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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and newborn health: systematic review</text>
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                <text>Bremen de Mucio, Pablo Durán, Suzanne Serruya, Rodolfo Gomez Ponce DE LEON, Thomas Jaenisch, Susan Niermeyer, Stephen Berman, Thaïs Forster</text>
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                <text>Objective. To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2. Methods. A systematic review was conducted by searching PubMed Central, LILACS, and Google Scholar using the keywords ‘covid’ AND ‘newborn’ OR ‘child’ OR ‘infant,’ on 18 March 2020, and again on 17 April 2020. One researcher conducted the search and extracted data on demographics, maternal outcomes, diagnostic tests, imaging, and neonatal outcomes. Results. Of 256 publications identified, 20 met inclusion criteria and comprised neonatal outcome data for 222 newborns whose mothers were suspected or confirmed to be SARS-CoV-2 positive perinatally (17 studies) or of newborns referred to hospital with infection/pneumonia (3 studies). Most (12 studies) were case-series reports; all were from China, except three (Australia, Iran, and Spain). Of the 222 newborns, 13 were reported as positive for SARS-CoV-2; most of the studies reported no or mild symptoms and no adverse perinatal outcomes. Two papers among those from newborns who tested positive reported moderate or severe clinical characteristics. Five studies using data on umbilical cord blood, placenta, and/or amniotic fluid reported no positive results. Nine studies reported radiographic imaging, including 5 with images of pneumonia, increased lung marking, thickened texture, or high-density nodular shadow. Minor, non-specific changes in biochemical variables were reported. Studies that tested breast milk reported negative SARS-CoV-2 results. Conclusions. Given the paucity of studies at this time, vertical transmission cannot be confirmed or denied. Current literature does not support abstaining from breastfeeding nor separating mothers and newborns. Further evidence and data collection networks, particularly in the Americas, are needed for establishing definitive guidelines and recommendations.</text>
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                <text>2020</text>
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                <text>Hereditary, Congenital, vertical, infectious disease transmission, Virus Diseases, Pandemics, Coronavirus infection, and neonatal diseases and abnormalities, SARS virus</text>
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                <text>DOI: 10.26633/RPSP.2020.54</text>
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            <name>Source</name>
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                <text>Revista Panamericana de Salud Pública</text>
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                <text>Pan American Health Organization</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Arctic medicine. Tropical medicine, Public aspects of medicine, Medicine</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>COVID-19 and Obesity: Dangerous Liaisons</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="83776">
                <text>Grazia Caci, Adriana Albini, Mario Malerba, Douglas M. Noonan, Patrizia Pochetti, Riccardo Polosa</text>
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                <text>Besides advanced age and the presence of multiple comorbidities as major contributors to increased risk of severe disease and fatal outcome from Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19), there is now emerging evidence that overweight and obesity predispose to severe symptoms and negative prognosis. Remarkably, the severity of COVID-19 appears to rise with increasing body mass index (BMI). The association between COVID-19 outcomes and overweight/obesity has biological and physiological plausibility. Potential pathophysiological mechanisms that may explain this strong association include the chronic pro-inflammatory state, the excessive oxidative stress response, and the impaired immunity that is commonly reported in these individuals. The role of cytokines, mammalian target of rapamycin (mTOR), and altered natural killer cell polarization in the dangerous liaison between COVID-19 and obesity are discussed here. These pathways can favor and accelerate the deleterious downstream cellular effects of SARS-CoV-2. Moreover, obesity is well known to be associated with reduced lung function and poor response to mechanical ventilation, thus placing these individuals at high risk of severe illness and mortality from COVID-19. Furthermore, obesity may lead to other complications, such as renal failure, cardiovascular dysfunction, hypertension, and vascular damage, which in turn can further accelerate negative clinical outcomes from COVID-19. Obese individuals should be shielded against any potential viral exposure to SARS-CoV-2 with consequential considerations for compulsory protection devices and social distancing. Health care providers should be aware that obesity predisposes to severe symptoms and negative prognosis in COVID-19 patients.</text>
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                <text>2020</text>
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                <text>covid-19, SARS-CoV-2, ACE2, cytokine storm, obesity, renin–angiotensin system (RAS) pathway</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.3390/jcm9082511</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>COVID-19 and Other Viral Pneumonias</text>
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            <name>Creator</name>
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              <elementText elementTextId="64437">
                <text>Nazlı Görmeli Kur, Melih Çamcı</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="64438">
                <text>Objectıve: Distinguishing COVID-19 pneumonia, which shares common symptoms with other respiratory viruses,from other pneumonia types will be of utmost importance for maintaining the sustainability of health services,preventing long waiting times of patients at emergency services, and isolating. We compared patients with COVID19 pneumonia and those with NONCOVID-19 pneumonia with a view to distinguishing COVID-19 pneumonia fromother pneumonias.Methods: Our study retrospectively reviewed the medical records of patients who were admitted to the emergencyservice of training and research hospital in Ağrı, Turkey between April 1-July 1, 2020. In our study two groups:patients with COVID-19 pneumonia and those with other pneumonias (non COVID-19) were compared in terms ofdemographic characteristics, laboratory data, and thoracic computerized tomography (CT) findings.Results: Our study included 201 patients in the non COVID-19 group and 165 patients in the COVID-19 group. Ananalysis based on the CT findings showed that the rate of ground glass opacities (GGO) was significantly higher inthe COVID-19 group (P &lt; 0.01). The rate of isolated lobar or segmental consolidation was significantly higher in thenon COVID-19 group (P &lt; 0.01). The lesions had a significantly higher rate of bilateral distribution and peripherallocation in the COVID-19 group (P &lt; 0.01). There was no significant difference between the two groups in terms ofthe mortality rate (P = 0.469).Conclusıon: We believe that in order to differentiate COVID-19 pneumonia from other pneumonias, a rapidthoracic computed tomography scan can be performed in the emergency department to be successfully patientmanagement.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, emergency services, viral pneumonias</text>
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                <text>10.5798/dicletip.887396</text>
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                <text>Dicle Medical Journal</text>
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                <text>Dicle University Medical School</text>
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                <text>Medicine, Medicine (General)</text>
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              <name>Title</name>
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                <text>COVID-19 and our DNA</text>
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                <text>Muhammad  Aslamkhan</text>
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            <description>An account of the resource</description>
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                <text>On December 31st 2019, Chinese Health Authorities in Wuhan city of their Hubei province, diagnosed 29 pneumonia cases of unknown etiology and informed WHO (World Health Organization). The unknown virus resembled SARS (severe acute respiratory syndrome), that occurred in China in November 2002, caused by a novel corona virus spilling over from an animal reservoir and transmitted by respiratory droplets. More than 8000 cases and 774 deaths were caused by SARS and circa US$20 billion coasted for its control.</text>
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                <text>2020</text>
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                <text>epidemiology, genome, Epidemic, covid-19, Pakistan, Wuhan, DNA, genetic susceptibility, rna enveloped viruses</text>
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                <text>10.37978/tijfs.v4i2.206</text>
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              <elementText elementTextId="63116">
                <text>The  International Journal of Frontier Sciences</text>
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                <text>Frontier Science Associates</text>
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                <text>Medicine, Microbiology</text>
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                <text>COVID-19 and people who use drugs; seizing opportunity in times of chaos.</text>
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                <text>The International journal on drug policy</text>
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                <text>COVID-19 and Power in Global Health</text>
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                <text>Amy Patterson, Mary A. Clark</text>
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                <text>Political scientists bring important tools to the analysis of the coronavirus disease 2019 (COVID-19) pandemic, particularly a focus on the crucial role of power in global health politics. We delineate different kinds of power at play during the COVID-19 crisis, showing how a dearth of compulsory, institutional, and epistemic power undermined global cooperation and fueled the pandemic, with its significant loss to human life and huge economic toll. Through the pandemic response, productive and structural power became apparent, as issue frames stressing security and then preserving livelihoods overwhelmed public health and human rights considerations. Structural power rooted in economic inequalities between and within countries conditioned responses and shaped vulnerabilities, as the crisis threatened to deepen power imbalances along multiple lines. Calls for global health security will surely take on a new urgency in the aftermath of the pandemic and the forms of power delineated here will shape their outcome.</text>
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                <text>covid-19, health disparities, pandemic response, power relations, issue framing</text>
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                <text>International Journal of Health Policy and Management</text>
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                <text>Kerman University of Medical Sciences</text>
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                <text>Public aspects of medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and Pregnancy Outcome: An Experience in ‘COVID-19 Management Designated’ Tertiary Care Hospital, Rawalpindi, Pakistan</text>
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                <text>Shazia Syed, Humera Noreen, Humaira Masood, Ismat Batool, Hina Gul, Nighat Naheed</text>
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                <text>Background: The current COVID-19 pandemic has affected almost 17.3 million victims worldwide with mortality of almost 674K. Pregnancy is one of the most susceptible conditions for COVID-19 infection, but limited data is currently available about the clinical characteristics of pregnant women with the disease. Objective; to describe the clinical characteristics, co-morbidities, management, feto-maternal, and neonatal outcome in COVID-19 positive pregnant women.  Methodology: A descriptive case series study was conducted in Obs/Gynae dept of Benazir Bhutto Tertiary Care Hospital, Rawalpindi, including all asymptomatic/symptomatic COVID-19 positive pregnant women and clinical suspects (COVID-19 PCR negative women) delivered in our hospital from 01st April 2020 to 31st July 2020. Their medical records were reviewed for clinical characteristics, management, feto-maternal and neonatal outcomes. Continuous variables were expressed in Mean &amp; Range and Categorical variables as number &amp; Percentage. Results: During the study period a total of 17 cases were reviewed. The mean maternal age was 28.94 yrs. Primigravida (07), Multipara (10). Mean gestational age was 37 wks (range; 30-41wks). Presenting symptomatology was varied. Asymptomatic; (29%), COVID-19 specific symptoms; fever &amp; flu (12%), fever&amp;cough (6%), shortness of breath(SOB) alone (6%), fever &amp; SOB(6%) and pregnancy-related manifestations were labour pains (17%), eclampsia(6%), hydrocephalous fetus (6%) and hepatic encephalopathy(6%). The commonest co-morbidity was Hypertensive disorders of pregnancy (24%). Five women (29%) required ICU care. Lower segment caesarean sections(LSCS) (59%), vaginal delivery (41%). Eleven babies delivered with good Apgar score and birth weight. Two were early neonatal deaths (ENND) and 04 were received intra-uterine fetal deaths (IUDs). Fetal demise was associated with strong obstetric risk factors. Out of 13 live-born babies, RT-PCR Covid-19 testing was done in 10 (77%) cases and was negative. One mother was expired due to complications of hepatic encephalopathy, sepsis, and burst abdomen.  Conclusion; The clinical course of COVID-19 disease in pregnancy seems to be no different from non-pregnant women. Clinical manifestations are diverse and infection contracted in the third trimester of pregnancy is associated with good feto-maternal and neonatal outcomes.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>covid-19, Pandemic, SARS-CoV-2, F eto maternal outcome, Neonatal Outcome</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.37939/jrmc.v24iSupp-1.1453</text>
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                <text>Journal of Rawalpindi Medical College</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Rawalpindi Medical University</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and Pregnancy: Risk, Symptoms, Diagnosis, and Treatment.</text>
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                <text>Mayur S Parmar, Vera Hapshy, Daniel Aziz, Payal Kahar, Deepesh Khanna, Kenneth E Johnson</text>
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            <description>An account of the resource</description>
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                <text>Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel virus responsible for causing an infection known as COVID-19. Several pulmonary and systemic manifestations of the illness have been described since the discovery of this virus. However, there have been higher-risk populations in which this infection has not been well studied nor documented. One of these populations includes the pregnant cohort. The purpose of this article is to describe the clinical manifestations of COVID-19 infection in the pregnant population and review the implications and sequelae of the infection throughout pregnancy and outcomes of live births. Also, we summarize the understanding and safety of current treatments and vaccination in pregnancy. This comprehensive review article comprises several case reports, case series, cohort studies, retrospective studies, and randomized clinical trials. Findings regarding maternal morbidity included an increased risk of acquiring severe COVID-19 infection requiring a higher level of inpatient hospital care along with an increased risk of preterm labor and cesarean delivery. Neonatal COVID-19 vertical transmission was shown to have conflicting data as there was a presence of transmission in certain retrospective studies and absence in others. There was also no evidence of teratogenicity from maternal COVID-19 infection. In conclusion, in part due to the unique physiologic state of pregnancy and part due to unknown factors, pregnant patients are at increased risk for negative outcomes of COVID-19 infection and must be classified as a high-risk population.</text>
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                <text>2021</text>
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                <text>vaccine, covid-19, treatment, Pregnancy, SARS-CoV-2, Vertical transmission, placenta, Neonatal outcomes</text>
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                <text>10.1007/s42399-021-00915-2</text>
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                <text>SN comprehensive clinical medicine</text>
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                <text>COVID-19 and primary care in six countries</text>
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                <text>Patricia Huston, John Campbell, Grant Russell, Felicity Goodyear-Smith, Robert L Phillips, Chris van Weel, William Hogg</text>
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                <text>10.3399/bjgpopen20X101128</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43936">
                <text>COVID-19 and publishing</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43937">
                <text>Kim, Kihong</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="43938">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="43939">
                <text>10.6087/kcse.203</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="43940">
                <text>Science Editing</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="43941">
                <text>Korean Council of Science Editors</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="43942">
                <text>Science (General)</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
