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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>4,4′-Diaminodiphenyl Sulfone (DDS) as An Inflammasome Competitor</text>
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                <text>Jong-hoon Lee, Ha  Kyeu An, Mun-Gi Sohn, Paul Kivela, Sangsuk Oh</text>
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            <description>An account of the resource</description>
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                <text>The aim of this study is to examine the use of an inflammasome competitor as a preventative agent. Coronaviruses have zoonotic potential due to the adaptability of their S protein to bind receptors of other species, most notably demonstrated by SARS-CoV. The binding of SARS-CoV-2 to TLR (Toll-like receptor) causes the release of pro-IL-1β, which is cleaved by caspase-1, followed by the formation and activation of the inflammasome, which is a mediator of lung inflammation, fever, and fibrosis. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is implicated in a variety of human diseases including Alzheimer’s disease (AD), prion diseases, type 2 diabetes, and numerous infectious diseases. By examining the use of 4,4′-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen’s disease, also diagnosed as Alzheimer’s disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. TLRs, due to genetic polymorphisms, can alter the immune response to a wide variety of microbial ligands, including viruses. In particular, TLR2Arg677Trp was reported to be exclusively present in Korean patients with lepromatous leprosy (LL). Previously, mutation of the intracellular domain of TLR2 has demonstrated its role in determining the susceptibility to LL, though LL was successfully treated using a combination of DDS with rifampicin and clofazimine. Of the three tested antibiotics, DDS was effective in the molecular regulation of NLRP3 inflammasome activators that are important in mild cognitive impairment (MCI), Parkinson’s disease (PD), and AD. The specific targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS may be responsible for its observed preventive effects, functioning as a competitor.</text>
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                <text>2020</text>
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                <text>Alzheimer’s disease, 4, Ad, DDS, L. L, 4′-diaminodiphenyl sulfone (dapsone), lepromatous leprosy (also known as Hansen’s disease)</text>
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            <name>Identifier</name>
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                <text>10.3390/ijms21175953</text>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General), Chemistry</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Intervention effects in the transmission of COVID-19 depending on the detection rate and extent of isolation</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Jong-Hun Kim, Okyu Kwon, Woo-Sik Son, Jin Yong Kim</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Objectives In 2020, the coronavirus disease 2019 (COVID-19) respiratory infection is spreading in Korea. In order to prevent the spread of an infectious disease, infected people must be quickly identified and isolated, and contact with the infected must be blocked early. This study attempted to verify the intervention effects on the spread of an infectious disease by using these measures in a mathematical model. Methods We used the susceptible-infectious-recovery (SIR) model for a virtual population group connected by a special structured network. In the model, the infected state (I) was divided into I in which the infection is undetected and Ix in which the infection is detected. The probability of transitioning from an I state to Ix can be viewed as the rate at which an infected person is found. We assumed that only those connected to each other in the network can cause infection. In addition, this study attempted to evaluate the effects of isolation by temporarily removing the connection among these people. Results In Scenario 1, only the infected are isolated; in Scenario 2, those who are connected to an infected person and are also found to be infected are isolated as well. In Scenario 3, everyone connected to an infected person are isolated. In Scenario 3, it was possible to effectively suppress the infectious disease even with a relatively slow rate of diagnosis and relatively high infection rate. Conclusions During the epidemic, quick identification of the infected is helpful. In addition, it was possible to quantitatively show through a simulation evaluation that the management of infected individuals as well as those who are connected greatly helped to suppress the spread of infectious diseases.</text>
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                <text>2020</text>
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                <text>isolation, covid-19, non-pharmaceutical intervention, social network, agent-based model</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="51360">
                <text>10.4178/epih.e2020045</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Evaluation of UR-UVGI System for Sterilization Effect on Microorganism Contamination in Negative Pressure Isolation Ward</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="22582">
                <text>Jong-Il Bang, Jeong-Yeon Park, Anseop Choi, Jae-Weon Jeong, Jin-Yong Kim, Minki Sung</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>A negative pressure isolation ward prevents the outflow of airborne microorganisms from inside the ward, minimizing the spread of airborne contamination causing respiratory infection. In response to recent outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), Korea has increased the number of these facilities. However, airborne contaminants that flow into the ward from adjacent areas may cause secondary harm to patients. In this study, the sterilization effect of upper-room ultraviolet germicidal irradiation (UR-UVGI) on microorganisms generated within the negative pressure isolation ward and those flowing inward from adjacent areas was evaluated through field experiments and computational fluid dynamics (CFD) analysis, to assess the potential of this approach as a supplementary measure to control such microorganisms. The sterilization effect was found to be not high because of high-level ventilation. CFD analysis under various conditions shows that the sterilization effect for indoor-generated microorganisms varies with the level of UV radiation, the source locations of the indoor-generated microorganisms, air supplies and exhausts, the UVGI system, and the airflow formed under the specified conditions. Our results show that when the UVGI system is installed in the upper part of the ward entrance, contaminated air from adjacent area is strongly sterilized.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2018</text>
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            <name>Subject</name>
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                <text>negative pressure isolation ward, upper room-ultraviolet germicidal irradiation, airborne microorganisms, numerical simulation</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3390/su10093192</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Sustainability</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Environmental sciences, Renewable energy sources, Environmental effects of industries and plants</text>
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                <text>EN</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Air Quality Change in Seoul, South Korea under COVID-19 Social Distancing: Focusing on PM&lt;sub&gt;2.5&lt;/sub&gt;</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="64052">
                <text>Jong-Jin Baik, Sungju Moon, Seung-Bu Park, Beom-Soon Han, Kyung-Hwan Kwak, Kyeongjoo Park, Han-Gyul Jin, Jong-Won Kim</text>
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                <text>Seoul, the most populous city in South Korea, has been practicing social distancing to slow down the spread of coronavirus disease 2019 (COVID-19). Fine particulate matter (PM2.5) and other air pollutants measured in Seoul over the two 30 day periods before and after the start of social distancing are analyzed to assess the change in air quality during the period of social distancing. The 30 day mean PM2.5 concentration decreased by 10.4% in 2020, which is contrasted with an average increase of 23.7% over the corresponding periods in the previous 5 years. The PM2.5 concentration decrease was city-wide and more prominent during daytime than at nighttime. The concentrations of carbon monoxide (CO) and nitrogen dioxide (NO2) decreased by 16.9% and 16.4%, respectively. These results show that social distancing, a weaker forcing toward reduced human activity than a strict lockdown, can help lower pollutant emissions. At the same time, synoptic conditions and the decrease in aerosol optical depth over the regions to the west of Seoul support that the change in Seoul’s air quality during the COVID-19 social distancing can be interpreted as having been affected by reductions in the long-range transport of air pollutants as well as local emission reductions.</text>
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                <text>2020</text>
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                <text>covid-19, social distancing, PM&lt;sub&gt;2.5&lt;/sub&gt;, Seoul, urban air quality, air quality monitoring station</text>
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                <text>10.3390/ijerph17176208</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="195962">
                <text>Efectos de la biodiversidad  en el control biológico  dentro de los  agroecosistemas</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Jonhy Alexander Hidalgo Martín, Álvaro Acevedo Osorio</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>El control biológico de plagas en los agroecosistemas se ve favorecido por los policultivos (cultivos asociados,  sistemas agroforestales) y de vegetación no cultivada (corredores biológicos, plantas arvenses), ya que  estos sirven como hábitats alternos para las poblaciones de insectos benéfi cos. Durante las últimas décadas,  los sistemas agrícolas se han transformado debido al establecimiento de monocultivos que han homogenizado  los paisajes agrícolas; así se han generado condiciones desfavorables para los enemigos naturales de  plagas al no encontrar en los monocultivos fuentes diversas para su alimentación como polen, presas, o  sitios de reproducción y de refugio. Como consecuencia, las poblaciones de insectos plaga han aumentado  dramáticamente en los monocultivos causando daños de importancia económica. Para su control se están  empleando productos de síntesis química con diversas dosis y grados de toxicidad, lo que provoca grandes  costos ambientales (impacto negativo sobre la fauna silvestre, los polinizadores, los enemigos naturales, la  pesca, la calidad del agua) y costos sociales (envenenamiento de trabajadores, contaminación de alimentos,  enfermedades humanas) no sufi cientemente considerados. Debido a estos problemas generados por la homogenización  de los cultivos y la intensifi cación en el uso de agrotóxicos, se ha incrementado la valoración  del uso adecuado de la biodiversidad como aspecto indispensable para restablecer el control biológico o natural;  la agroecología juega un papel fundamental en este objetivo mediante el diseño de agroecosistemas  diversifi cados que aumentan los sinergismos entre los componentes clave del agroecosistema.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2012</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="195966">
                <text>Agroecosistema, biodiversidad, control biológico</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="195967">
                <text>10.26620/uniminuto.inventum.7.13.2012.30-35</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="195968">
                <text>Inventum Ingeniería, Tecnología e Investigación</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="195969">
                <text>Corporación Universitaria Minuto de Dios</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="195970">
                <text>Engineering (General). Civil engineering (General), Ecology</text>
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          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="195971">
                <text>&lt;a href="http://revistas.uniminuto.edu/index.php/Inventum/article/view/486" target="_blank" rel="noreferrer noopener"&gt;http://revistas.uniminuto.edu/index.php/Inventum/article/view/486&lt;/a&gt;</text>
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