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                <text>Domestic Pig Unlikely Reservoir for MERS-CoV</text>
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                <text>Emmie de Wit, Friederike Feldmann, Eva Horne, Cynthia Martellaro, Elaine Haddock, Trenton Bushmaker, Kyle Rosenke, Atsushi Okumura, Rebecca Rosenke, Greg Saturday, Dana Scott, Heinz Feldmann</text>
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                <text>We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.</text>
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                <text>DOI: 10.3201/eid2306.170096</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Hui-Wen Chang, Herman  F. Egberink, Rebecca Halpin, David J Spiro, Peter J.M. Rottier</text>
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                <text>Coronaviruses are well known for their potential to change their host or tissue tropism, resulting in unpredictable new diseases and changes in pathogenicity; severe acute respiratory syndrome and feline coronaviruses, respectively, are the most recognized examples. Feline coronaviruses occur as 2 pathotypes: nonvirulent feline enteric coronaviruses (FECVs), which replicate in intestinal epithelium cells, and lethal feline infectious peritonitis viruses (FIPVs), which replicate in macrophages. Evidence indicates that FIPV originates from FECV by mutation, but consistent distinguishing differences have not been established. We sequenced the full genome of 11 viruses of each pathotype and then focused on the single most distinctive site by additionally sequencing hundreds of viruses in that region. As a result, we identified 2 alternative amino acid differences in the putative fusion peptide of the spike protein that together distinguish FIPV from FECV in &gt;95% of cases. By these and perhaps other mutations, the virus apparently acquires its macrophage tropism and spreads systemically.</text>
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                <text>2012</text>
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                <text>Zoonoses, Virulence, pathogenesis, virus tropism, Feline coronavirus, Feline infectious peritonitis virus</text>
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                <text>DOI: 10.3201/eid1807.120143</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Group C Betacoronavirus in Bat Guano Fertilizer, Thailand</text>
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                <text>Supaporn Wacharapluesadee, Chirapol Sintunawa, Thongchai Kaewpom, Kritsada Khongnomnan, Kevin J Olival, Jonathan H. Epstein, Apaporn Rodpan, Paiboon Sangsri, Nirun Intarut, Ariya Chindamporn, Kanyarat Suksawa, Thiravat Hemachudha</text>
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                <text>2013</text>
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                <text>coronavirus, betacoronavirus, bat guano fertilizer, insectivorous bat, Thailand, Viruses</text>
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                <text>DOI: 10.3201/eid1908.130119</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>EN</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>New Chimeric Porcine Coronavirus in Swine Feces, Germany, 2012</text>
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                <text>Valerij Akimkin, Martin Beer, Sandra Blome, Dennis Hanke, Dirk Höper, Maria Jenckel, Anne Pohlmann</text>
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                <text>porcine coronavirus, coronavirus, Viruses, chimeric virus, porcine epidemic diarrhea virus, PEDV</text>
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                <text>DOI: 10.3201/eid2207.160179</text>
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                <text>Emerging Infectious Diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates</text>
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                <text>Ping Tim Tsui, Man Leung Kwok, Hon Yuen, Sik To Lai</text>
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                <text>Severe acute respiratory syndrome (SARS) poses a major threat to the health of people worldwide. We performed a retrospective case series analysis to assess clinical outcome and identify pretreatment prognostic correlates of SARS, managed under a standardized treatment protocol. We studied 127 male and 196 female patients with a mean age of 41±14 (range 18–83). All patients, except two, received ribavirin and steroid combination therapy. In 115 (36%) patients, the course of disease was limited. Pneumonitis progressed rapidly in the remaining patients. Sixty-seven (21%) patients required intensive care, and 42 (13%) required ventilator support. Advanced age, high admission neutrophil count, and high initial lactate dehydrogenase level were independent correlates of an adverse clinical outcome. SARS-associated coronavirus caused severe illnesses in most patients, despite early treatment with ribavirin and steroid. This study has identified three independent pretreatment prognostic correlates.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="18589">
                <text>Samuel M.S. Chan, Batchuluun Damdinjav, Ranawaka A.P.M. Perera, Daniel K.W. Chu, Bodisaikhan Khishgee, Bazarragchaa Enkhbold, Leo L.M. Poon, Ahmad M. Hakawi</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="18590">
                <text>2015</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="18591">
                <text>Middle East respiratory syndrome, coronavirus, MERS-CoV, Bovine coronavirus, camels, Dromedary</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="18592">
                <text>DOI: 10.3201/eid2107.150178</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="18593">
                <text>Emerging Infectious Diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="18594">
                <text>Centers for Disease Control and Prevention</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="18595">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="18596">
                <text>EN</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
