408 10 20655 https://www.socictopen.socict.org/files/original/20bb2a208549e6b44a9ab502f3e994a0.pdf 9dc7b300e6ff7aebf638a1cdcd13629c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Q&A: The novel coronavirus outbreak causing COVID-19 Creator An entity primarily responsible for making the resource Dale Fisher, David Heymann Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12916-020-01533-w Source A related resource from which the described resource is derived BMC Medicine Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/e227734f3357b56c1cc255c5548fc6dd.pdf 636c4db36c4ae6b57bda8d2370ccd8cb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Examining the application of behaviour change theories in the context of infectious disease outbreaks and emergency response: a review of reviews Creator An entity primarily responsible for making the resource Dale Weston, Richard Amlôt, Athena Ip Description An account of the resource Abstract Background Behavioural science can play a critical role in combatting the effects of an infectious disease outbreak or public health emergency, such as the COVID-19 pandemic. The current paper presents a synthesis of review literature discussing the application of behaviour change theories within an infectious disease and emergency response context, with a view to informing infectious disease modelling, research and public health practice. Methods A scoping review procedure was adopted for the searches. Searches were run on PubMed, PsychInfo and Medline with search terms covering four major categories: behaviour, emergency response (e.g., infectious disease, preparedness, mass emergency), theoretical models, and reviews. Three further top-up reviews was also conducted using Google Scholar. Papers were included if they presented a review of theoretical models as applied to understanding preventative health behaviours in the context of emergency preparedness and response, and/or infectious disease outbreaks. Results Thirteen papers were included in the final synthesis. Across the reviews, several theories of behaviour change were identified as more commonly cited within this context, specifically, Health Belief Model, Theory of Planned Behaviour, and Protection Motivation Theory, with support (although not universal) for their effectiveness in this context. Furthermore, the application of these theories in previous primary research within this context was found to be patchy, and so further work is required to systematically incorporate and test behaviour change models within public health emergency research and interventions. Conclusion Overall, this review identifies a range of more commonly applied theories with broad support for their use within an infectious disease and emergency response context. The Discussion section details several key recommendations to help researchers, practitioners, and infectious disease modellers to incorporate these theories into their work. Specifically, researchers and practitioners should base future research and practice on a systematic application of theories, beginning with those reported herein. Furthermore, infectious disease modellers should consult the theories reported herein to ensure that the full range of relevant constructs (cognitive, emotional and social) are incorporated into their models. In all cases, consultation with behavioural scientists throughout these processes is strongly recommended to ensure the appropriate application of theory. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource literature review, infectious disease, emergency response, Human behaviour, Protective behaviour Identifier An unambiguous reference to the resource within a given context 10.1186/s12889-020-09519-2 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/430cf49904e6da4030eaa5d73160b869.pdf 680d4d875225588b8443dabfbe3972c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 Vaccine Hesitancy among Young Adults in Saudi Arabia: A Cross-Sectional Web-Based Study Creator An entity primarily responsible for making the resource Dalia Almaghaslah, Abdulrhman Alsayari, Geetha Kandasamy, Rajalakshimi Vasudevan Description An account of the resource Ending the COVID-19 pandemic requires achieving herd immunity, either by previous infection or by vaccination. However, concerns about the COVID-19 vaccine are growing around the globe. The current study was conducted to investigate young the adult population’s hesitancy towards the vaccine. The study used a prospective cross-sectional design. Data was collected using an online self-administered questionnaire. A total of 862 Saudi adults participated. Information was gathered on the participants’ perspectives towards the severity and susceptibility of the COVID-19 infection, reasons for their hesitancy to receive the vaccine, perceived benefits, and reasons for action. Just under a quarter (19.6%) of respondents had previously tested positive for COVID-19. A small minority of the participants had already received the vaccine (2.1%), while 20.3% had registered in the Sehaty app (application) to receive the vaccine. Just under half of them (48%) will take the vaccine when mass vaccination is achieved and approximately the same number (46.7%) will only take it if it is made mandatory. Vaccine reluctance is highly prevalent among the general public in Saudi Arabia during the COVID-19 pandemic. While many are aware of a high likelihood of getting the infection, the efficacy and safety of the COVID-19 vaccine were reported as barriers to vaccination. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Vaccination hesitancy, Saudi Arbia, vaccine reluctance Identifier An unambiguous reference to the resource within a given context 10.3390/vaccines9040330 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/b54f633acdaf14c95f3df6af1aff8012.pdf fbb384a2ad7e416b243df383146d8444 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource USA stockpiling of remdesivir: How should the world respond? Creator An entity primarily responsible for making the resource Dalia Dawoud, Kalipso Chalkidou, Richard Sullivan, Francis J Ruiz, Amanda Adler Description An account of the resource The race to find an effective treatment for coronavirus disease 2019 (COVID-19) is still on, with only two treatment options currently authorized for emergency use and/or recommended for patients hospitalized with severe respiratory symptoms: low-dose dexamethasone and remdesivir. The USA decision to stockpile the latter has resulted in widespread condemnation and in similar action being taken by some other countries. In this commentary we discuss whether stockpiling remdesivir is justified in light of the currently available evidence. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, antiviral, covid-19, SARS-CoV-2, Remdesivir, Dexamethasone, stockpiling Identifier An unambiguous reference to the resource within a given context 10.2217/cer-2020-0174 Source A related resource from which the described resource is derived Journal of comparative effectiveness research https://www.socictopen.socict.org/files/original/deb9802f0f04915e087e29ddbff5c680.pdf ae08a26d7821300729d16576339498a1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Diagnóstico socio-ambiental de la producción agrícola en el páramo de Rabanal (Colombia) como base para su reconversión agroecológica Creator An entity primarily responsible for making the resource Dalia Soraya Useche de Vega, Sara María Márquez-Girón Description An account of the resource En las partes más altas de las montañas andinas, entre los límites superior de bosques e inferior de zonas nivales, se encuentran los páramos; en Colombia se localizan en las cordilleras Occidental, Central y Oriental, y en la Sierra Nevada de Santa Marta; abarcan gran extensión del país y tienen máxima representatividad en el departamento de Boyacá, en donde abastecen acueductos municipales y veredales.  Dadas las características geológicas, climáticas y edáficas de los páramos, se han desarrollado en ellos la extracción minera (principalmente carbón) y actividades agropecuarias (principalmente papa y pastoreo de vacunos y ovinos) sobre 3.000 msnm; pero las ventajas ofrecidas por este medio natural para desarrollar estas actividades contrastan con su susceptibilidad al deterioro y la vulnerabilidad edáfica. La aplicación de agroquímicos y la ampliación de la frontera agropecuaria son actividades que alteran negativamente el ecosistema de páramo, impactan los recursos naturales, la biodiversidad y las fuentes hídricas; pero el enfoque agrícola actual del país no permite analizar las relaciones socio-económicas existentes entre la población, ni las necesidades, ni, mucho menos, las potencialidades de los campesinos asentados allí. Ante esta problemática se pretende, bajo un enfoque de sistemas ya partir del diagnóstico socioeconómico y ambiental y de la comprensión de la realidad campesina, vincular, mediante estrategias de sensibilización, a la comunidad para que participe activamente en la evaluación de la salud del suelo y del cultivo y en la identificación y reconocimiento de la biodiversidad existente, así como de la capacidad de resiliencia del agroecosistema. Todo esto teniendo como principio la agroecología, en la búsqueda de una alternativa socialmente viable y ambientalmente sostenible en este ecosistema de especial protección. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource Agroecosistema, Páramos, biodiversidad, frontera agropecuaria, resiliencia del agrosistema Identifier An unambiguous reference to the resource within a given context 10.19053/01228420.4111 Source A related resource from which the described resource is derived Ciencia y Agricultura Publisher An entity responsible for making the resource available Universidad Pedagógica y Tecnológica de Colombia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Agriculture Relation A related resource <a href="http://revistas.uptc.edu.co/revistas/index.php/ciencia_agricultura/article/view/4111" target="_blank" rel="noreferrer noopener">http://revistas.uptc.edu.co/revistas/index.php/ciencia_agricultura/article/view/4111</a> https://www.socictopen.socict.org/files/original/9b0903bcb58e80b95cfd93476373ee37.pdf 007810c682f9cdf58a93bfba0fce41ba Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Slow-release and organic fertilizers on early growth of Rangpur lime Creator An entity primarily responsible for making the resource Dalmo Lopes de Siqueira, Dierlei dos Santos, Cicero Cartaxo de Lucena, Daniel Lucas Magalhães Machado, Tiago Barbosa Struiving, Pedro Henrique Monteiro Matarazzo Description An account of the resource Slow-release and organic fertilizers are promising alternatives to conventional fertilizers, as both reduce losses by leaching, volatilization and problems of toxicity and/or salinity to plants. The objective of this work was to evaluate the effect of different rates of the organic fertilizer Humato-Macota® compared with the slow-release fertilizer Osmocote® on the growth and nitrogen content in the dry matter of Rangpur lime. A field experiment was conducted in a factorial completely randomized design with an additional treatment (4 x 4 +1). The first factor consisted of four Humato­Macota® rates (0, 1, 2, and 3%) applied to the substrate; the second factor consisted of the same Humato-Macota® concentrations, but applied as fortnightly foliar sprays; the additional treatment consisted of application of 5 kgm-3 Osmocote® 18-05-09. Means of all growth characteristics (plant height, total dry matter, root/shoot ratio and leaf area) and the potential quantum yield of photosystem II (Fv/Fm) were higher when plants were fertilized with the slow-release fertilizer. The organic fertilizer applied alone did not meet the N requirement of Rangpur lime. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource Adubação, Citrus limonia L. Osbeck, fertilizante orgânico Identifier An unambiguous reference to the resource within a given context 10.1590/S0034-737X2011000300017 Source A related resource from which the described resource is derived Revista Ceres Publisher An entity responsible for making the resource available Universidade Federal de Viçosa Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Biotechnology Relation A related resource <a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0034-737X2011000300017&amp;lng=en&amp;tlng=en" target="_blank" rel="noreferrer noopener">http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0034-737X2011000300017&amp;lng=en&amp;tlng=en</a> https://www.socictopen.socict.org/files/original/b1827c0ea9c22904a3f8703cdf176c59.pdf f62f9d8ac895f2cbd4091b05e2d901cd Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Herbicides in the Irrigated Rice Production System in Babahoyo, Ecuador, Using Neutrosophic Statistics Creator An entity primarily responsible for making the resource Dalton Cadena-Piedrahita, Salomón Helfgott-Lerner, Andrés Drouet-Candel, Fernando Cobos-Mora, Nessar Rojas-Jorgge Description An account of the resource Rice cultivation is of great importance worldwide, due to its nutritional properties and becauseit is part of many plates of the inhabitants of all continents. Weeds are part of the factors that affect riceproduction, which is why it is necessary to apply herbicides, including the modality of the presence ofherbicides in irrigation. This paper aims to carry out a statistical study on the effectiveness of differenttreatments to eliminate the weeds of the INDIA SFL 11 rice variety in Babahoyo, Ecuador. The evaluationof some results of the treatments was carried out visually based on both weed control and herbicidetoxicity by using linguistic terms that are associated with an indeterminate scale of percentages, wherethe data are given in the form of intervals and not in crisp values. Additionally other seven criteria arealso utilized. Thus, we decided to apply neutrosophic statistics as a study tool for this problem. Neutrosophic statistics extends classical statistics theory to the framework of neutrosophy, where intervals areused instead of analyzing crisp values. Specifically, Tukey's test is applied in comparing some data inform of intervals that denotes the imprecision of the obtained measurement Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Tukey’s test, herbicides, neutrosophic statistics, rice, weed Identifier An unambiguous reference to the resource within a given context 10.5281/zenodo.4444953 Source A related resource from which the described resource is derived Neutrosophic Sets and Systems Publisher An entity responsible for making the resource available University of New Mexico Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Mathematics, Electronic computers. Computer science Relation A related resource <a href="http://fs.unm.edu/NSS/HerbicidesInTheIrrigatedRiceProductionSystemInBabahoyo13.pdf" target="_blank" rel="noreferrer noopener">http://fs.unm.edu/NSS/HerbicidesInTheIrrigatedRiceProductionSystemInBabahoyo13.pdf</a> https://www.socictopen.socict.org/files/original/0c16e343d57b868fc53d421e29161e7d.pdf 094ca12948d8da9534fe056b1ae7071c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource PRODUTOS ORGÂNICOS Creator An entity primarily responsible for making the resource Dalva Santos Oliveira, Jéssica de Freitas Franco, Maria Claudete Alves de Campos Description An account of the resource Consideramos que somos o que comemos se necessário realizarmos uma seleção na busca da qualidade dos nossos alimentos. Entendemos que se priorizarmos o consumo de alimentos Orgânicos estaremos cuidando da nossa saúde física. Agricultura orgânica, ecológica, sustentável ou agroecológico são algumas das denominações para os sistemas agrícolas e alternativos. A agricultura alternativa busca evitar a ocorrência de impactos ambientais e sociais, com os resíduos de agrotóxico encontrados nos alimentos devido aos atuais sistemas agrícolas tradicionais modernos de produção. As práticas de produção agrícolas alternativas, ao contrário, procuram estabelecer uma relação de harmonia com a natureza. Para tanto, essa agricultura substitui o uso de adubos químicos tóxicos pela de origem orgânica (esterco, palhas forragens, restos de vegetais) e utilizam o controle biológico, que consiste em usar predadores naturais (fungos, larvas, vespas, besouros para controlar as doenças em pequenas e medias propriedades rurais que promovem a policultura cultivo de vários gêneros agrícolas) como forma de promover a biodiversidade necessária para manter o equilíbrio natural. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Identifier An unambiguous reference to the resource within a given context 10.15536/reducarmais.0.2014.%p.694 Source A related resource from which the described resource is derived Revista Educar + Publisher An entity responsible for making the resource available Instituto Federal Sul-Rio-Grandense (IFSul) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Education Relation A related resource <a href="https://periodicos.ifsul.edu.br/index.php/educarmais/article/view/694" target="_blank" rel="noreferrer noopener">https://periodicos.ifsul.edu.br/index.php/educarmais/article/view/694</a> https://www.socictopen.socict.org/files/original/3913e66a6d42a191d1cbfb379e3e7a6e.pdf 88328ab1eb9e702368fe411d5e6fe094 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Phytophthora Root Rot Modifies the Composition of the Avocado Rhizosphere Microbiome and Increases the Abundance of Opportunistic Fungal Pathogens Creator An entity primarily responsible for making the resource Damaris Desgarennes, Itzel A. Solís-García, Itzel A. Solís-García, Oscar Ceballos-Luna, Elvis Marian Cortazar-Murillo, Edith Garay-Serrano, Violeta Patiño-Conde, Edgar Guevara-Avendaño, Edgar Guevara-Avendaño, Alfonso Méndez-Bravo, Frédérique Reverchon Description An account of the resource The structure and function of rhizosphere microbial communities are affected by the plant health status. In this study, we investigated the effect of root rot on the avocado rhizosphere microbiome, using 16S rDNA and ITS sequencing. Furthermore, we isolated potential fungal pathogens associated with root rot symptoms and assessed their pathogenic activity on avocado. We found that root rot did not affect species richness, diversity or community structure, but induced changes in the relative abundance of several microbial taxa. Root rot increased the proportion of Pseudomonadales and Burkholderiales in the rhizosphere but reduced that of Actinobacteria, Bacillus spp. and Rhizobiales. An increase in putative opportunistic fungal pathogens was also detected in the roots of symptomatic trees; the potential pathogenicity of Mortierella sp., Fusarium spp., Lasiodiplodia sp. and Scytalidium sp., is reported for the first time for the State of Veracruz, Mexico. Root rot also potentially modified the predicted functions carried out by rhizobacteria, reducing the proportion of categories linked with the lipid and amino-acid metabolisms whilst promoting those associated with quorum sensing, virulence, and antibiotic resistance. Altogether, our results could help identifying microbial taxa associated to the disease causal agents and direct the selection of plant growth-promoting bacteria for the development of biocontrol microbial consortia. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Fusarium, Mortierella, Persea americana, rhizosphere microbial communities, root necrotizing fungi Identifier An unambiguous reference to the resource within a given context 10.3389/fmicb.2020.574110 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Relation A related resource <a href="https://www.frontiersin.org/articles/10.3389/fmicb.2020.574110/full" target="_blank" rel="noreferrer noopener">https://www.frontiersin.org/articles/10.3389/fmicb.2020.574110/full</a> https://www.socictopen.socict.org/files/original/e655e0e123fe0f017f68f1745cfad40e.pdf 6d916f5918e389bc141b7a8313279268 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19 Creator An entity primarily responsible for making the resource Damian G. Romero, Licy L. Yanes Cardozo, Alexandra M. Huffman, Samar Rezq, Jelina Basnet Description An account of the resource SARS-CoV-2, the causative agent of COVID-19, infects host cells using the angiotensin I converting enzyme 2 (ACE2) as its receptor after priming by host proteases, including TMPRSS2. COVID-19 affects multiple organ systems, and male patients suffer increased severity and mortality. Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in reproductive-age women and is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. PCOS is associated with obesity and cardiometabolic comorbidities, both being risk factors associated with severe COVID-19 pathology. We hypothesize that elevated androgens in PCOS regulate SARS-CoV-2 entry proteins in multiple tissues increasing the risk for this population. Female mice were treated with dihydrotestosterone (DHT) for 90 days. Body composition was measured by EchoMRI. Fasting glucose was determined by an enzymatic method. mRNA and protein levels of ACE2, Tmprss2, Cathepsin L, Furin, Tmprss4, and Adam17 were quantified by RT-qPCR, Western-blot, or ELISA in tissues, serum, and urine. DHT treatment increased body weight, fat and lean mass, and fasting glucose. Ace2 mRNA was upregulated in the lung, cecum, heart, and kidney, while downregulated in the brain by DHT. ACE2 protein was upregulated by DHT in the small intestine, heart, and kidney. The SARS-CoV-2 priming proteases Tmprss2, Cathepsin L, and Furin mRNA were upregulated by DHT in the kidney. ACE2 sheddase Adam17 mRNA was upregulated by DHT in the kidney, which corresponded with increased urinary ACE2 in DHT treated mice. Our results highlight the potential for increased cardiac, renal, and gastrointestinal dysfunction in PCOS women with COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, Polycystic ovary syndrome, Androgen receptor, Androgens, angiotensin I converting enzyme 2 Identifier An unambiguous reference to the resource within a given context 10.3390/ijms22094472 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry