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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>In silico Molecular Docking Analysis Targeting SARSCoV-2 Spike Protein and Selected Herbal Constituents</text>
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                <text>Pallab Chaudhuri, Raj Kumar Singh, Kuldeep Dhama, Yashpal S. Malik, Prasad Thomas, Muthu Sankar, Shiv Varan Singh, Karthikeyan Ravichandran, Anbazhagan Subbaiyan</text>
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                <text>In modern drug discovery, molecular docking analysis is routinely used to understand and predictthe interaction between a drug molecule and a target protein from a microbe. Drugs identified inthis way may inhibit the entry and replication of pathogens in host cells. The SARS-CoV-2 associatedcoronavirus disease, COVID-19, has become the most contagious and deadly pandemic disease in theworld today. In abeyance of any specific vaccine or therapeutic against SARS-CoV-2, the burgeoningsituation urges a need for effective drugs to treat the virus-infected patients. Herbal medicines havebeen used as natural remedies for treating various infectious diseases since ancient times. The spike(S) protein of SARS-CoV-2 is important for the attachment and pathogenesis of the virus. Therefore,this study focused on the search of useful ligands for S protein among active constituents present incommon herbs that could serve as efficient remedies for COVID-19. We analysed the binding efficiencyof twelve compounds present in common herbs with the S protein of SARS-CoV-2 through moleculardocking analysis and also results are validated with two different docking tools. The binding efficiencyof ligands was scored based on their predicted pharmacological interactions coupled with bindingenergy estimates. In docking analysis, compound “I” (Epigallocatechin gallate (EGCG)) was found tohave the highest binding affinity with the viral S protein, followed by compounds, “F” (Curcumin),“D”(Apigenin) and “E” (Chrysophanol). The present study corroborates that compound “I” (EGCG) mostlypresent in the integrants of green tea, shows the highest potentiality for acting as an inhibitor of SARSCoV-2. Further, characterization of the amino acid residues comprising the viral binding site and thenature of the hydrogen bonding involved in the ligand-receptor interaction revealed significant findingswith herbal compound “I” (EGCG) binding to the S protein at eight amino acid residues. The bindingsites are situated near to the amino acids which are required for virus pathogenicity. The findings ofthe present study need in vivo experiments to prove the utility of “I”, “F”,“D” and “E” compounds andtheir further use in making herb-based anti-SARS-CoV-2 product in near future. This analysis may helpto create a new ethno-drug formulation for preventing or curing the COVID-19.</text>
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                <text>2020</text>
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                <text>molecular docking, spike protein, Herbal medicine, Ligands, in silico, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.22207/JPAM.14.SPL1.37</text>
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                <text>Journal of Pure and Applied Microbiology</text>
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                <text>Journal of Pure and Applied Microbiology</text>
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                <text>Microbiology</text>
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                <text>Caution of retinal toxicity using chloroquine and hydroxychloroquine in the treatment of COVID-19</text>
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            <elementTextContainer>
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                <text>He Sun, Liyuan Wang</text>
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                <text>“Chloroquine phosphate” was listed as a trial drug in diagnosis and treatment program of COVID-19(trial sixth edition), and the application of chloroquine and hydroxychloroquine treatment for COVID-19 in medical institutions also increased. Chloroquine and hydroxychloroquine have certain retinal toxicity, its mechanism is still unclear, due to different drug tolerance, the risk degree of retinal toxicity in COVID-19 treatment is unclear. Therefore, when using chloroquine and hydroxychloroquine in the treatment of COVID-19, it is recommended to choose the appropriate dosage according to patients' situation, and adopt necessary ophthalmic screening for patients with high risk to prevent the occurrence of retinopathy. In this paper, we described the risk factors, clinical manifestations and screening methods of retinal toxicity caused by chloroquine and hydroxychloroquine, in order to provide references for the safer use of chloroquine and hydroxychloroquine in the treatment of COVID-19.</text>
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                <text>2020</text>
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                <text>-, chloroquine, hydroxychloroquine, retinal toxicity, COVID-19</text>
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                <text>DOI: 10.3980/j.issn.1672-5123.2020.7.39</text>
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                <text>Guoji Yanke Zazhi</text>
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                <text>Press of International Journal of Ophthalmology (IJO PRESS)</text>
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                <text>Ophthalmology</text>
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                <text>Coronavirus Infection Prevention by Wearing Masks</text>
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                <text>Thi Sinh Vo, Tran Thi Bich Chau Vo, Tran Thi Thu Ngoc Vo</text>
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                <text>2020</text>
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                <text>DOI: 10.5152/eurasianjmed.2020.20056</text>
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                <text>Eurasian Journal of Medicine</text>
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                <text>AVES</text>
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                <text>Medicine (General)</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Interaction between SARS-CoV-2 and human organism</text>
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                <text>Dan Croitoru, Victor Pantea, Gheorghe Placinta, Valentin Cebotarescu, Lilia Cojuhari, Lidia Placinta</text>
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                <text>Background: COVID-19 is a part of the betacoronaviridae group, sabercoviridae subgroup. At the moment we are confronting a pandemy, which has a completely new pathologic pattern for the whole world. Considering the highly contagious characteristics of the virus, which is the cause of death for many people, and also the fact that many people continue to be infected with this virus there is a stringing necesity of combating this pandemy. Because of that we need the knowledge that regards the physiopathologic mechanisms, particularities of the host-invader interactions, relevance of asymptomatic forms, explanations of the evolving divergencies, posibility of recurrent infections, clinical signs, comorbidities that harshen this pathology, pharmacologic agents that are effective to fight the infection and immune mechanisms of defense in the organism. A great importance is given for the identification of the intial criteria needed for a prognostic, to prevent the critical forms of pathology and to set the parameters for the severity indicators. Conclusions: The research in the field of SARS-CoV-2 requires the gathering of the databases that are related to the investigated persons, to establish the clinico-evolutive differences for the COVID-19 patients according to many factors that could influence the course of the disease. An important difference is the identification of early signs and prevention of the critical disease forms, by extending the laboratory investigations, establishing the parameters for severity indicators through determining the degree of the immune response.</text>
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                <text>2020</text>
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                <text>coronavirus, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.5281/zenodo.3866031</text>
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                <text>The Moldovan Medical Journal</text>
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                <text>Scientific Medical Association of Moldova</text>
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                <text>Medicine</text>
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                <text>Eugenio Pomarici, Roberta Sardone</text>
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                <text>Abstract The EU Common Agricultural Policy (CAP), and with it the EU wine policy, is experiencing a reform process, started in 2018, in order to address ambitious environmental and social objectives, in conjunction with the goal of a competitive agricultural sector. Given the role of the EU in wine supply, the aim of this paper is to present the design, the rationale and the potential effect of the proposed reform with specific reference to wine sector. To better understand the forthcoming process, it is firstly presented how CAP and its wine policy evolved in terms of objectives and tools over time. The EU wine policy is a paradigmatic example of a combination between the horizontal measures, valid for all agricultural sectors, and vertical measures, peculiarly encompassing the whole wine supply chain. The reform proposal confirms, with some interesting modifications, the set of tools already operating in the sector; however, it calls for a planning of the implementation of the available tools for all products in a unitary frame represented by a national CAP Strategic Plan, applying a lean administrative procedure. In the hypothesis that the COVID-19 outbreak will not cause a radical change in the global agri-food system, the proposed planning process should stimulate shared strategies. These are intended to effectively coordinate, according to the principle of complementarity, the implementation of available policy tools, in order to obtain a better use of resources and a more balanced achievement of all policy objectives.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37611">
                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37612">
                <text>cap reform, Wine sustainability, CAP Strategic Plan, EU wine sector performance</text>
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            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="37613">
                <text>DOI: 10.1186/s40100-020-00159-z</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37614">
                <text>Agricultural and Food Economics</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="37615">
                <text>SpringerOpen</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="37616">
                <text>Nutrition. Foods and food supply, Agricultural industries</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>A Review of Potential Antiviral Drugs and Vaccines to Treat COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="37618">
                <text>Sanjeet Singh, R Jayaram</text>
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            <description>An account of the resource</description>
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                <text>Coronavirus disease 19 (COVID-19) is a challenge to the whole humanity. COVID-19 was first reportedin China and rigorous researches are going on for developing vaccine for the pandemic. This review wasprepared by following PRISMA guidelines and used the resources from the Web of Science and PubMed.This research focuses on the niches of symptoms and vaccines for COVID-19. The research for vaccineinvolves research for new vaccine and drug repurposing. Out of various drug repurposing options,Remdesivir, and Favipiravir, Chloroquine and Lopinavir/Ritonavir were found to be the popular onesfor treating COVID-19 patients across the world. Even though there are concerns regarding asymptoticpatients, the most dominant symptoms of COVID-19 are fever and cough, followed by Dyspnoea andmuscle ache. This review concludes that the COVID-19 related research should focus on developingimmunity vaccines, and repurposing of drugs. Research on the problems of quarantine life, patientmonitoring, and usage of information technology in facing COVID-19 will improve the quality of patienthandling during the pandemic. The research on the effectiveness of various models of lockdown andregulation of social life during lockdown periods, improving the safety of health care workers in theworkplace will definitely help the governments in their fight against COVID-19.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37620">
                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37621">
                <text>vaccine, coronavirus, Pandemic, SARS-CoV-2, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="37622">
                <text>DOI: 10.22207/JPAM.14.SPL1.14</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37623">
                <text>Journal of Pure and Applied Microbiology</text>
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          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37624">
                <text>Journal of Pure and Applied Microbiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="37625">
                <text>Microbiology</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="37626">
                <text>Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37627">
                <text>Lei Fan, Jianyong Li, Yi Miao</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37628">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37629">
                <text>IL-6, ruxolitinib, Tocilizumab, hemophagocytic lymphohistiocytosis, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="37630">
                <text>DOI: 10.3389/fimmu.2020.01445</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37631">
                <text>Frontiers in Immunology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37632">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="37633">
                <text>Immunologic diseases. Allergy</text>
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  <item itemId="4116" public="1" featured="0">
    <fileContainer>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37634">
                <text>Olfaction and COVID: The little we Know and what else we need to know</text>
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          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37635">
                <text>Marco Aurélio Fornazieri, Fábio de Rezende Pinna, Richard Louis Voegels, Deusdedit Brandão Neto</text>
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          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37636">
                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="37637">
                <text>DOI: 10.1055/s-0040-1713143</text>
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          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37638">
                <text>International Archives of Otorhinolaryngology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37639">
                <text>Thieme Revinter Publicações</text>
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            </elementTextContainer>
          </element>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="37640">
                <text>Medicine, Otorhinolaryngology</text>
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  <item itemId="4117" public="1" featured="0">
    <fileContainer>
      <file fileId="4117">
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
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            <description>A name given to the resource</description>
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              <elementText elementTextId="37641">
                <text>COVID-19: An Appeal for an Intersectoral Approach to Tackle With the Emergency</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="37642">
                <text>Alberto Alberti, Alessandra Scagliarini</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="37643">
                <text>The knowledge of disease determinants is a pre-requisite for disease prevention. Infectious diseases determinants can be classified in three ways, as: primary or secondary; intrinsic or extrinsic; and associated with host, agent, or environment. In the specific case of COVID-19 several of these determinants are currently unknown leading to difficulties in public health approach to this disease. In this paper, we attempt to address several of the current gaps on COVID-19 using a systematic analysis on recent findings and some preliminary knowledge on animal coronaviruses. A discussion on the impact of COVID-19 determinants in disease prevention and control will be based on the Environmental Change and Infectious Disease (EnVID) systemic framework to address several challenges that may affect the control of the SARS- CoV-2 pandemic spread both in industrialized and in developing Countries.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37644">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="37645">
                <text>Public Health, One Health, Vertebrate Hosts, SARS-CoV-2, COVID-19, disease determinants</text>
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            <name>Identifier</name>
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              <elementText elementTextId="37646">
                <text>DOI: 10.3389/fpubh.2020.00302</text>
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              <elementText elementTextId="37647">
                <text>Frontiers in Public Health</text>
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              <elementText elementTextId="37648">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Public aspects of medicine</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
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                <text>Living With COVID-19: A Systemic and Multi-Criteria Approach to Enact Evidence-Based Health Policy</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="37651">
                <text>Didier Raboisson, Guillaume Lhermie</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37652">
                <text>The lifting of COVID-19 (coronavirus disease 2019) lockdown requires, in the short and medium terms, a holistic and evidence-based approach to population health management based on combining risk factors and bio-economic outcomes, including actors' behaviors. This dynamic and global approach to health control is necessary to deal with the new paradigm of living with an infectious disease, which disrupts our individual freedom and behaviors. The challenge for policymakers consists of defining methods of lockdown-lifting and follow-up (middle-term rules) that best meet the needs for resumption of economic activity, societal wellbeing, and containment of the outbreak. There is no simple and ready-to-use way to do this since it means considering several competing objectives at the same time and continuously adapting the strategy and rules, ideally at local scale. We propose a framework for creating a precision evidence-based health policy that simultaneously considers public health, economic, and societal dimensions while accounting for constraints and uncertainty. It is based on the four following principles: integrating multiple and heterogeneous information, accepting navigation with uncertainty, adjusting the strategy dynamically with feedback mechanisms, and managing clusters through a multi-scalar conception. The evidence-based policy intervention for COVID-19 obtained includes scientific background via epidemiological modeling and bio-economic modeling. A set of quantitative and qualitative indicators are used as feedback to precisely monitor the societal-economic-epidemiological dynamics, allowing tightening or loosening of measures before epidemic damage (re-)occurs. Altogether, this allows an evidence-based policy that steers the strategy with precision and avoids any political shock.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37653">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37654">
                <text>systemic approach, social-ecological system (SES), Evidence based policy, Population medicine, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="37655">
                <text>DOI: 10.3389/fpubh.2020.00294</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37656">
                <text>Frontiers in Public Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37657">
                <text>Frontiers Media S.A.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="37658">
                <text>Public aspects of medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
