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                  <text>Dominio científico: Coronavirus</text>
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                <text>Guidance for remote reporting of digital pathology slides during periods of exceptional service pressure: An emergency response from the UK royal college of pathologists</text>
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                <text>Muhammad Aslam, David Brettle, Darren Treanor, Alexander Wright, Clare Verrill, David Snead, Simon Cross, Paul Barrett, Bethany Jill Williams, Emily Clarke, Gareth Bryson</text>
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                <text>Pathology departments must rise to new staffing challenges caused by the coronavirus disease-19 pandemic and may need to work more flexibly for the foreseeable future. In light of this, many pathologists and departments are considering the merits of remote or home reporting of digital cases. While some individuals have experience of this, little work has been done to determine optimum conditions for home reporting, including technical and training considerations. In this publication produced in response to the pandemic, we provide information regarding risk assessment of home reporting of digital slides, summarize available information on specifications for home reporting computing equipment, and share access to a novel point-of-use quality assurance tool for assessing the suitability of home reporting screens for digital slide diagnosis. We hope this study provides a useful starting point and some practical guidance in a difficult time. This study forms the basis of the guidance issued by the Royal College of Pathologists, available at:https://www.rcpath.org/uploads/assets/626ead77-d7dd-42e1-949988e43dc84c97/RCPath-guidance-for-remote-digital-pathology.pdf.</text>
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                <text>patient safety, Digital pathology, technical specifications, home reporting, remote reporting</text>
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                <text>DOI: 10.4103/jpi.jpi_23_20</text>
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                <text>Journal of Pathology Informatics</text>
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                <text>Wolters Kluwer Medknow Publications</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Computer applications to medicine. Medical informatics, Pathology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Guide for Nuclear Medicine Applications During the COVID-19 Outbreak.</text>
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                <text>Aslı Ayan, F Suna Kıraç</text>
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            <description>An account of the resource</description>
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                <text>A viral pneumonia rapidly spread from Wuhan, China to all countries in late 2019. In February 2020, WHO named as Coronavirus Disease 2019 (COVID-19) and declared the pandemic on March 11, 2020. To prevent the spread of COVID-19, Ministry of Health of Republic of Turkey and international institutions have published documents defining hygiene rules. After the lung computerized tomography (CT) findings which are important in the diagnosis of COVID-19 are described, protection measures against infection were defined in radiology departments. There is no publication involving protection measures for diagnostic and therapeutic procedures in nuclear medicine (NM) (appointment, patient acceptance, imaging and treatment procedures, disinfection etc). There are two reports on CT findings suggesting COVID-19 in 18F-fluorodeoxyglucose positron emission tomography/CT scan. These lung findings detected in hybrid images will be helpful in the early diagnosis of pulmonary involvement. Infected cases may be asymptomatic and can unintentionally disseminate the virus to surrounding people. This advisory guide has been prepared to avoid infection risk in NM clinics. During the COVID-19 outbreak, staff must use proper personal protective equipment and patients should be evaluated as the elective case according to clinical status. A questionnaire should be made for COVID-19. In cancer cases requiring urgent treatment, radionuclide treatment (RNT) should be planned according to the COVID-19 test result. If the result is negative, RNT can be applied; but if not or if the symptoms are present, RNT must be postponed. Following imaging procedures, scanners and room surfaces should be cleaned by personnel with proper disinfection training.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>disinfection, coronavirus, positron emission tomography-computerized tomography, COVID-19 outbreak, infection protection rules, nuclear medicine staff</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="25569">
                <text>DOI: 10.4274/mirt.galenos.2020.33600</text>
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          <element elementId="48">
            <name>Source</name>
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              <elementText elementTextId="25570">
                <text>Molecular Imaging and Radionuclide Therapy</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="25571">
                <text>Galenos Yayinevi</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Guideline-Based Chinese Herbal Medicine Treatment Plus Standard Care for Severe Coronavirus Disease 2019 (G-CHAMPS): Evidence From China</text>
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            <name>Creator</name>
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              <elementText elementTextId="31666">
                <text>Yongan Ye, The G-CHAMPS Collaborative Group</text>
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                <text>Background: In January, national guidelines were developed and recommended for use throughout China to fight coronavirus disease 2019 (COVID-19). Chinese herbal medicine (CHM) was also included as part of the treatment plans at various stages of COVID-19.Methods: We conducted a pilot randomized, controlled trial in patients with severe COVID-19 in Wuhan, China. Eligible adult patients were randomly assigned in a 2:1 ratio to receive either CHM plus standard care or standard care alone for 7 days. The primary outcome was the change in the disease severity category of COVID-19 after treatment.Results: Between Jan 31, 2020, and Feb 19, 2020, 42 out of 100 screened patients were included in the trial: 28 in the CHM plus standard care group and 14 in the standard care alone group. Among 42 participants who were randomized (mean [SD] age 60.43 years [12.69 years]), 21 (21/42, 50%) were aged ≥65 years, 35 (35/42, 83%) were women, and 42 (42/42, 100%) had data available for the primary outcome. For the primary outcome, one patient from each group died during treatment; the odds of a shift toward death was lower in the CHM plus group than in the standard care alone group (common OR 0.59, 95% CI 0.148–2.352, P = 0.454). Three (two from the CHM plus group and one from the standard care alone group) patients progressed from severe to critical illness. After treatment, mild, moderate, and severe COVID-19 disease accounted for 17.86% (5/28) vs. 14.29% (2/28), 71.43% (20/28) vs. 64.29% (9/28), and 0% (0) vs. 7.14% (1/28) of the patients treated with CHM plus standard care vs. standard care alone.Conclusions: For the first time, the G-CHAMPS trial provided valuable information for the national guideline-based CHM treatment of hospitalized patients with severe COVID-19. The effects of CHM in COVID-19 may be clinically important and warrant further consideration and studies.Clinical Trial Registration:http://www.chictr.org.cn/index.aspx. Uniqueidentifier: ChiCTR2000029418.</text>
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                <text>2020</text>
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                <text>Randomized Controlled Trial, Chinese herbal medicine, guideline, pilot study, COVID-19</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3389/fmed.2020.00256</text>
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              <elementText elementTextId="31671">
                <text>Frontiers in Medicine</text>
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              <elementText elementTextId="31672">
                <text>Frontiers Media S.A.</text>
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                <text>Medicine (General)</text>
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                <text>Valentine Lobo, Umesh Khanna, Mohan Rajapurkar, Himanshu Sekhar Mahapatra, Himanshu Verma, Narayan Prasad, Sanjay K Agarwal, On behalf of Indian Society of Nephrology</text>
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                <text>10.4103/ijn.IJN_166_20</text>
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                <text>Indian Journal of Nephrology</text>
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                <text>Wolters Kluwer Medknow Publications</text>
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                <text>Diseases of the genitourinary system. Urology</text>
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                <text>Raj Kumar, Ashok Kumar Mahapatra, Radheshyam Mittal, Hanuman Prasad Prajapati</text>
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                <text>Transmission of Coronavirus Disease 2019 (COVID-19) infection can occur to health care workers while providing treatment. It is vital to ensure the safety and to avoid any undue exposure of health care workers, leading to collapse of the entire health care system. As the world is facing this grave threat due to COVID-19, a proper protocol should be there. Daily updates and modifications are being made available by the Ministry of Health &amp; Family Welfare and the ministry advises that protocols be tailored as per prevailing local conditions. We are trying to lay down guidelines based on available literature, data, and guidelines to take the procedures of neurosurgery and neurosciences.</text>
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                <text>In December 2019, a novel coronavirus pneumonia outbreak in Hubei Province spread rapidly to many provinces and cities. As organ transplantation is in the stage of high-quality development in China, how to carry out organ donation and transplantation in a scientific and orderly manner during the severe epidemic, summarize and analyze the clinical characteristics of COVID-19 on organ transplant recipients, and optimize the prevention, early diagnosis and treatment strategies of COVID-19 to ensure medical safety is essential to the development of organ transplantation and the treatment of the patients with end-stage organ failure as well as the overall situation of the prevention and control of COVID-19 epidemic. Thus, based on the instructions of the National Health Committee, the guidelines are issued by several experts organized by Branch of Organ Transplantation of Chinese Medical Association, providing help to the workers and managers of organ donation and transplantation in China. Approved by the Standing Committee of Branch of Organ Transplantation of Chinese Medical Association, the guidelines adopt the 'expert advice', 'prevention and control strategies' and 'guidance' published in China for reference, and will be revised upon changes of the further understanding of COVID-19 and epidemic control situation.</text>
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                <text>Coronavirus disease 2019 (COVID-19) is a significant cause for intensive care unit (ICU) admission worldwide. Most COVID-19 infections are associated with lower respiratory abnormalities but it has been increasingly associated with extra-pulmonary manifestations. Guillain-Barre syndrome (GBS) is a rarely diagnosed but severe disease associated with COVID-19 infection. We describe the diagnostic process behind diagnosing GBS in an elderly male who developed acute-onset quadriparesis and respiratory muscle failure associated with severe COVID-19 pneumonia in a military ICU. A 69-year-old male was admitted to the ICU for acute hypoxemic respiratory failure due to COVID-19 pneumonia. He was subsequently intubated and treated with dexamethasone and remdesivir with improvement. On hospital day 32, the patient was extubated. Three days later, he developed acute, symmetric limb quadriparesis and respiratory muscle failure requiring reintubation. Analysis of his cerebrospinal fluid showed a cytoalbuminologic dissociation, and electromyography/nerve conduction study showed slowed nerve conduction velocity. These findings are consistent with GBS. Blood cultures, serum polymerase chain reaction testing, and clinical symptoms were not suggestive of other common pathogens causing his GBS. The patient's acute GBS in the setting of recent severe COVID-19 infection strongly suggests association between the two entities, as supported by a growing body of case literature. The patient was subjected to intravenous immunoglobulin treatment and was discharged with greatly improved strength in the upper and lower extremities. Our goal in describing this case is to highlight the need for providers to consider, accurately diagnose, and treat GBS as a consequence of severe COVID-19 infection.</text>
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                <text>Phenotypic plasticity comprises a central concept in the understanding of how organisms interact with their environment, and thus, is a central topic in ecology and evolution. A particular case of phenotypic plasticity is phenotypic flexibility, which refers to reversible change in organism traits due to changes in internal or external environmental conditions. Flexibility of digestive features has been analyzed for more than a century in a myriad of different species and contexts. Studies in rodents on gut size flexibility have been developed mainly from two different áreas of the biological sciences, physiology and ecology. However, as for several other topics related with physiological ecology, both kinds of studies largely developed along sepárate paths. Herein, I evaluate altogether the information belonging to both áreas. The major conclusions reached are: (1) there is a clear match between digestive morphology adjustments and change in environmental conditions, and gut size flexibility could be considered a widespread physiological mechanism oceurring in laboratory and wild species, and under laboratory, semi-natural and natural conditions. (2) For laboratory species, the experimental factors that have been more investigated are diet quality, reproductive status, environmental temperature and fasting, while for wild species the more analyzed factors are diet quality and temperature. (3) For wild rodent species, no differences in small intestine length flexibility between methodological approaches ñor species feeding categories has been identified. (4) It appears that high energetic demands are mainly coped with by changes at the small intestine level, while changes in the amount of undigestible material in the diet are mainly coped with by changes in the hindgut. (5) Change in gut length may be related to a decrease in food retention time (e.g., during diet dilution), while change in gut mass appears to be related to a need of higher specific absorption (e.g., during highly demanding periods). (6) The qualities of an energetic demand (e.g., its relative intensity) rather than simply its presence or absence can affect the amount of digestive flexibility. (7) Quantitative comparisons of the existing data are difficult due to several factors, such as the disparity of experimental treatments and differences in the types of data collected. At the end of this review, further directions for the study of digestive flexibility in rodents are presented.La plasticidad fenotípica constituye un concepto medular en el entendimiento de cómo los organismos interactúan con su ambiente y, por tanto, un tema central en ecología y evolución. Un caso particular de la plasticidad fenotípica es la flexibilidad fenotípica, la cual refiere a los cambios reversibles en un organismo producto de cambios en las condiciones ambientales. La flexibilidad en los rasgos digestivos ha sido estudiada por más de un siglo en diversas especies y contextos. Para el caso de los roedores, los estudios sobre la flexibilidad en el tamaño del tracto digestivo han sido desarrollados principalmente desde dos áreas de la biología, la fisiología y la ecología. Sin embargo, como ha ocurrido con muchos tópicos relacionados con la fisiología ecológica, ambos tipos de estudios se desarrollaron por vías separadas. En este trabajo se intenta evaluar de forma conjunta la información proveniente de ambas áreas. Las principales conclusiones alcanzadas son: (1) la flexibilidad en el tamaño del tracto digestivo puede ser considerada un mecanismo fisiológico ampliamente distribuido, existiendo un clara congruencia entre los ajustes en la morfología digestiva y los cambios en las condiciones ambientales. (2) Los factores experimentales más investigados han sido la calidad de la dieta, el estatus reproductivo, la temperatura ambiental y el ayuno para las especies de laboratorio y la calidad de la dieta y la temperatura para las especies salvajes. (3) En especies salvajes no se han encontrado diferencias en la flexibilidad del largo intestinal entre estudios con distintas aproximaciones metodológicas ni entre especies con distintos hábitos tróficos. (4) Los cambios en la demanda energética parecen ser principalmente afrontados mediante ajustes en el intestino delgado, mientras que los cambios en la cantidad de material indigestible en la dieta parecen ser principalmente afrontados mediante ajustes en el ciego e intestino grueso. (5) Los cambios en el largo del tracto digestivo parecen estar relacionados con la necesidad de ajustar el tiempo de retención del alimento (e.g., durante la dilución de la dieta), mientras que cambios en la masa del tracto parecen estar relacionados con la necesidad de modificar la tasa de absorción específica (e.g., durante un periodo de alta demanda energética). (6) Las características de una demanda energética (e.g., su intensidad relativa), más que su simple presencia o ausencia, pueden afectar la magnitud de los ajustes en las dimensiones del tracto digestivo. (7) A pesar de la gran cantidad de trabajos publicados, comparaciones cuantitativas de los datos existentes son difíciles de realizar, debido a factores tales como la disparidad en los tratamientos experimentales y en el tipo de información reportada. Para finalizar esta revisión se presentan nuevas direcciones en cuanto al estudio de la flexibilidad digestiva en roedores.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2008</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Plasticidad fenotípica, Roedores, digestive physiology, fisiologia digestiva, flexibilidad fisiológica, phenotypic plasticity, physiological flexibility, rodents</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Revista Chilena de Historia Natural</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>BMC</text>
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                <text>Botany, Zoology</text>
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                <text>&lt;a href="http://www.scielo.cl/scielo.php?script=sci_arttext&amp;amp;pid=S0716-078X2008000400012" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.cl/scielo.php?script=sci_arttext&amp;amp;pid=S0716-078X2008000400012&lt;/a&gt;</text>
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