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Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection.
BACKGROUND: Feline infectious peritonitis (FIP) is a lethal immune-mediated disease caused by feline coronavirus (FCoV). Currently, no therapy with proven efficacy is available. In searching for agents that may prove clinically effective against FCoV…
Position: 6849 (30 views)
Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection.
BACKGROUND: Feline infectious peritonitis (FIP) is a lethal immune-mediated disease caused by feline coronavirus (FCoV). Currently, no therapy with proven efficacy is available. In searching for agents that may prove clinically effective against FCoV…
Position: 7386 (29 views)
Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach
There is no effective therapeutic or vaccine for Middle East Respiratory Syndrome and this study attempts to find therapy using peptide by establishing a basis for the peptide-protein interactions through in silico docking studies for the spike…
Position: 16098 (19 views)
Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains
Human coronavirus 229E (HCoV-229E) infection in infants, elderly people, and immunocompromised patients can cause severe disease, thus calling for the development of effective and safe therapeutics to treat it. Here we reported the design, synthesis…
Position: 6342 (31 views)
Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum
Molecular mimicry, defined as similar structures shared by molecules from dissimilar genes or proteins, is a general strategy used by pathogens to infect host cells. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious…
Position: 4903 (35 views)
People’s responses to the COVID-19 pandemic during its early stages and factors affecting those responses
Abstract The world has suffered from the COVID-19 pandemic. While it is expected that societies will learn lessons from this experience, knowledge about how people responded to the pandemic in its early stages is very limited. With the aim of…
Position: 17003 (18 views)
People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy
The coronavirus disease 2019 (COVID-19) epidemic affects people’s health and health-related quality of life (HRQoL), especially in those who have suspected COVID-19 symptoms (S-COVID-19-S). We examined the effect of modifications of health literacy…
Position: 12094 (23 views)
People Giving Hope in the Time of COVID-19: They Also Serve Who Care and Share
That murmur, soon replies, “God doth not need Either man’s work or his own gifts; who best Bear his mild yoke, they serve him best. His state Is Kingly. Thousands at his bidding speed And post o’er Land and Ocean without rest: They also serve…
Position: 9462 (26 views)
Penyusunan Petunjuk Praktikum Kimia Berorientasi Chemo-Entrepreneurship pada Larutan Penyangga
Penelitian penyusunan petunjuk praktikum berorientasi chemo-entrepreneurship (CEP) pada materi larutan penyangga berdasarkan karakteristik peserta didik yang lebih menyukai metode praktikum sebagai proses pembelajaran, namun hasil observasi di…
Position: 12094 (23 views)
Pentoxifylline: An Immunomodulatory Drug for the Treatment of COVID-19
Rapidly spreading outbreak of the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)is causing serious health concerns worldwide. It started as an epidemic in Wuhan, Hubei province,central China, and has now become a pandemic,…
Position: 15153 (20 views)