196 10 20655 https://www.socictopen.socict.org/files/original/dfdc345c061a84f7d40f63970e26d35f.pdf 2ee05af0245b757be3ff0a6388a225f0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves Creator An entity primarily responsible for making the resource Aspen M. Workman, Larry A. Kuehn, Tara G. McDaneld, Michael L Clawson, John Dustin Loy Description An account of the resource Abstract Background Bovine coronavirus (BCV) is associated with respiratory infections in cattle of all ages; however, a temporal study to evaluate the effect of BCV immunity on virus shedding and bovine respiratory disease (BRD) incidence in pre-weaned beef calves has not been reported. Thus, we report here a prospective study in three herds of crossbred beef calves (n = 817) with endemic BCV. Serial blood samples for measurement of serum anti-BCV antibody titers and nasal swabs for detection of BCV and other common viral and bacterial BRD pathogens were collected from all calves or subsets of calves at predetermined times from birth through weaning. The calves were monitored for BRD and those that developed signs of respiratory disease were sampled for diagnostic testing. To discover additional risk factors that could have influenced BRD development, sequence analysis of the BCV strain(s) circulating in each herd, and the prevalence of common opportunistic bacterial pathogens in the upper respiratory tract of sick and apparently healthy cattle were also evaluated. Results Two hundred forty-eight of the 817 study calves (30.4%) were treated for BRD prior to weaning; 246 of those were from a single herd involved in two outbreaks of BRD leading to mass treatment of all calves in that group. Molecular diagnostic testing found BCV and Histophilus somni in nasal swabs taken at the time of BRD treatment. Between herd analyses revealed anti-BCV serum antibody abundance did not associate with the incidence of BRD or BCV shedding, though these measurements may have been hindered by the long periods between sample collections. Analysis of the BCV spike gene hypervariable region revealed four polymorphisms in 15 isolates from the three herds, making strain variation unlikely to account for differences in treatment rates between herds. Persistent or recurrent shedding episodes of BCV occurred in some animals treated for BRD. Conclusion Co-detection of BCV and H. somni at the time of the disease outbreak suggests that these pathogens contributed to disease pathogenesis. Developing appropriate control measures for respiratory BCV infections may help decrease the incidence of pre-weaning BRD. The role of antibodies in protection must still be further defined. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Bovine coronavirus, Bovine Respiratory Disease, Histophilus somni, molecular epidemiology, Nursing-calf pneumonia, Summer pneumonia Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12917-019-1887-8 Source A related resource from which the described resource is derived BMC Veterinary Research Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/7befbabb960abe4fe354b0a6db56efb1.pdf 394173c68086310f2984fbce86efb0ce Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sarsılmış Bebek Sendromu Süt Çocukluğu Döneminde Konvulsiyon Çocuk İstismarı İlişkisi Üç Adli Olgu Sunumu Creator An entity primarily responsible for making the resource Birgül Tüzün, Raif Üçsel, Nevzat Alkan, Agop Çitak, Şebnem Korur Fincancı Description An account of the resource Süt çocukluğu dönemi fiziksel istismar olgularında, harici travmatik değişimlerin görülme olasılığı oldukça düşüktür. Olgular, daha çok aniden ortaya çıktığı söylenen ve hu yaş grubuna özgü çeşitli hastalık tablolarında gözlenen klinik bulgular sebebiyle özellikle çocuk acil-yoğun bakım ünitelerine getirilmektedir. Bu çalışmada, İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Acil-Yoğun Bakım Ünitesi'ne konvulsiyon klinik bulgusu ile başvuran süt çocukluğu dönemindeki 1 erkek, 2 kız çocuğu fiziksel istismar yönünden kliniğe yansıma şekli ve doğru tanıya yönelme aşamasında adli tıbbi yaklaşımın önemini vurgulamak ve belgelemek amacıyla sunulmuştur. Her üç olguda da, yakın zamanda düşme hikayesi, beyin tomografisinde subdural hematom ve göz dibi incelemesinde yaygın retinal kanama tespit edilmiştir. Öykü derinleştirildiğinde, olguların çocuk istismarı açısından izlenmesinin uygun olacağı sonucuna varılmıştır. Süt çocukluğu dönemi fiziksel istismar olgularında gecikmeden doğru tanı konulmasında, adli olgu olarak değerlendirilip, tespit edilen travmatik değişimlerin adli rapor şeklinde belgelendirilmesinde ve adli makamlara bildirilmesinde Adli Tıp Anabilim Dalları ile birlikte yürütülen koordine çalışmaların ivedilikle yaygınlaştırılması gerektiği düşünülmektedir. Anahtar Kelimeler: Çocuk istismarı, subdural hematom, sarsılmış bebek sendromu. Date A point or period of time associated with an event in the lifecycle of the resource 2000 Subject The topic of the resource çocuk istismarı, subdural hematom, sarsılmış bebek sendromu Identifier An unambiguous reference to the resource within a given context DOI: 10.17986/blm.200053423 Source A related resource from which the described resource is derived Adli Tıp Bülteni Publisher An entity responsible for making the resource available Adli Tıp Uzmanları Derneği Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN, TR https://www.socictopen.socict.org/files/original/dc347b4d180254db30446cac59d5612b.pdf 497c201a6441778e54f93fd8222443fb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Quality of life reported by survivors after hospitalization for Middle East respiratory syndrome (MERS) Creator An entity primarily responsible for making the resource Sarah Batawi, Nehal Tarazan, Rajaa Al-Raddadi, Eman Al Qasim, Anees Sindi, Sameera AL Johni, Fahad M. Al-Hameed, Yaseen M. Arabi, Timothy M. Uyeki, Basem M. Alraddadi Description An account of the resource Abstract Introduction Data are lacking on impact of Middle East Respiratory Syndrome (MERS) on health-related quality of life (HRQoL) among survivors. Methods We conducted a cross-sectional survey of MERS survivors who required hospitalization in Saudi Arabia during 2016–2017, approximately 1 year after diagnosis. The Short-Form General Health Survey 36 (SF-36) was administered by telephone interview to assess 8 quality of life domains for MERS survivors and a sample of survivors of severe acute respiratory infection (SARI) without MERS. We compared mean SF-36 scores of MERS and non-MERS SARI survivors using independent t-test, and compared categorical variables using chi-square test. Adjusted analyses were performed using multiple linear regression. Results Of 355 MERS survivors, 83 were eligible and 78 agreed to participate. MERS survivors were younger than non-MERS SARI survivors (mean ± SD): (44.9 years ±12.9) vs (50.0 years ±13.6), p = 0.031. Intensive care unit (ICU) admissions were similar for MERS and non-MERS SARI survivors (46.2% vs. 57.1%), p = 0.20. After adjusting for potential confounders, there were no significant differences between MERS and non-MERS SARI survivors in physical component or mental component summary scores. MERS ICU survivors scored lower than MERS survivors not admitted to an ICU for physical function (p = 0.05), general health (p = 0.01), vitality (p = 0.03), emotional role (p = 0.03) and physical component summary (p  Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource health related quality of life (HRQoL), coronavirus, Middle East respiratory syndrome (MERS), Pneumonia, Saudi Arabia, Severe acute respiratory infection (SARI) Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12955-019-1165-2 Source A related resource from which the described resource is derived Health and Quality of Life Outcomes Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Computer applications to medicine. Medical informatics Language A language of the resource EN https://www.socictopen.socict.org/files/original/3eb4663a2249db4cea2aaac16755bda1.pdf 037c6734955f5bd808f75e3f5943fb4b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Novel Insights Into Immune Systems of Bats Creator An entity primarily responsible for making the resource Arinjay Banerjee, Michelle L. Baker, Kirsten Kulcsar, Vikram Misra, Raina Plowright, Karen Mossman Description An account of the resource In recent years, viruses similar to those that cause serious disease in humans and other mammals have been detected in apparently healthy bats. These include filoviruses, paramyxoviruses, and coronaviruses that cause severe diseases such as Ebola virus disease, Marburg haemorrhagic fever and severe acute respiratory syndrome (SARS) in humans. The evolution of flight in bats seem to have selected for a unique set of antiviral immune responses that control virus propagation, while limiting self-damaging inflammatory responses. Here, we summarize our current understanding of antiviral immune responses in bats and discuss their ability to co-exist with emerging viruses that cause serious disease in other mammals. We highlight how this knowledge may help us to predict viral spillovers into new hosts and discuss future directions for the field. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource bats (Chiroptera), virus, innate and adaptive immune response, interferon, antiviral, Emerging viruses Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2020.00026 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/ccb40cadb70b418e64347ab1bc0b8022.pdf 6515aae40b32faecbc66938d89d2a72a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The new understatement penalty regime: A sharp ‘sword’? Creator An entity primarily responsible for making the resource Linda van Zyl Description An account of the resource The objective of this article was to form an opinion on the sharpness of the ‘sword’ of the new mandatory understatement penalty regime of the Tax Administration Act 28 of 2011 (as amended). Based on a review of the new bona fide inadvertent error exclusion and the burden of proof, it was found that it is imperative that comprehensive guidelines be issued expediently in order to prevent inconsistent application by South African Revenue Service (SARS) officials as well as to clarify the alleged automatic penalty position. The conclusion reached is that this sword is very sharp indeed based on its mandatory nature, the effect of the application of the highest penalty percentage and the current lack of guidance from SARS, especially regarding the practical application of the new bona fide inadvertent error exclusion. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource bona fide inadvertent error, burden of proof, understatement penalty, substantial understatement, reasonable care, reasonable grounds, gross negligence, intentional tax evasion Identifier An unambiguous reference to the resource within a given context DOI: 10.4102/jef.v7i3.243 Source A related resource from which the described resource is derived Journal of Economic and Financial Sciences Publisher An entity responsible for making the resource available African Online Scientific Information Systems Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Economics as a science Language A language of the resource EN https://www.socictopen.socict.org/files/original/24f361de1e4b652c2ad0f89fe19c42d4.pdf e1b3d9d2e379cf7c61b396a57a157092 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Identifying Group-Specific Sequences for Microbial Communities Using Long k-mer Sequence Signatures Creator An entity primarily responsible for making the resource Ying Wang, Lei Fu, Jie Ren, Zhaoxia Yu, Ting Chen, Fengzhu Sun Description An account of the resource Comparing metagenomic samples is crucial for understanding microbial communities. For different groups of microbial communities, such as human gut metagenomic samples from patients with a certain disease and healthy controls, identifying group-specific sequences offers essential information for potential biomarker discovery. A sequence that is present, or rich, in one group, but absent, or scarce, in another group is considered “group-specific” in our study. Our main purpose is to discover group-specific sequence regions between control and case groups as disease-associated markers. We developed a long k-mer (k ≥ 30 bps)-based computational pipeline to detect group-specific sequences at strain resolution free from reference sequences, sequence alignments, and metagenome-wide de novo assembly. We called our method MetaGO: Group-specific oligonucleotide analysis for metagenomic samples. An open-source pipeline on Apache Spark was developed with parallel computing. We applied MetaGO to one simulated and three real metagenomic datasets to evaluate the discriminative capability of identified group-specific markers. In the simulated dataset, 99.11% of group-specific logical 40-mers covered 98.89% disease-specific regions from the disease-associated strain. In addition, 97.90% of group-specific numerical 40-mers covered 99.61 and 96.39% of differentially abundant genome and regions between two groups, respectively. For a large-scale metagenomic liver cirrhosis (LC)-associated dataset, we identified 37,647 group-specific 40-mer features. Any one of the features can predict disease status of the training samples with the average of sensitivity and specificity higher than 0.8. The random forests classification using the top 10 group-specific features yielded a higher AUC (from ∼0.8 to ∼0.9) than that of previous studies. All group-specific 40-mers were present in LC patients, but not healthy controls. All the assembled 11 LC-specific sequences can be mapped to two strains of Veillonella parvula: UTDB1-3 and DSM2008. The experiments on the other two real datasets related to Inflammatory Bowel Disease and Type 2 Diabetes in Women consistently demonstrated that MetaGO achieved better prediction accuracy with fewer features compared to previous studies. The experiments showed that MetaGO is a powerful tool for identifying group-specific k-mers, which would be clinically applicable for disease prediction. MetaGO is available at https://github.com/VVsmileyx/MetaGO. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource long k-mer, classification, group-specific sequence, metagenomics, microbial community, Disease prediction Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2018.00872 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/6f4dd1071df82425b1c5f2dc3e16e83b.pdf fc3197428cb3f2ea1140649f3b6c6bdc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evaluation of GPR capabilities in the study of seismogenic faulting and deformation in the bottom sediments of Lake Upoloksha (northeast of the Fennoscandian shield) Creator An entity primarily responsible for making the resource A. I. Rodionov, S. B. Nikolaeva, P. A. Ryazantsev Description An account of the resource The article describes the experience of using the GPR method to study the bottom sediments of Lake Upoloksha located in the Kola Peninsula, Russia. Such sediments are viewed as good archives of various Holocene geodynamic processes, including tectonic and paleoseismic events. This small lake is located in the zone of the active NW-striking lineament, which length is more than 20 km. A series of åsars (eskers) stretches along the lineament. In the previous studies, the bottom sediments of the lake were investigated by geological methods, including core sampling, lithological and micro-palaeontological analysis of sediments. The studies have revealed a horizon which features are indicative of catastrophic changes in the sedimentation conditions due to a single impact. Our study aimed at evaluating the level of informativeness of the GPR method for detecting disturbances in the bottom sediments and new paleoseismic dislocations. The study referred to the hypothesis of the distribution of seismic foci in the Kola Peninsula in the Holocene. A ground-penetrating radar OKO-2 and an antenna unit (150 MHz) were used to survey of Lake Upoloksha in detail. The positions of the main stratigraphic horizons of the bottom sediments were clarified, and their thicknesses were measured more precisely. The GPR measurement error in comparison to the drilling data did not exceed ±0.2 m, which corresponds to the resolution of the antenna used in the survey. The GPR data confirmed the existence of seismic dislocations identified by the geological methods and discovered new zones of displacement and deformation in the organogenic and mineral bottom sediments. The survey detected vertical displacements, which amplitudes vary from 1.3 to 1.7 m, and landslides caused by seismogravitational rock collapse. Based on the GPR data, a bathymetric map was constructed. It shows the positions of the two basins of Lake Upoloksha. The survey provided the basis for a model showing the isosurface of the top of the mineragenous sequence. In the central part of the mineral-base model, there is a series of individual stepwise blocks of the sublatitudinal strike, which result from seismic movements. The GPR survey of Lake Upoloksha demonstrates that the GPR method can be successfully applied to estimate the mineral and organogenic parts of the bottom sediments, study their lithostratigraphic features, and detect changes in the structure of the bottom sediments. Based on the GPR data, it becomes possible to map even the small-scale disturbances. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource ground-penetrating radar, radar profiles, bottom sediments, seismic faults, Holocene, neotectonics, Kola Peninsula Identifier An unambiguous reference to the resource within a given context DOI: 10.5800/GT-2018-9-4-0390 Source A related resource from which the described resource is derived Geodinamika i Tektonofizika Publisher An entity responsible for making the resource available Institute of the Earth's crust, Siberian Branch of RAS Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Language A language of the resource EN, RU https://www.socictopen.socict.org/files/original/8202dbbdb163012bcab784a0659d595d.pdf f3cb24ecb5e7eb0b9ac8d40da7c11b94 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice Creator An entity primarily responsible for making the resource Lisa E Gralinski, Vineet D. Menachery, Andrew P. Morgan, Allison L. Totura, Anne Beall, Jacob Kocher, Jessica Plante, D. Corinne Harrison-Shostak, Alexandra Schäfer, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Ralph S. Baric Description An account of the resource Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from the Collaborative Cross mouse multi-parent population, we identified two lines showing highly divergent susceptibilities to SARS-CoV: the resistant CC003/Unc and the susceptible CC053/Unc. We generated 264 F2 mice between these strains, and infected them with SARS-CoV. Weight loss, pulmonary hemorrhage, and viral load were all highly correlated disease phenotypes. We identified a quantitative trait locus of major effect on chromosome 18 (27.1–58.6 Mb) which affected weight loss, viral titer and hemorrhage. Additionally, each of these three phenotypes had distinct quantitative trait loci [Chr 9 (weight loss), Chrs 7 and 12 (virus titer), and Chr 15 (hemorrhage)]. We identified Ticam2, an adaptor protein in the TLR signaling pathways, as a candidate driving differential disease at the Chr 18 locus. Ticam2−/− mice were highly susceptible to SARS-CoV infection, exhibiting increased weight loss and more pulmonary hemorrhage than control mice. These results indicate a critical role for Ticam2 in SARS-CoV disease, and highlight the importance of host genetic variation in disease responses. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource SARS-CoV, Collaborative Cross, F2, Ticam2, host susceptibility genes, Multiparent Advanced Generation Inter-Cross (MAGIC), multiparental populations, MPP Identifier An unambiguous reference to the resource within a given context DOI: 10.1534/g3.117.041434 Source A related resource from which the described resource is derived G3: Genes, Genomes, Genetics Publisher An entity responsible for making the resource available Genetics Society of America Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics Language A language of the resource EN https://www.socictopen.socict.org/files/original/448880d64a018bdd47af3d63a6820c37.pdf 576dae29b48271e3e16ae4c8c8f1acb9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mucosal Immune Response to Feline Enteric Coronavirus Infection Creator An entity primarily responsible for making the resource Morgan Pearson, Alora LaVoy, Samantha Evans, Allison Vilander, Craig Webb, Barbara Graham, Esther Musselman, Jonathan LeCureux, Sue VandeWoude, Gregg A Dean Description An account of the resource Feline infectious peritonitis is a devastating, fatal disease of domestic cats caused by a pathogenic mutant virus derived from the ubiquitous feline enteric coronavirus (FECV). Infection by FECV is generally subclinical, and little is known about the mucosal immune response that controls and eliminates the virus. We investigated the mucosal immune response against FECV in an endemically infected breeding colony over a seven-month period. Thirty-three cats were grouped according to FECV seropositivity and fecal virus shedding into na&#239;ve/immunologically quiescent, convalescent and actively infected groups. Blood, fecal samples and colon biopsies were collected to assess the mucosal and systemic immunologic and virologic profile. Results showed that cats with active FECV infections have strong systemic IgG and mucosal IgA responses that wane after virus clearance. Significant FECV-specific mucosal T cell IFN&#947; responses were not detected in any of the three groups. A shift toward an inflammatory state in the mucosa was suggested by increased IL17:FoxP3 expression. However, no histologic abnormalities were observed, and no shifts in lymphocyte subpopulation phenotype or proliferation were noted. Together, the results suggest that control of FECV is mediated by humoral mucosal and systemic responses and that perturbations in the primary reservoir organ (colon) are minimal. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource coronavirus, feline enteric coronavirus, mucosal immunity, feline infectious peritonitis Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11100906 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/c1d6585ff1b44a0930333dba3e9f6453.pdf e89455d83888e6f9e5ea9f9d00af8acc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-<i>O</i>-Amide Hesperetin Derivatives Creator An entity primarily responsible for making the resource Yilong Zhang, Yan Zheng, Wen Shi, Yahui Guo, Tao Xu, Zeng Li, Cheng Huang, Jun Li Description An account of the resource To develop new anti-inflammatory agents, a series of 7-O-amide hesperetin derivatives was designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. All compounds showed inhibitory effect on LPS-induced NO production. Among them, 7-O-(2-(Propylamino)-2-oxoethyl)hesperetin (4d) and 7-O-(2-(Cyclopentylamino)-2-oxoethyl)hesperetin (4k) with hydrophobic side chains exhibited the most potent NO inhibitory activity (IC50 = 19.32 and 16.63 &#956;M, respectively), showing stronger inhibitory effect on the production of pro- inflammatory cytokines tumor necrosis factor (TNF-&#945;), interleukin-6 (IL-6) and interleukin-1&#946; (IL-1&#946;) than indomethacin and celecoxib at 10 &#956;M. The structure-activity relationships (SARs) suggested that the 7-O-amide unit was buried in a medium-sized hydrophobic cavity of the bound receptor. Furthermore, compound 4d could also significantly suppress the expression of inducible nitric oxide synthase enzymes (iNOS) and cyclooxygenase-2 (COX-2), through the nuclear factor-kappa B (NF-&#954;B) signaling pathway. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource hesperetin derivatives, Synthesis, Inflammatory, NF-κB, structure-activity relationships Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/molecules24203663 Source A related resource from which the described resource is derived Molecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Organic chemistry Language A language of the resource EN