50 10 20655 https://www.socictopen.socict.org/files/original/54526e8b13957caf2f00131bf0749226.pdf f07e6d8de5b2dfbffd8468f8ea4367cc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Differentiation of Bovine coronavirus (BCoV) genotypes by a restriction enzyme assay Creator An entity primarily responsible for making the resource Sibele Pinheiro de Souza, Karen Miyuki Asano, Thaisa Lucas Sandri, Iracema Nunes de Barros, Leonardo José Richtzenhain, Paulo Eduardo Brandão Description An account of the resource This article reports the use of the GsuI restriction enzyme to differentiate genotypes of Bovine Coronavirus (BCoV), based on an 18-nucleotide deletion of S1-coding region found in one of the two genotypes. It was concluded that this assay can be used as a rapid tool for BCoV genotypes differentiation. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Bovine coronavirus, restriction enzyme, genotypes, Genes Identifier An unambiguous reference to the resource within a given context DOI: 10.1590/S1517-83822010000300034 Source A related resource from which the described resource is derived Brazilian Journal of Microbiology Publisher An entity responsible for making the resource available Sociedade Brasileira de Microbiologia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/645e2d0482db98e90f8b7deaf3eecee7.pdf a0e5d75efa33d9dbf9daacdffaa818bc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ocorrência de coronavírus entérico de ferrets no Brasil: nota prévia Creator An entity primarily responsible for making the resource Fabio Gregori, Márcia Helena Braga Catroxo, Vanessa da Silva Lopes, Vera Letticie de Azevedo Ruiz, Paulo Eduardo Brandão Description An account of the resource Coronavírus entérico de furões (FECV) é associado à enterite catarral epizoótica (ECE) em furões (Mustela putorius furo). Neste estudo, relatamos a ocorrência deste agente em quatro amostras fecais diarreicas de furões domésticos, analisadas por microscopia eletrônica de transmissão (contrastação negativa) e RT-PCR específica e direcionada ao gene de nucleocapsídeo (N). Estes achados constituem o primeiro relato de FECV no Brasil e remetem para a importância deste vírus na etiologia de quadros entéricos nestes animais. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Coronavirus entérico de ferrets, Enterite catarral epizoótica, Furão, Mustela putorius furo. Coronavirus Identifier An unambiguous reference to the resource within a given context DOI: 10.11606/issn.1678-4456.bjvras.2010.26840 Source A related resource from which the described resource is derived Brazilian Journal of Veterinary Research and Animal Science Publisher An entity responsible for making the resource available Universidade de São Paulo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Animal culture Language A language of the resource EN, PT https://www.socictopen.socict.org/files/original/5947514c3d4903dedbc643479377c4e0.pdf 527cd21ab0d2e183b8657ddf4bc1324c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans Creator An entity primarily responsible for making the resource Tony Schountz, Michelle L. Baker, John Butler, Vincent Munster Description An account of the resource Bats are reservoir hosts of many important viruses that cause substantial disease in humans, including coronaviruses, filoviruses, lyssaviruses, and henipaviruses. Other than the lyssaviruses, they do not appear to cause disease in the reservoir bats, thus an explanation for the dichotomous outcomes of infections of humans and bat reservoirs remains to be determined. Bats appear to have a few unusual features that may account for these differences, including evidence of constitutive interferon (IFN) activation and greater combinatorial diversity in immunoglobulin genes that do not undergo substantial affinity maturation. We propose these features may, in part, account for why bats can host these viruses without disease and how they may contribute to the highly pathogenic nature of bat-borne viruses after spillover into humans. Because of the constitutive IFN activity, bat-borne viruses may be shed at low levels from bat cells. With large naive antibody repertoires, bats may control the limited virus replication without the need for rapid affinity maturation, and this may explain why bats typically have low antibody titers to viruses. However, because bat viruses have evolved in high IFN environments, they have enhanced countermeasures against the IFN response. Thus, upon infection of human cells, where the IFN response is not constitutive, the viruses overwhelm the IFN response, leading to abundant virus replication and pathology. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource bats, Chiroptera, zoonosis, antibody repertoire, emerging infectious disease, virus ecology Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2017.01098 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/d844b4170ce522ec3e116a534d43e3f6.pdf d09ba3c581460a3f37b0b03594e4bd66 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells Creator An entity primarily responsible for making the resource Wen Shi, Wenlu Fan, Jing Bai, Yandong Tang, Li Wang, Yanping Jiang, Lijie Tang, Min Liu, Wen Cui, Yigang Xu, Yijing Li Description An account of the resource Type II transmembrane serine proteases (TTSPs) facilitate the spread and replication of viruses such as influenza and human coronaviruses, although it remains unclear whether TTSPs play a role in the progression of animal coronavirus infections, such as that by porcine epidemic diarrhea virus (PEDV). In this study, TTSPs including TMPRSS2, HAT, DESC1, and MSPL were tested for their ability to facilitate PEDV replication in Vero cells. Our results showed that TMPRSS2 and MSPL played significant roles in the stages of cell–cell fusion and virus–cell fusion, whereas HAT and DESC1 exhibited weaker effects. This activation may be involved in the interaction between TTSPs and the PEDV S protein, as the S protein extensively co-localized with TMPRSS2 and MSPL and could be cleaved by co-expression with TMPRSS2 or MSPL. Moreover, the use of Vero cells expressing TMPRSS2 and MSPL facilitated PEDV replication in the absence of exogenous trypsin. In sum, we identified two host proteases, TMPRSS2 and MSPL, which may provide insights and a novel method for enhancing viral titers, expanding virus production, and improving the adaptability of PEDV isolates in vitro. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource porcine epidemic diarrhea virus, type II transmembrane serine protease, TMPRSS2, MSPL, Virus replication Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v9050114 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/88748d273fb0b6aede3848e63c8ad552.pdf b4adaebb2ef5a2c9449602f87e1b6bc3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Surto de diarreia em vacas de um rebanho leiteiro na região sul de Minas Gerais: detecção de coronavírus bovino nas fezes Outbreak of diarrhea in cows from a dairy herd in the southern region of Minas Gerais State: detection of bovine coronavirus in the feces Creator An entity primarily responsible for making the resource P.S Bezerra Jr, P. E. Brandão, S.P. Pavarini, M.S Varaschin, F Wouters, L.Y.B. Villarreal, J.A. Jerez, G.M. Costa Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1590/S0102-09352009000400030 Source A related resource from which the described resource is derived Arquivo Brasileiro de Medicina Veterinária e Zootecnia Publisher An entity responsible for making the resource available Universidade Federal de Minas Gerais Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Animal culture Language A language of the resource EN, PT https://www.socictopen.socict.org/files/original/41bcc56a1544e126c33269f369454d61.pdf 1259d1595e99fe2a42808384bfcfc2c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Conceptual Framework to use Remediation of Errors Based on Multiple External Remediation Applied to Learning Objects Creator An entity primarily responsible for making the resource Maici Duarte Leite, Diego Marczal, Andrey Ricardo Pimentel, Alexandre Ibrahim Direne Description An account of the resource This paper presents the application of some concepts of Intelligent Tutoring Systems (ITS) to elaborate a conceptual framework that uses the remediation of errors with Multiple External Representations (MERs) in Learning Objects (LO). To this is demonstrated a development of LO for teaching the Pythagorean Theorem through this framework. This study explored the remediation process of error by a classification of error in mathematical, providing support for the use of MERs with the remediation of error. The main objective of the proposed framework is to assist the individual learner in the recovery of a mistake made during the interaction with the LO, either through carelessness or lack of knowledge. Initially, we present the compilation of the classification of mathematical errors and their relationship with MERs. Later the concepts involved with conceptual framework proposed. Finally, an experiment with LO developed with a authoring tool called FARMA, using the conceptual framework for teaching the Pythagorean Theorem is presented. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Intelligent Learning Objects, e-learning, Multiple External Representations Identifier An unambiguous reference to the resource within a given context DOI: 10.3926/jotse.111 Source A related resource from which the described resource is derived Journal of Technology and Science Education Publisher An entity responsible for making the resource available OmniaScience Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology, Education, Special aspects of education, Engineering (General). Civil engineering (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/da7e155b9a2a75c34aeea973118b8a29.pdf 3c64419f2fbfd3b0c04c960260e0f82e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test Creator An entity primarily responsible for making the resource Dai MY, Qiao JP, Xu YH, Fei GH Description An account of the resource Meng-Yuan Dai,1 Jin-Ping Qiao,2 Yuan-Hong Xu,2 Guang-He Fei1 1Pulmonary Department, 2Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China Purpose: To investigate the respiratory infectious phenotypes and their impact on length of stay (LOS) and the COPD Assessment Test (CAT) Scale in acute exacerbation of COPD (AECOPD). Patients and methods: We categorized 81 eligible patients into bacterial infection, viral infection, coinfection, and non-infectious groups. The respiratory virus examination was determined by a liquid bead array xTAG Respiratory Virus Panel in pharyngeal swabs, while bacterial infection was studied by conventional sputum culture. LOS and CAT as well as demographic information were recorded. Results: Viruses were detected in 38 subjects, bacteria in 17, and of these, seven had both. Influenza virus was the most frequently isolated virus, followed by enterovirus/rhinovirus, coronavirus, bocavirus, metapneumovirus, parainfluenza virus types 1, 2, 3, and 4, and respiratory syncytial virus. Bacteriologic analyses of sputum showed that Pseudomonas aeruginosa was the most common bacteria, followed by Acinetobacter baumannii, Klebsiella, Escherichia coli, and Streptococcus pneumoniae. The longest LOS and the highest CAT score were detected in coinfection group. CAT score was positively correlated with LOS. Conclusion: Respiratory infection is a common causative agent of exacerbations in COPD. Respiratory coinfection is likely to be a determinant of more severe acute exacerbations with longer LOS. CAT score may be a predictor of longer LOS in AECOPD. Keywords: COPD, acute exacerbation, respiratory infectious, phenotypes, LOS, CAT Date A point or period of time associated with an event in the lifecycle of the resource 2015 Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived International Journal of COPD Publisher An entity responsible for making the resource available Dove Medical Press Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the respiratory system Language A language of the resource EN https://www.socictopen.socict.org/files/original/cf96efd22ca58ae58004a15ab9bf6c26.pdf 282e31708d26e50db4788ebaa85a55d6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The CD8 T Cell Response to Respiratory Virus Infections Creator An entity primarily responsible for making the resource Megan E. Schmidt, Steven M. Varga Description An account of the resource Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and parainfluenza virus. While some viruses simply cause symptoms of the common cold, many respiratory viruses induce severe bronchiolitis, pneumonia, and even death following infection. Despite the immense clinical burden, the majority of the most common pulmonary viruses lack long-lasting efficacious vaccines. Nearly all current vaccination strategies are designed to elicit broadly neutralizing antibodies, which prevent severe disease following a subsequent infection. However, the mucosal antibody response to many respiratory viruses is not long-lasting and declines with age. CD8 T cells are critical for mediating clearance following many acute viral infections in the lung. In addition, memory CD8 T cells are capable of providing protection against secondary infections. Therefore, the combined induction of virus-specific CD8 T cells and antibodies may provide optimal protective immunity. Herein, we review the current literature on CD8 T cell responses induced by respiratory virus infections. Additionally, we explore how this knowledge could be utilized in the development of future vaccines against respiratory viruses, with a special emphasis on RSV vaccination. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource CD8 T cell, memory T cell, respiratory virus, Respiratory Syncytial Virus, Influenza A virus, human metapneumovirus Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2018.00678 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/6797eccc1347c7e220336f1a153a4170.pdf c2b446c0d469ea63f5899fb3847b2c4d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Slopes of Avian Species-Area Relationships, Human Population Density, and Environmental Factors Creator An entity primarily responsible for making the resource Karl L. Evans, Jack J. Lennon, Kevin J. Gaston Description An account of the resource There is increasing interest in how humans influence spatial patterns in biodiversity. One of the most frequently noted and marked of these patterns is the increase in species richness with area, the species-area relationship (SAR). SARs are used for a number of conservation purposes, including predicting extinction rates, setting conservation targets, and identifying biodiversity hotspots. Such applications can be improved by a detailed understanding of the factors promoting spatial variation in the slope of SARs, which is currently the subject of a vigorous debate. Moreover, very few studies have considered the anthropogenic influences on the slopes of SARs; this is particularly surprising given that in much of the world areas with high human population density are typically those with a high number of species, which generates conservation conflicts. Here we determine correlates of spatial variation in the slopes of species-area relationships, using the British avifauna as a case study. Whilst we focus on human population density, a widely used index of human activities, we also take into account (1) the rate of increase in habitat heterogeneity with increasing area, which is frequently proposed to drive SARs, (2) environmental energy availability, which may influence SARs by affecting species occupancy patterns, and (3) species richness. We consider environmental variables measured at both local (10 km à - 10 km) and regional (290 km à - 290 km) spatial grains, but find that the former consistently provides a better fit to the data. In our case study, the effect of species richness on the slope SARs appears to be scale dependent, being negative at local scales but positive at regional scales. In univariate tests, the slope of the SAR correlates negatively with human population density and environmental energy availability, and positively with the rate of increase in habitat heterogeneity. We conducted two sets of multiple regression analyses, with and without species richness as a predictor. When species richness is included it exerts a dominant effect, but when it is excluded temperature has the dominant effect on the slope of the SAR, and the effects of other predictors are marginal. Date A point or period of time associated with an event in the lifecycle of the resource 2007 Subject The topic of the resource habitat diversity, human population density, macroecology, spatial statistics, species-area relationships Identifier An unambiguous reference to the resource within a given context DOI: 10.5751/ACE-00155-020207 Source A related resource from which the described resource is derived Avian Conservation and Ecology Publisher An entity responsible for making the resource available Resilience Alliance Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences, Plant culture, Plant ecology Language A language of the resource EN https://www.socictopen.socict.org/files/original/78ce0080028ed3be6bcada304ff4eca1.pdf 1f01f781aa1f125d1c61da1c23dbdfd4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Aptamers in Diagnostics and Treatment of Viral Infections Creator An entity primarily responsible for making the resource Tomasz Wandtke, Joanna Woźniak, Piotr Kopiński Description An account of the resource Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have been conducted through the process known as SELEX (Systematic Evolution of Ligands by Exponential Enrichment). It serves to reach specificity and considerable affinity to target molecules, including those of viral origin, both proteins and nucleic acids. Properties of aptamers allow detecting virus infected cells or viruses themselves and make them competitive to monoclonal antibodies. Specific aptamers can be used to interfere in each stage of the viral replication cycle and also inhibit its penetration into cells. Many current studies have reported possible application of aptamers as a treatment or diagnostic tool in viral infections, e.g., HIV (Human Immunodeficiency Virus), HBV (Hepatitis B Virus), HCV (Hepatitis C Virus), SARS (Severe Acute Respiratory Syndrome), H5N1 avian influenza and recently spread Ebola. This review presents current developments of using aptamers in the diagnostics and treatment of viral diseases. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource aptamer, SELEX, HIV, HCV, H5N1, HSV, HPV, Ebola Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v7020751 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN