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Quantifying the role of social distancing, personal protection and case detection in mitigating COVID-19 outbreak in Ontario, Canada
Abstract Public health interventions have been implemented to mitigate the spread of coronavirus disease 2019 (COVID-19) in Ontario, Canada; however, the quantification of their effectiveness remains to be done and is important to determine if some…
Position: 13021 (22 views)
Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs
To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21–120 h postinoculation, pigs exhibited severe…
Position: 16072 (19 views)
Tweet Topics and Sentiments Relating to COVID-19 Vaccination Among Australian Twitter Users: Machine Learning Analysis
BackgroundCOVID-19 is one of the greatest threats to human beings in terms of health care, economy, and society in recent history. Up to this moment, there have been no signs of remission, and there is no proven effective cure. Vaccination is the…
Position: 4029 (38 views)
Coronavirus Genomics and Bioinformatics Analysis
The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the…
Position: 4273 (37 views)
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates [version 2; peer review: 3 approved]
We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CLpro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding…
Position: 18608 (16 views)
Possible Central Nervous System Infection by SARS Coronavirus
On day 22 of illness, generalized tonic-clonic convulsion developed in a 32-year-old woman with severe acute respiratory syndrome (SARS). Cerebrospinal fluid tested positive for SARS coronavirus (SARS-CoV) by reverse transcriptase–polymerase chain…
Position: 15127 (20 views)
Adapted Physical Activity through COVID-19
Editorial for Volume 13, Issue 1, 2020Staying physically activeStaying physically educatedStaying connected with research and practice
Position: 18608 (16 views)
Detection of SARS Coronavirus in Patients with Suspected SARS
Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom SARS was clinically diagnosed, 332 (60%) had SARS-CoV…
Position: 12057 (23 views)
A lesson learned from the MERS epidemic in Korea: an essay on MERS
Position: 52 (153 views)
Assessment of COVID-19 Pandemic in Nepal: A Lockdown Scenario Analysis
The Government of Nepal issued a nationwide lockdown from 24 March to 21 July 2020, prohibiting domestic and international travels, closure of the border and non-essential services. There were only two confirmed cases from 610 Reverse Transcription…
Position: 16982 (18 views)