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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Combining Clinical and Epidemiologic Features for Early Recognition of SARS</text>
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                <text>Donald E Low, John A. Jernigan, Rita F. Helfand</text>
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                <text>Early recognition and rapid initiation of infection control precautions are currently the most important strategies for controlling severe acute respiratory syndrome (SARS). No rapid diagnostic tests currently exist that can rule out SARS among patients with febrile respiratory illnesses. Clinical features alone cannot with certainty distinguish SARS from other respiratory illnesses rapidly enough to inform early management decisions. A balanced approach to screening that allows early recognition of SARS without unnecessary isolation of patients with other respiratory illnesses will require clinicians not only to look for suggestive clinical features but also to routinely seek epidemiologic clues suggestive of SARS coronavirus exposure. Key epidemiologic risk factors include 1) exposure to settings where SARS activity is suspected or documented, or 2) in the absence of such exposure, epidemiologic linkage to other persons with pneumonia (i.e., pneumonia clusters), or 3) exposure to healthcare settings. When combined with clinical findings, these epidemiologic features provide a possible strategic framework for early recognition of SARS.</text>
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                <text>2004</text>
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                <text>Epidemiology, diagnosis, clinical features, coronavirus, SARS, SARS-CoV</text>
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                <text>DOI: 10.3201/eid1002.030741</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue</text>
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                <text>Donald E Low, Tony Mazzulli, Jagdish Butany, Kevin C. Kain, Susan M Poutanen, Sylvia L. Asa, Barbara M Willey, Gabriella A. Farcas</text>
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                <text>Efforts to contain severe acute respiratory syndrome (SARS) have been limited by the lack of a standardized, sensitive, and specific test for SARS-associated coronavirus (CoV). We used a standardized reverse transcription-polymerase chain reaction assay to detect SARS-CoV in lung samples obtained from well-characterized patients who died of SARS and from those who died of other reasons. SARS-CoV was detected in all 22 postmortem lung tissues (to 109 viral copies/g) from 11 patients with probable SARS but was not detected in any of the 23 lung control samples (sample analysis was blinded). The sensitivity and specificity (95% confidence interval) were 100% (84.6% to 100%) and 100% (85.1% to 100%), respectively. Viral loads were significantly associated with a shorter course of illness but not with the use of ribavirin or steroids. CoV was consistently identified in the lungs of all patients who died of SARS but not in control patients, supporting a primary role for CoV in deaths.</text>
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                <text>2004</text>
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                <text>Canada, RT-PCR, coronavirus, SARS, lung tissue</text>
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                <text>DOI: 10.3201/eid1001.030404</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation</text>
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                <text>Donald J. Noble, Shawn Hochman</text>
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                <text>Control of respiration provides a powerful voluntary portal to entrain and modulate central autonomic networks. Slowing and deepening breathing as a relaxation technique has shown promise in a variety of cardiorespiratory and stress-related disorders, but few studies have investigated the physiological mechanisms conferring its benefits. Recent evidence suggests that breathing at a frequency near 0.1 Hz (6 breaths per minute) promotes behavioral relaxation and baroreflex resonance effects that maximize heart rate variability. Breathing around this frequency appears to elicit resonant and coherent features in neuro-mechanical interactions that optimize physiological function. Here we explore the neurophysiology of slow, deep breathing and propose that coincident features of respiratory and baroreceptor afferent activity cycling at 0.1 Hz entrain central autonomic networks. An important role is assigned to the preferential recruitment of slowly-adapting pulmonary afferents (SARs) during prolonged inhalations. These afferents project to discrete areas in the brainstem within the nucleus of the solitary tract (NTS) and initiate inhibitory actions on downstream targets. Conversely, deep exhalations terminate SAR activity and activate arterial baroreceptors via increases in blood pressure to stimulate, through NTS projections, parasympathetic outflow to the heart. Reciprocal SAR and baroreceptor afferent-evoked actions combine to enhance sympathetic activity during inhalation and parasympathetic activity during exhalation, respectively. This leads to pronounced heart rate variability in phase with the respiratory cycle (respiratory sinus arrhythmia) and improved ventilation-perfusion matching. NTS relay neurons project extensively to areas of the central autonomic network to encode important features of the breathing pattern that may modulate anxiety, arousal, and attention. In our model, pronounced respiratory rhythms during slow, deep breathing also support expression of slow cortical rhythms to induce a functional state of alert relaxation, and, via nasal respiration-based actions on olfactory signaling, recruit hippocampal pathways to boost memory consolidation. Collectively, we assert that the neurophysiological processes recruited during slow, deep breathing enhance the cognitive and behavioral therapeutic outcomes obtained through various mind-body practices. Future studies are required to better understand the physio-behavioral processes involved, including in animal models that control for confounding factors such as expectancy biases.</text>
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                <text>2019</text>
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                <text>slow, Deep breathing, relaxation, Neurophysiological mechanisms, slowly-adapting pulmonary afferents, slow brain rhythms</text>
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                <text>DOI: 10.3389/fphys.2019.01176</text>
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                <text>Frontiers in Physiology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Physiology</text>
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                <text>Challenges and responsibilities of family doctors in the new global coronavirus outbreak</text>
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                <text>Donald Kwok Tung Li</text>
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                <text>10.1136/fmch-2020-000333</text>
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                <text>Family Medicine and Community Health</text>
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                <text>Medicine (General)</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The coronavirus outbreak: the central role of primary care in emergency preparedness and response</text>
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                <text>Donald Li, Amanda Howe, Luke N Allen, Catherine Dunlop</text>
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                <text>general practice, Primary Health Care, coronavirus, respiratory illness, Health Promotion and Prevention, Infectious illness</text>
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                <text>The impact of the Covid-19 pandemic on psychological health is still far from being defined  and  understood  in its  entirety. However,  it is  important,  right  from  the be-ginning,  to  look  at  what  were  the  aspects  that  most  affected  the  population  and make a hypothesis on the consequences that they may have in the long run. Start-ing from a brief historical account of the intervention carried out in Italy during the first epidemic wave, the authors aim at highlighting the major difficulties reported by  the population  and collected  in the field by  the  Federation’s operators  through the  telephone  service  operated  on  behalf  of  the  Ministry  of  Health.  The  interven-tion model used will then be illustrated, and an examination of the epidemiological data  and  an  analysis  of  the  stressors  that  have  had  the  greatest  impact  on  the psychological  health of  citizens  will be provided.  In  the end,  starting from  the  ele-ments provided, a reflection will be proposed on the peculiar aspects of this situa-tion and on the effectiveness of the intervention strategies implemented, illustrat-ing their possible strengths and weaknesses in view of a future intervention</text>
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                <text>Therapeutics. Psychotherapy</text>
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                <text>Coronavirus and the Heterogenesis of Ends: Underpinning the Ecological and Health Catastrophe is a Political Crisis</text>
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                <text>Donato  Bergandi</text>
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                <text>The coronavirus catastrophe that we are experiencing is first of all the result of an ecological catastrophe, but its underlying fundamental cause is the political crisis that our democracies are living. The sustainable development model is a smokescreen that will lead not to making deep-going changes to the economic paradigm but to continuing with business as usual. The betrayal of the elites, both political and economic, supported by a system that is no longer democratic, has exposed the population to this type of sanitary problem. A deep transformation of our political system is urgently needed. The people must take part in a true democracy, a direct democracy, that initiates a new democratic revolution capable of countering the sinister interests of the elites, of the caste in power.</text>
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                <text>coronavirus, sustainable development, direct democracy, ecological catastrophe, health catastrophe, political crisis</text>
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                <text>DOI: 10.13128/Substantia-911</text>
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                <text>Firenze University Press</text>
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                <text>Chemistry, History (General) and history of Europe</text>
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                <text>Unsustainable monitoring of environmental pollutants, post UNEP report: The effects of leachates on Niger Delta Eco-zones, Nigeria</text>
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                <text>Donatus Anayo Okpara</text>
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                <text>This expository study revealed the continuum impact of unsustainable monitoring of environmental pollutants (oil-spills and leachates) nearly a decade after UNEP impact assessment report on Ogoniland and Niger Delta eco-zones. The background is focused on pollutants that have continued threats to the environment and ecologically sensitive areas in the region. It infers the dimensions and dynamics of management failures and poor attitude towards environmental policy implementations. A structured questionnaire was adopted using an online survey approach. The target audience includes academicians, undergraduates, and postgraduates. The majority are from Niger Delta, the region where this research was carried out. An online questionnaire was sent across to 30 respondents through e-mail and others, due to Covid-19 restrictions. Their feedback was processed, analysed, and presented in graphics. We found pollution contributions to the mangrove forest to be 47%, oil exploration 77%. The effects were more on soil, water, and air quality. The water bodies are constantly losing the variety of its resources caused by the release of untreated leachates, industrial waste, and petrochemicals. A rather deteriorating fate lies ahead of the people as population increases, and environmental policies and monitoring seem ineffective. The study will be beneficial to the government, policymakers, waste agencies, researchers, etc.</text>
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                <text>10.1051/e3sconf/202021103010</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Environmental sciences</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells</text>
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                <text>Dong Eon Kim, Jung Sun Min, Min Seong Jang, Jun Young Lee, Young Sup Shin, Jong Hwan Song, Hyoung Rae Kim, Seungtaek Kim, Young-Hee Jin, Sunoh Kwon</text>
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                <text>Stephania tetrandra and other related species of Menispermaceae are the major sources of the bis-benzylisoquinoline alkaloids tetrandrine (TET), fangchinoline (FAN), and cepharanthine (CEP). Although the pharmacological properties of these compounds include anticancer and anti-inflammatory activities, the antiviral effects of these compounds against human coronavirus (HCoV) remain unclear. Hence, the aims of the current study were to assess the antiviral activities of TET, FAN, and CEP and to elucidate the underlying mechanisms in HCoV-OC43-infected MRC-5 human lung cells. These compounds significantly inhibited virus-induced cell death at the early stage of virus infection. TET, FAN, and CEP treatment dramatically suppressed the replication of HCoV-OC43 as well as inhibited viral S and N protein expression. The virus-induced host response was reduced by compound treatment as compared with the vehicle control. Taken together, these findings demonstrate that TET, FAN, and CEP are potential natural antiviral agents for the prevention and treatment of HCoV-OC43 infection.</text>
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                <text>bis-benzylisoquinoline alkaloids, Tetrandrine, fangchinoline, cepharanthine, human coronavirus strain oc43, mrc-5 human lung cell, antiviral effect</text>
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                <text>DOI: 10.3390/biom9110696</text>
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                <text>Biomolecules</text>
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                <text>Microbiology</text>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="45574">
                <text>Emergency cesarean section performed in a patient with confirmed severe acute respiratory syndrome Coronavirus-2 -a case report-</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="45575">
                <text>Dong Hwan Lee, Jihyang Lee, Eunju Kim, Kyeongyoon Woo, Hak Youle Park, Jihyun An</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="45576">
                <text>Background Since the first case of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) occurred in Wuhan in December 2019, the virus has spread globally. The World Health Organization declared the virus outbreak a pandemic on March 11, 2020. On January 19, 2020, a 35-year-old woman who returned from China was confirmed as the first SARS-CoV-2 infected case in Korea. Since then, it has spread all over Korea. Case We report the first case of a SARS-CoV-2 positive woman delivering a baby through cesarean section at 37+6 weeks of pregnancy in the Republic of Korea. Conclusions This case suggested that negative pressure operating room, skillful medical team, and enhanced personal protective equipment including N95 masks, surgical cap, double gown, double gloves, shoe covers, and powered air-purifying respirator are required at the hospital for safe delivery in such a case.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="45577">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="45578">
                <text>coronavirus infections, covid-19, pandemics, severe acute respiratory syndrome coronavirus 2, Pregnant Women, Cesarean section</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="45579">
                <text>10.4097/kja.20116</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="45580">
                <text>Korean Journal of Anesthesiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="45581">
                <text>Korean Society of Anesthesiologists</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="45582">
                <text>Anesthesiology</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
