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                  <text>Dominio científico: Coronavirus</text>
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                <text>Chloroquine and hydroxychloroquine for COVID-19 treatment</text>
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                <text>Dwi Aris Agung Nugrahaningsih, Eko Purnomo</text>
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                <text>Coronavirus disease 2019 (COVID-19) is an emerging disease caused bysevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that has been causing many people around the world affected. There is no approved treatment for COVID-19. Meanwhile, vaccine development still needs a long time before it becomes available to protect people from contracting COVID-19. Repurposing the available drugs is one of the fastest ways to get COVID-19 treatment. Studies have been conducted to discover for COVID-19 treatment that results in the finding of potential medication for COVID-19. Chloroquine and hydroxychloroquine are some of the available medication that shows potential for COVID-19 treatment. Preclinical study showed that the both drugs are active against SARS-CoV-2 in vitro. A pilot clinical study also showed their efficacy in COVID-19 treatment. Many clinical trials are now being conducted to prove their safety and efficacy for the prevention and treatment of COVID-19. However, until now there are not enough data to support the use of these drugs in COVID-19 management. Under the pressure to treat COVID-19 patients with chloroquine or hydroxychloroquine, clinicians shouldnot use these drugs for COVID-19 without considering the available information regarding theiruse for COVID-19. This review summarized the evidence regarding the potential of chloroquine and hydroxychloroquine in COVID-19 management.</text>
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                <text>2020</text>
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                <text>covid-19, Hydroxychloroquine, chloroquine</text>
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                <text>10.19106/JMedSciSI005203202002</text>
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                <text>Journal of the Medical Sciences</text>
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                <text>Universitas Gadjah Mada</text>
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                <text>Medicine, Medicine (General)</text>
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                <text>How to make it work: a framework for rapid research to inform evidence-based decision –making about the implementation of online learning during the COVID-19 pandemic</text>
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                <text>Poh Sun  Goh, John Sandars</text>
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                <text>Evidence- based decision making about the implementation of online learning in medical education during the COVID-19 pandemic is a challenge for decision-makers since it is a time of rapid change.  We present a new framework that offers a potential highly useful response to meet this challenge. Our proposed framework for rapid research of online learning during the COVID-19 pandemic recognises the challenge of understanding the complexity of the socio-technical system in which the online learning is implemented, including the behaviour change of individuals in the system and the system's absorptive capacity. The framework provides a structured approach for rapid research to understand the complexity of the implementation of online learning during the COVID-19 pandemic.  We recommend that rapid research to inform decision-making about the implementation of online learning during the COVID-19 pandemic should focus on early identification of the needs of the decision-makers and the use of high quality rapid research approaches to provide relevant and timely information about context, processes and outcomes.</text>
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                <text>2020</text>
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                <text>research, covid-19, online learning, policy</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine, Special aspects of education</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
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                <text>Investigating Virological, Immunological, and Pathological Avenues to Identify Potential Targets for Developing COVID-19 Treatment and Prevention Strategies</text>
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                <text>Helal F. Hetta, Zafar Mahmood, Hani Alrefai, Hidaya A. Kader, Nayla Munawar, Sheikh Abdul Rahman, Shereen Elshaer, Gaber  EI-Saber Batiha, Khalid Muhammad</text>
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                <text>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus causing respiratory disease commonly known as COVID-19. This novel coronavirus transmits from human to human and has caused profound morbidity and mortality worldwide leading to the ongoing pandemic. Moreover, disease severity differs considerably from individual to individual. Investigating the virology of COVID-19 and immunological pathways underlying its clinical manifestations will enable the identification and design of effective vaccines and potential therapies. In this review, we explore COVID-19 virology, the contribution of the immune system (innate and adaptive) during infection and control of the virus. Finally, we highlight vaccine development and implications of immune system modulation for potential therapeutic interventions to design better therapeutic strategies to guide future cure.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>vaccine development, covid-19, T cells, B cells</text>
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                <text>10.3390/vaccines8030443</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
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                <text>Medicine</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
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                <text>Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.</text>
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                <text>Vittorio Pavoni, Lara Gianesello</text>
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                <text>2021</text>
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                <text>10.1007/s11239-020-02115-6</text>
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                <text>Journal of thrombosis and thrombolysis</text>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
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                <text>The Relationship between Health Consciousness and Home-Based Exercise in China during the COVID-19 Pandemic</text>
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            <name>Creator</name>
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                <text>Bo Pu, Zhiwei Tang, Lu Zhang, Yanjun Qiu</text>
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                <text>During the COVID-19 pandemic, people have reduced the frequency of going out, and need to engage in health behaviors at home. Home-based exercise has aroused people’s attention. This paper aims to examine the influencing mechanism of health consciousness on home-based exercise during the COVID-19 pandemic. A questionnaire method was used to select 449 Chinese respondents on an online platform; the questionnaire includes a health consciousness scale, health life goal scale, perceived behavioral control scale, and the home-based exercise scale. A T-test was used to conduct differential analysis. The hierarchical regression analysis method was used to examine the relationship between health consciousness and home-based exercise, and the Hayes’ SPSS PROCESS macro was used to test mediating effect. The results show that there are significant differences in home-based exercise with respect to gender, age, and marital status. Health consciousness has a significant positive effect on home-based exercise. Perceived behavioral control acts as the mediator between health consciousness and home-based exercise. Health consciousness can influence home-based exercise through health life goals and perceived behavioral control in turn. This paper takes a home-based exercise survey, and expands the theoretical research of home-based exercise. The findings suggest that people should pay attention to promoting the transformation of health consciousness into home-based exercise. It provides enlightenment for people to adopt health behaviors during the COVID-19 pandemic.</text>
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                <text>2020</text>
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                <text>covid-19, Home-based exercise, Health Consciousness, perceived behavioral control, health life goal</text>
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                <text>10.3390/ijerph17165693</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19</text>
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                <text>Hashemian SM, Farhadi T, Velayati AA</text>
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                <text>Seyed MohammadReza Hashemian,1,2 Tayebeh Farhadi,2 Ali Akbar Velayati2 1Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranCorrespondence: Tayebeh FarhadiChronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranTel/ Fax +982126109931Email tayebehfarhadi@yahoo.comAbstract: The novel coronavirus 2019 (2019-nCoV), formally named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a novel human infectious coronavirus. The disease caused by SARS-CoV-2 is named COVID-19. Development and manufacturing of specific therapeutics and vaccines to treat COVID-19 are time-consuming processes. At this time, using available conventional therapeutics along with other treatment options may be useful to fight COVID-19. In different clinical trials, efficacy of remdesivir (GS-5734) against Ebola virus has been demonstrated. Moreover, remdesivir may be an effective therapy in vitro and in animal models infected by SARS and MERS coronaviruses. Hence, the drug may be theoretically effective against SARS-CoV-2. Remdesivir is a phosphoramidate prodrug of an adenosine C-nucleoside. By entrance into respiratory epithelial cells in human, the prodrug is metabolized to a nucleoside triphosphate as the active form. The nucleoside analog inhibits the viral RNA-dependent RNA polymerase (RdRp) by competing with the usual counterpart adenosine triphosphate (ATP). The nucleoside analog is incorporated into the generating RNA strand and causes a delayed stop in the viral replication process. Knowledge about the potential efficacy of remdesivir against coronaviruses has been restricted to in vitro studies and animal models. However, information related to COVID-19 is rapidly growing. Several clinical trials are ongoing for the management of COVID-19 using remdesivir. In this study, characteristics of remdesivir and its usage for treatment of COVID-19 are reviewed based on an electronic search using PubMed and Google Scholar.Keywords: remdesivir, COVID-19, SARS-CoV-2, RNA-dependent RNA polymerase</text>
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                <text>2020</text>
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                <text>covid-19, SARS-CoV-2, Remdesivir, RNA dependent RNA polymerase</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Therapeutics. Pharmacology</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>El Sistema Integrado de radios de la UNER pone en valor en su programación todo lo que las Universidades aportan a la sociedad en la emergencia del COVID-19</text>
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                <text>Aldo Rotman, Carlos Milito</text>
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            <description>An account of the resource</description>
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                <text>Durante la vigencia del aislamiento social preventivo y obligatorio dispuesto por el Gobierno Nacional Argentino a raíz de la pandemia, aparecieron nuevas modalidades en los consumos culturales, no obstante, la radio ha sido consecuente con su rol de informar e interpretar lo que sucede en una sociedad, acosada por el COVID-19. En este marco, las radios universitarias argentinas cumplen al informar con responsabilidad e interpretar lo que sucede. Cada una de las radios que integran ARUNA, la Asociación de Radios universitarias argentinas lo hace con su huella institucional y con la responsabilidad de ser un medio de comunicación Público. Aldo Rotman, explica la estrategia comunicacional que definió el Sistema Integrado de radios de la UNER.</text>
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                <text>2020</text>
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                <text>pandemia, Tecnologias, infodemia, Estrategias, Periodismo, RADIOS UNIVERSITARIAS</text>
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                <text>10.24215/16696581e381</text>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="50573">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Communication. Mass media</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Efficacy of chloroquine versus lopinavir/ritonavir in mild/general COVID-19 infection: a prospective, open-label, multicenter, randomized controlled clinical study</text>
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                <text>Jinyu Xia, Xi Liu, Zhong-Si Hong, Hui-Li Chen, Yuqi Shang, Hongqiong Zhu, Gongqi Chen, Yuanli Chen, Shaoxuan Liu, Yaoyong Zhou, Mingxing Huang</text>
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                <text>Abstract Background The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. The adage “old drug, new trick” in this context may suggest the important therapeutic potential of existing drugs. We found that the lopinavir/ritonavir treatment recommended in the fifth edition of the Treatment Plan of China can only help to improve a minority of throat-swab nucleic-acid results (3/15) in hospitals. Our previous use of chloroquine to treat patients with COVID-19 infection showed an improvement in more throat-swab nucleic-acid results (5/10) than the use of lopinavir/ritonavir. Methods/design This is a prospective, open-label, randomized controlled, multicenter clinical study. The study consists of three phases: a screening period, a treatment period of no more than 10 days, and a follow-up period for each participant. Participants with COVID-19 infection who are eligible for selection for the study will be randomly allocated to the trial group or the control group. The control group will be given lopinavir/ritonavir treatment for no more than 10 days. The trial group will be given chloroquine phosphate treatment for no more than 10 days. The primary outcome is the clinical recovery time at no more than 28 days after the completion of therapy and follow-up. The secondary outcomes include the rate of treatment success after the completion of therapy and follow-up, the time of treatment success after no more than 28 days, the rate of serious adverse events during the completion of therapy and follow-up, and the time to return to normal temperature (calculated from the onset of illness) during the completion of therapy and follow-up. Comparisons will be performed using two-sided tests with a statistical significance level of 5%. Discussion This experiment should reveal the efficacy and safety of using chloroquine versus lopinavir/ritonavir for patients with mild/general COVID-19 infection. If the new treatment including chloroquine shows a higher rate of throat-swab SARS-CoV-2 real-time fluorescent reverse transcription polymerase chain reaction (RT-PCR) negativity and is safe, it could be tested as a future COVID-19 treatment. Trial registration Chinese Clinical Trial Registry, ID: ChiCTR2000029741 . Registered on 11 February 2020.</text>
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                <text>2020</text>
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                <text>covid-19, lopinavir/ritonavir, chloroquine, Efficacy, randomized controlled clinical study</text>
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            <name>Identifier</name>
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              <elementText elementTextId="50580">
                <text>10.1186/s13063-020-04478-w</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="50581">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="50582">
                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine (General)</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Cambios esperados en las funciones administrativas después de la emergencia sanitaria: estudio en directivos de España y Colombia</text>
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            <elementTextContainer>
              <elementText elementTextId="50585">
                <text>Marcela Navia-Núñez, Yanna Stefanu-Lidorikiotu</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>La enfermedad COVID-19 ha generado una parálisis mundial. Una empresa colombiana y una española analizaron el caso de directivos en la etapa de confinamiento por medio de un estudio asincrónico con el método cualitativo Delphi. En el estudio, participaron encargados de recursos humanos, mercadeo o ambas áreas. Se evaluaron grandes empresas, pequeñas y medianas empresas (pymes), organizaciones sin fines de lucro y agremiaciones ubicadas en España y Colombia. Si bien el objetivo inicial fue estudiar los cambios esperados en las relaciones interpersonales, a medida que los participantes abrieron temas de debate, se abordaron las funciones administrativas, que es el foco del presente  artículo. La función administrativa de planeación ha sido la más afectada por la pandemia. Se encontró que se han extendido otras formas de organización. Tal es el caso del teletrabajo, cuyas dificultades para la interacción y la manera de ejercer su control simultáneo preocupan a los directivos. Por ello, se debe trabajar en lazos de confianza y comunicación. Por otro lado, en el período de cuarentena, se aprendió a tomar decisiones más rápidamente. Con respecto a las expectativas futuras, se espera que los directivos muestren más empatía hacia las necesidades ajenas y que prevalezca la funcionalidad de ellos en el desempeño de las tareas administrativas.</text>
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              <elementText elementTextId="50587">
                <text>2020</text>
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                <text>covid-19, crisis, TELETRABAJO, Directivos, Funciones administrativas</text>
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            <name>Identifier</name>
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                <text>10.18800/contabilidad.202002.001</text>
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              <elementText elementTextId="50590">
                <text>Contabilidad y Negocios: Revista del Departamento Académico de Ciencias Administrativas</text>
              </elementText>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="50591">
                <text>Pontificia Universidad Católica del Perú</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="50592">
                <text>Business, Accounting. Bookkeeping</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50594">
                <text>Wilson Savino, Wilson Savino, Ícaro Raony, Ícaro Raony, Camila Saggioro de Figueiredo, Pablo Pandolfo, Elizabeth Giestal-de-Araujo, Elizabeth Giestal-de-Araujo, Priscilla Oliveira-Silva Bomfim, Priscilla Oliveira-Silva Bomfim, Priscilla Oliveira-Silva Bomfim, Wilson Savino</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond the respiratory system, also affecting mental health. Several factors may be involved in the association between COVID-19 and psychiatric outcomes, such as fear inherent in the pandemic, adverse effects of treatments, as well as financial stress, and social isolation. Herein we discuss the growing evidence suggesting that the relationship between SARS-CoV-2 and host may also trigger changes in brain and behavior. Based on the similarity of SARS-CoV-2 with other coronaviruses, it is conceivable that changes in endocrine and immune response in the periphery or in the central nervous system may be involved in the association between SARS-CoV-2 infection and impaired mental health. This is likely to be further enhanced, since millions of people worldwide are isolated in quarantine to minimize the transmission of SARS-CoV-2 and social isolation can also lead to neuroendocrine-immune changes. Accordingly, we highlight here the hypothesis that neuroendocrine-immune interactions may be involved in negative impacts of SARS-CoV-2 infection and social isolation on psychiatric issues.</text>
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            <name>Date</name>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>central nervous system, mental health, covid-19, Pandemic, cytokine, HPA axis</text>
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            <name>Identifier</name>
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              <elementText elementTextId="50598">
                <text>10.3389/fimmu.2020.01170</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="50599">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="50600">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="50601">
                <text>Immunologic diseases. Allergy</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
