570 10 20655 https://www.socictopen.socict.org/files/original/7919db8d4a7b8056f9fbbb4f3e551fa9.pdf e3a346daaec7a1deb9ce99289265e0b1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decoupling of urban CO₂ and air pollutant emission reductions during the European SARS-CoV-2 lockdown Creator An entity primarily responsible for making the resource C. Lamprecht, M. Graus, M. Striednig, M. Stichaner, T. Karl Description An account of the resource Lockdown and the associated massive reduction in people's mobility imposed by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) mitigation measures across the globe provide a unique sensitivity experiment to investigate impacts on carbon and air pollution emissions. We present an integrated observational analysis based on long-term in situ multispecies eddy flux measurements, allowing for quantifying near-real-time changes of urban surface emissions for key air quality and climate tracers. During the first European SARS-CoV-2 wave we find that the emission reduction of classic air pollutants decoupled from CO2 and was significantly larger. These differences can only be rationalized by the different nature of urban combustion sources and point towards a systematic bias of extrapolated urban NOx emissions in state-of-the-art emission models. The analysis suggests that European policies, shifting residential, public, and commercial energy demand towards cleaner combustion, have helped to improve air quality more than expected and that the urban NOx flux remains to be dominated (e.g., &gt;90 %) by traffic. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.5194/acp-21-3091-2021 Source A related resource from which the described resource is derived Atmospheric Chemistry and Physics Publisher An entity responsible for making the resource available Copernicus Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chemistry, Physics https://www.socictopen.socict.org/files/original/76a356f10a8656a71bfe40b041a2232c.pdf 860e06aacd55365576f356a24a7ccf0f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decrease in Ambient Fine Particulate Matter during COVID-19 Crisis and Corresponding Health Benefits in Seoul, Korea Creator An entity primarily responsible for making the resource Changwoo Han, Yun-Chul Hong Description An account of the resource Both domestic emissions and transported pollutants from neighboring countries affect the ambient fine particulate matter (PM2.5) concentration of Seoul, Korea. Diverse measures to control the coronavirus disease 2019 (COVID-19), such as social distancing and increased telecommuting in Korea and the stringent lockdown measures of China, may reduce domestic emissions and levels of transported pollutants, respectively. In addition, wearing a particulate-filtering respirator may have decreased the absolute PM2.5 exposure level for individuals. Therefore, this study estimated the acute health benefits of PM2.5 reduction and changes in public behavior during the COVID-19 crisis in Seoul, Korea. To calculate the mortality burden attributable to PM2.5, we obtained residents’ registration data, mortality data, and air pollution monitoring data for Seoul from publicly available databases. Relative risks were derived from previous time-series studies. We used the attributable fraction to estimate the number of excessive deaths attributable to acute PM2.5 exposure during January to April, yearly, from 2016 to 2020, and the number of mortalities avoided from PM2.5 reduction and respirator use observed in 2020. The average PM2.5 concentration from January to April in 2020 (25.6 μg/m3) was the lowest in the last 5 years. At least −4.1 μg/m3 (95% CI: −7.2, −0.9) change in ambient PM2.5 in Seoul was observed in 2020 compared to the previous 4 years. Overall, 37.6 (95% CI: 32.6, 42.5) non-accidental; 7.0 (95% CI: 5.7, 8.4) cardiovascular; and 4.7 (95% CI: 3.4, 6.1) respiratory mortalities were avoided due to PM2.5 reduction in 2020. By considering the effects of particulate respirator, decreases of 102.5 (95% CI: 89.0, 115.9) non-accidental; 19.1 (95% CI: 15.6, 22.9) cardiovascular; and 12.9 (95% CI: 9.2, 16.5) respiratory mortalities were estimated. We estimated that 37 lives were saved due to the PM2.5 reduction related to COVID-19 in Seoul, Korea. The health benefit may be greater due to the popular use of particulate-filtering respirators during the COVID-19 crisis. Future studies with daily mortality data are needed to verify our study estimates. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource mortality, Korea, covid-19, lockdown, particulate matter, health burden Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph17155279 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/3ac1be9dbf1e3c88210f6b37d84522cf.pdf 01a64de7e4e09237e35810dc2eb12a5b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decrease in Enteroviral Meningitis - An Unexpected Benefit of COVID-19 Mitigation? Creator An entity primarily responsible for making the resource Kami D Kies, Amber S Thomas, Matthew J Binnicker, Kelli L Bashynski, Robin Patel Description An account of the resource Enteroviral meningitis is seasonal, typically exhibiting a rise in prevalence in late summer/early fall. Based on clinical microbiology laboratory testing data of cerebrospinal fluid, the expected August/September/October peak in enteroviral meningitis did not occur in 2020, possibly related to COVID-19 mitigation strategies. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1093/cid/ciaa1881 Source A related resource from which the described resource is derived Clinical infectious diseases : an official publication of the Infectious Diseases Society of America https://www.socictopen.socict.org/files/original/3e4c4fa3eed148f82880e01b02bdad70.pdf c4f8aa37a0b4350dccf47a2359733e00 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decrease in Trauma Admissions with COVID-19 Pandemic Creator An entity primarily responsible for making the resource Tovy H. Kamine, Adam Rembisz, Rebecca J. Barron, Carey Baldwin, Mark Kromer Description An account of the resource Introduction: The COVID-19 pandemic has led to social distancing and decreased travel in the United States. The impact of these interventions on trauma and emergency general surgery patient volume has not yet been described. Methods: We compared trauma admissions and emergency general surgery (EGS) cases between February 1–April 14 from 2017–2020 in five two-week time periods. Data were compared across time periods with Poisson regression analysis. Results: There were significant decreases in overall trauma admissions (57.4% decrease, p Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.5811/westjem.2020.5.47780 Source A related resource from which the described resource is derived Western Journal of Emergency Medicine Publisher An entity responsible for making the resource available eScholarship Publishing, University of California Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medical emergencies. Critical care. Intensive care. First aid https://www.socictopen.socict.org/files/original/32db65d9d49f1ec8293bfd70b82e6c17.pdf 10684dfd5797f80ef076cbb970be1e79 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decreased Anthropogenic CO₂ Emissions during the COVID-19 Pandemic Estimated from FTS and MAX-DOAS Measurements at Urban Beijing Creator An entity primarily responsible for making the resource Cheng Liu, Zhaonan Cai, Ke Che, Yi Liu, Dongxu Yang, Xu Yue Description An account of the resource The COVID-19 pandemic has led to ongoing reductions in economic activity and anthropogenic emissions. Beijing was particular badly affected by lockdown measures during the early months of the COVID-19 pandemic. It has significantly reduced the CO2 emission and toxic air pollution (CO and NO2). We use column-averaged dry-air mole fractions of CO2 and CO (XCO2 and XCO) observed by a ground-based EM27/SUN Fourier transform spectrometer (FTS), the tropospheric NO2 column observed by MAX-DOAS and satellite remote sensing data (GOSAT and TROPOMI) to investigate the variations in anthropogenic CO2 emission related to COVID-19 lockdown in Beijing. The anomalies describe the spatio-temporal enhancement of gas concentration, which relates to the emission. Anomalies in XCO2 and XCO, and XNO2 (ΔXCO2, ΔXCO, and ΔXNO2) for ground-based measurements were calculated from the diurnal variability. Highly correlated daily XCO and XCO2 anomalies derived from FTS time series data provide the ΔXCO to ΔXCO2 ratio (the correlation slope). The ΔXCO to ΔXCO2 ratio in Beijing was lower in 2020 (8.2 ppb/ppm) than in 2019 (9.6 ppb/ppm). The ΔXCO to ΔXCO2 ratio originating from a polluted area was significantly lower in 2020. The reduction in anthropogenic CO2 emission was estimated to be 14.2% using FTS data. A comparable value reflecting the slowdown in growth of atmospheric CO2 over the same time period was estimated to be 15% in Beijing from the XCO2 anomaly from GOSAT, which was derived from the difference between the target area and the background area. The XCO anomaly from TROPOMI is reduced by 8.7% in 2020 compared with 2019, which is much smaller than the reduction in surface air pollution data (17%). Ground-based NO2 observation provides a 21.6% decline in NO2. The NO2 to CO2 correlation indicates a 38.2% decline in the CO2 traffic emission sector. Overall, the reduction in anthropogenic CO2 emission relating to COVID-19 lockdown in Beijing can be detected by the Bruker EM27/SUN Fourier transform spectrometer (FTS) and MAX-DOAS in urban Beijing. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, lockdown, XCO₂, total column measurements, XCO, XNO₂ Identifier An unambiguous reference to the resource within a given context 10.3390/rs13030517 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science https://www.socictopen.socict.org/files/original/97b06be9212b42f55f008f2403bf345e.pdf d349108ae2e588f1548a5c8942bb14a3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Decreased Power but Preserved Bursting Features of Subthalamic Neuronal Signals in Advanced Parkinson's Patients under Controlled Desflurane Inhalation Anesthesia Creator An entity primarily responsible for making the resource Sheng-Huang Lin, Hsin-Yi Lai, Yu-Chun Lo, Chin Chou, Yi-Ting Chou, Shih-Hung Yang, I Sun, Bo-Wei Chen, Ching-Fu Wang, Guan-Tze Liu, Fu-Shan Jaw, Shin-Yuan Chen, You-Yin Chen Description An account of the resource Deep brain stimulation (DBS) surgery of the subthalamic nucleus (STN) under general anesthesia (GA) had been used in Parkinson's disease (PD) patients who are unable tolerate awake surgery. The effect of anesthetics on intraoperative microelectrode recording (MER) remains unclear. Understanding the effect of anesthetics on MER is important in performing STN DBS surgery with general anesthesia. In this study, we retrospectively performed qualitive and quantitative analysis of STN MER in PD patients received STN DBS with controlled desflurane anesthesia or LA and compared their clinical outcome. From January 2005 to March 2006, 19 consecutive PD patients received bilateral STN DBS surgery in Hualien Tzu-Chi hospital under either desflurane GA (n = 10) or LA (n = 9). We used spike analysis (frequency and modified burst index [MBI]) and the Hilbert transform to obtain signal power measurements for background and spikes, and compared the characterizations of intraoperative microelectrode signals between the two groups. Additionally, STN firing pattern characteristics were determined using a combined approach based on the autocorrelogram and power spectral analysis, which was employed to investigate differences in the oscillatory activities between the groups. Clinical outcomes were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) before and after surgery. The results revealed burst firing was observed in both groups. The firing frequencies were greater in the LA group and MBI was comparable in both groups. Both the background and spikes were of significantly greater power in the LA group. The power spectra of the autocorrelograms were significantly higher in the GA group between 4 and 8 Hz. Clinical outcomes based on the UPDRS were comparable in both groups before and after DBS surgery. Under controlled light desflurane GA, burst features of the neuronal firing patterns are preserved in the STN, but power is reduced. Enhanced low-frequency (4–8 Hz) oscillations in the MERs for the GA group could be a characteristic signature of desflurane's effect on neurons in the STN. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Parkinson's disease, Subthalamic Nucleus, deep brain stimulation, microelectrode recording, desflurane general anesthesia, low-frequency oscillation Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fnins.2017.00701 Source A related resource from which the described resource is derived Frontiers in Neuroscience Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neurosciences. Biological psychiatry. Neuropsychiatry Language A language of the resource EN https://www.socictopen.socict.org/files/original/2a47fd82d2ae8ff5a6402be87c5b8c9f.pdf 11e4567f618477d8ffc9f0d78ee1b4d5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Deep Brain Stimulation for Parkinson’s Disease During the COVID-19 Pandemic: Patient Perspective Creator An entity primarily responsible for making the resource Eric A. Storch, Chencheng Zhang, Chencheng Zhang, Chencheng Zhang, Jing Zhang, Jing Zhang, Xian Qiu, Xian Qiu, Yingying Zhang, Yingying Zhang, Zhengyu Lin, Zhengyu Lin, Peng Huang, Peng Huang, Yixin Pan, Yixin Pan, Bomin Sun, Bomin Sun, Dianyou Li, Dianyou Li Description An account of the resource BackgroundPublic health guidelines have recommended that elective medical procedures, including deep brain stimulation (DBS) surgery for Parkinson’s disease (PD), should not be scheduled during the coronavirus (COVID-19) pandemic to prevent further virus spread and overload on health care systems. However, delaying DBS surgery for PD may not be in the best interest of individual patients and is not called for in regions where virus spread is under control and inpatient facilities are not overloaded.MethodsWe administered a newly developed phone questionnaire to 20 consecutive patients with PD who received DBS surgery in Ruijin Hospital in Shanghai during the COVID-19 pandemic. The questionnaire was designed to gather the patients’ experiences and perceptions on the impact of COVID-19 on their everyday activities and access to medical care.ResultsMost of the patients felt confident about the preventive measures taken by the government and hospitals, and they have changed their daily living activities accordingly. Moreover, a large majority of patients felt confident obtaining access to regular and COVID-19-related health care services if needed. Routine clinical referral, sense of security in the hospital during the outbreak, and poor control of PD symptoms were the three main reasons given by patients for seeking DBS surgery during the COVID-19 pandemic.ConclusionThe COVID-19 pandemic has considerably impacted medical care and patients’ lives but elective procedures, such as DBS surgery for PD, do not need to be rescheduled when the health care system is not overloaded and adequate public health regulations are in place. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Parkinson’s disease, elective surgery, person centered care, deep brain stimulation Identifier An unambiguous reference to the resource within a given context 10.3389/fnhum.2021.628105 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neurosciences. Biological psychiatry. Neuropsychiatry https://www.socictopen.socict.org/files/original/a0dcae6e8958c04040c4fb0892b8daf9.pdf d811f02866039c28ee35eb15bcc3506e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Deep drug-target binding affinity prediction with multiple attention blocks. Creator An entity primarily responsible for making the resource Yuni Zeng, Xiangru Chen, Yujie Luo, Xuedong Li, Dezhong Peng Description An account of the resource Drug-target interaction (DTI) prediction has drawn increasing interest due to its substantial position in the drug discovery process. Many studies have introduced computational models to treat DTI prediction as a regression task, which directly predict the binding affinity of drug-target pairs. However, existing studies (i) ignore the essential correlations between atoms when encoding drug compounds and (ii) model the interaction of drug-target pairs simply by concatenation. Based on those observations, in this study, we propose an end-to-end model with multiple attention blocks to predict the binding affinity scores of drug-target pairs. Our proposed model offers the abilities to (i) encode the correlations between atoms by a relation-aware self-attention block and (ii) model the interaction of drug representations and target representations by the multi-head attention block. Experimental results of DTI prediction on two benchmark datasets show our approach outperforms existing methods, which are benefit from the correlation information encoded by the relation-aware self-attention block and the interaction information extracted by the multi-head attention block. Moreover, we conduct the experiments on the effects of max relative position length and find out the best max relative position length value $k \in \{3, 5\}$. Furthermore, we apply our model to predict the binding affinity of Corona Virus Disease 2019 (COVID-19)-related genome sequences and $3137$ FDA-approved drugs. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, deep learning, drug-target interaction, self-attention Identifier An unambiguous reference to the resource within a given context 10.1093/bib/bbab117 Source A related resource from which the described resource is derived Briefings in bioinformatics https://www.socictopen.socict.org/files/original/36590341b59924078c6bf9aa9a9b141b.pdf 72154ce14680d5f507d3d518b1b6eb9b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource DEEP ECOLOGY: THE AWAKENING PROCESS TO A COMPLEX ENVIRONMENTAL EDUCATION Creator An entity primarily responsible for making the resource Patricia Braga Lovatto, Eduardo Alexis Lobo, Shirley Altemburg Nascimento Altemburg, Hélvio Casalinho Description An account of the resource Facing the contemporary environmental crisis, the environmental education emerges as a tool for coping and minimizing the impacts of human civilization on natural resources. So, in most of the works, what is observed is the predominance of environmental thinking, often devoid of ecosystem vision. The speech is limited to the need of preserving resources related to a distorted and uncritical development. Little attention is given to the dimensions of sustainability, the environment being treated as a part of the individual, mere outer portion of the human body. This perspective demonstrates the fragility of this speech to an effective awareness by revealing the disorder of the actions that occur within a deterministic ecological process, with little attention to the educational sphere, related to cognitive, ethical and cultural factors. Within these aspects, Complex Environmental Education suggests self-knowledge, awareness and environmental action in pursuit of the development that considers the integral quality of life, rather than the economic variable. In this sense, the deep ecology booster acts as an agent in the process of awakening to environmental education that is self-sustainability and so complex, because it helps the human perception on the integrative and dependent view of all beings, unifying them for the life. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource desenvolvimento, ecología, percepção Identifier An unambiguous reference to the resource within a given context 10.17058/redes.v16i3.1347 Source A related resource from which the described resource is derived Redes Publisher An entity responsible for making the resource available Universidade de Santa Cruz do Sul Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social Sciences, Social sciences (General), Human ecology. Anthropogeography Relation A related resource <a href="https://online.unisc.br/seer/index.php/redes/article/view/1347" target="_blank" rel="noreferrer noopener">https://online.unisc.br/seer/index.php/redes/article/view/1347</a> https://www.socictopen.socict.org/files/original/5c763bf145c74a11600a50401e99174c.pdf aa280b826f43575026c5f94db8259ce8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds Creator An entity primarily responsible for making the resource Luca Piemontese, Roberta Sergio, Federica Rinaldo, Leonardo Brunetti, Filippo M. Perna, M. Amélia Santos, Vito Capriati Description An account of the resource An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer&#8217;s disease (AD) treatment. Building upon these findings, we have now designed and completed the whole synthesis of PZ1 in the so-called deep eutectic solvents (DESs), which have emerged as an unconventional class of bio-renewable reaction media in green synthesis. Under optimized reaction conditions, the preparation of a series of 2-hydroxyphenylbenzimidazole-based nuclei has also been perfected in DESs, and comparison with other routes which employ toxic and volatile organic solvents (VOCs) provided. The functionalization of the aromatic ring can have implications on some important biological properties of the described derivatives and will be the subject of future studies of structure-activity relationships (SARs). Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource deep eutectic solvents, 2-hydroxyphenylbenzimidazole, Alzheimer’s disease Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules25030574 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN