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                <text>Reflexiones sobre el COVID-19, el Colegio Médico del Perú y la Salud Pública</text>
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                <text>Ciro Maguiña Vargas</text>
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                <text>Esta nueva enfermedad (COVID-19), ha desnudado de manera cruda y real, la terrible situación sanitaria del Perú: hospitales viejos, falta de materiales, laboratorios especializados, camas, ventiladores, especialistas, y una población geriátrica abandonada, médicos mal remunerados, sin seguro médico, y como nunca, falta de equipos de bioseguridad para combatir a este nuevo flagelo.</text>
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                <text>Acta Médica Peruana</text>
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                <text>The role of hydroxychloroquine sulfate in the geriatric patient with coronavirus disease 2019 (COVID-19). What is useful to know for the geriatrician?</text>
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                <text>Ciro Manzo</text>
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                <text>The role of hydroxychroloquine (HCQ) sulfate as therapeutic option in coronavirus disease 2019 (COVID-19) patients aroused great interest and hope, so much so as to authorize several studies in the world. Despite the beneficial effects demonstrated in vitro and in some case-series, doubts remain about its clinical use, so that at present more than 20 different therapeutic study protocols have been proposed. Very recently, a protocol has been authorized by the Italian Medicines Agency (AIFA), in order to evaluate the efficacy of out-of-hospital treatment with HCQ in the reducing viral loads and need for hospitalization in symptomatic COVID-19 infected patients who are confined at home. The article describes lights and shadows of HCQ therapy in the elderly and geriatric patients affected by COVID-19, and suggests that the geriatrician should use HCQ only after careful patient selection and be aware of its pharmacokinetic properties and adverse effects, before better-designed studies determine their benefit, if any, in treating COVID-19.</text>
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                <text>geriatric patient, Hydroxychloroquine sulfate, COVID-19</text>
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                <text>DOI: 10.4081/gc.2020.9015</text>
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                <text>Impact of Confinement on the Burden of Caregivers of Patients with the Behavioral Variant of Frontotemporal Dementia and Alzheimer Disease during the COVID-19 Crisis in France</text>
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                <text>Claire Boutoleau-Bretonnière, Hélène Pouclet-Courtemanche, Aurélie Gillet, Amélie Bernard, Anne-Laure Deruet, Inès Gouraud, Estelle Lamy, Aurélien Mazoué, Laëtitia Rocher, Cédric Bretonnière, Mohamad El Haj</text>
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                <text>Introduction: The clinical presentation of the behavioral variant of frontotemporal dementia (bvFTD) differs from that of Alzheimer disease (AD), with major impairments in behavioral functions in bvFTD and cognitive impairment in AD. Both behavioral disturbances in bvFTD and cognitive impairment in AD contribute to caregiver burden. Objective: To investigate the impact of home confinement during the COVID-19 crisis on the burden of caregivers of bvFTD or AD patients. Methods: During the COVID-19 lockdown in France, neurologists and neuropsychologists from the Memory Center of Nantes Hospital conducted teleconsultations for 38 AD patients and 38 bvFTD patients as well as for their caregivers. During these consultations, caregivers were invited to rate the change in their burden during home confinement. They were also invited to rate behavioral or emotional changes in the patients during, compared with before, the confinement. Results: Twenty-two bvFTD caregivers and 14 AD caregivers experienced an increase in burden. For bvFTD caregivers, this increased burden occurred regardless of behavioral changes, while AD caregivers experienced an increased burden related to changes in patients’ neuropsychiatric symptoms. Among the whole cohort, 2 factors were associated with increased caregiver burden: behavioral change and bvFTD. Conclusion: The results demonstrate that during home confinement in the COVID-19 crisis, neuropsychiatric symptoms were the core factor that impacted caregiver burden in different ways depending on the disease.</text>
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                <text>covid-19, Confinement, Alzheimer disease, behavioral disorders, Behavioral variant of frontotemporal dementia</text>
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                <text>10.1159/000511416</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Neurology. Diseases of the nervous system, Geriatrics</text>
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