Pandemia SARS-CoV-2: A Perspetiva do Laboratório de Patologia Clínica do Hospital CUF Infante Santo E tudo o SARS-CoV-2 mudou...
covid-19, SARS-CoV-2, pandemia, Laboratórios hospitalares
A infeção a SARS-CoV-2, o coronavírus, obrigou à alteração da dinâmica de todos os serviços e unidades hospitalares que prontamente se evidenciaram como estruturas hospitalares diferenciadas e especializadas no diagnóstico e tratamento desta doença que aos poucos fomos conhecendo. Os primeiros artigos e conhecimento chegava-nos da China, a uma velocidade alucinante, mas cautelosa, e todos os conceitos, estratégias de diagnóstico e de terapêutica eram desmoronadas todas as semanas. [...]
Margarida Albuquerque, Maria José Sousa, Maria Favila Menezes, Ana Guia Pereira, Rita Ribeiro, José Germano de Sousa, Germano de Sousa
Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
SARS-CoV, inflammation, vimentin, cell surface vimentin, vimentin–pathogen interactions, anti-vimentin autoantibodies
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune response, but it can also act as an autoantigen in autoimmune diseases or as a damage signal. Although vimentin is a predominantly cytoplasmic protein, it can also appear at extracellular locations, either in a secreted form or at the surface of numerous cell types, often in relation to cell activation, inflammation, injury or senescence. Cell surface targeting of vimentin appears to associate with the occurrence of certain posttranslational modifications, such as phosphorylation and/or oxidative damage. At the cell surface, vimentin can act as a receptor for bacterial and viral pathogens. Indeed, vimentin has been shown to play important roles in virus attachment and entry of severe acute respiratory syndrome-related coronavirus (SARS-CoV), dengue and encephalitis viruses, among others. Moreover, the presence of vimentin in specific virus-targeted cells and its induction by proinflammatory cytokines and tissue damage contribute to its implication in viral infection. Here, we recapitulate some of the pathophysiological implications of vimentin, including the involvement of cell surface vimentin in interaction with pathogens, with a special focus on its role as a cellular receptor or co-receptor for viruses. In addition, we provide a perspective on approaches to target vimentin, including antibodies or chemical agents that could modulate these interactions to potentially interfere with viral pathogenesis, which could be useful when multi-target antiviral strategies are needed.
Irene Ramos, Konstantinos Stamatakis, Clara L. Oeste, Dolores Pérez-Sala
Three Black Women’s Reflections on COVID-19 and Creative Arts Therapies
COVID-19 has revealed underlying social inequities that disproportionately impact Black communities. This commentary offers three different reflections by creative arts therapists on this critical moment of widespread protest, organizing and demands for justice led by Black activists worldwide.
Leah Ra'chel Gipson, Britton Williams, Marisol Norris
Giuseppe Pascarella, Alessandro Strumia, Michael Benjamin Stone, Chiara Piliego
Airway Alert Bracelets: Enhancing Safety in the COVID-19 Era.
Laura J Matthews, Michael O'Connor, Rajinder Singh Chaggar, David Vaughan
Quando um vírus nos desafia: pandemia, novas tecnologias e teletrabalho – desafios do século XXI
teletrabalho. novas tecnologias. quarta revolução insdustrial
Este artigo aborda os principais desafios trazidos pelas novas tecnologias, pela Quarta Revolução Industrial e pela pandemia de COVID-19 no que se refere às relações de trabalho, ao teletrabalho e à preservação dos princípios constitucionais da dignidade humana, primazia do trabalho e do trabalho humano. Partindo da análise normativa e da literatura, observa que é necessária uma previsão mais abrangente do fenômeno do teletrabalho na legislação brasileira. Usa como referência comparativa a regulamentação da Organização Internacional do Trabalho e de Portugal.
Augusto César Leite de Carvalho, Ana Carla Bliacheriene, Luciano Vieira Araújo
Law in general. Comparative and uniform law. Jurisprudence, Law
Covid-19 revolutionising higher education: An educator’s viewpoint of the challenges, benefits and the way forward
covid-19, online learning, higher education, e-learning, distance learning
The global COVID-19 pandemic has radically change the higher education landscape that caused closures of all education institutions in adherence to social distancing. It has forced the education sector to adopt online teaching and learning, and reminded educators that a flexible and robust education system is needed as the future is unpredictable. This paper focuses on educator’s viewpoint in adapting and adopting online teaching and learning, highlights the challenges experienced and the ways to overcome it that could serve as a reference for other educators to assimilate in similar circumstances. This paper also explores and discusses the benefit brought by these changes to higher education and the way forward in progressing, revolutionising and sustaining quality online teaching and learning where globalised, borderless and seamless teaching and learning with technology may become “the new normal” in higher education.
Biology (General), Medicine (General), Biotechnology
The Impact of Covid-19 Outbreak on the Tourism Needs of the Algerian Population
covid-19, Pandemic, Tourism, tourist behavior, Algeria, tourism sustainability
This research aims to understand the vision and the reaction of the population towards tourism and holidays during this period of the COVID-19 pandemic. It also investigates the tourist needs of the Algerian population after the closure of international borders. Methods: The data were collected using a mixture of quantitative and qualitative methods through a questionnaire applied to 203 people in different regions of Algeria (a North African country) from 1st June to 13 July 2020. Results: The needs of Algerian tourists were characterized by a great need for leisure to relieve psychological stress caused by COVID-19 (M = 25.33) among the study sample (p < 0.05). The results also show an average need to rationalize the costs of tourist services (M = 5.26) according to the respondents (p < 0.01). This is in addition to the great need (M = 7.75) among respondents (p < 0.05) of the awareness that the tourism sector can contribute to the economic recovery in Algeria after the confinement period. About 75.86% of respondents requested the cleanliness of tourist sites, while 69.95% recommended improving safety because of the size of tourist sites in the Algerian territory as well as measures related to social distancing. The results show that 53.69% of respondents preferred the month of August to go on vacation, 29.06% chose the month of September, and 17.25% would prefer the months of October, November, and December since they expected a reduction in the risks of the COVID-19 pandemic. Conclusions: The COVID-19 pandemic has affected the tourism needs of the Algerian population, which has become increasingly aware of the consequences of the pandemic in relation to their health and in relation to the country’s economy. These results can help the authorities of the tourism sector to better understand and identify the tourism needs of this population in the current period and after the COVID-19 pandemic.
Azzeddine Madani, Saad Eddine Boutebal, Hinde Benhamida, Christopher Robin Bryant
Environmental effects of industries and plants, Renewable energy sources, Environmental sciences
Evaluating the Effectiveness of COVID-19 Bluetooth-Based Smartphone Contact Tracing Applications
covid-19, epidemic modeling, mobile computing, mobile crowdsensing, opportunistic networking, digital epidemiology
One of the strategies to control the spread of infectious diseases is based on the use of specialized applications for smartphones. These apps offer the possibility, once individuals are detected to be infected, to trace their previous contacts in order to test and detect new possibly-infected individuals. This paper evaluates the effectiveness of recently developed contact tracing smartphone applications for COVID-19 that rely on Bluetooth to detect contacts. We study how these applications work in order to model the main aspects that can affect their performance: precision, utilization, tracing speed and implementation model (centralized vs. decentralized). Then, we propose an epidemic model to evaluate their efficiency in terms of controlling future outbreaks and the effort required (e.g., individuals quarantined). Our results show that smartphone contact tracing can only be effective when combined with other mild measures that can slightly reduce the reproductive number R0 (for example, social distancing). Furthermore, we have found that a centralized model is much more effective, requiring an application utilization percentage of about 50% to control an outbreak. On the contrary, a decentralized model would require a higher utilization to be effective.
Carlos T. Calafate, Juan-Carlos Cano, Pietro Manzoni, Enrique Hernández-Orallo
Biology (General), Chemistry, Engineering (General). Civil engineering (General), Technology, Physics
تازه های علمی کرونا ویروس ها در سازمان بهداشت جهانی؛ (19) گروه اپیدمیولوژی دانشکده بهداشت و ایمنی دانشگاه علوم پزشکی شهید بهشتی و کرمان
مطالب علمی و اخبار از سایت سازمان جهانی بهداشت سخنان آغازین مدیرکل سازمان جهانی بهداشت در نشست خبری رسانه‌ای درباره COVID-19 10 آوریل 2020 در سطح جهان، در حال حاضر نزدیک به 5/1 میلیون مورد تائید شده و بیش از 92 هزار مرگ در اثر ابتلا به COVID-19 به سازمان جهانی بهداشت گزارش ‌شده است. در هفته گذشته، ما شاهد روند تدریجی کاهش در برخی از کشورهای اروپایی که سخت درگیر بودند، مانند اسپانیا، ایتالیا، آلمان و فرانسه بودیم. من خوشحال شدم که دوستم بوریس جانسون دیگر در بخش مراقبت­های ویژه نیست. بهترین آرزوها را نه‌تنها برای بوریس بلکه برای تمام کسانی که با این مشکل مواجه هستند دارم. در همین زمان، ما شاهد شتاب ابتلا نگران‌کننده‌ای در کشورهای دیگر بودیم. در آفریقا، ما شاهد گسترش ویروس در مناطق روستایی هستیم. اکنون شاهد خوشه­هایی از موارد بیماری و شیوع در بیش از 16 کشور جهان هستیم.
محمد آقاعلی, انیس اشرف گنجوی, علیرضا امان اللهی, الهام بزمی, سجاد رحیمی, و . . .
Medical emergencies. Critical care. Intensive care. First aid