67 10 20655 https://www.socictopen.socict.org/files/original/744e25e135a7ba5170c7dc72472dc179.pdf c3235c5de496ce9f5ed80e5828154381 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource k-mer Similarity, Networks of Microbial Genomes, and Taxonomic Rank Creator An entity primarily responsible for making the resource Guillaume Bernard, Paul Greenfield, Mark A. Ragan, Cheong Xin Chan Description An account of the resource Genome evolution of microbes involves parent-to-offspring descent, and lateral genetic transfer that convolutes the phylogenomic signal. This study investigated phylogenomic signals among thousands of microbial genomes based on short subsequences without using multiple-sequence alignment. The signal from ribosomal RNAs is strong across all taxa, and the signal of plasmids is strong only in closely related groups, particularly Proteobacteria. However, the signal from other chromosomal regions (∼99% of the genomes) is remarkably restricted in breadth. The similarity of subsequences is found to correlate with taxonomic rank and informs on conserved and differential core functions relative to niche specialization and evolutionary diversification of microbes. These results provide a comprehensive, alignment-free view of microbial genome evolution as a network, beyond a tree-like structure.Microbial genomes have been shaped by parent-to-offspring (vertical) descent and lateral genetic transfer. These processes can be distinguished by alignment-based inference and comparison of phylogenetic trees for individual gene families, but this approach is not scalable to whole-genome sequences, and a tree-like structure does not adequately capture how these processes impact microbial physiology. Here we adopted alignment-free approaches based on k-mer statistics to infer phylogenomic networks involving 2,783 completely sequenced bacterial and archaeal genomes and compared the contributions of rRNA, protein-coding, and plasmid sequences to these networks. Our results show that the phylogenomic signal arising from ribosomal RNAs is strong and extends broadly across all taxa, whereas that from plasmids is strong but restricted to closely related groups, particularly Proteobacteria. However, the signal from the other chromosomal regions is restricted in breadth. We show that mean k-mer similarity can correlate with taxonomic rank. We also link the implicated k-mers to genome annotation (thus, functions) and define core k-mers (thus, core functions) in specific phyletic groups. Highly conserved functions in most phyla include amino acid metabolism and transport as well as energy production and conversion. Intracellular trafficking and secretion are the most prominent core functions among Spirochaetes, whereas energy production and conversion are not highly conserved among the largely parasitic or commensal Tenericutes. These observations suggest that differential conservation of functions relates to niche specialization and evolutionary diversification of microbes. Our results demonstrate that k-mer approaches can be used to efficiently identify phylogenomic signals and conserved core functions at the multigenome scale. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource core functions, Kmers, networks, Phylogenetic analysis, phylogenomics Identifier An unambiguous reference to the resource within a given context DOI: 10.1128/mSystems.00257-18 Source A related resource from which the described resource is derived mSystems Publisher An entity responsible for making the resource available American Society for Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/f92483c2107cdf7b296377b108aea6c9.pdf 6d3c9da7290367abeb7b2f6fdabd86de Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Search for a Practical Approach to Emerging Diseases: The Case of Severe Acute Respiratory Syndrome (SARS) Creator An entity primarily responsible for making the resource Carlo Selmi, Aftab A. Ansari, Pietro Invernizzi, Mauro Podda, M. Eric Gershwin Date A point or period of time associated with an event in the lifecycle of the resource 2002 Identifier An unambiguous reference to the resource within a given context DOI: 10.1080/1044667031000137575 Source A related resource from which the described resource is derived Clinical and Developmental Immunology Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/b9592ced497ba126e6f5c0b7ab5e7596.pdf 86d368db74b0f7e2cb31cd8abc3f9759 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Trypsin-independent porcine epidemic diarrhea virus US strain with altered virus entry mechanism Creator An entity primarily responsible for making the resource Yunjeong Kim, Changin Oh, Vinay Shivanna, Richard A. Hesse, Kyeong-Ok Chang Description An account of the resource Abstract Background Porcine Epidemic Diarrhea Virus (PEDV) is a coronavirus that infects the intestinal tract and causes diarrhea and vomiting in older pigs or extreme dehydration and death that could reach 100% mortality in neonatal piglets. In the US, the first PEDV outbreaks occurred in 2013 and since then US PEDV strains have quickly spread throughout the US and worldwide, causing significant economic and public health concerns. Currently two conditionally approved vaccines exist in the US, but there is no live attenuated vaccine, which is considered the best option in controlling PEDV by inducing transferrable mucosal immunity to susceptible neonatal piglets. In this study, we passaged an US PEDV isolate under various conditions to generate three strains and characterized their growth and antigenicity in cell culture using various assays including Western blot analysis, serum neutralization assay, sequencing analysis and confocal microscopy. Finally, these strains were evaluated for pathogenicity in nursing piglets (1–4 days old). Results One of the PEDV strains generated in this study (designated as PEDV 8aa) is able to replicate in cells without any protease and grows to a high titer of >8 log10 TCID50/ml in cell culture. Interestingly, replication of PEDV 8aa was severely reduced by trypsin and this correlated with the inhibition of virus attachment and entry into the cells. In neonatal nursing piglets, PEDV 8aa (passage number 70 or 105) was found to be fully attenuated with limited virus shedding. Conclusions These results suggest that applying selective pressure during viral passages can facilitate attainment of viral attenuation and that PEDV 8aa warrants further investigation as an attenuated vaccine. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource porcine epidemic diarrhea virus, coronavirus, Virus entry, attenuation, live attenuated vaccine, trypsin independent, entry Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12917-017-1283-1 Source A related resource from which the described resource is derived BMC Veterinary Research Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/2acb0a60b497ade6877f920ca8477fb2.pdf 8ae68181c397ac8ad47ba502ce8273d7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Spread of Mutant Middle East Respiratory Syndrome Coronavirus with Reduced Affinity to Human CD26 during the South Korean Outbreak Creator An entity primarily responsible for making the resource Yu-Ri Kim, Shinhye Cheon, Chan-Ki Min, Kyung Mok Sohn, Ying Jin Kang, Young-Je Cha, Ju-Il Kang, Seong Kyu Han, Na-Young Ha, Gwanghun Kim, Abdimadiyeva Aigerim, Hyun Mu Shin, Myung Sik Choi, Sanguk Kim, Hyun-Soo Cho, Yeon Sook Kim, Nam-Hyuk Cho Description An account of the resource The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (~35%). MERS-CoV has been a global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May to July 2015, a large outbreak initiated by an infected traveler from the Arabian peninsula swept South Korea and resulted in 186 confirmed cases with 38 deaths (case fatality rate, 20.4%). Here, we show the rapid emergence and spread of a mutant MERS-CoV with reduced affinity to the human CD26 receptor during the South Korean outbreak. We isolated 13 new viral genomes from 14 infected patients treated at a hospital and found that 12 of these genomes possess a point mutation in the receptor-binding domain (RBD) of viral spike (S) protein. Specifically, 11 of these genomes have an I529T mutation in RBD, and 1 has a D510G mutation. Strikingly, both mutations result in reduced affinity of RBD to human CD26 compared to wild-type RBD, as measured by surface plasmon resonance analysis and cellular binding assay. Additionally, pseudotyped virus bearing an I529T mutation in S protein showed reduced entry into host cells compared to virus with wild-type S protein. These unexpected findings suggest that MERS-CoV adaptation during human-to-human spread may be driven by host immunological pressure such as neutralizing antibodies, resulting in reduced affinity to host receptor, and thereby impairs viral fitness and virulence, rather than positive selection for a better affinity to CD26. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Identifier An unambiguous reference to the resource within a given context DOI: 10.1128/mBio.00019-16 Source A related resource from which the described resource is derived mBio Publisher An entity responsible for making the resource available American Society for Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/1f8582830d5485f62e9afd06305ec116.pdf 417f4076970ab2f78e914a5725c6c714 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Entre deux mers, d’un savoir à l’autre, Francisco de Quevedo (1580-1645) : aspects de l’imaginaire espagnol au temps des Habsbourg Creator An entity primarily responsible for making the resource Josette Riandière La Roche Description An account of the resource De 1580 à 1652, le Roi des Espagnes, de la Méditerranée à l’Océan et au-delà, règne sur le territoire le plus étendu de son histoire. Ses royaumes, réunis sous la seule autorité du roi de Castille, semblent avoir retrouvé l’extension de la Province conquise par Rome, augmentée des terres nouvellement découvertes. Sa puissance, à la fois admirée et détestée, va donner naissance en Europe, et en premier lieu aux Pays-Bas, à ce qu’il convient d’appeler la légende noire. Francisco de Quevedo (1580-1645), écrivain de génie, s’emploie dès 1609 à défendre l’Espagne contre cette légende : grâce à sa prodigieuse érudition et à son savoir de philosophe, d’historien, de philologue, il entend prouver la supériorité de sa patrie sur les autres, pour la splendeur de son passé, les richesses de sa terre, la valeur de ses enfants, la prééminence de ses écrivains, la suprématie de sa langue. De ses démonstrations se dégage, fondée sur les savoirs qu’il partage avec les élites de son temps, la perception qu’il a de l’Espagne et des Espagnols, de lui-même par conséquent, ainsi que celle qu’il a de l’autre, Allemand ou Flamand, mais aussi Indien, Africain, ou Juif. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource altérité, Education, esclavage, Habsbourg, Histoire vs. légende noire, Savoirs Identifier An unambiguous reference to the resource within a given context DOI: 10.4000/babel.3610 Source A related resource from which the described resource is derived Babel : Littératures Plurielles Publisher An entity responsible for making the resource available Université du Sud Toulon-Var Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant French literature - Italian literature - Spanish literature - Portuguese literature, Literature (General) Language A language of the resource EN, FR, IT https://www.socictopen.socict.org/files/original/04222428a3b94dd87f016797b0e9f281.pdf 0facf00dacfd15e90f18d4003089e100 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Synthesis and Biological Evaluation of Novel 4-Morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine Derivatives Bearing Phenylpyridine/ Phenylpyrimidine-Carboxamides Creator An entity primarily responsible for making the resource Huimin Liu, Wenhui Wang, Chengyu Sun, Caolin Wang, Wufu Zhu, Pengwu Zheng Description An account of the resource Four series of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives 11a–j, 12a–j, 13a–g and 14a–g bearing phenylpyridine/phenylpyrimidine- carboxamide scaffolds were designed, synthesized and their IC50 values against three cancer cell lines (A549, PC-3 and MCF-7) were evaluated. Eleven of the compounds showed moderate cytotoxicity activity against the cancer cell lines. Structure-activity relationships (SARs) and pharmacological results indicated that the introduction of phenylpyridine-carboxamide scaffold was beneficial for the activity. What’s more, the oxidation of the sulfur atom in thiopyran and various types of substituents on the aryl group have different impacts on different series of compounds. Furthermore, the positions of aryl group substituents have a slight impact on the activity of the phenylpyridine-carboxamide series compounds. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource thiopyrano[4, 3-d]pyrimidine, phenylpyridine/phenylpyrimidine carboxamides, Synthesis, cytotoxicity activity, PI3Kα kinase Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules21111447 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN https://www.socictopen.socict.org/files/original/b5d8a6bade95c4c26a4bd145c75cbcd7.pdf 0d09c82cdeef42c5420ed30514818c5a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bats, Coronaviruses, and Deforestation: Toward the Emergence of Novel Infectious Diseases? Creator An entity primarily responsible for making the resource Aneta Afelt, Roger Frutos, Christian Devaux Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource bat, coronavirus, deforestation, emergence, Anthropization, novel contacts Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2018.00702 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/af98cdd169d85fed23aa429b4db9d8f9.pdf a0fc39bd40082b4797d0bd157332ca30 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Infections: a Threat to Humanity from the Middle East Caused by MERS-CoV? Creator An entity primarily responsible for making the resource O.K. Duda, L.P. Kotsiubailo Description An account of the resource This article describes epidemic situation in terms of diseases caused by coronaviruses, pathogenic for humans. Clinical features and principles of laboratory diagnostics of coronaviruses are presented. Epidemiological situation in the world in terms of Middle East respiratory syndrome caused by MERS-CoV, which forced the professionals to significantly increase the levels of epidemiological risk of coronaviruses, is analyzed. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource coronavirus infections, Middle East respiratory syndrome (MERS-CoV), SARS-CoV, diagnosis Identifier An unambiguous reference to the resource within a given context DOI: 10.22141/2312-413x.3.08.2015.78694 Source A related resource from which the described resource is derived Aktualʹnaâ Infektologiâ Publisher An entity responsible for making the resource available Publishing House Zaslavsky Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN, RU, UK https://www.socictopen.socict.org/files/original/082984847e9b0051ec96fb44e4ee5e50.pdf 41b3d174e9ec54494f6e655062ddea47 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Human coronavirus ocurrence in different populations of Sao Paulo: a comprehensive nine-year study using a pancoronavirus RT-PCR assay Creator An entity primarily responsible for making the resource Tatiane K. Cabeça, Ana Maria Passos, Celso Granato, Nancy Bellei Description An account of the resource Human coronaviruses (HCoVs) are considered one of the most common respiratory viruses associated with respiratory tract illnesses. An emergent human coronavirus was identified as the causal agent of an epidemic of severe acute respiratory syndrome (SARS) during 2002-2003. The severity of the disease combined with its rapid spread requires the continuous surveillance of coronaviruses in worldwide populations. Epidemiological and clinical data of HCoVs infectious in the Brazilian population are scarce and restricted to one or two groups of patients. Our study aimed to investigate retrospectively the presence of HCoVs in different populations of São Paulo presenting acute respiratory tract infections (ARIs) during the years of 2001-2010. A pancoronavirus RT-PCR was performed in this study. Coronaviruses were detected in 126 (11.5%) of 1,087 specimens. Peaks detection frequency was observed during 2002-2004 and 2008-2009, with the highest detection in 2008. The prevalence of HCoVs was higher among children with heart diseases (24.6%), patients under stem cell transplantation program (24.3%) and renal transplanted patients (20.2%). Coryza, cough and fever were the most common symptoms at presentation of positive cases and wheezing, a lower respiratory tract infection symptom was reported by 12% of the total, and 27% of high at-risk patients. HCoVs may have an important role among patients with underlying conditions and transplanted ones. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource human coronaviruses, Epidemiology, Respiratory tract illness, pancoronavirus RT-PCR Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Brazilian Journal of Microbiology Publisher An entity responsible for making the resource available Sociedade Brasileira de Microbiologia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/51e15f39d62a19ecd57d053d5797e8ef.pdf 9d0b30da8c6f8f7843fde0c54bdea14e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Suppression of Coronavirus Replication by Cyclophilin Inhibitors Creator An entity primarily responsible for making the resource Takashi Sasaki, Yoshikazu Tanaka, Yuka Sato Description An account of the resource Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious bronchitis, respectively. No effective vaccine or treatment has been developed for SARS-coronavirus or FIP virus, both of which cause lethal diseases. It has been reported that a cyclophilin inhibitor, cyclosporin A (CsA), could inhibit the replication of coronaviruses. CsA is a well-known immunosuppressive drug that binds to cellular cyclophilins to inhibit calcineurin, a calcium-calmodulin-activated serine/threonine-specific phosphatase. The inhibition of calcineurin blocks the translocation of nuclear factor of activated T cells from the cytosol into the nucleus, thus preventing the transcription of genes encoding cytokines such as interleukin-2. Cyclophilins are peptidyl-prolyl isomerases with physiological functions that have been described for many years to include chaperone and foldase activities. Also, many viruses require cyclophilins for replication; these include human immunodeficiency virus, vesicular stomatitis virus, and hepatitis C virus. However, the molecular mechanisms leading to the suppression of viral replication differ for different viruses. This review describes the suppressive effects of CsA on coronavirus replication. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource cyclophilin, Cyclosporin A, coronavirus, NFAT Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v5051250 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN