458 10 20655 https://www.socictopen.socict.org/files/original/d9cb59ec135c885dfbfb7f0d9c121a30.pdf 08e94831e1c6f6d8c7c6530a42d450fc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource La justicia hídrica y el desarrollo: más allá de los discursos de la economía verde, los derechos humanos neoliberales y los bienes comunes rentables / Justiça hídrica e desenvolvimento: além dos discursos de economia verde, direitos humanos neoliberais e bens comuns lucrativos / Water justice and development: beyond discourses of green economy, neoliberal human rights and lucrative commons Creator An entity primarily responsible for making the resource Denisse Roca-Servat, María Botero-Mesa Description An account of the resource Resumen: El agua es considerada un recurso estratégico para los procesos de desarrollo económico o progreso neoliberal, los cuales la han canalizado a través de una infraestructura que gira en torno a su acumulación, concentración y centralización. Partiendo de un marco teórico anclado en la ecología política, este artículo revisa críticamente los debates actuales sobre esta compleja relación agua – desarrollo, identificando tres maneras en las que las lógicas del capital han cooptado ciertos alcances emancipatorios. En primer lugar, se identifica el discurso de la economía verde o “desarrollo sostenible”, la cual entiende al agua como una mercancía o servicio para el ser humano. En segundo lugar, se encuentra el discurso del derecho humano que sitúa a las empresas privadas como principales proveedoras del agua como derecho dentro de la lógica del mercado. Y, el tercero, el discurso del bien común que entiende al agua como un objeto rentable. Finalmente se discute el alcance de la justicia hídrica en el contexto actual. Resumo: A água é considerada um recurso estratégico para os processos de desenvolvimento econômico ou progresso neoliberal, que a canalizaram por meio de uma infraestrutura que gira em torno de sua acumulação, concentração e centralização. Partindo de um referencial teórico ancorado na ecologia política, este artigo revisa criticamente os debates atuais sobre essa complexa relação água-desenvolvimento, identificando três maneiras pelas quais a lógica do capital tem cooptado certos alcances emancipatórios. Em primeiro lugar, identifica-se o discurso da economia verde ou “desenvolvimento sustentável”, que entende a água como uma mercadoria ou serviço para o ser humano. Em segundo lugar, existe o discurso dos direitos humanos que coloca as empresas privadas como as principais provedoras de água como um direito dentro da lógica do mercado. E, a terceira, o discurso do bem comum que entende a água como objeto lucrativo. Finalmente, o escopo da justiça hídrica no contexto atual é discutido. Abstract: Water is considered a strategic resource for the processes of economic development or neoliberal progress, which have channeled it through an infrastructure that revolves around its accumulation, concentration and centralization. Based on a theoretical framework anchored in political ecology, this article critically reviews current debates on this complex relationship between water and development, identifying three ways in which the logics of capital have co-opted certain emancipatory scopes. First, the discourse of the green economy or “sustainable development” is identified, which understands water as a merchandise or service for the human being. Secondly, there is the human rights discourse that places private companies as the main suppliers of water as a right within the logic of the market. And, the third, the discourse of the common good that understands water as a profitable object. Finally, the scope of water justice in the current context is discussed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Common good, DERECHO HUMANO, Desarrollo, Development, Direito humano, Water justice, bem comum, bien común, desenvolvimento, ecologia política da água, ecología política del agua, human right, justicia hídrica, justiça hídrica, political ecology of water Source A related resource from which the described resource is derived Revista nuestrAmérica Publisher An entity responsible for making the resource available Ediciones nuestrAmérica desde Abajo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social history and conditions. Social problems. Social reform, Social sciences (General) Relation A related resource <a href="http://revistanuestramerica.cl/ojs/index.php/nuestramerica/article/view/283" target="_blank" rel="noreferrer noopener">http://revistanuestramerica.cl/ojs/index.php/nuestramerica/article/view/283</a> https://www.socictopen.socict.org/files/original/40f63e247f3ea9c03898a8902add64f0.pdf d0dc3821c217953008a065a43a49e1a1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Hazards of a Practicing Respirologist Creator An entity primarily responsible for making the resource Dennis Bowie Description An account of the resource The advent of severe acute respiratory syndrome (SARS) in March 2003 reminded us that health care workers are at risk of being stricken with the very diseases that we are treating. Health care workers accounted for 65% of the SARS cases in Canada (1) and represented at least one-quarter of the cases in Hong Kong (2). Because SARS presents as a severe pneumonia and is diagnosed by certain epidemiological characteristics, history and a positive chest x-ray, respirologists are often the first-line consultants to see patients with an unusual pneumonia. If we are lucky, there may be telling clues to the diagnosis such as a travel history or contact with other cases. However, in the absence of these clues, it behooves the medical profession to use universal precautions. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2004/523265 Source A related resource from which the described resource is derived Canadian Respiratory Journal Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the respiratory system https://www.socictopen.socict.org/files/original/92d66b7e3675309ba4f1eae3b368eeb3.pdf b9504f08d9a98dd375f85e0ded5bdb19 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Pustulan Activates Chicken Bone Marrow-Derived Dendritic Cells In Vitro and Promotes Ex Vivo CD4⁺ T Cell Recall Response to Infectious Bronchitis Virus Creator An entity primarily responsible for making the resource Dennis Christensen, Bernt Guldbrandtsen, Jacob Pitcovski, Tina S. Dalgaard, Frederik T. Larsen, Rikke B. Kjærup Description An account of the resource Infectious bronchitis virus (IBV) is a highly contagious avian coronavirus. IBV causes substantial worldwide economic losses in the poultry industry. Vaccination with live-attenuated viral vaccines, therefore, are of critical importance. Live-attenuated viral vaccines, however, exhibit the potential for reversion to virulence and recombination with virulent field strains. Therefore, alternatives such as subunit vaccines are needed together with the identification of suitable adjuvants, as subunit vaccines are less immunogenic than live-attenuated vaccines. Several glycan-based adjuvants directly targeting mammalian C-type lectin receptors were assessed in vitro using chicken bone marrow-derived dendritic cells (BM-DCs). The β-1-6-glucan, pustulan, induced an up-regulation of MHC class II (MHCII) cell surface expression, potentiated a strong proinflammatory cytokine response, and increased endocytosis in a cation-dependent manner. Ex vivo co-culture of peripheral blood monocytes from IBV-immunised chickens, and BM-DCs pulsed with pustulan-adjuvanted recombinant IBV N protein (rN), induced a strong recall response. Pustulan-adjuvanted rN induced a significantly higher CD4+ blast percentage compared to either rN, pustulan or media. However, the CD8+ and TCRγδ+ blast percentage were significantly lower with pustulan-adjuvanted rN compared to pustulan or media. Thus, pustulan enhanced the efficacy of MHCII antigen presentation, but apparently not the cross-presentation on MHCI. In conclusion, we found an immunopotentiating effect of pustulan in vitro using chicken BM-DCs. Thus, future in vivo studies might show pustulan as a promising glycan-based adjuvant for use in the poultry industry to contain the spread of coronaviridiae as well as of other avian viral pathogens. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource adjuvant, chicken, IBV, BMDC, pustulan, subunit vaccination Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/vaccines8020226 Source A related resource from which the described resource is derived Vaccines Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/9261ca204b1d01ee103e4aaa7abf0dc0.pdf e87be76fa34af0d809e4d2e6cf7f3894 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Impactos multifactoriales del cambio climático en Nicaragua y estrategias de adaptación Creator An entity primarily responsible for making the resource Dennis José Salazar-Centeno Description An account of the resource En Nicaragua, el cambio climático está asociado al fenómeno de El Niño y La Niña, que en situaciones extremas tienen efectos económicos, sociales y ambientales fatales. El fenómeno de El Niño es una condición anómala en la temperatura del océano pacifico tropical del este. Ocurre cuando el agua del océano pacifico ecuatorial se hace más caliente que el promedio (1°C - 3°C). Cuando esto sucede, la atmosfera encima del océano también reacciona. Ese cambio de temperatura afecta la circulación del viento reduciendo considerablemente las lluvias (Cruz Roja Nicaragüense, 2014). Este calentamiento de las aguas sucede cada dos o siete años y puede durar entre 12 y 18 meses. Según los cambios en el clima así se comporta El Niño y puede ser clasificado como débil o moderado, pero también como fuerte o muy fuerte, en estos últimos casos provocando sequías extremas. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Source A related resource from which the described resource is derived La Calera Publisher An entity responsible for making the resource available Universidad Nacional Agraria Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Agriculture Relation A related resource <a href="https://lacalera.una.edu.ni/index.php/CALERA/article/view/215" target="_blank" rel="noreferrer noopener">https://lacalera.una.edu.ni/index.php/CALERA/article/view/215</a> https://www.socictopen.socict.org/files/original/4800137205b951c9325cde34be5f5970.pdf e87be76fa34af0d809e4d2e6cf7f3894 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource NICARAGUA: POTENCIAL FARO REGIONAL PARA EL DISEÑO Y EVALUACIÓN DE AGROECOSISTEMAS AGROECOLÓGICOS Creator An entity primarily responsible for making the resource Dennis Salazar Centeno Description An account of the resource En este artículo se expresa la imperiosa necesidad de convertir los sistemas de producción convencionales en fincas agroecológicas como alternativa para que la nueva empresa agraria garantice la implementación de buenas prácticas productivas y de manufactura que contribuyan a ofrecer productos de calidad e inocuos y servicios con un enfoque de calidad total. Desde esta perspectiva, la Universidad Nacional Agraria oferta un programa de formación de talentos humanos a diferentes niveles en agroecología, que consta de cinco grandes proyectos. También, se expresa el andamiaje jurídico nacional actual para implementar la política de la producción agroecológica y orgánica, así como los pasos para el diseño y evaluación de sistemas agroecológicos del presente siglo, cuyos tópicos son: grupos y características de agro ecosistemas, tipos de agro ecosistemas complejos o diversificados, biodiversidad a considerar para el diseño de sistemas diversificados sostenibles en el trópico, ejes a considerar para el diseño de sistemas diversificados sostenibles en el trópico que incluya un manejo integral de los recursos naturales, procesos para el diseño de sistemas diversificados sostenibles en el trópico, pasos y herramientas para el diseño de sistemas diversificados sostenibles en el trópico oferentes de bienes y servicios a la sociedad, ejemplos de sistemas diversificados sostenibles en el trópico oferentes de bienes y servicios, desafíos para el diseño de sistemas diversificados sostenibles en el trópico y la evaluación de sistemas diversificados sostenibles. El propósito es fomentar una agricultura resiliente al cambio climático, productiva y eficiente (energética, económica y biodiversa), pero también que garantice la seguridad alimentaria y nutricional. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Source A related resource from which the described resource is derived La Calera Publisher An entity responsible for making the resource available Universidad Nacional Agraria Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Agriculture Relation A related resource <a href="https://lacalera.una.edu.ni/index.php/CALERA/article/view/183" target="_blank" rel="noreferrer noopener">https://lacalera.una.edu.ni/index.php/CALERA/article/view/183</a> https://www.socictopen.socict.org/files/original/e794dff84dce7c1dc708cef522150dff.pdf 87e992e46557e0650db2487c4fb07a2b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic Origins Creator An entity primarily responsible for making the resource Denong Wang, Jin Tang, Jiulai Tang, Lai-Xi Wang Description An account of the resource Identifying molecular targets for eliciting broadly virus-neutralizing antibodies is one of the key steps toward development of vaccines against emerging viral pathogens. Owing to genomic and somatic diversities among viral species, identifying protein targets for broad-spectrum virus neutralization is highly challenging even for the same virus, such as HIV-1. However, viruses rely on host glycosylation machineries to synthesize and express glycans and, thereby, may display common carbohydrate moieties. Thus, exploring glycan-binding profiles of broad-spectrum virus-neutralizing agents may provide key information to uncover the carbohydrate-based virus-neutralizing epitopes. In this study, we characterized two broadly HIV-neutralizing agents, human monoclonal antibody 2G12 and Galanthus nivalis lectin (GNA), for their viral targeting activities. Although these agents were known to be specific for oligomannosyl antigens, they differ strikingly in virus-binding activities. The former is HIV-1 specific; the latter is broadly reactive and is able to neutralize viruses of distinct phylogenetic origins, such as HIV-1, severe acute respiratory syndrome coronavirus (SARS-CoV), and human cytomegalovirus (HCMV). In carbohydrate microarray analyses, we explored the molecular basis underlying the striking differences in the spectrum of anti-virus activities of the two probes. Unlike 2G12, which is strictly specific for the high-density Man9GlcNAc2Asn (Man9)-clusters, GNA recognizes a number of N-glycan cryptic sugar moieties. These include not only the known oligomannosyl antigens but also previously unrecognized tri-antennary or multi-valent GlcNAc-terminating N-glycan epitopes (Tri/m-Gn). These findings highlight the potential of N-glycan cryptic sugar moieties as conserved targets for broad-spectrum virus neutralization and suggest the GNA-model of glycan-binding warrants focused investigation. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource carbohydrate microarrays, oligomannoses, AGOR, ASOR, GNA, 2G12, HIV-1, HCMV, SARS-CoV Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules20034610 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN https://www.socictopen.socict.org/files/original/c1daaa3e2ce20baefc904217f2d951bf.pdf 62e0f8950d901da641bb3d55c2210d37 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review Creator An entity primarily responsible for making the resource Der-Yuan Chen, Der-Yuan Chen, Kuo-Tung Tang, Kuo-Tung Tang, Kuo-Tung Tang, Bo-Chueh Hsu, Der-Yuan Chen Description An account of the resource Background: Numerous cases of the coronavirus disease 2019 (COVID-19) with autoimmune and rheumatic manifestations have been reported. Despite the available reviews that summarized its autoimmune/rheumatic manifestations, a systematic approach is still lacking. Therefore, we conducted a comprehensive systematic review in order to give an overview upon these rare but clinically significant manifestations.Methods: We performed a literature search of PubMed and EMBASE as of October 9, 2020. All articles relevant to either systemic or organ-specific autoimmune and rheumatic manifestations potentially associated with COVID-19 were collected. The reviewed literature were limited to adults ≥18 years.Results: Although most of the existing evidence was based on case reports or case series without a long-term follow-up, a variety of autoimmune/rheumatic manifestations were associated with COVID-19. The manifestations that have a consistent association with COVID-19 include autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. Such association is conflicting as regards to antiphospholipid syndrome, hemophagocytic lymphohistiocytosis, and myasthenia gravis.Conclusion: Our systematic review indicated the potential of the COVID-19 virus to trigger a myriad of autoimmune and rheumatic manifestations, which should be considered amid global efforts to combat COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, treatment, SARS-CoV-2, Rheumatic disease, Autoimmune Disease Identifier An unambiguous reference to the resource within a given context 10.3389/fimmu.2021.645013 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/cf64a40faafa7d978d04dc2d3c6bfb9a.pdf cb81179c70d10da14a0e82922029e099 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fall 2020 COVID-19 Needs Assessment among New Jersey Secondary School Educational Professionals Creator An entity primarily responsible for making the resource Derek G. Shendell, Juhi Aggarwal, Maryanne L. F. Campbell, Lauren N. Gonzalez, Elizabeth Kaplun, Koshy Koshy, Thomas I. Mackie Description An account of the resource Secondary or high school (HS) educational professionals expressed concerns about dealing with environmental and occupational health and safety protocols due to COVID-19. Concerns related to fall 2020 school re-opening and getting back into in-person teaching—whether full-time, part-time or some other approved hybrid model—plus ongoing uncertainty with how the state and federal government will be handling matters about mandates for virtual learning, rapid testing, vaccine distribution, etc. These concerns were related to both their experience as educational professionals and genuine interest in personal and student well-being. This study was a cross-sectional online survey in early fall from mid-September–early October 2020. Of a possible maximum participation of 740 New Jersey (NJ) supervisory-level HS teachers and administrators (e.g., department chairs, district and school principals), 100 confirmed unique respondents (13.5%) consented and completed the survey. Of 100 experienced (mean 18 years teaching) participants, 70% responded to the gender identity question (overall, 61% female, 39% male; by NJ region, gender ratios were similar). There were statistically significant differences (using Fischer’s exact test) between NJ regions regarding provision of online counseling and support services for teachers (p < 0.001); for resources and equipment for teachers to mediate online learning (p = 0.02); for assistive video technology tools (p = 0.03) and accessibility to structured online learning and professional development (p = 0.002); concerning learning aids to engage students in online instruction, online counseling, and support services for students and their families (p = 0.006); appropriate protocol is clean and disinfect areas used by a person with COVID-19 (p = 0.002); and, immediately separate staff and students who screen positive for COVID-19 (p = 0.03). There were few statistical differences by gender. This study reported what participants wanted regarding the development of future policies then implemented as reopening practices. Data can inform recommendations in NJ and elsewhere at federal, state, and local levels. Data provide new insights and valuable information to inform the consideration of acceptability of various policy measures among HS education professionals. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Safety, covid-19, SARS-CoV-2, Personal Protective Equipment (PPE), Schools, biological hazards Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph18084083 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/0b38e5e28851d65eb9086bafb71c9376.pdf 5285738246699105070e4516ef452132 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource RNase L mediated protection from virus induced demyelination. Creator An entity primarily responsible for making the resource Derek D. C. Ireland, Stephen A. Stohlman, David R. Hinton, Parul Kapil, Robert H. Silverman, Roscoe A Atkinson, Cornelia C. Bergmann Description An account of the resource IFN-alpha/beta plays a critical role in limiting viral spread, restricting viral tropism and protecting mice from neurotropic coronavirus infection. However, the IFN-alpha/beta dependent mechanisms underlying innate anti-viral functions within the CNS are poorly understood. The role of RNase L in viral encephalomyelitis was explored based on its functions in inhibiting translation, inducing apoptosis, and propagating the IFN-alpha/beta pathway through RNA degradation intermediates. Infection of RNase L deficient (RL(-/-)) mice with a sub-lethal, demyelinating mouse hepatitis virus variant revealed that the majority of mice succumbed to infection by day 12 p.i. However, RNase L deficiency did not affect overall control of infectious virus, or diminish IFN-alpha/beta expression in the CNS. Furthermore, increased morbidity and mortality could not be attributed to altered proinflammatory signals or composition of cells infiltrating the CNS. The unique phenotype of infected RL(-/-) mice was rather manifested in earlier onset and increased severity of demyelination and axonal damage in brain stem and spinal cord without evidence for enhanced neuronal infection. Increased tissue damage coincided with sustained brain stem infection, foci of microglia infection in grey matter, and increased apoptotic cells. These data demonstrate a novel protective role for RNase L in viral induced CNS encephalomyelitis, which is not reflected in overall viral control or propagation of IFN-alpha/beta mediated signals. Protective function is rather associated with cell type specific and regional restriction of viral replication in grey matter and ameliorated neurodegeneration and demyelination. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1000602 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/d5c077e32a5494522d4612d4cd2ee7c7.pdf feb2fae9f25b45a5a2efa3975eb26625 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Elucidation on the Physicochemical Properties of Potential and Clinically Approved Antiviral Drugs: A Search for Effective Therapies against SARS-CoV-2 Infection Creator An entity primarily responsible for making the resource Derick Erl P. Sumalapao Description An account of the resource COVID-19 has been confirmed in millions of individuals worldwide, rendering it a global medicalemergency. In the absence of vaccines and the unavailability of effective drugs for the SARS-CoV-2infection, vaccine development is being continuously explored and several antiviral compoundsand immunotherapies are currently being investigated. Given the high similarity in genetic identitybetween SARS-CoV and SARS-CoV-2, the present investigation identified the interaction between thephysicochemical properties and the antiviral activity of different potential and clinically approvedantiviral drugs against SARS-CoV using hierarchically weighted principal component analysis.Representative drugs from the classes of neuraminidase inhibitors, reverse transcriptase inhibitors,protease inhibitors, nucleoside analogues, and other compounds with potential antiviral activity wereexamined. The pharmacologic classification and the biological activity of the different antiviral drugswere described using indices, namely, rotatable bond count, molecular weight, heavy atom count, andmolecular complexity (92.32% contribution rate). The physicochemical properties and inhibitory actionagainst SARS-CoV-2 of lopinavir, chloroquine, ivermectin, and ciclesonide validated the adequacy ofthe current computational approach. The findings of the present study provide additional information,although further investigation is warranted to identify potential targets and establish exact mechanisms,in the emergent search and design of antiviral drug candidates and their subsequent synthesis aseffective therapies for COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource principal component analysis, Neuraminidase inhibitors, Protease inhibitors, Nucleoside analogues, reverse transcriptase inhibitors, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.41 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology