95 10 20655 https://www.socictopen.socict.org/files/original/4c8c4da96b99cea20080581d1ffca335.pdf 6366dcc522396a400fd18325cb9bfd51 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Multiplex Detection of Five Canine Viral Pathogens for Dogs as Laboratory Animals by the Luminex xTAG Assay Creator An entity primarily responsible for making the resource Miaoli Wu, Feng Cong, Yujun Zhu, Yuexiao Lian, Meili Chen, Ren Huang, Pengju Guo Description An account of the resource More and more dogs have been used as a disease model for medical research and drug safety evaluation. Therefore, it is important to make sure that the dogs and their living houses are special pathogen free. In this study, the development and evaluation of a Luminex xTAG assay for simultaneous detection of five canine viruses was carried out, including canine distemper virus, canine parvovirus, canine parainfluenza virus, canine adenovirus, and rabies virus. Assay specificity was accomplished by targeting conserved genomic regions for each virus. Hybridization between multiplexed PCR products and the labeled fluorescence microspheres was detected in a high throughput format using a Luminex fluorescence reader. The Luminex xTAG assay showed high sensitivity with limits of detection for the five viruses was 100 copies/μL. Specificity of the xTAG assay showed no amplification of canine coronavirus, pseudorabies virus and canine influenza virus indicating that the xTAG assay was specific. Seventy-five clinical samples were tested to evaluate the xTAG assay. The results showed 100% coincidence with the conventional PCR method. This is the first report of a specific and sensitive multiplex Luminex xTAG assay for simultaneous detection of five major canine viral pathogens. This assay will be a useful tool for quality control and environmental monitoring for dogs used as laboratory animals, may even be applied in laboratory epidemiological investigations. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource Canine Distemper Virus, canine parvovirus, canine parainfluenza virus, Canine adenovirus, Rabies virus, multiplex-PCR Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2018.01783 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/c857f4916d94846ed4afc2d025784320.pdf 0b1bb9ef3be7f21cc2c4c8be78ef0840 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Genetics and Pathogenesis of Feline Infectious Peritonitis Virus Creator An entity primarily responsible for making the resource Meredith A. Brown, Jennifer L. Troyer, Jill Pecon-Slattery, Melody E. Roelke, Stephen J. O’Brien Description An account of the resource Feline coronavirus (FCoV) is endemic in feral cat populations and cat colonies, frequently preceding outbreaks of fatal feline infectious peritonitis (FIP). FCoV exhibits 2 biotypes: the pathogenic disease and a benign infection with feline enteric coronavirus (FECV). Uncertainty remains regarding whether genetically distinctive avirulent and virulent forms coexist or whether an avirulent form mutates in vivo, causing FIP. To resolve these alternative hypotheses, we isolated viral sequences from FCoV-infected clinically healthy and sick cats (8 FIP cases and 48 FECV-asymptomatic animals); 735 sequences from 4 gene segments were generated and subjected to phylogenetic analyses. Viral sequences from healthy cats were distinct from sick cats on the basis of genetic distances observed in the membrane and nonstructural protein 7b genes. These data demonstrate distinctive circulating virulent and avirulent strains in natural populations. In addition, 5 membrane protein amino acid residues with functional potential differentiated healthy cats from cats with FIP. These findings may have potential as diagnostic markers for virulent FIP-associated FCoV. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource coronavirus, infectious peritonitis, feline, Virulence, Genetic, Marker Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1509.081573 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/4ad164fc3bb59606aad70283794a6f1a.pdf 35e807bb3bebcfa21ac8578a7e556c1d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Contagion and Chaos: Disease, Ecology, and National Security in the Era of Globalization Creator An entity primarily responsible for making the resource Stephen A Morse Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource epidemics, SARS, pandemic influenza, influenza, bioterrorism and preparedness, book review Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1511.090577 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/d2e9eda79625fd933135b6bbe9a54b6a.pdf 6c5371eb81ad9f8f882721256280f810 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource LOS MISIDÁCEOS (LOPHOGASTRIDA, STYGIOMYSIDA Y MYSIDA), DE CUBA: HISTORIA, CLAVES DICOTÓMICAS, FIGURAS Y BIBLIOGRAFÍA/ The opossum shrimps (LOPHOGASTRIDA, STYGIOMYSIDA Y MYSIDA): History, dichotomic keys, figures and bibliography. Creator An entity primarily responsible for making the resource Manuel Ortiz, Rogelio Lalana Description An account of the resource Se presentan la morfología general, incluyendo los caracteres de interés diagnóstico, una breve historia del grupo, la actualización taxonómica y las claves dicotómicas y figuras para la clasificación de los tres géneros y las cuatro especies de estigiomísidos y las ocho tribus,12 géneros y las 30 especies de mísidos cubanos. Los lofogástridos están representados únicamente por el género Lophogaster Sars, 1857. Los mísidos mejor representados en las aguas cubanas pertenecen a los géneros Heteromysis Smith, 1873, con ocho especies y Mysidium Dana, 1852, con cuatro. ABSTRACTThe general morphology, including the characters of diagnostic interest, a brief history of the group, the actualized taxonomy and the dicothomic keys and figures for the classification of the 3 genera and 4 species of stigiomysids, as well as the 8 tribes, 12 genera and 30 species of Cuban mysids are given. The lofogastrids are represented only by the genus Lophogaster. The best represented genera in the Cuban waters are Heteromysis Smith, 1873, with 8 species and Mysidium Dana, 1852, with 4. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Mysid shrimps, identification keys, Cuban archipelago, Misidáceos, claves de identificación, archipiélago cubano Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Revista de Investigaciones Marinas Publisher An entity responsible for making the resource available Universidad de La Habana Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Geography. Anthropology. Recreation, Oceanography Language A language of the resource EN, ES https://www.socictopen.socict.org/files/original/c397698156b55493b98845c6e8ac3762.pdf 4586590699d3dffcd7d34902def35f83 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study Creator An entity primarily responsible for making the resource Michael Berry, Burtram C. Fielding, Junaid Gamieldien Description An account of the resource Human coronaviruses represent a significant disease burden; however, there is currently no antiviral strategy to combat infection. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) less than 10 years later demonstrates the potential of coronaviruses to cross species boundaries and further highlights the importance of identifying novel lead compounds with broad spectrum activity. The coronavirus 3CLpro provides a highly validated drug target and as there is a high degree of sequence homology and conservation in main chain architecture the design of broad spectrum inhibitors is viable. The ZINC drugs-now library was screened in a consensus high-throughput pharmacophore modeling and molecular docking approach by Vina, Glide, GOLD and MM-GBSA. Molecular dynamics further confirmed results obtained from structure-based techniques. A highly defined hit-list of 19 compounds was identified by the structure-based drug design methodologies. As these compounds were extensively validated by a consensus approach and by molecular dynamics, the likelihood that at least one of these compounds is bioactive is excellent. Additionally, the compounds segregate into 15 significantly dissimilar (p < 0.05) clusters based on shape and features, which represent valuable scaffolds that can be used as a basis for future anti-coronaviral inhibitor discovery experiments. Importantly though, the enriched subset of 19 compounds identified from the larger library has to be validated experimentally. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource human coronaviruses, molecular docking, 3CLpro, virtual screening, Structure-based drug design, Molecular dynamics Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v7122963 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/b494363ac51273be810ffbbb208b642b.pdf 5386338ef6fb09de2e4ec9b2f497eb2e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview Creator An entity primarily responsible for making the resource Luciano Amarelle, Emilia Lecuona Description An account of the resource Since being first described more than 60 years ago, Na,K-ATPase has been extensively studied, while novel concepts about its structure, physiology, and biological roles continue to be elucidated. Cardiac glycosides not only inhibit the pump function of Na,K-ATPase but also activate intracellular signal transduction pathways, which are important in many biological processes. Recently, antiviral effects have been described as a novel feature of Na,K-ATPase inhibition with the use of cardiac glycosides. Cardiac glycosides have been reported to be effective against both DNA viruses such as cytomegalovirus and herpes simplex and RNA viruses such as influenza, chikungunya, coronavirus, and respiratory syncytial virus, among others. Consequently, cardiac glycosides have emerged as potential broad-spectrum antiviral drugs, with the great advantage of targeting cell host proteins, which help to minimize resistance to antiviral treatments, making them a very promising strategy against human viral infections. Here, we review the effect of cardiac glycosides on viral biology and the mechanisms by which these drugs impair the replication of this array of different viruses. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource cardiac glycosides, virus, n/a, K-ATPase, Antiviral treatment Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijms19082154 Source A related resource from which the described resource is derived International Journal of Molecular Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry Language A language of the resource EN https://www.socictopen.socict.org/files/original/581faf368535475261c6fd0d08fd068f.pdf 54116c6c00ae3b22b0b13d52e690fd56 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Categorization of species based on their microRNAs employing sequence motifs, information-theoretic sequence feature extraction, and k-mers Creator An entity primarily responsible for making the resource Malik Yousef, Dawit Nigatu, Dalit Levy, Jens Allmer, Werner Henkel Description An account of the resource Abstract Background Diseases like cancer can manifest themselves through changes in protein abundance, and microRNAs (miRNAs) play a key role in the modulation of protein quantity. MicroRNAs are used throughout all kingdoms and have been shown to be exploited by viruses to modulate their host environment. Since the experimental detection of miRNAs is difficult, computational methods have been developed. Many such tools employ machine learning for pre-miRNA detection, and many features for miRNA parameterization have been proposed. To train machine learning models, negative data is of importance yet hard to come by; therefore, we recently started to employ pre-miRNAs from one species as positive data versus another species’ pre-miRNAs as negative examples based on sequence motifs and k-mers. Here, we introduce the additional usage of information-theoretic (IT) features. Results Pre-miRNAs from one species were used as positive and another species’ pre-miRNAs as negative training data for machine learning. The categorization capability of IT and k-mer features was investigated. Both feature sets and their combinations yielded a very high accuracy, which is as good as the previously suggested sequence motif and k-mer based method. However, for obtaining a high performance, a sufficiently large phylogenetic distance between the species and sufficiently high number of pre-miRNAs in the training set is required. To examine the contribution of the IT and k-mer features, an information gain-based feature ranking was performed. Although the top 3 are IT features, 80% of the top 100 features are k-mers. The comparison of all three individual approaches (motifs, IT, and k-mers) shows that the distinction of species based on their pre-miRNAs k-mers are sufficient. Conclusions IT sequence feature extraction enables the distinction among species and is less computationally expensive than motif calculations. However, since IT features need larger amounts of data to have enough statistics for producing highly accurate results, future categorization into species can be effectively done using k-mers only. The biological reasoning for this is the existence of a codon bias between species which can, at least, be observed in exonic miRNAs. Future work in this direction will be the ab initio detection of pre-miRNA. In addition, prediction of pre-miRNA from RNA-seq can be done. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource microRNA, Sequence motifs, pre-microRNA, machine learning, Differentiate miRNAs among species, k-mer Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13634-017-0506-8 Source A related resource from which the described resource is derived EURASIP Journal on Advances in Signal Processing Publisher An entity responsible for making the resource available SpringerOpen Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Electronics, Telecommunication Language A language of the resource EN https://www.socictopen.socict.org/files/original/7d0b9ed066d82103fb33a8bf4e5a95fa.pdf 67526b1fd415fe68c39f63e0ff1e4c0b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Emergency Department Response to SARS, Taiwan Creator An entity primarily responsible for making the resource Wei-Kung Chen, Hong-Dar Isaac Wu, Cheng-Chieh Lin, Yi-Chang Cheng Description An account of the resource How emergency departments of different levels and types cope with a large-scale contagious infectious disease is unclear. We retrospectively analyzed the response of 100 emergency departments regarding use of personal protective equipment (PPE) and implementation of infection control measures (ICMs) during the severe acute respiratory syndrome outbreak in Taiwan. Emergency department workers in large hospitals were more severely affected by the epidemic. Large hospitals or public hospitals were more likely to use respirators. Small hospitals implemented more restrictive ICMs. Most emergency departments provided PPE (80%) and implemented ICMs (66%) at late stages of the outbreak. Instructions to use PPE or ICMs more frequently originated by emergency department administrators. The difficulty of implementing ICMs was significantly negatively correlated with their effectiveness. Because ability to prepare for and respond to emerging infectious diseases varies among hospitals, grouping infectious patients in a centralized location in an early stage of infection may reduce the extent of epidemics. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Keywords: epidemic, infection control, Outbreak, severe acute respiratory syndrome, Taiwan, emergency services Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1107.040917 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/dbe2faeb5c97a07f03e4c225929d1d28.pdf 57b32fe3aced9c53219673cc00148eb5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS Coronavirus Detection Methods Creator An entity primarily responsible for making the resource Susanna K. P. Lau, Xiao-Yan Che, Kwok-yung Yuen, Beatrice H.L. Wong, Vincent C.C. Cheng, Gibson K.S. Woo, Ivan F.N. Hung, Rosana W.S. Poon, Kwok-Hung Chan, JS Malik Peiris Description An account of the resource Using clinical samples from patients with severe acute respiratory syndrome, we showed that the sensitivities of a quantitative reverse transcription–polymerase chain reaction (80% for fecal samples and 25% for urine samples) were higher than those of the polyclonal (50% and 5%) and monoclonal (35% and 8%) antibody-based nucleocapsid antigen capture enzyme-linked immunosorbent assays. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource SARS-CoV, qRT-PCR, Nucleocapsid, Capture ELISA, Hong Kong Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1107.041045 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/e5e28f6cb642533271c2745a49e71868.pdf 30ceb1588d9d0665336c553babe8a4f4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Wildlife Trade and Global Disease Emergence Creator An entity primarily responsible for making the resource William B. Karesh, Robert Cook, Elizabeth L. Bennett, James Newcomb Description An account of the resource The global trade in wildlife provides disease transmission mechanisms that not only cause human disease outbreaks but also threaten livestock, international trade, rural livelihoods, native wildlife populations, and the health of ecosystems. Outbreaks resulting from wildlife trade have caused hundreds of billions of dollars of economic damage globally. Rather than attempting to eradicate pathogens or the wild species that may harbor them, a practical approach would include decreasing the contact rate among species, including humans, at the interface created by the wildlife trade. Since wildlife marketing functions as a system of scale-free networks with major hubs, these points provide control opportunities to maximize the effects of regulatory efforts. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource Keywords: Hepatitis, HIV, SARS, Tuberculosis, healthcare worker, occupational safety Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1107.050194 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN