612 10 20655 https://www.socictopen.socict.org/files/original/34be0b02400eb23a7cde09f8670fe72c.pdf aeb294e54a9a484552c88552fcddcca2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development and Validation of the Knowledge and Attitude Scale Toward COVID-19 Pandemic Breaking Transmission Chain (KA-C) Among Iranian Population Creator An entity primarily responsible for making the resource Hamid Sharif Nia, Mahdi Abounoori, Mohammad Moein Maddah, Pardis Rahmatpour, Shaghayegh Khosravifar, Mohammad SamadiKouchaksaraei, Shahrzad Khosravifar Description An account of the resource Objectives: We aimed to develop a scale and evaluate this scale's validity and reliability to measure factors affecting people's knowledge and attitudes toward the pandemic breaking transmission chain.Methods: This exploratory mixed-method study was carried out in two phases: (1) item generation using literature reviews and interviews and, (2) item reduction by psychometric assessments of the developed scale. The face, content, construct (exploratory and confirmatory factor analysis), convergent, and discriminant validity of the scale were assessed in the Iranian population (n = 500) from March to June 2020. The Composite Reliability (CR) and the internal consistency correlation coefficient were estimated.Results: The Knowledge and Attitude Scale Toward COVID-19 Pandemic Breaking Transmission Chain (KA-C) among the Iranian population included 18 items. Two factors with a whole variance of 66.05% were identified by exploratory factor analysis. Factors were labeled as “health literacy” and “home health empowerment.” The confirmatory factor analysis showed the goodness of fit. The CR of the scale for first and second factors were 0.965 and 0.833 receptively. The scale's internal consistency correlation coefficient was acceptable (Cronbach's alpha = 0.960 and 0.823, average interitem correlation = 0.643 and 0.635, McDonald's omega = 0.963 and 0.829, for the first and second factor, receptively).Conclusion: The KA-C scale can be exerted to screen the people's knowledge and attitude about the COVID-19 pandemic breaking the transmission chain as a valid and reliable scale for further policymaking, health care providers, and for a multi-dimensional psychosocial assessment of the pandemic period. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Knowledge, attitude, Pandemic, populations Identifier An unambiguous reference to the resource within a given context 10.3389/fpubh.2021.627013 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/914026848bd1b3972d5aabaa4a590531.pdf f763873cebb70a059fdb03e398f13f05 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development Model Sustainable Promoted by the Family Agriculture in Function of Environmental Preservation Creator An entity primarily responsible for making the resource Sônia Maria Agra Zamith, Mário César de Queiroz Albuquerque Description An account of the resource The objective of the research is to indicate directions of alternatives to self-sustainable development outlined at the principle of a family socioeconomic context, and sustainability, environmental  protection  promoted  by  family  agriculture.  The  inclusion  of  Family agriculture model in the discussion, of the preliminary verification of the agricultural production methods used by family units at the time ensuring the livelihood and allows the marketing  of  surplus  production  levels.  The  method  employed  was  the  hypothetical- deductive, with explanatory purpose, which means corresponded to the selection of authors who have the necessary support to the understanding of the precautionary principle in environmental law. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Agricultura Familiar, Desenvolvimento sustentável, Prevenção ambiental, sustentabilidade Identifier An unambiguous reference to the resource within a given context 10.26668/IndexLawJournals/2526-0081/2016.v2i1.570 Source A related resource from which the described resource is derived Revista de Direito Agrário e Agroambiental Publisher An entity responsible for making the resource available Conselho Nacional de Pesquisa e Pós-graduação em Direito (CONPEDI) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Law in general. Comparative and uniform law. Jurisprudence, Law Relation A related resource <a href="http://www.indexlaw.org/index.php/rdaa/article/view/570" target="_blank" rel="noreferrer noopener">http://www.indexlaw.org/index.php/rdaa/article/view/570</a> https://www.socictopen.socict.org/files/original/d82ddd59e193900d46eb2f7f5187573e.pdf 55e3342b68a1bcd2e061b2b868a53dd6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a Colorimetric Tool for SARS-CoV-2 and Other Respiratory Viruses Detection Using Sialic Acid Fabricated Gold Nanoparticles Creator An entity primarily responsible for making the resource Haya A. Alfassam, Majed S. Nassar, Manal M. Almusaynid, Bashayer A. Khalifah, Abdullah S. Alshahrani, Fahad A. Almughem, Abdullah A. Alshehri, Majed O. Alawad, Salam Massadeh, Manal Alaamery, Ibrahim M. Aldeailej, Aref A. Alamri, Abdulwahab Z. Binjomah, Essam A. Tawfik Description An account of the resource Sialic acid that presents on the surface of lung epithelial cells is considered as one of the main binding targets for many respiratory viruses, including influenza and the current coronavirus (SARS-CoV-2) through the viral surface protein hemagglutinin. Gold nanoparticles (Au NPs) are extensively used in the diagnostic field owing to a phenomenon known as ‘surface plasmonic resonance’ in which the scattered light is absorbed by these NPs and can be detected via UV-Vis spectrophotometry. Consequently, sialic acid conjugated Au NPs (SA-Au NPs) were utilized for their plasmonic effect against SARS-CoV-2, influenza B virus, and Middle-East respiratory syndrome-related coronavirus (MERS) in patients’ swab samples. The SA-Au NPs system was prepared by a one-pot synthesis method, through which the NPs solution color changed from pale yellow to dark red wine color, indicting its successful preparation. In addition, the SA-Au NPs had an average particle size of 30 ± 1 nm, negative zeta potential (−30 ± 0.3 mV), and a UV absorbance of 525 nm. These NPs have proven their ability to change the color of the NPs solutions and patients’ swabs that contain SARS-CoV-2, influenza B, and MERS viruses, suggesting a rapid and straightforward detection tool that would reduce the spread of these viral infections and accelerate the therapeutic intervention. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource sialic acid, gold nanoparticles, Hemagglutinin, surface plasmonic resonance, Viral detection, colorimetric tool Identifier An unambiguous reference to the resource within a given context 10.3390/pharmaceutics13040502 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica https://www.socictopen.socict.org/files/original/82a775aee7a1fcb91afa16fcb616f248.pdf 56f109a54caef0ee1ca572d7961e0b9d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a Conventional RT-PCR Assay for Rapid Detection of Porcine Deltacoronavirus with the Same Detection Limit as a SYBR Green-Based Real-Time RT-PCR Assay Creator An entity primarily responsible for making the resource Lei Ma, Jingyun Ma, Feng Cong, Ren Huang, Pengju Guo, Fanwen Zeng, Bihong Huang Description An account of the resource Porcine deltacoronavirus (PDCoV) is a newly discovered coronavirus, which belongs to the family Coronaviridae. It causes watery diarrhea, vomiting, and dehydration in newborn piglets. A sensitive RT-PCR method is urgently required to detect PDCoV infection. In this study, we developed and evaluated a conventional RT-PCR assay and a SYBR green-based real-time RT-PCR assay that targeted the PDCoV n gene. Both assays are specific and have the same limit of detection at 2 × 101 copies of RNA molecules per reaction. Eighty-four clinical samples were subjected to both conventional RT-PCR and real-time RT-PCR, and the same positive rate (41.7%) was achieved, which was much higher than the positive rate (26.2%) using a previously described one-step RT-PCR technique. In summary, a conventional RT-PCR technique was successfully established for the detection of PDCoV with the same detection limit as a SYBR green-based real-time RT-PCR assay. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2018/5035139 Source A related resource from which the described resource is derived BioMed Research International Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/a48b897adee3f343c1b50e0c813430c8.pdf ca349edb6da51068fac91c4120685e2f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a hyperimmune equine serum therapy for COVID-19 in Argentina Creator An entity primarily responsible for making the resource Vanesa Zylberman, Santiago Sanguineti, Andrea V. Pontoriero, Sandra V. Higa, María L. Cerutti, Susana M. Morrone Seijo, Romina Pardo, Luciana Muñoz, María E. Acuña Intrieri, Vanina A. Alzogaray, Martín M. Avaro, Estefanía Benedetti, Paula M. Berguer, Laura Bocanera, Lucas Bukata, Marina S. Bustelo, Ana M. Campos, Mariana Colonna, Elisa Correa, Lucía Cragnaz, María E. Dattero, María Dellafiore, Sabrina Foscaldi, Joaquín V. González, Luciano L. Guerra, Sebastián Klinke, María S. Labanda, Constanza Lauché, Juan C. López, Anabela M. Martínez, Lisandro H. Otero, Elías H. Peyric, Pablo F. Ponziani, Romina Ramondino, Jimena Rinaldi, Santiago Rodríguez, Javier E. Russo, Mara L. Russo, Soledad L. Saavedra, Mauricio Seigelchifer, Santiago Sosa, Claudio Vilariño, Patricia López Biscayart, Esteban Corley, Linus Spatz, Elsa G. Baumeister, Fernando A. Goldbaum Description An account of the resource The disease named COVID-19, caused by the SARS-CoV-2 coronavirus, is currently generating a global pandemic. Vaccine development is no doubt the best long-term immunological approach, but in the current epidemiologic and health emergency there is a need for rapid and effective solutions. Convalescent plasma is the only antibody-based therapy available for COVID-19 patients to date. Equine polyclonal antibodies (EpAbs) put forward a sound alternative. The new generation of processed and purified EpAbs containing highly purified F(ab')2 fragments demonstrated to be safe and well tolerated. EpAbs are easy to manufacture allowing a fast development and scaling up for a treatment. Based on these ideas, we present a new therapeutic product obtained after immunization of horses with the receptor-binding domain of the viral Spike glycoprotein. Our product shows around 50 times more potency in in vitro seroneutralization assays than the average of convalescent plasma. This result may allow us to test the safety and efficacy of this product in a phase 2/3 clinical trial to be conducted in July 2020 in the metropolitan area of Buenos Aires, Argentina. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Argentina, hyperimmune horse sera, f(ab')2 fragments Source A related resource from which the described resource is derived Medicina (Buenos Aires) Publisher An entity responsible for making the resource available Fundación Revista Medicina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Infectious and parasitic diseases, Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/2aa9c0fe38b359386b38e1ddbe827bdc.pdf de98106d791842bebd5330503264a20b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a Low-Cost Device for Measuring Ultraviolet Solar Radiation Creator An entity primarily responsible for making the resource Antonio Serrano, Jesús Abril-Gago, Jesús Abril-Gago, Carlos J. García-Orellana Description An account of the resource Accurate measurements of solar ultraviolet radiation are needed for air quality monitoring, especially to understand the formation and photolysis of tropospheric ozone near the ground. It is interesting to investigate whether this demand could be met using recently developed low-cost UV sensors and new communication technologies. Despite the promising possibilities, their use is still scarce and their potential applications have not yet been thoroughly explored. This study aims to use low-cost sensors to develop devices that accurately measure solar ultraviolet radiation. The de vices should be low-cost, small, portable, and have low power consumption and IoT connectivity. For this purpose, three popular low-cost commercial sensors ML8511, UVM30A and VEML6075 are selected and implemented in several prototypes. The sensors are analyzed in terms of their spectral response, leveling, angular response and comparison with reference data. For that aim, experimental measurements are performed at the radiometric station of the Physics Department of the University of Extremadura in Badajoz, Spain. Results indicate that sensors of the same model might have different calibrations. The leveling and the angular response measurements indicate a strong azimuth dependence for the ML8511 and, especially, VEML6075 sensors, while the UVM30A sensor shows a much weaker dependence, probably due to the use of a circular diffuser. The angular response is identified as the main issue of the sensors, notably limiting their accuracy and preventing a widespread use. With the knowledge gained, a final version with LoRa communication and optimized power consumption is developed. The strength of the LoRa connection is measured at different locations on the University Campus using Receiver Signal Strength Indication. It ranges from -27 dB near the gateway to -122 dB at the farthest location on the Campus. The optimization of the power consumption allows 14 days of autonomy if operating only during daylight hours. The study illustrates the suitability of low-cost sensors for UV applications, provided that a good angular response of the sensors is ensured. It contributes to a wider use of these sensors for the measurement of air quality variables by identifying those characteristics that need to be improved by manufacturers to meet the standards. Date A point or period of time associated with an event in the lifecycle of the resource 2022 Subject The topic of the resource angular response, lora, low cost sensors, solar radiation, spectral response, ultraviolet Identifier An unambiguous reference to the resource within a given context 10.3389/fenvs.2021.737875 Source A related resource from which the described resource is derived Frontiers in Environmental Science Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences Relation A related resource <a href="https://www.frontiersin.org/articles/10.3389/fenvs.2021.737875/full" target="_blank" rel="noreferrer noopener">https://www.frontiersin.org/articles/10.3389/fenvs.2021.737875/full</a> https://www.socictopen.socict.org/files/original/a08b5904b3b09d0d0f89554cc122177b.pdf ed29263829da9c48449dc65cfd44d837 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform Creator An entity primarily responsible for making the resource Flavia Chiuppesi, Marcela d’Alincourt Salazar, Heidi Contreras, Vu H. Nguyen, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Mindy Kha, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Roman Levytskyy, Nancy D. Ebelt, Tae Hyuk Kang, Xiwei Wu, Thomas F. Rogers, Edwin R. Manuel, Yuriy Shostak, Don J. Diamond, Felix Wussow Description An account of the resource Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1038/s41467-020-19819-1 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science https://www.socictopen.socict.org/files/original/1a341869904be8fb88bbf3bbbb3c4cfb.pdf 14961cdd0bfd4371c621fd463de3abb9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a Multi-Criteria Model for Sustainable Reorganization of a Healthcare System in an Emergency Situation Caused by the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Mališa Žižović, Dragan Pamučar, Dragan Marinković, Dragan Doljanica, Saša Virijević Jovanović, Pavle Brzaković Description An account of the resource Healthcare systems worldwide are facing problems in providing health care to patients in a pandemic caused by the SARS-CoV-2 virus (COVID-19). The pandemic causes an extreme disease to spread with fluctuating needs among patients, which significantly affect the capacity and overall performance of healthcare systems. In addition, its impact on the sustainability of the entire economic and social system is enormous and certain sustainable management strategies need to be selected. To meet the challenges of the COVID-19 pandemic and ensure sustainable performance, national healthcare systems must adapt to new circumstances. This paper proposes an original multi-criteria methodology for the sustainable selection of strategic guidelines for the reorganization of a healthcare system under the conditions of the COVID-19 pandemic. The selection of an appropriate strategic guideline is made on the basis of defined criteria and depending on infection capacity and pandemic spread risk. The criteria for the evaluation of strategic guidelines were defined on the basis of a survey in which the medical personnel engaged in the crisis response team during the COVID-19 pandemic in the Republic of Serbia participated. The Level-Based Weight Assessment (LBWA) model and Measuring Attractiveness by a Categorical-Based Evaluation Technique (MACBETH) method were used to determine the weight coefficient criteria, while a novel fuzzy Ranking of Alternatives through Functional Mapping of Criterion Subintervals into a Single Interval (RAFSI) model was used to evaluate the strategic guidelines. The proposed multi-criteria methodology was tested in a case study in the Republic of Serbia. The validity of the proposed methodology is shown through the simulation of changes in input parameters of Bonferroni aggregation functions and through a comparison with other multi-criteria methodologies. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, sustainability, fuzzy sets, Multi criteria, level-based weight assessment Identifier An unambiguous reference to the resource within a given context 10.3390/su12187504 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental effects of industries and plants, Renewable energy sources, Environmental sciences https://www.socictopen.socict.org/files/original/4337cb87ba698e056a9d4361b0ded234.pdf 71887a93fdca09ec0a8e466c8d55d356 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis Creator An entity primarily responsible for making the resource Graf C, Bernkop-Schnürch A, Egyed A, Koller C, Prieschl-Grassauer E, Morokutti-Kurz M Description An account of the resource Christine Graf,1 Andreas Bernkop-Schn&uuml;rch,2 Alena Egyed,1 Christiane Koller,1 Eva Prieschl-Grassauer,1 Martina Morokutti-Kurz1 1Marinomed Biotech AG, Vienna, Austria; 2ThioMatriX, Innsbruck, Austria Introduction: Xylometazoline hydrochloride (HCl) is a nasal decongestant that causes vasoconstriction in the nasal submucosa. It has been used for more than 50 years for the treatment of nasal congestion caused by rhinitis/sinusitis. Iota-carrageenan is effective against a broad variety of respiratory viruses, which are the most common cause of infections of the upper respiratory tract. Therefore, it is used as the active component in the antiviral nasal spray &shy;Coldamaris prophylactic (1.2 mg/mL iota-carrageenan in 0.5% NaCl) and other medical device nasal sprays that are approved and marketed in the EU. Recently, we developed a nasal spray formulation containing both xylometazoline HCl (0.05%) and iota-carrageenan (0.12%) that provides decongestion and antiviral protection of the nasal mucosa at the same time. Results: A set of in vitro experiments revealed that the vasoconstrictive properties of xylometazoline HCl and the antiviral effectiveness of iota-carrageenan against human rhinovirus (hRV) 1a, hRV8 and human coronavirus OC43 were maintained in the formulation containing these two compounds. Permeation experiments using bovine nasal mucosa showed that iota-carrageenan had no significant influence on the permeation of xylometazoline HCl. Finally, in the local tolerance and toxicity study, it was shown that the formulation was well tolerated at the application site with no occurrence of erythema or edema in the nostrils of all rabbits or any signs of toxicity in any of the organs and tissues inspected. Conclusion: Investigations on compatibility of xylometazoline HCl and iota-carrageenan demonstrated that the substances do not influence each other, allowing both to fulfill their known specific clinical efficacy (xylometazoline HCl) and effectiveness (iota-carrageenan). Keywords: antiviral, permeation, toxicity, vasoconstriction Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource antiviral, permeation, toxicity, vasoconstriction Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived International Journal of General Medicine Publisher An entity responsible for making the resource available Dove Medical Press Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/fa1de2dcda13692a0eea4416f508d936.pdf 5fed6e6f68183407df1762ccf37d369f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens Creator An entity primarily responsible for making the resource Cyril Chik-Yan Yip, Chi-Chun Ho, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Helen Shuk-Ying Chan, Sally Cheuk-Ying Wong, Kit-Hang Leung, Agnes Yim-Fong Fung, Anthony Chin-Ki Ng, Zijiao Zou, Anthony Raymond Tam, Tom Wai-Hin Chung, Kwok-Hung Chan, Ivan Fan-Ngai Hung, Vincent Chi-Chung Cheng, Owen Tak-yin Tsang, Stephen Kwok-Wing Tsui, Kwok-yung Yuen Description An account of the resource The pandemic novel coronavirus infection, Coronavirus Disease 2019 (COVID-19), has affected at least 190 countries or territories, with 465,915 confirmed cases and 21,031 deaths. In a containment-based strategy, rapid, sensitive and specific testing is important in epidemiological control and clinical management. Using 96 SARS-CoV-2 and 104 non-SARS-CoV-2 coronavirus genomes and our in-house program, GolayMetaMiner, four specific regions longer than 50 nucleotides in the SARS-CoV-2 genome were identified. Primers were designed to target the longest and previously untargeted nsp2 region and optimized as a probe-free real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. The new COVID-19-nsp2 assay had a limit of detection (LOD) of 1.8 TCID50/mL and did not amplify other human-pathogenic coronaviruses and respiratory viruses. Assay reproducibility in terms of cycle threshold (Cp) values was satisfactory, with the total imprecision (% CV) values well below 5%. Evaluation of the new assay using 59 clinical specimens from 14 confirmed cases showed 100% concordance with our previously developed COVID-19-RdRp/Hel reference assay. A rapid, sensitive, SARS-CoV-2-specific real-time RT-PCR assay, COVID-19-nsp2, was developed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource SARS-CoV-2, COVID-19, Nsp2, Real-time RT-PCR, genome subtraction, GolayMetaMiner Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijms21072574 Source A related resource from which the described resource is derived International Journal of Molecular Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry Language A language of the resource EN