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                <text>Simona Iaccarino, Giuseppe Di Lorenzo, Giuseppina Busto, Mario Polverino, Claudia Ferrara, Gianluca Ragone, Concetta Ingenito, Luciana Buonerba, Annamaria Libroia, Emilio Leo, Beatrice Savastano, Concetta Dello Ioio, Ferdinando De Falco, Luciano Tarantino</text>
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                <text>cancer, treatment, Management, Patients, Coronavirus disease</text>
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                <text>DOI: 10.3389/fmed.2020.00189</text>
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                <text>Frontiers in Medicine</text>
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                <text>Ahmad Hormati, Sajjad Ahmadpour, Seyed Kamal Eshagh Hossaini, Zahra Movahedi, Hosein Heydari, Seyed Jalal Eshagh Hosseini, Fatemeh Khodadust, Mahboubeh Afifian</text>
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                <text>10.3345/cep.2020.01711</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Pediatrics</text>
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            <element elementId="50">
              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Coronavirus disease 2019 in children: Clinical &amp; epidemiological implications</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Vijesh Sreedhar Kuttiatt, Philip Raj Abraham, Ramesh P Menon, Pankaj C Vaidya, Manju Rahi</text>
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                <text>Despite the global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there are limited data emerging in children. This review provides an update on clinical features, diagnosis, epidemiology, management and prevention of coronavirus disease 2019 (COVID-19) in children. Specific characteristics noted in children and their implications in disease management as well as transmission control are highlighted. Besides respiratory symptoms, gastrointestinal and atypical features such as chilblains, neurological symptoms and multisystem inflammation are also reported. Younger infants and those with comorbidity were found to be at risk of severe illness. Infected pregnant women and neonates were reported to have good prognosis. It is possible to manage the children with mild disease at home, with strict infection prevention control measures; severely affected require respiratory support and intensive care management. There are anecdotal reports of using antiviral and immunomodulatory drugs, benefit of which needs to be confirmed in clinical trials. A significant percentage of asymptomatic infection in children has epidemiological implication as these may act as links in transmission chain in the community. There is a need for systematic data on extra-pulmonary manifestations and atypical features, risk factors of severity, role of imaging and biomarkers, testing and management strategies and trials with antivirals and immunomodulatory drugs in children. The psychosocial effects of quarantine, closure of schools, lack of play activities and impact of lockdown need to be addressed. Understanding the biological basis for the profound age-dependent differential outcome of COVID-19 infection is important. Elucidating the protective mechanisms in children may aid in developing novel treatment strategies.</text>
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                <text>2020</text>
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            <name>Subject</name>
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              <elementText elementTextId="84749">
                <text>children - clinical features - covid-2019 - epidemiology - prevention - sars-cov-2 - severity of illness - treatment</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="84750">
                <text>10.4103/ijmr.IJMR_977_20</text>
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              <elementText elementTextId="84751">
                <text>Biotemas</text>
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            <name>Publisher</name>
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              <elementText elementTextId="84752">
                <text>Universidade Federal de Santa Catarina</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Coronavirus disease 2019 pandemic: Upscaling the preparedness and public health emergency response at the point of entry</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46730">
                <text>Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="46732">
                <text>10.4103/jcrsm.jcrsm_18_20</text>
              </elementText>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="46733">
                <text>Journal of Current Research in Scientific Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="46734">
                <text>Wolters Kluwer Medknow Publications</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="46735">
                <text>Medicine</text>
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    <fileContainer>
      <file fileId="5225">
        <src>https://www.socictopen.socict.org/files/original/c993795e7b4d06c8a90bd8209e6f9270.pdf</src>
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          <name>Dublin Core</name>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46871">
                <text>Coronavirus Disease 2019 Related Clinical Studies: A Cross-Sectional Analysis</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46872">
                <text>Xiantao Zeng, Ying-Hui Jin, Jianguang Ji, Di Huang, Lin-Lu Ma, Yun-Yun Wang, Bing-Hui Li, Xuan Yin, Bing-Hui Li, Jia-Yu Yang, Jia-Yu Yang, Tong Deng, Xue-Qun Ren</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="46873">
                <text>ObjectiveThe quality and rationality of many recently registered clinical studies related to coronavirus disease 2019 (COVID-19) needs to be assessed. Hence, this study aims to evaluate the current status of COVID-19 related registered clinical trial.MethodsWe did an electronic search of COVID-19 related clinical studies registered between December 1, 2019 and February 21, 2020 (updated to May 28, 2020) from the ClinicalTrials.gov, and collected registration information, study details, recruitment status, characteristics of the subjects, and relevant information about the trial implementation process.ResultsA total of 1,706 studies were included 10.0% of which (n=171) were from France, 943 (55.3%) used an interventional design, and 600 (35.2%) used an observational design. Most of studies (73.6%) aimed to recruit fewer than 500 people. Interferon was the main prevention program, and antiviral drugs were the main treatment program. Hydroxychloroquine and chloroquine (230/943, 24.4%) were widely studied. Some registered clinical trials are incomplete in content, and 37.4% of the 1,706 studies may have had insufficient sample size.ConclusionThe quality of COVID-19 related studies needs to be improved by strengthening the registration process and improving the quality of clinical study protocols so that these clinical studies can provide high-quality clinical evidence related to COVID-19.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Clinical trial, SARS-CoV-2, Coronavirus disease 2019, ClinicalTrials.gov, registration</text>
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            <name>Identifier</name>
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              <elementText elementTextId="46876">
                <text>10.3389/fphar.2020.540187</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="46877">
                <text>Epidemiology and Health</text>
              </elementText>
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          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Therapeutics. Pharmacology</text>
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