197 10 20655 https://www.socictopen.socict.org/files/original/20069cc2a537ea6ad22e0a2e76098f66.pdf dfc449eff280593ed23ab4d5ef121fac Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health Creator An entity primarily responsible for making the resource Alghamdi IG, Hussain II, Almalki SS, Alghamdi MS, Alghamdi MM, El-Sheemy MA Description An account of the resource Ibrahim G Alghamdi,1,2 Issam I Hussain,1 Shaia S Almalki,2 Mohamed S Alghamdi,3 Mansour M Alghamdi,4 Mohammed A El-Sheemy5 1University of Lincoln, Brayford Pool, Lincoln, UK; 2University of Al-Baha, 3General Directorate of Health Affairs, Ministry of Health, Al-Baha, Kingdom of Saudi Arabia; 4King Fahad Specialist Hospital, Dammam, Kingdom of Saudi Arabia; 5Research and Development, Lincoln Hospital, United Lincolnshire Hospitals National Health Service Trust, Lincoln, UK Purpose: This study describes the epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia. Patients and methods: Epidemiological analysis was performed on data from all MERS-CoV cases recorded by the Saudi Ministry of Health between June 6, 2013 and May 14, 2014. The frequency of cases and deaths was calculated and adjusted by month, sex, age group, and region. The average monthly temperature and humidity of infected regions throughout the year was also calculated. Results: A total of 425 cases were recorded over the study period. The highest number of cases and deaths occurred between April and May 2014. Disease occurrence among men (260 cases [62%]) was higher than in women (162 cases [38%]), and the case fatality rate was higher for men (52%) than for women (23%). In addition, those in the 45–59 years and ≥60 years age groups were most likely to be infected, and the case fatality rate for these people was higher than for other groups. The highest number of cases and deaths were reported in Riyadh (169 cases; 43 deaths), followed by Jeddah (156 cases; 36 deaths) and the Eastern Region (24 cases; 22 deaths). The highest case fatality rate was in the Eastern Region (92%), followed by Medinah (36%) and Najran (33%). MERS-CoV infection actively causes disease in environments with low relative humidity (<20%) and high temperature (15°C–35°C). Conclusion: MERS-CoV is considered an epidemic in Saudi Arabia. The frequency of cases and deaths is higher among men than women, and those above 45 years of age are most affected. Low relative humidity and high temperature can enhance the spread of this disease in the entire population. Further analytical studies are required to determine the source and mode of infection in Saudi Arabia. Keywords: Middle East respiratory syndrome, case fatality rate, descriptive epidemiology, temperature, humidity Date A point or period of time associated with an event in the lifecycle of the resource 2014 Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived International Journal of General Medicine Publisher An entity responsible for making the resource available Dove Medical Press Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/f78cad9d2b482b7d16f946c7d22a77a5.pdf 9e0630a459257394fab5309054bc2116 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource MERS Coronavirus: An Emerging Zoonotic Virus Creator An entity primarily responsible for making the resource Fang Li, Lanying Du Description An account of the resource Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that was first reported in humans in June 2012 [...] Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource n/a Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11070663 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/7898d69fb648f050a5a085c27fd736ab.pdf 7e814fb8186c13490801c031f521edd6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells Creator An entity primarily responsible for making the resource Istvan Marczell, Petra Balogh, Gabor Nyiro, Anna L. Kiss, Balázs Kovács, Gabor Bekesi, Károly Rácz, Attila Patocs Description An account of the resource Abstract Background Although membrane-associated estrogen receptors (mERs) have been known to play important role in steroid-induced signal transmission, we still know little about their function in the estrogen-induced proliferation of breast cancer cells. Methods In our current work we tried to separate membrane-initiated estrogen receptor signaling from the overall estrogenic effect in MCF-7 breast carcinoma cells. Re-analyzing expression data from multiple microarray experiments, we selected a set of key regulatory genes involved in proliferation regulation and estrogen signaling to monitor estrogen-induced transcription changes. We then compared these expression changes after 17β-estradiol and a membrane receptor selective estrogen–BSA treatment using quantitative real-time PCR. In order to follow receptor trafficking we used light and electron microscopy. Results Our quantitative real-time PCR results confirmed that the selective membrane receptor agonist, estrogen–BSA induces similarly pronounced expression changes regarding these genes as 17β-estradiol. Morphological study revealed that the membrane-bound form of classical estrogen receptor alpha is internalized after ligand binding via dynamin-dependent, caveola-mediated endocytosis. Inhibition of this internalization with dynamin inhibitor, dynasore practically abolished the regulatory effect of E2-BSA, suggesting that interaction and internalization with the scaffold protein is necessary for effective signaling. Conclusions The physiological role of plasma membrane estrogen receptor alpha is intensively studied, yet there are still several aspects of it to be resolved. The dynamin-dependent, ligand-mediated internalization of mERs seems to play an important role in estrogen signaling. Our results may serve as another example of how membrane initiated estrogen signaling and nuclear receptor initiated signaling overlap and form an intertwined system. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource MCF-7, Estrogen–BSA, Estrogen membrane receptor, MER Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s40001-018-0328-7 Source A related resource from which the described resource is derived European Journal of Medical Research Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/1d0e9e0dc359efd4828087b9174e18a1.pdf d45a35f9708d107b2fe7ec1890f0b663 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Acute phase response in bovine coronavirus positive post-weaned calves with diarrhea Creator An entity primarily responsible for making the resource Jeong-Byoung Chae, Jin-ho Park, Suk-Han Jung, Jin Hee Kang, Joon-Seok Chae, Kyoung-Seong Choi Description An account of the resource Abstract Bovine coronavirus (BCoV) is associated with severe diarrhea in calves, winter dysentery in adult cattle, and respiratory diseases in cattle of all ages. This study aimed to investigate the relationship between white blood cell counts and haptoglobin (Hp) and serum amyloid A (SAA) levels in post-weaned calves with diarrhea caused by BCoV and those that recovered from diarrhea. Blood and fecal samples were collected twice from the same animals; 17 post-weaned calves with diarrhea (first) and 15 post-weaned calves that recovered from diarrhea (second). Real-time polymerase chain reaction revealed that all 17 fecal samples from post-weaned calves with diarrhea and one out of 15 from diarrhea-recovered calves were positive for BCoV and negative for Cryptosporidium spp., Escherichia coli K99, Salmonella spp., bovine rotavirus, and bovine viral diarrhea virus. No Eimeria oocysts were detected using the flotation method. In comparison with post-weaned calves with diarrhea, in diarrhea-recovered calves, the lymphocyte count was significantly higher (P = 0.018), and the monocyte count was significantly lower (P = 0.001); however, the number of monocytes was still high. Post-weaned calves with diarrhea had a significantly higher Hp concentration (P Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Bovine coronavirus, Haptoglobin, Serum amyloid A Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13028-019-0471-3 Source A related resource from which the described resource is derived Acta Veterinaria Scandinavica Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/3a21a59583446818ae7d23de5b5590b5.pdf c567dc35c93215b99ad9750264cd4d22 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Enhancement of anti-murine colon cancer immunity by fusion of a SARS fragment to a low-immunogenic carcinoembryonic antigen Creator An entity primarily responsible for making the resource Lin Chen-Si, Kao Shih-Han, CHEN Yu-cheng, Li Chi-Han, Hsieh Yuan-Ting, Yang Shang-Chih, Wu Chang-Jer, Lee Ru-Ping, Liao Kuang-Wen Description An account of the resource Abstract Background It is widely understood that tumor cells express tumor-associated antigens (TAAs), of which many are usually in low immunogenicity; for example, carcinoembryonic antigen (CEA) is specifically expressed on human colon cancer cells and is viewed as a low-immunogenic TAA. How to activate host immunity against specific TAAs and to suppress tumor growth therefore becomes important in cancer therapy development. Results To enhance the immune efficiency of CEA in mice that received, we fused a partial CEA gene with exogenous SARS-CoV fragments. Oral vaccination of an attenuated Salmonella typhimurium strain transformed with plasmids encoding CEA-SARS-CoV fusion gene into BALB/c mice elicited significant increases in TNF-α and IL-10 in the serum. In addition, a smaller tumor volume was observed in CT26/CEA-bearing mice who received CEA-SARS-CoV gene therapy in comparison with those administered CEA alone. Conclusion The administration of fusing CEA-SARS-CoV fragments may provide a promising strategy for strengthening the anti-tumor efficacy against low-immunogenic endogenous tumor antigens. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource immunotherapy, tumor-derived peptide, tumor vaccine, Low immunogenicity Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1480-9222-14-2 Source A related resource from which the described resource is derived Biological Procedures Online Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Medicine (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/3765ca6acc0aa046142903bd9be6f556.pdf 2c0245dd8880c5919a6f805136563faf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation Creator An entity primarily responsible for making the resource Donald J. Noble, Shawn Hochman Description An account of the resource Control of respiration provides a powerful voluntary portal to entrain and modulate central autonomic networks. Slowing and deepening breathing as a relaxation technique has shown promise in a variety of cardiorespiratory and stress-related disorders, but few studies have investigated the physiological mechanisms conferring its benefits. Recent evidence suggests that breathing at a frequency near 0.1 Hz (6 breaths per minute) promotes behavioral relaxation and baroreflex resonance effects that maximize heart rate variability. Breathing around this frequency appears to elicit resonant and coherent features in neuro-mechanical interactions that optimize physiological function. Here we explore the neurophysiology of slow, deep breathing and propose that coincident features of respiratory and baroreceptor afferent activity cycling at 0.1 Hz entrain central autonomic networks. An important role is assigned to the preferential recruitment of slowly-adapting pulmonary afferents (SARs) during prolonged inhalations. These afferents project to discrete areas in the brainstem within the nucleus of the solitary tract (NTS) and initiate inhibitory actions on downstream targets. Conversely, deep exhalations terminate SAR activity and activate arterial baroreceptors via increases in blood pressure to stimulate, through NTS projections, parasympathetic outflow to the heart. Reciprocal SAR and baroreceptor afferent-evoked actions combine to enhance sympathetic activity during inhalation and parasympathetic activity during exhalation, respectively. This leads to pronounced heart rate variability in phase with the respiratory cycle (respiratory sinus arrhythmia) and improved ventilation-perfusion matching. NTS relay neurons project extensively to areas of the central autonomic network to encode important features of the breathing pattern that may modulate anxiety, arousal, and attention. In our model, pronounced respiratory rhythms during slow, deep breathing also support expression of slow cortical rhythms to induce a functional state of alert relaxation, and, via nasal respiration-based actions on olfactory signaling, recruit hippocampal pathways to boost memory consolidation. Collectively, we assert that the neurophysiological processes recruited during slow, deep breathing enhance the cognitive and behavioral therapeutic outcomes obtained through various mind-body practices. Future studies are required to better understand the physio-behavioral processes involved, including in animal models that control for confounding factors such as expectancy biases. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource slow, Deep breathing, relaxation, Neurophysiological mechanisms, slowly-adapting pulmonary afferents, slow brain rhythms Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fphys.2019.01176 Source A related resource from which the described resource is derived Frontiers in Physiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Physiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/8ada9ada705720972fed1da9a1885111.pdf 4a21a252ed9cfd2bfd011a1dd20e6f9e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evolutionary Implications of the microRNA- and piRNA Complement of Lepidodermella squamata (Gastrotricha) Creator An entity primarily responsible for making the resource Bastian Fromm, Juan Pablo Tosar, Felipe Aguilera, Marc R. Friedländer, Lutz Bachmann, Andreas Hejnol Description An account of the resource Gastrotrichs—’hairy bellies’—are microscopic free-living animals inhabiting marine and freshwater habitats. Based on morphological and early molecular analyses, gastrotrichs were placed close to nematodes, but recent phylogenomic analyses have suggested their close relationship to flatworms (Platyhelminthes) within Spiralia. Small non-coding RNA data on e.g., microRNAs (miRNAs) and PIWI-interacting RNAs (piRNA) may help to resolve this long-standing question. MiRNAs are short post-transcriptional gene regulators that together with piRNAs play key roles in development. In a ‘multi-omics’ approach we here used small-RNA sequencing, available transcriptome and genomic data to unravel the miRNA- and piRNA complements along with the RNAi (RNA interference) protein machinery of Lepidodermella squamata (Gastrotricha, Chaetonotida). We identified 52 miRNA genes representing 35 highly conserved miRNA families specific to Eumetazoa, Bilateria, Protostomia, and Spiralia, respectively, with overall high similarities to platyhelminth miRNA complements. In addition, we found four large piRNA clusters that also resemble flatworm piRNAs but not those earlier described for nematodes. Congruently, transcriptomic annotation revealed that the Lepidodermella protein machinery is highly similar to flatworms, too. Taken together, miRNA, piRNA, and protein data support a close relationship of gastrotrichs and flatworms. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MicroRNAs, piRNAs, RNAi protein machinery, Gastrotricha, Lepidodermella squamata, Platyhelminthes Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ncrna5010019 Source A related resource from which the described resource is derived Non-Coding RNA Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics Language A language of the resource EN https://www.socictopen.socict.org/files/original/f56b5702294d95353c59d23a5bf8b4bf.pdf 28f308da4bcad4e44b6a0229f44f5f42 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Les territoires de la Gestion intégrée des zones côtières et marines Creator An entity primarily responsible for making the resource Mahfoud Ghézali Description An account of the resource Cet article consacré aux fonctions de la Gestion intégrée des zones côtières (GIZC), considérées comme une des composantes essentielles de la GIZC, en tant qu’espace à géométrie variable, développe deux idées primordiales : la lente conversion du littoral aux principes stratégiques de la GIZC et la difficile articulation de la GIZC avec les politiques publiques locales et la gestion des mers et des océans par la politique maritime intégrée de l’Union Européenne (PMIE). Le choix raisonné de la pluralité d’échelles stratégiques, conception-évaluation et gestion de proximité et la nouvelle stratégie de la mise en œuvre de la GIZC par les Comités interministériels d’aménagement et de développement des territoires (CIADT) et CIM ont contribué à approfondir la substance de la GIZC, à travers notamment la culture et la rencontre du projet de gestion et du territoire. L’articulation de la GIZC avec les politiques publiques notamment locales et la macro-gestion des mers et océans, rendent compte des obstacles dressés par les politiques publiques sur le chemin de l’intégration et de la rationalité et des efforts développés par la GIZC, en tant qu’entreprise de séduction pour réduire ou éliminer ces obstacles, en renouvelant notamment son appareil instrumental et conceptuel. This paper focus on the majors functions of Integrated Coastal Zone Management (ICZM), as a concept that deals with varying scale territories for management or governance. We develop here two mains ideas. First of all, we present the slow transformation of coastal zone governance to the ICZM, and secondly the difficult junction between local public policies and sea/ ocean management in the Integrated Maritime Policy of the European Union. The choice of multi-scale strategies, management approach, conception and evaluation of the proximity in this concept, and the new strategy developed to realize the ICZM by different national comities in France, contribute to exploring more deeply the concept of ICZM, especially through culture aspects and junction of management issues in projects at local and territory scale. The linkage of ICZM with public policies at local level and sea/ocean macro-management, reveal the politic barriers in place on the road of integration, rationality and efforts of the actors of ICZM to reduce or eliminate those barriers, particularly by renew conceptual and instrumental tools for coastal governance. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource Europe, marine, Politics, coastal zones, France, territory Identifier An unambiguous reference to the resource within a given context DOI: 10.4000/vertigo.14305 Source A related resource from which the described resource is derived VertigO Publisher An entity responsible for making the resource available Éditions en environnement VertigO Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences Language A language of the resource FR https://www.socictopen.socict.org/files/original/3e669063dd9e734a777e47cab6f712ee.pdf c8449f67579cd4b09686f7928f70fbc0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV Creator An entity primarily responsible for making the resource Li-li WANG, Jiyan Xu, Yu Kong, Ruiying Liang, Wei Li, Jinyao Li, Jun Lu, Dimiter S. Dimitrov, Fei Yu, Yan-Ling Wu, Tianlei Ying Description An account of the resource In recent years, tremendous efforts have been made in the engineering of bispecific or multi-specific antibody-based therapeutics by combining two or more functional antigen-recognizing elements into a single construct. However, to the best of our knowledge there has been no reported cases of effective antiviral antibody-peptide bispecific fusion proteins. We previously developed potent fully human monoclonal antibodies and inhibitory peptides against Middle East Respiratory Syndrome Coronavirus (MERS-CoV), a novel coronavirus that causes severe acute respiratory illness with high mortality. Here, we describe the generation of antibody-peptide bispecific fusion proteins, each of which contains an anti-MERS-CoV single-chain antibody m336 (or normal human IgG1 CH3 domain as a control) linked with, or without, a MERS-CoV fusion inhibitory peptide HR2P. We found that one of these fusion proteins, designated as m336 diabody-pep, exhibited more potent inhibitory activity than the antibody or the peptide alone against pseudotyped MERS-CoV infection and MERS-CoV S protein-mediated cell-cell fusion, suggesting its potential to be developed as an effective bispecific immunotherapeutic for clinical use. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS-CoV, MAbs, polypeptides, bispecific, Immunotherapeutics Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/antib8040053 Source A related resource from which the described resource is derived Antibodies Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/7100abfe89883c7ced9d4e8943727d2e.pdf 661f5fd603b1d6e078f6f95d2314a0f4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Red Fox Y-Chromosome in Comparative Context Creator An entity primarily responsible for making the resource Halie M. Rando, William H. Wadlington, Jennifer L. Johnson, Jeremy T. Stutchman, Lyudmila N. Trut, Marta Farré, Anna V. Kukekova Description An account of the resource While the number of mammalian genome assemblies has proliferated, Y-chromosome assemblies have lagged behind. This discrepancy is caused by biological features of the Y-chromosome, such as its high repeat content, that present challenges to assembly with short-read, next-generation sequencing technologies. Partial Y-chromosome assemblies have been developed for the cat (Felis catus), dog (Canis lupus familiaris), and grey wolf (Canis lupus lupus), providing the opportunity to examine the red fox (Vulpes vulpes) Y-chromosome in the context of closely related species. Here we present a data-driven approach to identifying Y-chromosome sequence among the scaffolds that comprise the short-read assembled red fox genome. First, scaffolds containing genes found on the Y-chromosomes of cats, dogs, and wolves were identified. Next, analysis of the resequenced genomes of 15 male and 15 female foxes revealed scaffolds containing male-specific k-mers and patterns of inter-sex copy number variation consistent with the heterogametic chromosome. Analyzing variation across these two metrics revealed 171 scaffolds containing 3.37 Mbp of putative Y-chromosome sequence. The gene content of these scaffolds is consistent overall with that of the Y-chromosome in other carnivore species, though the red fox Y-chromosome carries more copies of BCORY2 and UBE1Y than has been reported in related species and fewer copies of SRY than in other canids. The assignment of these scaffolds to the Y-chromosome serves to further characterize the content of the red fox draft genome while providing resources for future analyses of canid Y-chromosome evolution. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Y chromosome, Carnivore, Vulpes vulpes, sex chromosomes, MSY, Y-chromosome genes, copy number variation, BCORY2, UBE1Y, Next-generation sequencing Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/genes10060409 Source A related resource from which the described resource is derived Genes Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics Language A language of the resource EN