99 10 20655 https://www.socictopen.socict.org/files/original/4d6fc57d4381e15e73bbe52def68476b.pdf 0f6ffb01f16d936d3c36215be39ccedd Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bovine respiratory disease associated with Histophilus somni and bovine respiratory syncytial virus in a beef cattle feedlot from Southeastern Brazil Creator An entity primarily responsible for making the resource Selwyn Arligton Headley, Luciana Carvalho Balbo, Alice Fernandes Alfieri, João Paulo Elsen Saut, Anderson Lopes Baptista, Amauri Alfieri Description An account of the resource Bovine respiratory disease (BRD) is a complex multifactorial and multi-etiological disease entity that is responsible for the morbidity and mortality particularly in feedlot cattle from North America. Information relative to the occurrence of BRD in Brazil and the associated infectious agents are lacking. This study investigated the participation of infectious agents of BRD in a beef cattle feedlot from Southeastern Brazil. Nasopharyngeal swabs of 11% (10/90) of cattle (n, 450) with clinical manifestations of respiratory distress were analyzed by targeting specific genes of the principal infectious pathogens of BRD. In addition, pulmonary fragments of one the animals that died were collected for histopathological and molecular diagnoses. The nucleic acids of Histophilus somni and bovine respiratory syncytial virus (BRSV) were identified in 20% (2/10) of the nasopharyngeal swabs of the animals with respiratory distress; another contained only BRSV RNA. Moreover, the nucleic acids of both infectious agents were amplified from the pulmonary fragments of the animal that died with histopathological evidence of bronchopneumonia and interstitial pneumonia; the nasopharyngeal swab of this animal also contained the nucleic acids of both pathogens. Additionally, all PCR and/or RT-PCR assays designed to detect the specific genes of Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis, bovine viral diarrhea virus, bovine herpesvirus -1, bovine parainfluenza virus-3, and bovine coronavirus yielded negative results. Phylogenetic analyses suggest that the isolates of H. somni circulating in Brazil are similar to those identified elsewhere, while there seem to be diversity between the isolates of BRSV within cattle herds from different geographical locations of Brazil. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource BRONCHOPNEUMONIA, Respiratory disease, molecular diagnostics, phylogenetic relationships Identifier An unambiguous reference to the resource within a given context DOI: 10.5433/1679-0359.2017v38n1p283 Source A related resource from which the described resource is derived Semina: Ciências Agrárias Publisher An entity responsible for making the resource available Universidade Estadual de Londrina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General) Language A language of the resource EN, PT https://www.socictopen.socict.org/files/original/f1e8d8f74171d8129b73363c082a8c2d.pdf 5750f3abbd5b3a972251aa742e4fd738 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Contribution to the knowledge of meiobenthic Copepoda (Crustacea) from the Sardinian coast, Italy Creator An entity primarily responsible for making the resource Noli, N., Sbrocca, C., Sandulli, R., Balsamo, M., Semprucci, F. Description An account of the resource Data available on the Italian species of Copepoda Canuelloida Khodami, Vaun MacArthur, Blanco-Bercial and Martínez Arbizu, 2017 and Harpacticoida Sars, 1903 report overall 210 species, but their diversity and biogeography are still poorly investigated. We carried out a faunistic survey along the eastern coast of Sardinia (Ogliastra region) in order to document these taxa in the area. A total of 41 species in 36 genera and 18 families were found. Although many species were identified as putative, the current Italian checklist was updated with 12 new records of genera and 4 of species. Longipedia coronata Claus, 1862 (Canuelloida), Diosaccus tenuicornis (Claus, 1863), Asellopsis hispida Brady and Robertson, 1873, Wellsopsyllus (intermediopsyllus) intermedius (Scott and Scott, 1895) (all Harpacticoida) are reported for the first time from Sardinia coasts. The copepod community was particularly rich at Ogliastra Island, a small rocky island with natural reefs, rocky shoals and Posidonia oceanica meadows. Species found there were mainly related to coarse sands and macrophytal detritus.Data published in GBIF: doi:10.15470/dxru6l Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource Meiobenthic Copepoda, meiof auna, Biogeography, Check list, Sardinia, Italy Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Arxius de Miscel-lània Zoològica Publisher An entity responsible for making the resource available Museu de Ciències Naturals de Barcelona Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Zoology Language A language of the resource CA, EN, ES https://www.socictopen.socict.org/files/original/e070c6ee41d15343fe86368f013a82fa.pdf 1b80c68809a3c43f67c2312e6d57df0e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Identify-Isolate-Inform: A Modified Tool for Initial Detection and Management of Middle East Respiratory Syndrome Patients in the Emergency Department Creator An entity primarily responsible for making the resource Kristi L. Koenig Description An account of the resource Middle East respiratory syndrome (MERS) is a novel infectious disease caused by a coronavirus(MERS-CoV) first reported in Saudi Arabia in September 2012. MERS later spread to other countriesin the Arabian Peninsula, followed by an outbreak in South Korea in 2015. At least 26 countrieshave reported MERS cases, and these numbers may increase over time. Due to internationaltravel opportunities, all countries are at risk of imported cases of MERS, even if outbreaks do notspread globally. Therefore, it is essential for emergency department (ED) personnel to be able torapidly assess MERS risk and take immediate actions if indicated. The Identify-Isolate-Inform (3I)tool, originally conceived for initial detection and management of Ebola virus disease patients in theED and later adjusted for measles, can be adapted for real-time use for any emerging infectiousdisease. This paper reports a modification of the 3I tool for use in initial detection and managementof patients under investigation for MERS. Following an assessment of epidemiologic risk factors,including travel to countries with current MERS transmission and contact with patients with confirmedMERS within 14 days, patients are risk stratified by type of exposure coupled with symptoms of feverand respiratory illness. If criteria are met, patients must be immediately placed into airborne infectionisolation (or a private room until this type of isolation is available) and the emergency practitionermust alert the hospital infection prevention and control team and the local public health department.The 3I tool will facilitate rapid categorization and triggering of appropriate time-sensitive actions forpatients presenting to the ED at risk for MERS. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Identifier An unambiguous reference to the resource within a given context DOI: 10.5811/westjem.2015.7.27915 Source A related resource from which the described resource is derived Western Journal of Emergency Medicine Publisher An entity responsible for making the resource available eScholarship Publishing, University of California Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medical emergencies. Critical care. Intensive care. First aid Language A language of the resource EN https://www.socictopen.socict.org/files/original/b0e6b4344356cd9c6d5884fefbfa736b.pdf 7629a538bc3eb93b97db63cd1d88d624 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Matrix Method of Representation, Analysis and Classification of Long Genetic Sequences Creator An entity primarily responsible for making the resource Ivan V. Stepanyan, Sergey V. Petoukhov Description An account of the resource The article is devoted to a matrix method of comparative analysis of long nucleotide sequences by means of presenting each sequence in the form of three digital binary sequences. This method uses a set of symmetries of biochemical attributes of nucleotides. It also uses the possibility of presentation of every whole set of N-mers as one of the members of a Kronecker family of genetic matrices. With this method, a long nucleotide sequence can be visually represented as an individual fractal-like mosaic or another regular mosaic of binary type. In contrast to natural nucleotide sequences, artificial random sequences give non-regular patterns. Examples of binary mosaics of long nucleotide sequences are shown, including cases of human chromosomes and penicillins. The obtained results are then discussed. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource matrix genetics, long genetic sequences, symmetries, algebraic biology Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/info8010012 Source A related resource from which the described resource is derived Information Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Information technology Language A language of the resource EN https://www.socictopen.socict.org/files/original/15093f4b6e459824cc2e4f9eaecf3ff7.pdf 8d3f6cde15b86b50cf0052ed9f23a8d2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS Transmission and Hospital Containment Creator An entity primarily responsible for making the resource Gowri Gopalakrishna, Philip Choo, Yee Sin Leo, Boon Keng Tay, Yean Teng Lim, Ali S Khan, Chorh Chuan Tan Description An account of the resource An outbreak of severe acute respiratory syndrome (SARS) was detected in Singapore at the beginning of March 2003. The outbreak, initiated by a traveler to Hong Kong in late February 2003, led to sequential spread of SARS to three major acute care hospitals in Singapore. The critical factor in containing this outbreak was early detection and complete assessment of movements and follow-up of patients, healthcare workers, and visitors who were contacts. Visitor records were important in helping identify exposed persons who could carry the infection into the community. In the three hospital outbreaks, three different containment strategies were used to contain spread of infection: closing an entire hospital, removing all potentially infected persons to a dedicated SARS hospital, and managing exposed persons in place. On the basis of this experience, if a nosocomial outbreak is detected late, a hospital may need to be closed in order to contain spread of the disease. Outbreaks detected early can be managed by either removing all exposed persons to a designated location or isolating and managing them in place. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource coronavirus, cross infections, hospital, infection control, nosocomial infections, severe acute respiratory syndrome Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1003.030650 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/0c025f5523ba062d7e254487e07552a1.pdf 18ada824a3112f612368cf7d19e1f504 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Human Metapneumovirus-associated Atypical Pneumonia and SARS Creator An entity primarily responsible for making the resource Paul K. S. Chan, Ka-Fai To, Alan Wu, Gary MK Tse, Kui-Fat Chan, Siu-Fai Lui, Joseph J. Y. Sung, John S. Tam, Brian Tomlinson Description An account of the resource Acute pneumonia developed in a previously healthy man during the outbreak of severe acute respiratory syndrome (SARS) in southern China in March 2003. Antibiotic treatment was ineffective, and he died 8 days after illness onset. Human metapneumovirus was isolated from lung tissue. No other pathogen was found. Other etiologic agents should thus be sought in apparent SARS cases when coronavirus infection cannot be confirmed. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource human metapneumovirus, respiratory tract infection, post mortem, SARS, Hong Kong Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1003.030513 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/1802bc40336c7ec0c640ce35a981e416.pdf 31818ac8d2b0071ad6cca220c5d2d5b0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Middle East Respiratory Syndrome Coronavirus and the One Health concept Creator An entity primarily responsible for making the resource Maged Gomaa Hemida Description An account of the resource Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is one of the major threats to the healthcare systems in some countries, especially in the Arabian Peninsula. MERS-CoV is considered an ideal example of the One Health concept. This is due to the animals, especially dromedary camels, play important roles in the transmission and sustainability of the virus, and the virus can be transmitted through aerosols of infected patients into the environment. However, there is some debate regarding the origin of MERS-CoV either from bats or other unknown reservoirs. The dromedary camel is the only identified animal reservoir to date. These animals play important roles in sustaining the virus in certain communities and may act as an amplifier of the virus by secreting it in their body fluids, especially in nasal and rectal discharges. MERS-CoV has been detected in the nasal and rectal secretions of infected camels, and MERS-CoV of this origin has full capacity to infect human airway epithelium in both in vitro and in vivo models. Other evidence confirms the direct transmission of MERS-CoV from camels to humans, though the role of camel meat and milk products has yet to be well studied. Human-to-human transmission is well documented through contact with an active infected patient or some silently infected persons. Furthermore, there are some significant risk factors of individuals in close contact with a positive MERS-CoV patient, including sleeping in the same patient room, removing patient waste (urine, stool, and sputum), and touching respiratory secretions from the index case. Outbreaks within family clusters have been reported, whereby some blood relative patients were infected through their wives in the same house were not infected. Some predisposing genetic factors favor MERS-CoV infection in some patients, which is worth investigating in the near future. The presence of other comorbidities may be another factor. Overall, there are many unknown/confirmed aspects of the virus/human/animal network. Here, the most recent advances in this context are discussed, and the possible reasons behind the emergence and sustainability of MERS-CoV in certain regions are presented. Identification of the exact mechanism of transmission of MERS-CoV from camels to humans and searching for new reservoir/s are of high priority. This will reduce the shedding of the virus into the environment, and thus the risk of human infection can be mitigated. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource dromedary camel, transmisión, zoonosis, one health concept, MERS-CoV, human Identifier An unambiguous reference to the resource within a given context DOI: 10.7717/peerj.7556 Source A related resource from which the described resource is derived PeerJ Publisher An entity responsible for making the resource available PeerJ Inc. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/b263a76c6faf09d586f44aa48b61b656.pdf 11d3e02e53cdb607ab370a5b42a1bc8b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein Creator An entity primarily responsible for making the resource Stevermann Lea, Drosten Christian, Pfefferle Susanne, Voß Daniel, Traggiai Elisabetta, Lanzavecchia Antonio, Becker Stephan Description An account of the resource Abstract The glycosylated membrane protein M of the severe acute respiratory syndrome associated coronavirus (SARS-CoV) is the main structural component of the virion and mediates assembly and budding of viral particles. The membrane topology of SARS-CoV M and the functional significance of its N-glycosylation are not completely understood as is its interaction with the surface glycoprotein S. Using biochemical and immunofluorescence analyses we found that M consists of a short glycosylated N-terminal ectodomain, three transmembrane segments and a long, immunogenic C-terminal endodomain. Although the N-glycosylation site of M seems to be highly conserved between group 1 and 3 coronaviruses, studies using a recombinant SARS-CoV expressing a glycosylation-deficient M revealed that N-glycosylation of M neither influence the shape of the virions nor their infectivity in cell culture. Further functional analysis of truncated M proteins showed that the N-terminal 134 amino acids comprising the three transmembrane domains are sufficient to mediate accumulation of M in the Golgi complex and to enforce recruitment of the viral spike protein S to the sites of virus assembly and budding in the ERGIC. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1743-422X-6-79 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/a02c4c711a1b88c473daf346472f4415.pdf 4659a39634ff75f3a4b1c4d10d81ecc9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource All and only CpG containing sequences are enriched in promoters abundantly bound by RNA polymerase II in multiple tissues Creator An entity primarily responsible for making the resource Myakishev Maxim V, Rishi Vikas, Glass Kimberly, Shlyakhtenko Andrey, Rozenberg Julian M, FitzGerald Peter C, Vinson Charles Description An account of the resource Abstract Background The promoters of housekeeping genes are well-bound by RNA polymerase II (RNAP) in different tissues. Although the promoters of these genes are known to contain CpG islands, the specific DNA sequences that are associated with high RNAP binding to housekeeping promoters has not been described. Results ChIP-chip experiments from three mouse tissues, liver, heart ventricles, and primary keratinocytes, indicate that 94% of promoters have similar RNAP binding, ranging from well-bound to poorly-bound in all tissues. Using all 8-base pair long sequences as a test set, we have identified the DNA sequences that are enriched in promoters of housekeeping genes, focusing on those DNA sequences which are preferentially localized in the proximal promoter. We observe a bimodal distribution. Virtually all sequences enriched in promoters with high RNAP binding values contain a CpG dinucleotide. These results suggest that only transcription factor binding sites (TFBS) that contain the CpG dinucleotide are involved in RNAP binding to housekeeping promoters while TFBS that do not contain a CpG are involved in regulated promoter activity. Abundant 8-mers that are preferentially localized in the proximal promoters and exhibit the best enrichment in RNAP bound promoters are all variants of six known CpG-containing TFBS: ETS, NRF-1, BoxA, SP1, CRE, and E-Box. The frequency of these six DNA motifs can predict housekeeping promoters as accurately as the presence of a CpG island, suggesting that they are the structural elements critical for CpG island function. Experimental EMSA results demonstrate that methylation of the CpG in the ETS, NRF-1, and SP1 motifs prevent DNA binding in nuclear extracts in both keratinocytes and liver. Conclusion In general, TFBS that do not contain a CpG are involved in regulated gene expression while TFBS that contain a CpG are involved in constitutive gene expression with some CpG containing sequences also involved in inducible and tissue specific gene regulation. These TFBS are not bound when the CpG is methylated. Unmethylated CpG dinucleotides in the TFBS in CpG islands allow the transcription factors to find their binding sites which occur only in promoters, in turn localizing RNAP to promoters. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2164-9-67 Source A related resource from which the described resource is derived BMC Genomics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics, Biotechnology Language A language of the resource EN https://www.socictopen.socict.org/files/original/3606825afc45419ebc08446385760246.pdf b3a9f443d5fd9af2c4ef463405f1aab9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus Creator An entity primarily responsible for making the resource Weber Friedemann, Spiegel Martin Description An account of the resource Abstract Background SARS coronavirus (SARS-CoV) is the etiologic agent of the severe acute respiratory syndrome. SARS-CoV mainly infects tissues of non-lymphatic origin, and the cytokine profile of those cells can determine the course of disease. Here, we investigated the cytokine response of two human non-lymphatic cell lines, Caco-2 and HEK 293, which are fully permissive for SARS-CoV. Results A comparison with established cytokine-inducing viruses revealed that SARS-CoV only weakly triggered a cytokine response. In particular, SARS-CoV did not activate significant transcription of the interferons IFN-α, IFN-β, IFN-λ1, IFN-λ2/3, as well as of the interferon-induced antiviral genes ISG56 and MxA, the chemokine RANTES and the interleukine IL-6. Interestingly, however, SARS-CoV strongly induced the chemokines IP-10 and IL-8 in the colon carcinoma cell line Caco-2, but not in the embryonic kidney cell line 293. Conclusion Our data indicate that SARS-CoV suppresses the antiviral cytokine system of non-immune cells to a large extent, thus buying time for dissemination in the host. However, synthesis of IP-10 and IL-8, which are established markers for acute-stage SARS, escapes the virus-induced silencing at least in some cell types. Therefore, the progressive infiltration of immune cells into the infected lungs observed in SARS patients could be due to the production of these chemokines by the infected tissue cells. Date A point or period of time associated with an event in the lifecycle of the resource 2006 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1743-422X-3-17 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN