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                  <text>Dominio científico: Coronavirus</text>
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                <text>Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use</text>
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                <text>Tarun Bhatnagar, Manoj V Murhekar, Manish Soneja, Nivedita Gupta, Sidhartha Giri, Naveet Wig, Raman Gangakhedkar</text>
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                <text>As of February 29, 2020, more than 85,000 cases of coronavirus disease 2019 (COVID-19) have been reported from China and 53 other countries with 2,924 deaths. On January 30, 2020, the first laboratory-confirmed case of COVID was reported from Kerala, India. In view of the earlier evidence about effectiveness of repurposed lopinavir/ritonavir against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus (CoV), as well as preliminary docking studies conducted by the ICMR-National Institute of Virology, Pune, the Central Drugs Standard Control Organization approved the restricted public health use of lopinavir/ritonavir combination amongst symptomatic COVID-19 patients detected in the country. Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2of</text>
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                <text>coronavirus disease 2019 - covid-19 - lopinavir/ritonavir - severe acute respiratory syndrome coronavirus 2 - treatment outcome</text>
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                <text>10.4103/ijmr.IJMR_502_20</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination</text>
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                <text>Ji Likai, Li Shasha, Zhu Wenxian, Ma Jingjiao, Sun Jianhe, Wang Hengan, Yan Yaxian</text>
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                <text>Porcine deltacoronavirus (PDCoV) is a newly detected porcine coronavirus causing serious vomiting and diarrhea in piglets, especially newborn piglets. There has been an outbreak of PDCoV in worldwide since 2014, causing significant economic losses in the pig industry. The interferon (IFN)-mediated antiviral response is an important component of virus-host interactions and plays an essential role in inhibiting virus infection. However, the mechanism of PDCoV escaping the porcine immune surveillance is unclear. In the present study, we demonstrated that the PDCoV nucleocapsid (N) protein antagonizes porcine IFN-β production after vesicular stomatitis virus (VSV) infection or poly(I:C) stimulation. PDCoV N protein also suppressed the activation of porcine IFN-β promoter when it was stimulated by porcine RLR signaling molecules. PDCoV N protein targeted porcine retinoic acid-inducible gene I (pRIG-I) and porcine TNF receptor associated factor 3 (pTRAF3) by directly interacting with them. The N-terminal region (1–246 aa) of PDCoV N protein was important for interacting with pRIG-I and interfere its function. We confirmed that PDCoV N antagonizes IFN-β production by associating with pRIG-I to impede it from binding double-stranded RNA. Furthermore, porcine Riplet (pRiplet) was an important activator for pRIG-I by mediating the K63-linked polyubiquitination. However, PDCoV N protein restrained the pRiplet binding pRIG-I to inhibit pRIG-I K63-linked polyubiquitination. Taken together, our results revealed a novel mechanism by which PDCoV N protein interferes with the early activation of pRIG-I in the host antiviral response. The novel findings provide a new insight into PDCoV on evading the host innate immune response and may provide new therapeutic targets and more efficacious vaccines strategies for PDCoV infections.</text>
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                <text>2019</text>
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                <text>PDCoV, Nucleocapsid protein, ubiquitination, IFN-β, porcine RIG-I</text>
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                <text>10.3389/fimmu.2019.01024</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Prudent public health intervention strategies to control the coronavirus disease 2019 transmission in India: A mathematical model-based approach</text>
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                <text>Sandip Mandal, Tarun Bhatnagar, Nimalan Arinaminpathy, Anup Agarwal, Amartya Chowdhury, Manoj Murhekar, Raman R Gangakhedkar, Swarup Sarkar</text>
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                <text>Background &amp; objectives: Coronavirus disease 2019 (COVID-19) has raised urgent questions about containment and mitigation, particularly in countries where the virus has not yet established human-to-human transmission. The objectives of this study were to find out if it was possible to prevent, or delay, the local outbreaks of COVID-19 through restrictions on travel from abroad and if the virus has already established in-country transmission, to what extent would its impact be mitigated through quarantine of symptomatic patients? Methods: These questions were addressed in the context of India, using simple mathematical models of infectious disease transmission. While there remained important uncertainties in the natural history of COVID-19, using hypothetical epidemic curves, some key findings were illustrated that appeared insensitive to model assumptions, as well as highlighting critical data gaps. Results: It was assumed that symptomatic quarantine would identify and quarantine 50 per cent of symptomatic individuals within three days of developing symptoms. In an optimistic scenario of the basic reproduction number (R0) being 1.5, and asymptomatic infections lacking any infectiousness, such measures would reduce the cumulative incidence by 62 per cent. In the pessimistic scenario of R0=4, and asymptomatic infections being half as infectious as symptomatic, this projected impact falls to two per cent. Interpretation &amp; conclusions: Port-of-entry-based entry screening of travellers with suggestive clinical features and from COVID-19-affected countries, would achieve modest delays in the introduction of the virus into the community. Acting alone, however, such measures would be insufficient to delay the outbreak by weeks or longer. Once the virus establishes transmission within the community, quarantine of symptomatics may have a meaningful impact on disease burden. Model projections are subject to substantial uncertainty and can be further refined as more is understood about the natural history of infection of this novel virus. As a public health measure, health system and community preparedness would be critical to control any impending spread of COVID-19 in the country.</text>
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                <text>2020</text>
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                <text>airport screening - covid-19 - deterministic model - mathematical model - mitigation - quarantine - transmission</text>
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                <text>10.4103/ijmr.IJMR_504_20</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Extensive Testing May Reduce COVID-19 Mortality: A Lesson From Northern Italy</text>
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                <text>Mauro Di Bari, Mauro Di Bari, Daniela Balzi, Giulia Carreras, Graziano Onder</text>
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                <text>The effects of different COVID-19 swab testing policies in Italy need investigation. We examined the relationship between the number of COVID-19 swab tests (per 10,000 population) performed from February 24 through March 27 and 7-day lagged COVID-19 mortality (per 10,000 population) in four regions of northern Italy. Lombardy, Piedmont, and initially, also Emilia-Romagna, which followed recommendations for limiting swab testing to symptomatic subjects requiring hospitalization, had a much steeper increase in mortality with increasing number of tests performed than Veneto, which applied a policy of broader testing. The relationship between tests performed and mortality declined in Emilia-Romagna in coincidence with a substantial increase in the number of tests performed on March 18. When the cumulative number of tests performed was regressed linearly toward lagged mortality in Lombardy and Veneto, the slope of the regression was 133 in Veneto and 10.4 tests per one death in Lombardy. These findings suggest that the strategy adopted in Veneto, similar to that in South Korea, was effective in containing COVID-19 epidemics and should be applied in other regions of Italy and countries in Europe.</text>
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                <text>2020</text>
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                <text>mortality, surveillance, covid-19, epidemics, swab testing, echologic studies</text>
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                <text>10.3389/fmed.2020.00402</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine (General)</text>
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            <description>A name given to the resource</description>
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                <text>Is COVID-19 Expanding its Symptom List? The Case of Acute Acro-ischemia and Skin Rash</text>
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                <text>Teh Exodus Akwa, Abdul A. Jalloh</text>
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                <text>As the spread of SARS-CoV2 continues to increase globally, newer information gets reported every day. We are learning more and more about the presentation, symptoms and treatment of this infection. Earlier cardinal symptoms of COVID-19 had been fever, cough, and shortness of breath. New findings in its symptoms are now being reported some of which includes neurological symptoms, dizziness and diarrhoea. Of recent skin manifestations due to COVID-19 have drawn the attention of medical experts. The presence of a livedoid pattern (red mottled-net like coloration) rash and a rare skin lesion at the extremities also known as acro-ischemia in patients diagnosed with COVID-19 or patients presenting with symptoms of COVID-19 is now on a surge. Though the correlation between acute acro-ischemia, skin rash and COVID-19 is yet to be fully documented these dermatological and clinical observations in patients might just be another possible key indicator for the presence of the COVID-19 disease.</text>
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                <text>2021</text>
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            <name>Subject</name>
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                <text>SARS–CoV-2, Dermatology, receptors, lesions</text>
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              <elementText elementTextId="55495">
                <text>10.29333/jcei/10774</text>
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              <elementText elementTextId="55496">
                <text>Journal of Clinical and Experimental Investigations</text>
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                <text>Association of Health Investigations</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Prevalence and Correlates of Depressive Symptoms among Bangladeshi Young Adults due to COVID-19 Outbreak</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="55500">
                <text>Md. Ayatullah Khan</text>
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                <text>A web-based cross-sectional study was conducted among 1072 Bangladeshi young adults to identify the prevalence and correlates of depressive symptoms due to COVID-19 pandemic. The 9-item patient health questionnaire (PHQ-9) was used to measure depressive symptoms. Kruskal-Wallis H test and ordered logistic regression were employed to identify the drivers correlated with the levels of depressive symptoms. The estimated prevalence rates of moderate to severe depressive symptoms were 54.1%. Older age, residing urban area, not having stable family income, having relatives or acquaintances infected with COVID-19, being worried about educational delays or jobs, having the disturbance of daily activities, and being worried about social support were significantly associated with the levels of depressive symptoms among Bangladeshi young adults due to COVID-19 pandemic.</text>
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            <name>Date</name>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="55503">
                <text>covid-19, depressive symptoms, Bangladeshi young adults</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="55504">
                <text>10.29333/jcei/9766</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="55505">
                <text>Journal of Clinical and Experimental Investigations</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="55506">
                <text>Association of Health Investigations</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="55507">
                <text>Medicine</text>
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        <src>https://www.socictopen.socict.org/files/original/f9b371290cce9255bc0a54a61d0fed85.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55508">
                <text>Epidemiology and Pathogenesis of Coronavirus Disease (COVID-19)</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55509">
                <text>Ram Bahadur Khadka, Ravin Bhandari, Rabin Gyawali, Balram Neupane, Dhakaraj Pant</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="55510">
                <text>An acute respiratory syndrome (ARDS) episode was first identified in Wuhan, China, and later officiallydesignated as COVID-19 by the WHO. It is caused by SARS-CoV-2 that is likely associated with zoonotictransmission. Based on the live data from live reference website Worldometer which provides counters and realtime statistics for diverse topics data, COVID-19 has influenced 186 nations. China reported 25% of cases, while75% of the remaining cases were reported in other nations. The clinical and genetic characteristics of SARSCoV-2 support the similar pathogenesis pattern between SARS-CoV and MERS-CoV. The elevated level ofcytokine release during the infection caused the failure of multiple organs leading to the patient death. Treatmentof patients depends on the clinical course and symptoms associated with the COVID-19. Several prevention andcontrol measures including; active surveillance, use of masks, and hand sanitizers are recommended to stop thespread of this virus. Besides, COVID-19 was sampled using a throat swab to detect the viral nucleic acid usingReal Time Polymerase Chain Reaction (RT-PCR), for early detection and treatments evaluation. In this review,we comprehensively summarized the COVID-19 epidemiology, pathogenesis and diagnosis, using suitableliteratures obtained from reliable sources.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55511">
                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55512">
                <text>epidemiology, MERS-CoV, coronavirus, pathogenesis, covid-19, SARS-CoV-2</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="55513">
                <text>10.21608/nrmj.2020.84016</text>
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            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="55514">
                <text>Novel Research in Microbiology Journal</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="55515">
                <text>Ain Shams University</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="55516">
                <text>Microbiology</text>
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  <item itemId="6237" public="1" featured="0">
    <fileContainer>
      <file fileId="6237">
        <src>https://www.socictopen.socict.org/files/original/7667c266434e09330eab869c9d3d1658.pdf</src>
        <authentication>0f5cd01b8ae714ccf1c3061b4acccbb7</authentication>
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          <name>Dublin Core</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55517">
                <text>Coronavirus and the need for strong government institutions: defeating the pandemic and reviving economies</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55518">
                <text>Alexis S. Esposto</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="55519">
                <text>This paper discusses the importance of government and economic institutions in dealing with economic shocks such as the COVID-19. In attempting to deal with this massive health, social and economic upheaval, governments around the world have been using a variety of social and economic policies. These policies have two aims. First, to reduce the spread of the virus and second to mitigate the economy wide damage that the spread of the virus is causing. The paper describes the initial economic impact of the virus worldwide and on the Australian economy. It also argues that unless a rapid response is made, the likelihood of a world depression is high. The analysis focuses on the importance of government institutions in respond-ing to major economic shocks. It showcases the work of the Treasury of Australia as a model of best practice for the development of economic policies designed to respond to extreme events. The paper concludes by providing a set of economy wide policy responses to tackle the current economic shocks.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55520">
                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55521">
                <text>coronavirus, Australia, covid-19, crisis, institutions, shocks</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="55522">
                <text>Biotemas</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="55523">
                <text>Universidade Federal de Santa Catarina</text>
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          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="55524">
                <text>Economic theory. Demography, Economic history and conditions</text>
              </elementText>
            </elementTextContainer>
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    </elementSetContainer>
  </item>
  <item itemId="6238" public="1" featured="0">
    <fileContainer>
      <file fileId="6238">
        <src>https://www.socictopen.socict.org/files/original/ac26cd52cf5cda9f8239c4e16b1fc8ae.pdf</src>
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          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              </elementTextContainer>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55525">
                <text>Stress and Coping in a Self-Isolated Family during COVID-19 Pandemic</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55526">
                <text>Kryukova T.L., Ekimchik O.A., Opekina T.P., Shipova N.S.</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="55527">
                <text>Objective. To find out the level of stressfulness of inside family isolation in Russia; coping with the negative effects of a pandemic, fear and isolation.Background. The situation of a health threat causes unexpected stress enhancing the fear of get- ting infected, uncertainty, anxiety. The coronavirus disease outbreak has introduced special demands: to lockdown not to get infected. But it also “triggers” adaptive coping behavior. It`s suggested that situa- tion-adequate coping, as well as close relationships based on support, reduce the effects of coronavirus threat. Domestic violence and its effects (physical abuse, mental illness, PTSD) negatively affect family relationships, maybe as deadly as the coronavirus, require immediate prevention.Study design. A mini-longitudinal empirical study was conducted online at the beginning (27.03.2020—12.04.2020) (N1=248) and in the second half of lockdown (28.04.2020—03.05.2020) (N2=310). The role of stressors in changing family relationships has been correlated with the impact of catching COVID-19 threat and self-isolation on the psychological state of family members.Participants. 558 volunteers aged 18—87, including 425 women and 117 men; the majority of them (66%) have their own family — 369 are married/in a relationship; work.Measurements. A questionnaire created by the authors on the basis of international projects as- sessing impact of stress and self-isolation on family relationships, standardized anxiety and depression scales; coping scales.Results. Negative outcomes of the threat of infection and isolation are reduced if coping is ad- equate, emotional support from family members, and their views on the necessary daily changes are con- sistent. Stress levels are higher in single people. Having a partner is important for ways of coping choice.Conclusions. Stress generating from the threat of catching virus/COVID-19 experienced by people during lockdown in close/family relationships is normative as long as they use coping strategies, ade- quate to the situation (acceptance, positive reappraisal) with a low frequency of choosing less adequate strategies.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55528">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="55529">
                <text>Stress, Family, Coping strategies, close relationships, Emotional support, Anxiety/depression, threat of catching coronavirus</text>
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            </elementTextContainer>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="55530">
                <text>10.17759/sps.2020110409</text>
              </elementText>
            </elementTextContainer>
          </element>
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                <text>Социальная психология и общество</text>
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                <text>James Ngamije, Callixte Yadufashije</text>
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                <text>10.1016/j.heliyon.2020.e05229</text>
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