>The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide, seriously endangering human health. In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. It is known that a healthy intestinal flora is closely related to the maintenance of pulmonary and systemic health by regulating the host immune homeostasis. Role of the “gut-lung axis” has also been well-articulated. This review provides a novel suggestion that intestinal flora may be one of the mediators of the gastrointestinal responses and abnormal immune responses in hosts caused by SARS-CoV-2; improving the composition of intestinal flora and the proportion of its metabolites through probiotics, and personalized diet could be a potential strategy to prevent and treat COVID-19. More clinical and evidence-based medical trials may be initiated to determine the strategy.</text>
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                <text>DOI: 10.3389/fmicb.2020.01388</text>
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                <text>Frontiers in Microbiology</text>
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                <text>Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19</text>
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                <text>Martin Herrmann, Marko Radic, Vincent T. K. Chow, Sylviane Muller, Teluguakula Narasaraju, Benjamin M. Tang</text>
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                <text>There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. Many patients, who recover, experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release. Moreover, we suggest that currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19. In our view, targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.</text>
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                <text>neutrophil extracellular traps, Neutrophils, acute respiratory distress syndrome, neutrophilia, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3389/fphar.2020.00870</text>
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                <text>Frontiers in Pharmacology</text>
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                <text>Therapeutics. Pharmacology</text>
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                <text>Thabet Abdeljawad, Kamal Shah, Fahd Jarad, Ibrahim Mahariq</text>
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                <text>In this article, a qualitative analysis of the mathematical model of novel corona virus named COVID-19 under nonsingular derivative of fractional order is considered. The concerned model is composed of two compartments, namely, healthy and infected. Under the new nonsingular derivative, we, first of all, establish some sufficient conditions for existence and uniqueness of solution to the model under consideration. Because of the dynamics of the phenomenon when described by a mathematical model, its existence must be guaranteed. Therefore, via using the classical fixed point theory, we establish the required results. Also, we present the results of stability of Ulam’s type by using the tools of nonlinear analysis. For the semianalytical results, we extend the usual Laplace transform coupled with Adomian decomposition method to obtain the approximate solutions for the corresponding compartments of the considered model. Finally, in order to support our study, graphical interpretations are provided to illustrate the results by using some numerical values for the corresponding parameters of the model.</text>
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                <text>DOI: 10.1155/2020/5098598</text>
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                <text>BioMed Research International</text>
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                <text>Hindawi Limited</text>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Volunteer Down: How COVID-19 Created the Largest Idling Supercomputer on Earth</text>
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                <text>Nane Kratzke</text>
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                <text>From close to scratch, the COVID-19 pandemic created the largest volunteer supercomputer on earth. Sadly, processing resources assigned to the corresponding Folding@home project cannot be shared with other volunteer computing projects efficiently. Consequently, the largest supercomputer had significant idle times. This perspective paper investigates how the resource sharing of future volunteer computing projects could be improved. Notably, efficient resource sharing has been optimized throughout the last ten years in cloud computing. Therefore, this perspective paper reviews the current state of volunteer and cloud computing to analyze what both domains could learn from each other. It turns out that the disclosed resource sharing shortcomings of volunteer computing could be addressed by technologies that have been invented, optimized, and adapted for entirely different purposes by cloud-native companies like Uber, Airbnb, Google, or Facebook. Promising technologies might be containers, serverless architectures, image registries, distributed service registries, and all have one thing in common: They already exist and are all tried and tested in large web-scale deployments.</text>
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                <text>2020</text>
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                <text>cloud computing, HPC, grid computing, supercomputing, volunteer computing, micro-service</text>
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                <text>DOI: 10.3390/fi12060098</text>
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                <text>Future Internet</text>
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                <text>MDPI AG</text>
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                <text>Information technology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Early preemptive immunomodulators (corticosteroids) for severe pneumonia patients infected with SARS-CoV-2</text>
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                <text>Jin Han Kang, Kyung Yil Lee, Jungwoo Rhim</text>
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                <text>DOI: 10.3345/cep.2020.00290</text>
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                <text>Ping Xu, Zhiqiang Zhang, Bo NING, Tian Xia, Jun SONG, Xiaoyan Ni, Chuang Qian, Da-Hui Wang, Yiming Zheng, Yanhui Jing, Xin-Hong Pei, Chunxing Wu, Yueqiang Mo, Wanlin Sun, Junrong Meng</text>
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                <text>The outbreak of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged and spread rapidly throughout the world. As of February 29, 2020, 79 389 cases of COVID-19 have been reported, and the outbreak is linked to 2838 deaths. The population is generally susceptible to the disease, and differences in incubation periods after infection exist among individuals. These two aspects of COVID-19 pose significant challenges to pediatric orthopedic diagnosis and treatment. As a dedicated center for managing pediatric cases of SARS-CoV-2 in Shanghai, our hospital has mobilized all branches and departments to undertake joint actions for scientific prevention and control, precise countermeasure and comprehensive anti-epidemic efforts. Combined with our experience, we have consulted the relevant national regulations and the latest research advances and have formulated the prevention and control measures of SARS-CoV-2 infection, including outpatient, emergency, inpatient and surgical cares, for clinical practices of pediatric orthopedics according to the physicochemical properties of SARS-CoV-2. It may serve as practical references and recommendations for managing SARS-CoV-2 infection in other pediatric specialties and in other hospitals.</text>
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                <text>DOI: 10.1136/wjps-2020-000124</text>
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                <text>World Journal of Pediatric Surgery</text>
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                <text>Surgery, Pediatrics</text>
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                <text>COVID-19: time for paradigm shift in the nexus between local, national and global health</text>
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                <text>Elisabeth Paul, Garrett W. Brown</text>
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                <text>DOI: 10.1136/bmjgh-2020-002622</text>
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                <text>Medicine (General), Infectious and parasitic diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
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                <text>Transmission Dynamics Model of Coronavirus COVID-19 for the Outbreak in Most Affected Countries of the World</text>
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              <elementText elementTextId="33763">
                <text>Mudassar Imran, Muhammad Dur-e-Ahmad</text>
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            <description>An account of the resource</description>
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                <text>The wide spread of coronavirus (COVID-19) has threatened millions of lives and damaged the economy worldwide. Due to the severity and damage caused by the disease, it is very important to fore-tell the epidemic lifetime in order to take timely actions. Unfortunately, the lack of accurate information and unavailability of large amount of data at this stage make the task more difficult. In this paper, we used the available data from the mostly affected countries by COVID-19, (China, Iran, South Korea and Italy) and fit this with the SEIR type model in order to estimate the basic reproduction number R_0. We also discussed the development trend of the disease. Our model is quite accurate in predicting the current pattern of the infected population. We also performed sensitivity analysis on all the parameters used that are affecting the value of R0.</text>
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                <text>2020</text>
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                <text>Sensitivity, basic reproductive number, coronavirus covid-19</text>
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            <name>Identifier</name>
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                <text>DOI: 10.9781/ijimai.2020.04.001</text>
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                <text>International Journal of Interactive Multimedia and Artificial Intelligence</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Universidad Internacional de La Rioja (UNIR)</text>
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                <text>Technology</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
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                <text>COVID-19 and Stroke Risk: A Double Whammy</text>
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              <elementText elementTextId="33772">
                <text>Alvee Saluja, Rajinder K Dhamija</text>
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                <text>The emphasis so far during the COVID-19 pandemic has been on the respiratory manifestations with little attention being given to neurological manifestations. Literature has shown multiple cases of stroke being associated with COVID-19. Thus, there is great interest in the role of the virus in stroke pathogenesis. Regarding hyperacute and acute stroke treatment, the routine guidelines for thrombolysis and thrombectomy are to be followed with emphasis on high suspicion of COVID-19 in stroke cases with respiratory symptoms or with contact/travel history. Secondary risk factor treatment for hypertension, diabetes, dyslipidemia is a must. We recommend continuing angiotensin converting enzyme 2 inhibitors/angiotensin II receptor blockers (ARBs) in those who are taking these medications as per evidence available. Mandatory lockdown has led to delay in presentation to the hospital with a decrease in thrombolysis due to ineligibility and a corresponding increase in primary thrombectomies being performed. Telemedicine could be an important tool to triage cases worthy of tertiary referral from other strokes and must be encouraged.</text>
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                <text>2020</text>
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                <text>Stroke, Risk factors, Pandemic, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.1055/s-0040-1712703</text>
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                <text>Annals of the National Academy of Medical Sciences (India)</text>
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                <text>National Academy of Medical Sciences</text>
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                <text>General Works</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
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                <text>Remote Eye-Tracking for Cognitive Telerehabilitation and Interactive School Tasks in Times of COVID-19</text>
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            <name>Creator</name>
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              <elementText elementTextId="33781">
                <text>Rosa Angela Fabio, Tindara Caprì, Andrea Nucita, Lucia Lo Bello, Giancarlo Iannizzotto</text>
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            <description>An account of the resource</description>
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                <text>In the attempt to mitigate the effects of COVID-19 lockdown, most countries have recently authorized and promoted the adoption of e-learning and remote teaching technologies, often with the support of teleconferencing platforms. Unfortunately, not all students can benefit from the adoption of such a surrogate of their usual school. We were asked to devise a way to allow a community of children affected by the Rett genetic syndrome, and thus unable to communicate verbally, in writing or by gestures, to actively participate in remote rehabilitation and special education sessions by exploiting eye-gaze tracking. As not all subjects can access commercial eye-tracking devices, we investigated new ways to facilitate the access to eye gaze-based interaction for this specific case. The adopted communication platform is a videoconferencing software, so all we had at our disposal was a live video stream of the child. As a solution to the problem, we developed a software (named SWYG) that only runs at the “operator” side of the communication, at the side of the videoconferencing software, and does not require to install other software in the child’s computer. The preliminary results obtained are very promising and the software is ready to be deployed on a larger base. While this paper is being written, several children are finally able to communicate with their caregivers from home, without relying on expensive and cumbersome devices.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>telerehabilitation, video conferencing, COVID-19, video-based eye-gaze tracking, remote interactive education</text>
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                <text>DOI: 10.3390/info11060296</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Information</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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            </elementTextContainer>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="33788">
                <text>Information technology</text>
              </elementText>
            </elementTextContainer>
          </element>
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</itemContainer>
