293 10 20655 https://www.socictopen.socict.org/files/original/33712bddcb3382d52eab8982c056d93c.pdf 412a8e6455c3c1d0da35a411125deb05 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach Creator An entity primarily responsible for making the resource Hanan Balkhy, Sabeena Mustafa, Musa Gabere Description An account of the resource There is no effective therapeutic or vaccine for Middle East Respiratory Syndrome and this study attempts to find therapy using peptide by establishing a basis for the peptide-protein interactions through in silico docking studies for the spike protein of MERS-CoV. The antimicrobial peptides (AMPs) were retrieved from the antimicrobial peptide database (APD3) and shortlisted based on certain important physicochemical properties. The binding mode of the shortlisted peptides was measured based on the number of clusters which forms in a protein-peptide docking using Piper. As a result, we identified a list of putative AMPs which binds to the spike protein of MERS-CoV, which may be crucial in providing the inhibitory action. It is observed that seven putative peptides have good binding score based on cluster size cutoff of 208. We conclude that seven peptides, namely, AP00225, AP00180, AP00549, AP00744, AP00729, AP00764, and AP00223, could possibly have binding with the active site of the MERS-CoV spike protein. These seven AMPs could serve as a therapeutic option for MERS and enhance its treatment outcome. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2019/6815105 Source A related resource from which the described resource is derived Advances in Bioinformatics Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Statistics https://www.socictopen.socict.org/files/original/debde9d9fb4a5262a7e6627edabb30e8.pdf cbdaf7ed9745f3c0216ed715d832cd66 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development Creator An entity primarily responsible for making the resource Maged Gomaa Hemida, Ayman Mubarak, Wael Alturaiki Description An account of the resource Middle East respiratory syndrome coronavirus (MERS-CoV) first emerged in late 2012. Since its emergence, a total of 2279 patients from 27 countries have been infected across the globe according to a World Health Organization (WHO) report (Feb. 12th, 2019). Approximately 806 patients have died. The virus uses its spike proteins as adhesive factors that are proinflammatory for host entry through a specific receptor called dipeptidyl peptidase-4 (DPP4). This receptor is considered a key factor in the signaling and activation of the acquired and innate immune responses in infected patients. Using potent antigens in combination with strong adjuvants may effectively trigger the activation of specific MERS-CoV cellular responses as well as the production of neutralizing antibodies. Unfortunately, to date, there is no effective approved treatment or vaccine for MERS-CoV. Thus, there are urgent needs for the development of novel MERS-CoV therapies as well as vaccines to help minimize the spread of the virus from infected patients, thereby mitigating the risk of any potential pandemics. Our main goals are to highlight and describe the current knowledge of both the innate and adaptive immune responses to MERS-CoV and the current state of MERS-CoV vaccine development. We believe this study will increase our understanding of the mechanisms that enhance the MERS-CoV immune response and subsequently contribute to the control of MERS-CoV infections. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2019/6491738 Source A related resource from which the described resource is derived Journal of Immunology Research Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/b65b429aebf98429ff4e2d10236e8332.pdf f780eb17f7baa8479d61b66995cd5c97 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Effects of Coronavirus Infections in Children Creator An entity primarily responsible for making the resource Nicola Principi, Susanna Esposito, Samantha Bosis Description An account of the resource The isolation of the coronavirus (CoV) identified as the cause of severe acute respiratory syndrome and the detection of 2 new human CoVs (HCoV-NL63 and HCoV-HKU1) have led to studies of the epidemiology and clinical and socioeconomic effects of infections caused by all HCoVs, including those known since the late 1960s (HCoV-229E and HCoV-OC43). HCoV infections can be associated with respiratory and extrarespiratory manifestations, including central nervous system involvement. Furthermore, unlike other RNA viruses, HCoVs can easily mutate and recombine when different strains infect the same cells and give rise to a novel virus with unpredictable host ranges and pathogenicity. Thus, circulating HCoVs should be closely monitored to detect the spread of particularly virulent strains in the community at an early stage and to facilitate the development of adequate preventive and therapeutic measures. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Respiratory viruses, childhood, Viruses, Emerging viruses, SARS, human coronaviruses Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1602.090469 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine https://www.socictopen.socict.org/files/original/fb352bd8b1d15995a6eb771104e8fada.pdf 5001cbf305e661491cb02772e0448474 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correction: Functional and Genetic Analysis of Coronavirus Replicase-Transcriptase Proteins. Creator An entity primarily responsible for making the resource Volker Thiel, Stuart G Siddell, Stanley G Sawicki, Dorothea L Sawicki, Diane Younker, Yvonne Meyer, Helen Stokes Date A point or period of time associated with an event in the lifecycle of the resource 2006 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.0020017 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/7b72ee538d1e55c1abb1377872b27926.pdf 9bf8b5e9d77df99a21d089477a983e90 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comparative Serological Study for the Prevalence of Anti-MERS Coronavirus Antibodies in High- and Low-Risk Groups in Qatar Creator An entity primarily responsible for making the resource Hamad E. Al-Romaihi, Lingshu Wang, Mohamed E. El Zowalaty, Gheyath K. Nasrallah, Hadi M. Yassine, Barney S. Graham, Marcel A. Müller, Erik Lattwein, Asmaa A Althani, Elmoubasher A. Farag, Reham A. Al Kahlout Description An account of the resource Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) could be asymptomatic or cause mild influenza-like illness. Therefore, the prevalence of MERS-CoV infections in the general population could be underestimated, which necessitates active surveillance to determine the epidemiological importance of asymptomatic cases. The aim of this study is to evaluate the performance of various serological assays and to estimate the seroprevalence of anti-MERS-CoV antibodies in high- and low-risk groups in Qatar. A total of 4858 samples were screened, including 4719 samples collected from healthy blood donors (BD) over a period of five years (2012-2016), 135 samples from baseline case contacts (CC) collected from individuals in close contact with three positive PCR-confirmed patients (CP), and four samples from MERS-CoV CP. Initial screening using anti-MERS-CoV IgG (IgG rS1-ELISA kit) revealed ten reactive samples from BD (10/4719, 0.21%), one from CC (1/135, 0.74%), and three from CP (3/4, 75%). Samples from CP but not from BD were also reactive by whole-virus anti-MERS-CoV IgG (n=3/4) and IgM (n=1/4) indirect immunefluorescent tests (IIFT) and pseudoparticle neutralization test (ppNT). The reactive sample from CC was also confirmed by ppNT. Surprisingly, one out of thirteen (7.7%) randomly selected IgG rS1-ELISA-negative BD samples from the initial screening was reactive by the IgM-IIFT (but not by the IgG-IIFT) and was subsequently confirmed by ppNT. All IgG rS1-ELISA-reactive samples from BD exhibited considerable reactivity to the four circulating human coronaviruses (HKU1, OC43, 229E, and NL63). Cross-reactivity with SARS was only reported for samples from CP using IgG and IgM-IIFT. In conclusion, we report a low prevalence of anti-MERS antibodies in the general population, which coincides with the low number of all reported cases by the time of our study (2017) in Qatar (n=21). The false-positive results and the observed cross-reactivity between MERS-CoV and other circulating human coronavirus necessitate more detailed evaluation of available serological assays. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2019/1386740 Source A related resource from which the described resource is derived Journal of Immunology Research Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/8ea6360cf098ae15cafe742f210dce36.pdf ec7c0bde920decd33b73b17ee786219c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Viral and bacterial infection among hospitalized-suspected influenza A/H5N1 patients in Indonesia, 2008-2009 Creator An entity primarily responsible for making the resource Reni Herman, Agustiningsih Agustiningsih, Vivi Setiawaty, Eka Pratiwi, Ririn Ramadhany, Kartika D. Puspa Description An account of the resource Background: Since a lot of suspected H5N1 cases with severe ARI manifestation were hospitalized and negative for H5N1, it raised a concern to investigate the other etiologies among hospitalized-suspected H5N1 cases. The aim of present study is to investigate the other respiratory pathogens of hospitalized-suspected H5N1 cases in which will provide valuable insight in the etiologies and epidemiology data of ARI.Methods: We tested the archived respiratory clinical specimens (nasal or throat swab, tracheal aspirate and bronchoalveolar lavage) that were already confirmed as negative H5N1 for 16 viruses and 8 bacteria existence by Multiplex PCR and Real-Time PCR from 230 hospitalized-suspected H5N1 cases received in July 2008 to June 2009.Results: Of the 230 hospitalized-suspected H5N1 cases, Klebsiella pneumoniae was the most dominant bacterial pathogen in children and adult. Moreover, the common viral pathogens in children was influenza A (non H5), while it was varied in adults as influenza A (non H5), Enterovirus, HRV A/B, Coronavirus 229E/NL63 were found very low. Bacterial mix infection of Klebsiella pneumoniae, Streptococcus pneumoniae and Haemophillus influenzae mainly occurred in children while co-infections of Klebsiella pneumoniae and Streptococcus pneumoniae were frequently found in adults. In addition, the major bacterial-viral mix infection found among children was influenza A and Klebsiella pneumoniae.Conclusion: From all of the samples tested, bacterial infections remain the most common etiologies of ARI in adults and children although there were infections caused by viruses. Mix infection of bacterial and viral also found among adults and children. (Med J Indones. 2012;21:77-82)Keywords: Acute respiratory infection, H5N1, PCR Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.13181/mji.v21i2.485 Source A related resource from which the described resource is derived Medical Journal of Indonesia Publisher An entity responsible for making the resource available Faculty of Medicine Universitas Indonesia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/e8372f1be473a2b8b4cbf70b485212d3.pdf cdbdc1cf014a4549a9e5ffac6f31d512 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource On a knife’s edge of a COVID-19 pandemic: is containment still possible? Creator An entity primarily responsible for making the resource C. Raina MacIntyre Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource infectious diseases, Pandemic, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.17061/phrp3012000 Source A related resource from which the described resource is derived Public Health Research & Practice Publisher An entity responsible for making the resource available Sax Institute Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/f674781a54369d34dbc4d10187b6e791.pdf 536c32a557bccf99c86d3a7d12567b5c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular Diagnosis of Pneumonia Using Multiplex Real-Time PCR Assay RespiFinder® SMART 22 FAST in a Group of Moroccan Infants Creator An entity primarily responsible for making the resource Amina Barkat, Houssain Tligui, Majdouline Obtel, Kenza Hattoufi, Sobha El Ftouh, Aicha Kharbach Description An account of the resource Background. In Morocco, pediatric pneumonia remains a serious public health problem, as it constitutes the first cause of mortality due to infectious diseases. The etiological diagnosis of acute respiratory tract infections is difficult. Therefore, it is necessary to use Multiplex real-time polymerase chain reaction assay tests in a routine setting for exact and fast identification. Objectives. In this paper, we present the clinical results of pediatric pneumonia and describe their etiology by using molecular diagnosis. Study design: Tracheal secretion was collected from infants presenting respiratory distress isolated or associated with systemic signs, attending the unit of Neonatology between December 1, 2016, and Mai 31, 2018. Samples were tested with the multiplex RespiFinder® SMART 22 FAST which potentially detects 18 viruses and 4 bacteria. Results. Of the 86 infants considered in this study (mean age 31 ± 19 days) suspected of acute respiratory tract infections, 71 (83%) were positive for one or multiple viruses or/and bacteria. The majority of acute respiratory tract infections had a viral origin (95%): respiratory syncytial viruses (A and B) (49%), rhinovirus (21%), coronaviruses 229E (11%), humain metapneumovirus (5%), influenza A (3%), influenza H1N1 (1%), adenovirus (2%), and parainfluenza virus type 4 (2%). Among our patients, 6% had Mycoplasma pneumoniae. Coinfections were not associated with severe respiratory symptoms. Conclusion. The clinical spectrum of respiratory infections is complex and often nonspecific. Thus, the early and fast detection of related causative agents is crucial. The use of multiplex real time polymerase chain reaction may help choose an accurate treatment, reduce the overall use of unnecessary antibiotics, preserve intestinal flora, and decrease nosocomial infection by reducing the length of hospitalization. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2020/6212643 Source A related resource from which the described resource is derived Advances in Virology Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/9309c0bdec6e002f0fb34ae8a3e19d6c.pdf 3b7543057f91fba45cbfae0fc791476e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Brief review of coronavirus for healthcare professionals February 10, 2020 Creator An entity primarily responsible for making the resource Robbins RA, Klotz SA Description An account of the resource No abstract available. Article truncated after 150 words. The epidemic of coronavirus (2019-nCoV) near Wuhan City and the surrounding Hubei Province in China has received extensive news coverage. Some have predicted the virus will cause a worldwide pandemic (1). The CDC has an extensive website discussing over numerous pages whom to suspect, how to diagnose and how to treat 2019-nCoV. 2019-nCoV represents the most recent of the severe coronaviral infections. Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) are also caused by coronaviruses that have jumped from animals to humans like 2019-nCoV. It should be remembered that there are only 12 confirmed cases of 2019-nCoV in the US and the mortality rate appears to be only about 3% which is lower than SARS or MERS (2,3). This could be offset by a greater infectiousness of 2019-nCoV resulting in more aggregate infectious, and hence, deaths. Anyone with a fever who has recently visited the epidemic area … Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource diagnosis, treatment, China, Mortality, symptoms, coronavirus, Wuhan, Hubei, 2019ncov Identifier An unambiguous reference to the resource within a given context DOI: 10.13175/swjpcc011-20 Source A related resource from which the described resource is derived Southwest Journal of Pulmonary and Critical Care Publisher An entity responsible for making the resource available Arizona Thoracic Society Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical emergencies. Critical care. Intensive care. First aid, General works https://www.socictopen.socict.org/files/original/04da2a6d5eaf0c2a897baa953c930649.pdf e35cab9f71517f9f331135cb150c013c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Peptide Mimicrying Between SARS Coronavirus Spike Protein and Human Proteins Reacts with SARS Patient Serum Creator An entity primarily responsible for making the resource Yi Hou, W. M. Lin, K.-Y. Hwa, T.-M. Yeh Description An account of the resource Molecular mimicry, defined as similar structures shared by molecules from dissimilar genes or proteins, is a general strategy used by pathogens to infect host cells. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The spike (S) protein of SARS-CoV plays an important role in the virus entry into a cell. In this study, eleven synthetic peptides from the S protein were selected based on its sequence homology with human proteins. Two of the peptides D07 (residues 927–937) and D08 (residues 942–951) were recognized by the sera of SARS patients. Murine hyperimmune sera against these peptides bound to proteins of human lung epithelial cells A549. Another peptide D10 (residues 490–502) stimulated A549 to proliferate and secrete IL-8. The present results suggest that the selected S protein regions, which share sequence homology with human proteins, may play important roles in SARS-CoV infection. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2008/326464 Source A related resource from which the described resource is derived Journal of Biomedicine and Biotechnology Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Biotechnology