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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Infodemic in the Global Coronavirus Crisis</text>
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                <text>Vahideh Zareh Gavgani</text>
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                <text>In December 26, 2019, 4 unusual cases of pneumonia were recorded in China, three of those were from the same family. Another 3 cases of pneumonia were found in the same hospital in December 28 and 29(1). The virus started to expand rapidly so that doctors in Wuhan Hospital reported the phenomenon to China’s CDC and WHO. The research articles began to publish online from the first of January.  The Coronavirus news spread out as quickly as the virus. The virus was named new coronavirus 2019 (nCoV 2019). In January 7, 2020 the disease caused by the virus was identified as CoVID 19 (1). The altmetrics database indicates the first mentions to the peer reviewed articles about coronavirus has been tracked in social media like Twitter and Facebook since January 16,2020. The majority of mentions aggregated from the public profiles. The scientists, practitioners (like doctors) and science communicators (like journalists) were the other group of people who mentioned the scientific articles. This could be a dangerous sign for risk communication, at the same time. The public are the main group who follow the news and information on the social media but not all of the public know how to distinguish misinformation from the truth.&amp;nbsp;  In January 30, the coronavirus was identified as a global health threat requiring collaboration of all countries (2). In February, the virus spread out of the China and immediately became the headline of news media. In Mach 8,2020 the China health department claimed that the outbreak has been controlled and Wuhan closed makeshift hospitals(4,5) but the disease surges in Iran. The first cases of coronavirus were formally reported in 19 February 2020 in Qum city of Iran (3). At the moment, the highest rank of mortality caused by the pandemic relates to Italy, Iran, and South Korea (6). People surf the web and social media impatiently for information on cause, transmission, control and prevention of coronavirus disease (CoViD 19).&amp;nbsp; They often use and re-publish the information they find online before recognizing their trustworthiness and the evidence behind them.&amp;nbsp;&amp;nbsp;&amp;nbsp;&amp;nbsp;  The open access and democratic nature of health communication in social media and the Internet provide opportunity for distribution of myths and truths about coronavirus. Distribution of misinformation among public, damages public health and creates distrust to authorized sources of information. Therefore, misinformation epidemic is more dangerous than the crises.  Goffman in 1964 (13) and then Eysenbach recognized and introduced the prevalence of misinformation epidemic through online health information seeking in 2002 (7). He found that most of health information that disseminate during epidemic in social media and internet disagree the evidence (8,9). He called the methods of identifying, studying and management of misinformation as infodemiology. Infodemiology progresses in crises, specially the public health crises, in which abundant of misinformation becomes accessible for public and creates complexity instead of solving the problem.  WHO director in the Munich Security Conference held in 15 February doubted about distribution of misinformation about the epidemic of coronavirus and called it the infodemic by declaring that we are not fighting an epidemic, we are fighting infodemic and this requires global collaboration (10,11).  In crises, public informing of the methods of evaluation of information resources is not a right strategy for tackling with dissemination of misinformation. Novel strategies are needed to tackle with new infodemic crises and to assure that right information disseminated from the trusted sources to people at the right time. We also need to guarantee that people take the right action by receiving the right information in coronavirus epidemic. Hence, the WHO’s Risk Communication Team launched a new information platform called WHO Information Network for Epidemics (EPI-WIN) (2). One of the methods that this team follows is identifying misinformation in social media, searching and finding related scientific evidence with them from sources such as scientific papers and publishing them on EPIWIN website to provide accurate information for information hunger of the people. Today, infodemic crises have become one of the priorities of health decision making authorities in the world. We also warn our society about misinformation distributed among public in the form of news, recommendation and guidelines about coronavirus. Misinformation caused more than 27 deaths by direct consumption of alcohol and detergents to avoid the risk of coronavirus in Iran (12).&amp;nbsp; Recommending use of some foods, drugs and plants without scientific evidence increases rapidly among people. Some of these products like Descurainia sophia, garlic, cinnamon, nigella seeds, wild rue seeds have no evidence and some like Vitamin D have been proved to be effective by the evidence but are misinformed and distorted.&amp;nbsp;&amp;nbsp;  These are just examples of misinformation epidemic on coronavirus 2019 pneumonic. Still there are further issues to discuss and to study about the psychological adverse effects. The spread of misinformation about coronavirus has political, industrial, economical and health related aspects which require specific strategies for treatment. It is required that a team is formed in Iran for tracking, controlling and managing the contamination of information to assess information evidence.</text>
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                <text>health communication, communication, Information literacy, Health System, Information dissemination, online social networking, coronavirus disease (covid-19)</text>
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                <text>Taṣvīr-i salāmat</text>
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                <text>Tabriz University of Medical Sciences</text>
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                <text>Sara Manti, Salvatore Leonardi, Giuseppe Fabio Parisi, Maria Papale, Novella Rotolo, Enza Mulè, Donatella Aloisio</text>
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                <text>DOI: 10.3389/fmed.2020.00307</text>
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                <text>Frontiers in Medicine</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Medicine (General)</text>
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                <text>Recent Understandings Toward Coronavirus Disease 2019 (COVID-19): From Bench to Bedside</text>
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                <text>Jie Yu, Xianqun Fan, Shengfang Ge, Peiwei Chai</text>
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                <text>In late December 2019, an unprecedented outbreak of coronavirus disease 2019 (COVID-19) caused by SARS coronavirus 2 (SARS-CoV-2) (previously named 2019-nCoV) in Wuhan became the most challenging health emergency. Since its rapid spread in China and many other countries, the World Health Organization (WHO) declared COVID-19 a public health emergency of international concern (PHEIC) on 30th January 2020 and a pandemic on 11th March 2020. Thousands of people have died, and there are currently no vaccines or specific antiviral drugs for COVID-19. Therefore, it is critical to have a comprehensive understanding of the virus. In this review, we highlight the etiology, epidemiology, pathogenesis and pathology, clinical characteristics, diagnosis, clinical management, prognosis, infection control and prevention of COVID-19 based on recent studies.</text>
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                <text>DOI: 10.3389/fcell.2020.00476</text>
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                <text>Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus?</text>
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                <text>COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients.</text>
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                <text>DOI: 10.3389/fcimb.2020.00327</text>
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                <text>Frontiers in Cellular and Infection Microbiology</text>
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                <text>Schools That ‘Open Doors’ to Prevent Child Abuse in Confinement by COVID-19</text>
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                <text>Patricia Melgar, Esther Roca, Regina Gairal Casadó, Miguel  A. Pulido-Rodríguez</text>
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            <description>An account of the resource</description>
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                <text>Background: Due to the expected increase in child abuse during the period of COVID-19 confinement, it is essential that social researchers and other professionals work together very quickly to provide alternatives that protect children. To respond to this extremely urgent demand, evidence-based actions are presented that are being carried out in nine schools in the autonomous communities of Valencia and Murcia, Spain, during the confinement with the goal of “opening doors” to foster supportive relationships and a safe environment to prevent child abuse. Methods: The research was conducted through the inclusion of teachers who are implementing these actions in dialogue with the researchers to define the study design, analysis, and discussion of the results. Results: Knowledge regarding six evidence-based actions is provided: (1) dialogic workspaces, (2) dialogic gatherings, (3) class assemblies, (4) dialogic pedagogical gatherings with teachers, (5) mixed committees, and (6) dynamisation of social networks with preventive messages and the creation of a sense of community, which are being implemented virtually.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>prevention, Child abuse, COVID-19</text>
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                <text>DOI: 10.3390/su12114685</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Sustainability</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
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                <text>MDPI AG</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
              </elementText>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Transmission of SARS-CoV-2, Required Developments in Research and Associated Public Health Concerns</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="34872">
                <text>Jianbo Liu, Suliman Khan, Mengzhou Xue</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading across the world to cause thousands of mortalities each day. Poor responses from the authorities to the spread of infection, lack of effective measures for prevention, unavailability of promising treatment options, and sufficient diagnostic options have created an alarming for the world. The transmission routes from human to human of SARS-CoV-2 can be the direct transmission, droplet inhalation transmission, contact transmission, transmission through saliva, and transmission via fecal–oral routes. Due to the asymptomatic spread of SARS-CoV-2's, developing control and prevention measures is challenging. Implementing proper strategies addressing the infection control and clinical supplies, understanding the mechanism associated with pathogenesis, advancing in preventive measures and effective treatment and diagnostic options are necessary to control the ongoing pandemic. In this article, we briefly discuss the features, entry mechanism, infectiousness, and health consequences related to the COVID-19 outbreak.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Challenges, prevention, Infectiousness, medical consequences, Coronavirus outbreak</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="34876">
                <text>DOI: 10.3389/fmed.2020.00310</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Frontiers in Medicine</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine (General)</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <description>A name given to the resource</description>
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                <text>Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="34881">
                <text>Müşerref Duygu Saçar Demirci, Aysun Adan</text>
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            <description>An account of the resource</description>
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                <text>MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression found in more than 200 diverse organisms. Although it is still not fully established if RNA viruses could generate miRNAs, there are examples of miRNA like sequences from RNA viruses with regulatory functions. In the case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there are several mechanisms that would make miRNAs impact the virus, like interfering with viral replication, translation and even modulating the host expression. In this study, we performed a machine learning based miRNA prediction analysis for the SARS-CoV-2 genome to identify miRNA-like hairpins and searched for potential miRNA-based interactions between the viral miRNAs and human genes and human miRNAs and viral genes. Overall, 950 hairpin structured sequences were extracted from the virus genome and based on the prediction results, 29 of them could be precursor miRNAs. Targeting analysis showed that 30 viral mature miRNA-like sequences could target 1,367 different human genes. PANTHER gene function analysis results indicated that viral derived miRNA candidates could target various human genes involved in crucial cellular processes including transcription, metabolism, defense system and several signaling pathways such as Wnt and EGFR signalings. Protein class-based grouping of targeted human genes showed that host transcription might be one of the main targets of the virus since 96 genes involved in transcriptional processes were potential targets of predicted viral miRNAs. For instance, basal transcription machinery elements including several components of human mediator complex (MED1, MED9, MED12L, MED19), basal transcription factors such as TAF4, TAF5, TAF7L and site-specific transcription factors such as STAT1 were found to be targeted. In addition, many known human miRNAs appeared to be able to target viral genes involved in viral life cycle such as S, M, N, E proteins and ORF1ab, ORF3a, ORF8, ORF7a and ORF10. Considering the fact that miRNA-based therapies have been paid attention, based on the findings of this study, comprehending mode of actions of miRNAs and their possible roles during SARS-CoV-2 infections could create new opportunities for the development and improvement of new therapeutics.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>microRNA, host–virus interaction, SARS-CoV-2, COVID-19</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="34885">
                <text>DOI: 10.7717/peerj.9369</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="34886">
                <text>PeerJ</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="34887">
                <text>PeerJ Inc.</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>COVID-19: The Case of Three Patients with the Same Diagnosis but Different Clinical and Laboratory Features</text>
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                <text>Sukhdev Singh, Zohaib Khan, Muhammed Atere, Lloyd Muzangwa, Krisha Arora, Urvi Bhavsar, Jay M. Nfonoyim</text>
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                <text>SARS-CoV-2 is an RNA virus that causes COVID-19, which has been responsible for the pandemic that was declared in early 2020. Its pathological effect is majorly in the respiratory tract, but its full pathogenicity remains a mystery. Symptoms associated with COVID-19 include fever, cough, and shortness of breath. Some patients develop other symptoms like diarrhea. However, it is possible for other organs to be affected including the central nervous system, liver, and blood cells. The purpose of this case series is to unravel other factors associated with this disease, so we report three cases of COVID-19 that were hospitalized during the pandemic.</text>
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                <text>DOI: 10.1155/2020/9185041</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Case Reports in Medicine</text>
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                <text>Hindawi Limited</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>ACE2, Much More Than Just a Receptor for SARS-COV-2</text>
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                <text>Lobelia Samavati, Bruce D. Uhal</text>
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                <text>The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. As such, it is now receiving renewed attention as a potential target for anti-viral therapeutics. We review the physiological functions of ACE2 in the cardiovascular system and the lungs, and how the activation of ACE2/MAS/G protein coupled receptor contributes in reducing acute injury and inhibiting fibrogenesis of the lungs and protecting the cardiovascular system. In this perspective, we predominantly focus on the impact of SARS-CoV-2 infection on ACE2 and dysregulation of the protective effect of ACE2/MAS/G protein pathway vs. the deleterious effect of Renin/Angiotensin/Aldosterone. We discuss the potential effect of invasion of SARS-CoV-2 on the function of ACE2 and the loss of the protective effect of the ACE2/MAS pathway in alveolar epithelial cells and how this may amplify systemic deleterious effect of renin-angiotensin aldosterone system (RAS) in the host. Furthermore, we speculate the potential of exploiting the modulation of ACE2/MAS pathway as a natural protection of lung injury by modulation of ACE2/MAS axis or by developing targeted drugs to inhibit proteases required for viral entry.</text>
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                <text>lung, angiotensin, Alveolar, Coagulopathy, COVID-19</text>
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                <text>DOI: 10.3389/fcimb.2020.00317</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Frontiers in Cellular and Infection Microbiology</text>
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                <text>Microbiology</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Adolescents’ face mask usage and contact transmission in novel Coronavirus</text>
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                <text>Fang-Lin Chao</text>
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                <text>The global outbreak of coronavirus has become an international public health threat. Prevention is of paramount importance to contain its spread. This study observes face mask wearing behavior and contact transmission problems in Taiwan. Teachers track student status in class. In addition to measuring body temperature and regular disinfection, classrooms require ventilation wear mask, provide alcohol spray and avoid sharing the microphone. Both questionnaire surveys and experimental were utilized. A total of 160 adults residing in Taiwan participated in the survey. The dye simulated the possible virus area on the mask surface during usage. Subjects were required to complete a questionnaire and simulate the spread of contact transmission when using a computer. Eighty-one % of respondents reported consistent use of surgical masks several times a day. They reported taking their masks off in relatively safe areas. Most people reported using one mask per day and storing the masks in their pockets. As a result, masks surface become a contamination source. In the contact experiment, ten adults were requested to don and doff a surgical mask while doing a word processing task. The extended contamination areas were recorded and identified by image analysis. The results show an average contamination area of the workspace is significant 530 cm2. When the hand touches the surface of the mask, it may spread the virus to the subsequent contact area.</text>
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                <text>2020</text>
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                <text>Contact transmission, novel coronavirus, face mask usage</text>
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                <text>DOI: 10.4081/jphr.2020.1771</text>
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                <text>Journal of Public Health Research</text>
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                <text>PAGEPress Publications</text>
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                <text>Public aspects of medicine</text>
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