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                <text>De von Bertalanffy a Luhmann: Deconstrucción del concepto “agroecosistema” a través de las generaciones sistémicas</text>
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                <text>El pensamiento sistémico contribuyó al origen de l pensamiento agroecológico con aportaciones desde la  teoría  general  de  sistemas  y  la  cibernética  como  su  base  teórica  primigenia.  Así,  la  agroecología  en  los  años 70 del siglo pasado pudo erigirse como una nueva forma de pensar y hacer ciencia en relación con  el  quehacer  agrícola  al  intentar  ir  más  allá  del  enfoque  reduccionista  predominante.  El  estudio  de  la  realidad   agrícola   contemporánea   exige   planteamientos   nuevos   que   permitan   comprender   sus  dimensiones,  para  lo  cual  los  principios  basados  en  el  modelo input - output  que  funciona  bajo  un  controlador  cibernético  resultan  insuficientes.  En  consecuencia,  el  propósito  de  este  manuscrito  fue  analizar la evolución del pensamiento sistémico y su trascendencia en el pensamiento agroecológico, al  brindar  a  éste  úl timo  herramientas  teórico - conceptuales  para  estudiar  fenómenos  agrícolas  actuales  a  través  de  los  sistemas  complejos,  y  con  ello,  involucrar  aspectos  poco  explorados  en  su  abordaje  tradicional como la historia, la política y la cultura.</text>
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                <text>Abstract We introduce a k-mer-based computational protocol, DE-kupl, for capturing local RNA variation in a set of RNA-seq libraries, independently of a reference genome or transcriptome. DE-kupl extracts all k-mers with differential abundance directly from the raw data files. This enables the retrieval of virtually all variation present in an RNA-seq data set. This variation is subsequently assigned to biological events or entities such as differential long non-coding RNAs, splice and polyadenylation variants, introns, repeats, editing or mutation events, and exogenous RNA. Applying DE-kupl to human RNA-seq data sets identified multiple types of novel events, reproducibly across independent RNA-seq experiments.</text>
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                <text>Dealing with suspended new routine general dermatology referrals during the COVID-19 pandemic: a virtual model from our local departmental experience.</text>
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                <text>A Pararajasingam, A Lowe, W Khan, P Hancock, N Stone</text>
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                <text>2021</text>
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                <text>10.1111/ced.14580</text>
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                <text>Clinical and experimental dermatology</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Dealing with the high-risk potential of COVID-19 cross-infection in dental practice</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="39784">
                <text>Heribertus Dedy Kusuma Yulianto, Nunuk Purwanti, Trianna Wahyu Utami, Anne Handrini Dewi, Dyah Listyarifah, Intan Ruspita, Asikin Nur, Heni Susilowati</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>The World Health Organization reported that the SARS-CoV-2 virus has infected more than 5 million people around the world. Dental care providers and health care professionals need to be aware of the high-risk potential of crossinfection since the routes of virus transmission commonly happen through droplets and aerosols. This review aimed at collecting essential knowledge about the COVID-19 needed by dental practitioners. The review focused on the oral involvement in COVID-19, the role of oral transmission as the high-risk potential of cross-infection and recommended strategies to minimize the risk of cross-infection in dental practice. We searched all the published clinical features from PubMed, Google Scholar, Scopus and hand searched library online databases, from January 2015 until May 2020. Keywords used were “COVID-19”, “Dentistry”, “Dental protection”, “Cross-contamination”, “Aerosol and non aerosol”, and ”Povidone-iodine” with their combinations. We identified 52 articles to review after the initial selection with inclusion and exclusion criteria. Results showed use of topical applications of povidine-iodine and viricidal mouthwash could significantly reduce the high-risk of cross-infection from dentistry patients who are asymptomatic with COVID-19 infection. Further safeguards include suspending all non-emergency procedures temporarily and closely screening patients for symptoms which may be suspected to be COVID-19 infection.</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="39787">
                <text>oral transmission, povidone-iodine, systemic manifestation, covid-19 cross-infection, emergency dental</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.22146/majkedgiind.56588</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="39789">
                <text>Majalah Kedokteran Gigi Indonesia</text>
              </elementText>
            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="39790">
                <text>Universitas Gadjah Mada</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Dentistry</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="83598">
                <text>Sergio Enríquez-Flores, Luis  Antonio Flores-López, Itzhel García-Torres, Ignacio de la Mora-de la Mora, Nallely Cabrera, Pedro Gutiérrez-Castrellón, Yoalli Martínez-Pérez, Gabriel López-Velázquez</text>
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          <element elementId="41">
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            <description>An account of the resource</description>
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                <text>Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. The human genome encodes only 600–1500 targets for small-molecule drugs, but posttranslational modifications lead to a considerably larger druggable proteome. The spontaneous conversion of asparagine (Asn) residues to aspartic acid or isoaspartic acid is a frequent modification in proteins as part of the process called deamidation. Triosephosphate isomerase (TIM) is a glycolytic enzyme whose deamidation has been thoroughly studied, but the prospects of exploiting this phenomenon for drug design remain poorly understood. The purpose of this study is to demonstrate the properties of deamidated human TIM (HsTIM) as a selective molecular target. Using in silico prediction, in vitro analyses, and a bacterial model lacking the tim gene, this study analyzed the structural and functional differences between deamidated and nondeamidated HsTIM, which account for the efficacy of this protein as a druggable target. The highly increased permeability and loss of noncovalent interactions of deamidated TIM were found to play a central role in the process of selective enzyme inactivation and methylglyoxal production. This study elucidates the properties of deamidated HsTIM regarding its selective inhibition by thiol-reactive drugs and how these drugs can contribute to the development of cell-specific therapeutic strategies for a variety of diseases, such as COVID-19 and cancer.</text>
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            <description>The topic of the resource</description>
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                <text>SARS-CoV-2, protein structure, Glycolysis, ages, omeprazole, Triosephosphate isomerase</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="83602">
                <text>10.3390/biom10071050</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="83603">
                <text>Epidemiology and Health</text>
              </elementText>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="83604">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="83605">
                <text>Microbiology</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Death Anxiety in Social Workers as a Consequence of the COVID-19 Pandemic</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="79742">
                <text>José  Ángel Martínez-López, Cristina Lázaro-Pérez, José Gómez-Galán</text>
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            <description>An account of the resource</description>
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                <text>The COVID-19 pandemic has affected all social spaces, conditioning our daily routines, including those at work. All professions have been affected by stressful situations and anxiety in the proximity’s face of death generated by the pandemic. In this context, some professionals have emerged as essential, as social workers, acting in extreme situations in the face of increased demands and social uncertainty arising from the health crisis. The present study aimed to determine the levels of anxiety about death among social workers in Spain. For this purpose, an ad hoc questionnaire was designed, taking the Collett and Lester Fear of Death Scale as a reference (n = 304). The exploitation of the data was carried out from a quantitative perspective. First, a descriptive analysis was performed. Then, binary logistic regressions were carried out on the general scale. The dependent variable in all of them was the risk of suffering death anxiety to the set of its subscales. The main research results show high values of this anxiety in social workers concerning the general value of the scale—and the subscales—and the point of view of state and process. The highest values were Fear of Death of Others (81.6%) and Fear of the Process of Dying of Others (78.3%). Regarding the binary logistic regressions applied, predictor variables were identified in all of them, but the following stand out: Lack of personal protection equipment and Need psychological or psychiatric support. In addition, being a woman increases the risk of suffering Fear of the Dying Process of others.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="79744">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="79745">
                <text>Prevention, covid-19, health crisis, Death Anxiety, social workers</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="79746">
                <text>10.3390/bs11050061</text>
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          <element elementId="48">
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="79747">
                <text>Biotemas</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="79748">
                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Psychology</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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          <element elementId="50">
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                <text>Deaths associated with newly launched SARS-CoV-2 vaccination (Comirnaty®).</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Carolin Edler, Anke Klein, Ann Sophie Schröder, Jan-Peter Sperhake, Benjamin Ondruschka</text>
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            <description>An account of the resource</description>
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                <text>Since 27th December 2020, a mRNA vaccine from BioNTech / Pfizer (Comirnaty®) has been used across Germany. As of 12th March 2021, 286 fatalities of vaccinated German individuals were registered at the Paul-Ehrlich-Institute with time intervals after vaccination between one hour to 40 days. From our catchment area in northern Germany, we have so far become aware of 22 deaths in connection with vaccination in a 5 week period (range: 0-28 days after vaccination). Three death cases after vaccination with Comirnaty®, which were autopsied at the Institute of Legal Medicine Hamburg, are presented in more detail. All three deceased had severe cardiovascular diseases, among other comorbidities, and died in the context of these pre-existing conditions, while one case developed a COVID-19 pneumonia as cause of death. Taking into account the results of the postmortem examination a causal relation between the vaccination and the death was not established in any case. If there are indications of an allergic reaction, histological and postmortem laboratory examinations should be performed subsequent to the autopsy (tryptase, total IgE, CRP, interleukin-6, complement activity C3/C5).</text>
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                <text>2021</text>
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                <text>SARS-CoV-2, Vaccination, autopsy, covid-19 vaccine, Comirnaty®</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="58346">
                <text>10.1016/j.legalmed.2021.101895</text>
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                <text>Legal medicine (Tokyo, Japan)</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>10.4103/ijsp.ijsp_226_20</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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