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                <text>Com a pandemia de COVID-19, o mundo está a mudar de forma rápida. É preciso agir e encontrar novas formas de ajustamento à nova realidade ao mesmo tempo que é preciso refletir e encontrar estratégias mais sustentáveis, em termos sociais e ambientais. Este artigo tem por objetivo analisar o fenómeno do turismo nas cidades portuguesas, com um breve enquadramento sobre a atual conjuntura económica e uma revisão da literatura sobre a temática do “turismo urbano”, para, em seguida, perspetivar princípios e medidas de dinamização deste sector, ao nível local, considerando os novos desafios impostos pela pandemia e a renovação da atratividade dos destinos turísticos.</text>
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                <text>The preventive measures implemented to contain the coronavirus pandemic in Italy involve the self-confinement of the population. At the same time, I argue, an ethos of self-discipline is promoted, leading to ambiguous results. Although the pandemic may allow some people to imagine a different future, others have perceived it as the beginning of a war, in which the most critical aspect becomes placing blame and punish the agents responsible for the contagion, the undisciplined ones who threaten social collectivity.</text>
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                <text>The current emergency due to the worldwide spread of the COVID-19 caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for global public health. Already in the past, the outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle Eastern respiratory syndrome (MERS) in 2012 demonstrates the potential of coronaviruses to cross-species borders and further underlines the importance of identifying new-targeted drugs. An ideal antiviral agent should target essential proteins involved in the lifecycle of SARS-CoV. Currently, some HIV protease inhibitors (i.e., Lopinavir) are proposed for the treatment of COVID-19, although their effectiveness has not yet been assessed. The main protease (Mpr) provides a highly validated pharmacological target for the discovery and design of inhibitors. We identified potent Mpr inhibitors employing computational techniques that entail the screening of a Marine Natural Product (MNP) library. MNP library was screened by a hyphenated pharmacophore model, and molecular docking approaches. Molecular dynamics and re-docking further confirmed the results obtained by structure-based techniques and allowed this study to highlight some crucial aspects. Seventeen potential SARS-CoV-2 Mpr inhibitors have been identified among the natural substances of marine origin. As these compounds were extensively validated by a consensus approach and by molecular dynamics, the likelihood that at least one of these compounds could be bioactive is excellent.</text>
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                  <text>Dominio científico: Coronavirus</text>
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              <elementText elementTextId="20946">
                <text>Pre-Flight SAOCOM-1A SAR Performance Assessment by Outdoor Campaign</text>
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                <text>Davide Giudici, Andrea Monti-Guarnieri, Juan Pablo Cuesta Gonzalez</text>
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            <description>An account of the resource</description>
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                <text>In the present paper, we describe the design, execution, and the results of an outdoor experimental campaign involving the Engineering Model of the first of the two Argentinean L-band Synthetic Aperture Radars (SARs) of the Satélite Argentino de Observación con Microondas (SAOCOM) mission, SAOCOM-1A. The experiment’s main objectives were to test the end-to-end SAR operation and to assess the instrument amplitude and phase stability as well as the far-field antenna pattern, through the illumination of a moving target placed several kilometers away from the SAR. The campaign was carried out in Bariloche, Argentina, during June 2016. The experiment was successful, demonstrating an end-to-end readiness of the SAOCOM-SAR functionality in realistic conditions. The results showed an excellent SAR signal quality in terms of amplitude and phase stability.</text>
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                <text>2017</text>
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                <text>SAR, pre-flight testing, SAR performance</text>
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                <text>DOI: 10.3390/rs9070729</text>
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                <text>MDPI AG</text>
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                <text>Science</text>
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                <text>EN</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
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                <text>The association between ABO blood group and SARS-CoV-2 infection: A meta-analysis</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="53639">
                <text>Davide Golinelli, Erik Boetto, Elisa Maietti, Maria Pia Fantini, Vijayaprakash Suppiah</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="53640">
                <text>At present, existing evidence about the association between SARS-CoV-2 infection and ABO blood group polymorphism is preliminary and controversial. In this meta-analysis we investigate this association and determine SARS-CoV-2 positive individuals’ odds of having a specific blood group compared to controls. We performed a systematic search on MEDLINE and LitCovid databases for studies published through July 15, 2020. Seven studies met inclusion criteria for meta-analysis, including a total of 13 subgroups of populations (7503 SARS-CoV-2 positive cases and 2962160 controls). We analysed the odds of having each blood group among SARS-CoV-2 positive patients compared with controls. Random-effects models were used to obtain the overall pooled odds ratio (OR). Subgroup and sensitivity analyses were performed in order to explore the source of heterogeneity and results consistency. The results of our meta-analysis indicate that SARS-CoV-2 positive individuals are more likely to have blood group A (pooled OR 1.23, 95%CI: 1.09–1.40) and less likely to have blood group O (pooled OR = 0.77, 95%CI: 0.67–0.88). Further studies are needed to investigate the mechanisms at the basis of this association, which may affect the kinetics of the pandemic according to the blood group distribution within the population.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="53643">
                <text>Korean Society of Epidemiology</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Science, Medicine</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Legume Crops and Biotrophic Pathogen Interactions: A Continuous Cross-Talk of a Multilayered Array of Defense Mechanisms</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="151110">
                <text>Davide Martins, Susana  de Sousa Araújo, Diego Rubiales, Maria  Carlota Vaz Patto</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="151111">
                <text>Legume species are recognized for their nutritional benefits and contribution to the sustainability of agricultural systems. However, their production is threatened by biotic constraints with devastating impacts on crop yield. A deep understanding of the molecular and genetic architecture of resistance sources culminating in immunity is critical to assist new biotechnological approaches for plant protection. In this review, the current knowledge regarding the major plant immune system components of grain and forage legumes challenged with obligate airborne biotrophic fungi will be comprehensively evaluated and discussed while identifying future directions of research. To achieve this, we will address the multi-layered defense strategies deployed by legume crops at the biochemical, molecular, and physiological levels, leading to rapid pathogen recognition and carrying the necessary information to sub-cellular components, on-setting a dynamic and organized defense. Emphasis will be given to recent approaches such as the identification of critical components of host decentralized immune response negatively regulated by pathogens while targeting the loss-of-function of susceptibility genes. We conclude that advances in gene expression analysis in both host and pathogen, protocols for effectoromics pipelines, and high-throughput disease phenomics platforms are rapidly leading to a deeper understanding of the intricate host-pathogen interaction, crucial for efficient disease resistance breeding initiatives.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="151113">
                <text>Legumes, Resistance mechanisms, airborne biotrophic pathogens, powdery mildew, rust</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="151114">
                <text>10.3390/plants9111460</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="151115">
                <text>Plants</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="151116">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="151117">
                <text>Botany</text>
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            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="151118">
                <text>&lt;a href="https://www.mdpi.com/2223-7747/9/11/1460" target="_blank" rel="noreferrer noopener"&gt;https://www.mdpi.com/2223-7747/9/11/1460&lt;/a&gt;</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
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            <description>A name given to the resource</description>
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                <text>Neuro-telehealth for fragile patients in a tertiary referral neurological institute during the COVID-19 pandemic in Milan, Lombardy.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="62978">
                <text>Davide Pareyson, Chiara Pantaleoni, Roberto Eleopra, Giuseppe De Filippis, Isabella Moroni, Elena Freri, Federica Zibordi, Sara Bulgheroni, Emanuela Pagliano, Daniela Sarti, Antonio Silvani, Licia Grazzi, Pietro Tiraboschi, Giuseppe Didato, Elena Anghileri, Anna Bersano, Laura Valentini, Sylvie Piacentini, Cristina Muscio, Matilde Leonardi, Caterina Mariotti, Marica Eoli, Sara Nuzzo, Fabrizio Tagliavini, Paolo Confalonieri, Francesca De Giorgi</text>
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            <description>An account of the resource</description>
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                <text>Lombardy was severely hit by the COVID-19 pandemic since February 2020 and the Health System underwent rapid reorganization. Outpatient clinics were stopped for non-urgent patients: it became a priority to manage hundreds of fragile neurological patients who suddenly had less reference points. In Italy, before the pandemic, Televisits were neither recognized nor priced. At the Fondazione IRCCS Istituto Neurologico C. Besta, we reorganized outpatient clinics to deliver Neuro-telemedicine services, including Televisits and Teleneurorehabilitation, since March 2020. A dedicated Working Group prepared the procedure, tested the system, and designed satisfaction questionnaires for adults and children. After a pilot phase, we prepared a procedure for Telemedicine outpatient clinics which was approved by hospital directions. It included prescription, booking, consenting, privacy and data protection, secure connection with patients (Teams Microsoft 365), electronic report preparation and delivery, reporting, and accountability of the services. During the March-September 2020 period, we delivered 3167 Telemedicine services, including 1618 Televisits, to 1694 patients (972 adults, 722 children) with a wide range of chronic neurological disorders. We successfully administered different clinical assessment and scales. Satisfaction among patients and caregivers was very high. During the dramatic emergency, we were able to take care of more than 1600 patients by organizing Neuro-telehealth in a few weeks, lessening the impact of the pandemic on fragile patients with chronic neurological disorders; this strategy is now stably embedded in our care pathways. In Italy, Telehealth is at present recognized and priced and is becoming a stable pillar of the health system.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="62981">
                <text>covid-19, telemedicine, neurology, Neuro-telehealth, Teleneurorehabilitation, Televisit</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="62982">
                <text>10.1007/s10072-021-05252-9</text>
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              <elementText elementTextId="62983">
                <text>Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Neonatal and Pediatric Emergency Room Visits in a Tertiary Center during the COVID-19 Pandemic in Italy</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="60814">
                <text>Davide Silvagni, Laura Baggio, Patrizia Lo Tartaro Meragliotta, Pietro Soloni, Giovanna La Fauci, Chiara Bovo, Stefania Ielo, Paolo Biban</text>
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            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="60815">
                <text>The COVID-19 pandemic is affecting healthcare services worldwide. We investigated the impact of a strict lockdown policy on the characteristics of neonatal and pediatric attendances to our pediatric emergency department (PED). The clinical features of PED visits in March–April 2020 (COVID-19) and March–April 2019 (non-COVID-19) were analyzed. During the COVID-19 lockdown period, visits reduced by 67%, from 3159 to 1039. Neonatal access decreased from 78 to 59, mainly due to fewer pathological conditions, with a complete disappearance of respiratory infections. On the other hand, minor neonatal clinical conditions rose from 44 (56.4%) to 48 (81.4%), mostly due to feeding-related issues. Communicable diseases, particularly respiratory infections and gastroenteritis, dropped from 1552 (49.1%) to 288 (27.7%). Accident-related visits also decreased during COVID-19, from 535 (16.9%) to 309 (29.7%), becoming the most common cause of PED access. Hospital admissions reduced from 266 to 109, while PICU (pediatric intensive care unit) admissions decreased from 27 to 11, with a comparable rate of 10.1% in both periods. The lockdown due to COVID-19 had a substantial impact on our PED visits, which markedly decreased, mainly due to fewer respiratory infections. Unexpectedly, neonatal visits for minor conditions did not decline, but rather slightly increased. Among the children admitted to the PICU, none had respiratory disease.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="60816">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="60817">
                <text>child, covid-19, newborn, pediatric emergency department, triage code</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="60818">
                <text>10.3390/pediatric13020023</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="60819">
                <text>Pediatric Reports</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="60820">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="60821">
                <text>Medicine, Pediatrics</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
