458 10 20655 https://www.socictopen.socict.org/files/original/6ccc48bdec9b2838619a8d26fd140e06.pdf 5ab2a47527bfee60ca4f66562c4eb3b8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Disease-2019: Knowledge, Attitude, and Practices of Health Care Workers at Makerere University Teaching Hospitals, Uganda Creator An entity primarily responsible for making the resource Felix Bongomin, Ronald Olum, Gaudencia Chekwech, Godfrey Wekha, Dianah Rhoda Nassozi Description An account of the resource Background: Coronavirus disease-2019 (COVID-19) is an emerging public health problem threatening the life of over 2.4 million people globally. The present study sought to determine knowledge, attitude and practices (KAP) of health care workers (HCWs) toward COVID-19 in Makerere University Teaching Hospitals (MUTHs) in Uganda.Methods: An online cross sectional, descriptive study was undertaken through WhatsApp Messenger among HCWs in four MUTHs. HCWs aged 18 years and above constituted the study population. KAP toward COVID-19 was assessed by using a pre-validated questionnaire. Bloom's cut-off of 80% was used to determine sufficient knowledge (≥80%), positive attitude (≥4), and good practice (≥2.4). All analyses were performed using STATA 15.1 and GraphPad Prism 8.3.Results: Of the 581 HCWs approached, 136 (23%) responded. A vast majority of the participants were male (n = 87, n = 64%), with a median age of 32 (range: 20–66) years. Eighty-four (62%) were medical doctors and 125 (92%) had at least a bachelor's degree. Overall, 69% (n = 94) had sufficient knowledge, 21% (n = 29) had positive attitude, and 74% (n = 101) had good practices toward COVID-19. Factors associated with knowledge were age >40 years (aOR: 0.3; 95% CI: 0.1–1.0; p = 0.047) and news media (aOR: 4.8; 95% CI: 1.4–17.0; p = 0.015). Factors associated with good practices were age 40 years or more (aOR: 48.4; 95% CI: 3.1–742.9; p = 0.005) and holding a diploma (aOR: 18.4; 95% CI: 1–322.9; p = 0.046).Conclusions: Continued professional education is advised among HCWs in Uganda to improve knowledge of HCWs hence averting negative attitudes and promoting positive preventive and therapeutic practices. We recommend follow up studies involving teaching and non-teaching hospitals across the country. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource healthcare workers, Uganda, KAPs, COVID-19, Makerere University Teaching Hospitals Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fpubh.2020.00181 Source A related resource from which the described resource is derived Frontiers in Public Health Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/676bac1dcea68d7501e8a51d8d88fb93.pdf 5ab2a47527bfee60ca4f66562c4eb3b8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Disease-2019: Knowledge, Attitude, and Practices of Health Care Workers at Makerere University Teaching Hospitals, Uganda Creator An entity primarily responsible for making the resource Ronald Olum, Gaudencia Chekwech, Godfrey Wekha, Dianah Rhoda Nassozi, Felix Bongomin, Felix Bongomin Description An account of the resource Background: Coronavirus disease-2019 (COVID-19) is an emerging public health problem threatening the life of over 2.4 million people globally. The present study sought to determine knowledge, attitude and practices (KAP) of health care workers (HCWs) toward COVID-19 in Makerere University Teaching Hospitals (MUTHs) in Uganda.Methods: An online cross sectional, descriptive study was undertaken through WhatsApp Messenger among HCWs in four MUTHs. HCWs aged 18 years and above constituted the study population. KAP toward COVID-19 was assessed by using a pre-validated questionnaire. Bloom's cut-off of 80% was used to determine sufficient knowledge (≥80%), positive attitude (≥4), and good practice (≥2.4). All analyses were performed using STATA 15.1 and GraphPad Prism 8.3.Results: Of the 581 HCWs approached, 136 (23%) responded. A vast majority of the participants were male (n = 87, n = 64%), with a median age of 32 (range: 20–66) years. Eighty-four (62%) were medical doctors and 125 (92%) had at least a bachelor's degree. Overall, 69% (n = 94) had sufficient knowledge, 21% (n = 29) had positive attitude, and 74% (n = 101) had good practices toward COVID-19. Factors associated with knowledge were age >40 years (aOR: 0.3; 95% CI: 0.1–1.0; p = 0.047) and news media (aOR: 4.8; 95% CI: 1.4–17.0; p = 0.015). Factors associated with good practices were age 40 years or more (aOR: 48.4; 95% CI: 3.1–742.9; p = 0.005) and holding a diploma (aOR: 18.4; 95% CI: 1–322.9; p = 0.046).Conclusions: Continued professional education is advised among HCWs in Uganda to improve knowledge of HCWs hence averting negative attitudes and promoting positive preventive and therapeutic practices. We recommend follow up studies involving teaching and non-teaching hospitals across the country. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Healthcare workers, covid-19, Uganda, KAPs, Makerere University Teaching Hospitals Identifier An unambiguous reference to the resource within a given context 10.3389/fpubh.2020.00181 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/dbdcad771099b403cbfc389cdf43f619.pdf 8347291a2281e780cafa2025219c47ff Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review Creator An entity primarily responsible for making the resource Francesco Di Gennaro, Damiano Pizzol, Claudia Marotta, Mario Antunes, Vincenzo Racalbuto, Nicola Veronese, Lee Smith Description An account of the resource At the end of 2019 a novel virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing severe acute respiratory syndrome expanded globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus a global pandemic. We performed a narrative review to describe existing literature with regard to Corona Virus Disease 2019 (COVID-19) epidemiology, pathophysiology, diagnosis, management and future perspective. MEDLINE, EMBASE and Scopus databases were searched for relevant articles. Although only when the pandemic ends it will be possible to assess the full health, social and economic impact of this global disaster, this review represents a picture of the current state of the art. In particular, we focus on public health impact, pathophysiology and clinical manifestations, diagnosis, case management, emergency response and preparedness. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, COVID-19, pathogenesis, preparedness, emergency, Pandemic Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijerph17082690 Source A related resource from which the described resource is derived International Journal of Environmental Research and Public Health Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/a101f6add53e238b3c7b1e70895c0135.pdf 00cdec0d6844b6481925aa3086935c9e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource coronavírus e a necessidade dos tribunais de contas incentivarem o aprimoramento do federalismo cooperativo brasileiro Creator An entity primarily responsible for making the resource Severiano José Costa Andrade de Aguiar, Júlio Edstron S. Santos Description An account of the resource Este paper acadêmico, por meio do método hipotético dedutivo e das técnicas de revisão bibliográfica e estudos de casos, busca responder se, além das suas funções constitucionais previstas principalmente nos artigos 70 e 71 da Constituição Republicana de 1988, seria possível que os tribunais de contas brasileiros, que são órgãos de controle autônomos, com alto grau de especialização e interdisciplinaridade, auxiliassem na proposição, elaboração, execução e avaliação de políticas públicas, sob o paradigma do federalismo cooperativo? Traz como objetivo geral: apresentar uma nova via de atuação das cortes de contas nacionais. Objetivos específicos: demonstrar os principais efeitos da pandemia mundial causada pelo Covid-19, principalmente no Brasil; discutir o federalismo no Brasil. Os achados indicam que tribunais de contas podem municiar o agente público com dados e ferramentas que otimizem seus resultados, como por exemplo, a prática de ações de governança pública, ainda que os tribunais de contas auxiliem nas comunicações entre a União, estados-membros e Distrito Federal, otimizando a distribuição de recursos, minimizando equívocos administrativos e, se necessário, penalizando infrações dos gestores públicos que causem danos ao erário, sobretudo em momento de pandemia. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19. federalismo cooperativo. atuação dos tribunais de contas Identifier An unambiguous reference to the resource within a given context 10.32586/rcda.v18i2.626 Source A related resource from which the described resource is derived Revista Controle Publisher An entity responsible for making the resource available Tribunal de Contas do Estado do Ceará Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Law in general. Comparative and uniform law. Jurisprudence, Law https://www.socictopen.socict.org/files/original/95883f4ceace09a4efb19b9f457d9428.pdf cb959c3f233caab3c2666e0da556aa7c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus envelope protein: current knowledge Creator An entity primarily responsible for making the resource Dewald Schoeman, Burtram C. Fielding Description An account of the resource Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to be capable of infecting humans as well. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and, more recently, Middle-East respiratory syndrome (MERS) has demonstrated the lethality of CoVs when they cross the species barrier and infect humans. A renewed interest in coronaviral research has led to the discovery of several novel human CoVs and since then much progress has been made in understanding the CoV life cycle. The CoV envelope (E) protein is a small, integral membrane protein involved in several aspects of the virus’ life cycle, such as assembly, budding, envelope formation, and pathogenesis. Recent studies have expanded on its structural motifs and topology, its functions as an ion-channelling viroporin, and its interactions with both other CoV proteins and host cell proteins. Main body This review aims to establish the current knowledge on CoV E by highlighting the recent progress that has been made and comparing it to previous knowledge. It also compares E to other viral proteins of a similar nature to speculate the relevance of these new findings. Good progress has been made but much still remains unknown and this review has identified some gaps in the current knowledge and made suggestions for consideration in future research. Conclusions The most progress has been made on SARS-CoV E, highlighting specific structural requirements for its functions in the CoV life cycle as well as mechanisms behind its pathogenesis. Data shows that E is involved in critical aspects of the viral life cycle and that CoVs lacking E make promising vaccine candidates. The high mortality rate of certain CoVs, along with their ease of transmission, underpins the need for more research into CoV molecular biology which can aid in the production of effective anti-coronaviral agents for both human CoVs and enzootic CoVs. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource coronavirus, envelope protein, topology, assembly, Budding, Viroporin Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12985-019-1182-0 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/5b8361ec25c94ba65ef4419e9a00f03e.pdf 2094364cc502b541edc6fc7ca36115c8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource CORONAVIRUS EPIDEMIC OUTBREAK IN EUROPE. COMPARISON WITH THE DYNAMICS IN MAINLAND CHINA Creator An entity primarily responsible for making the resource Igor G. Nesteruk Description An account of the resource Unfortunately, we can already talk about the coronavirus COVID-19 epidemic outbreak in Europe. This is evidenced by the large number of confirmed cases in Italy, registered in recent days. Prospects for epidemic development can be estimated from the accumulated information on the cases growth rate in mainland China. Comparison with the data on China will allow us to evaluate the effectiveness of quarantine measures and the level of individual protection, since we are dealing with the same pathogen. This short message provides a simple method of data comparison that can be useful for both governmental organizations and anyone. The first data points for the epidemic in Italy corresponded to the epidemic dynamics in mainland China. Fortunately, the growth rate of coronavirus patients in Europe has not become as threatening since February 29, 2020. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus epidemic, coronavirus epidemic in italy, coronavirus epidemic in china, coronavirus covid-19, coronavirus 2019-ncov, statistical methods Identifier An unambiguous reference to the resource within a given context DOI: 10.20535/kpi-sn.2020.1.198043 Source A related resource from which the described resource is derived KPI Science News Publisher An entity responsible for making the resource available National Technical University of Ukraine Igor Sikorsky Kyiv Polytechnic Institute"" Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology (General) Language A language of the resource EN, RU, UK https://www.socictopen.socict.org/files/original/e37c9ec24798173ac2c04d36c553b1b7.pdf 2094364cc502b541edc6fc7ca36115c8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource CORONAVIRUS EPIDEMIC OUTBREAK IN EUROPE. COMPARISON WITH THE DYNAMICS IN MAINLAND CHINA Creator An entity primarily responsible for making the resource Igor G. Nesteruk Description An account of the resource Unfortunately, we can already talk about the coronavirus COVID-19 epidemic outbreak in Europe. This is evidenced by the large number of confirmed cases in Italy, registered in recent days. Prospects for epidemic development can be estimated from the accumulated information on the cases growth rate in mainland China. Comparison with the data on China will allow us to evaluate the effectiveness of quarantine measures and the level of individual protection, since we are dealing with the same pathogen. This short message provides a simple method of data comparison that can be useful for both governmental organizations and anyone. The first data points for the epidemic in Italy corresponded to the epidemic dynamics in mainland China. Fortunately, the growth rate of coronavirus patients in Europe has not become as threatening since February 29, 2020. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus 2019-ncov, coronavirus (COVID-19), coronavirus epidemic, statistical methods, coronavirus epidemic in china, coronavirus epidemic in italy Identifier An unambiguous reference to the resource within a given context 10.20535/kpi-sn.2020.1.198043 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology (General) https://www.socictopen.socict.org/files/original/1e2bfef80cc3d13a9b4b9bcf90ae0751.pdf 360bbc9cf72e48032e6a88b00d768d09 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus et la pratique ophtalmologique Creator An entity primarily responsible for making the resource Hassan Moutei, ahmed Bennis, Fouad Chraibi, Meriem Abdellaoui, Idriss Andaloussi Benatiya Description An account of the resource Le nouveau coronavirus a été initialement nommé 2019-nCoV et officiellement appelé coronavirus 2 du syndrome respiratoire aigu sévère (SRAS-CoV-2). Au 26 février, le COVID-19 a été reconnu dans 34 pays, avec un total de 80 239 cas confirmés en laboratoire et 2 700 décès. L'épidémie de coronavirus 2019 (COVID-19), originaire de Wuhan, en Chine, est devenue un défi de santé publique majeur non seulement pour la Chine mais aussi pour les pays du monde entier. En raison de la pratique ophtalmologique, le risque d'infection croisée peut être élevé entre les patients et les ophtalmologues, des protocoles stricts et efficaces de contrôle des infections sont nécessaires.  L'épidémie de COVID-19 est devenue une menace clinique pour la population générale et les professionnels de la santé du monde entier. Cependant, les connaissances sur ce nouveau virus restent limitées. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, Épidémie, ophtalmologie Identifier An unambiguous reference to the resource within a given context 10.48400/IMIST.PRSM/JSMO/20042 Source A related resource from which the described resource is derived Journal de la Société Marocaine d’Ophtalmologie Publisher An entity responsible for making the resource available Societé Marocaine d’Ophtalmologie Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Ophthalmology https://www.socictopen.socict.org/files/original/48a6936e1ece4bcbdc21dfb2e16a8ead.pdf cd2951e8e53f0edc7f468e82aac2fc1f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus gene 7 counteracts host defenses and modulates virus virulence. Creator An entity primarily responsible for making the resource Jazmina L. G. Cruz, Isabel Sola, Martina Bécares, Berta Alberca, Joan Plana, Luis Enjuanes, Sonia Zuñiga Description An account of the resource Transmissible gastroenteritis virus (TGEV) genome contains three accessory genes: 3a, 3b and 7. Gene 7 is only present in members of coronavirus genus a1, and encodes a hydrophobic protein of 78 aa. To study gene 7 function, a recombinant TGEV virus lacking gene 7 was engineered (rTGEV-Δ7). Both the mutant and the parental (rTGEV-wt) viruses showed the same growth and viral RNA accumulation kinetics in tissue cultures. Nevertheless, cells infected with rTGEV-Δ7 virus showed an increased cytopathic effect caused by an enhanced apoptosis mediated by caspase activation. Macromolecular synthesis analysis showed that rTGEV-Δ7 virus infection led to host translational shut-off and increased cellular RNA degradation compared with rTGEV-wt infection. An increase of eukaryotic translation initiation factor 2 (eIF2α) phosphorylation and an enhanced nuclease, most likely RNase L, activity were observed in rTGEV-Δ7 virus infected cells. These results suggested that the removal of gene 7 promoted an intensified dsRNA-activated host antiviral response. In protein 7 a conserved sequence motif that potentially mediates binding to protein phosphatase 1 catalytic subunit (PP1c), a key regulator of the cell antiviral defenses, was identified. We postulated that TGEV protein 7 may counteract host antiviral response by its association with PP1c. In fact, pull-down assays demonstrated the interaction between TGEV protein 7, but not a protein 7 mutant lacking PP1c binding motif, with PP1. Moreover, the interaction between protein 7 and PP1 was required, during the infection, for eIF2α dephosphorylation and inhibition of cell RNA degradation. Inoculation of newborn piglets with rTGEV-Δ7 and rTGEV-wt viruses showed that rTGEV-Δ7 virus presented accelerated growth kinetics and pathology compared with the parental virus. Overall, the results indicated that gene 7 counteracted host cell defenses, and modified TGEV persistence increasing TGEV survival. Therefore, the acquisition of gene 7 by the TGEV genome most likely has provided a selective advantage to the virus. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1002090 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/b8211c4ccd62e38f26975e3fa1b6799d.pdf c852a1f24a51d62734847d0024c6441c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Genomics and Bioinformatics Analysis Creator An entity primarily responsible for making the resource Kwok-yung Yuen, Yi Huang, Susanna K. P. Lau, Patrick C. Y. Woo Description An account of the resource The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the largest genomes (26.4 to 31.7 kb) among all known RNA viruses, with G + C contents varying from 32% to 43%. Variable numbers of small ORFs are present between the various conserved genes (ORF1ab, spike, envelope, membrane and nucleocapsid) and downstream to nucleocapsid gene in different coronavirus lineages. Phylogenetically, three genera, Alphacoronavirus, Betacoronavirus and Gammacoronavirus, with Betacoronavirus consisting of subgroups A, B, C and D, exist. A fourth genus, Deltacoronavirus, which includes bulbul coronavirus HKU11, thrush coronavirus HKU12 and munia coronavirus HKU13, is emerging. Molecular clock analysis using various gene loci revealed that the time of most recent common ancestor of human/civet SARS related coronavirus to be 1999-2002, with estimated substitution rate of 4´10-4 to 2´10-2 substitutions per site per year. Recombination in coronaviruses was most notable between different strains of murine hepatitis virus (MHV), between different strains of infectious bronchitis virus, between MHV and bovine coronavirus, between feline coronavirus (FCoV) type I and canine coronavirus generating FCoV type II, and between the three genotypes of human coronavirus HKU1 (HCoV-HKU1). Codon usage bias in coronaviruses were observed, with HCoV-HKU1 showing the most extreme bias, and cytosine deamination and selection of CpG suppressed clones are the two major independent biological forces that shape such codon usage bias in coronaviruses. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource coronavirus, genome, Bioinformatics Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v2081803 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN