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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Coronavirus infections in hospitalized pediatric patients with acute respiratory tract disease</text>
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                <text>Lusa Lara, Petrovec Miroslav, Krivec Uros, Jevšnik Monika, Uršič Tina, Žigon Nina</text>
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                <text>Abstract Background Acute viral respiratory infections are an important cause of morbidity and mortality in humans worldwide. The etiological backgrounds of these infections remain unconfirmed in most clinical cases. The aim of this study was to estimate the prevalence of human coronavirus infections in a series of children hospitalized with symptoms of acute respiratory tract disease in a one-year period in Slovenia. Methods The 664 specimens from 592 children under six years of age hospitalized at the University Children’s Hospital in Ljubljana were sent for the routine laboratory detection of respiratory viruses. Respiratory viruses were detected with a direct immunofluorescence assay and human coronaviruses were detected with a modified real-time RT–PCR. Results HCoV RNA was detected in 40 (6%, 95% CI: 4.3%–8.1%) of 664 samples. Of these specimens, 21/40 (52.5%) were identified as species HKU1, 7/40 (17.5%) as OC43, 6/40 (15%) as 229E, and 6/40 (15%) as NL63. Infection with HCoV occurred as a coinfection with one or more other viruses in most samples (70%). Of the HCoV-positive children, 70.3% had lower respiratory tract infections. Conclusion The results of our study show that HCoV are frequently detected human pathogens, often associated with other respiratory viruses and acute respiratory tract infections in hospitalized children. An association between age and the viral load was found. The highest viral load was detected in children approximately 10 months of age.</text>
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                <text>2012</text>
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            <name>Subject</name>
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                <text>human coronavirus, Hospitalized children, respiratory viral infection</text>
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                <text>DOI: 10.1186/1471-2334-12-365</text>
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                <text>BMC Infectious Diseases</text>
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                <text>BMC</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Porcine Coronavirus HKU15 Detected in 9 US States, 2014</text>
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                <text>Yan Zhang, Leyi Wang, Beverly Byrum</text>
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                <text>2014</text>
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            <name>Subject</name>
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                <text>United States, Coronaviridae, deltacoronavirus, porcine coronavirus, Deltacoronavirus genus, HKU15</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="27738">
                <text>DOI: 10.3201/eid2009.140756</text>
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            <name>Source</name>
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                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
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                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases, Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="27742">
                <text>Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27743">
                <text>Musa A. Garbati, Leila Skakni, Daniel K.W. Chu, Ahmed M. Hakawi, Shamsudeen F. Fagbo, Mercy Joseph</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>We investigated an outbreak of Middle East respiratory syndrome (MERS) at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, during March 29–May 21, 2014. This outbreak involved 45 patients: 8 infected outside KFMC, 13 long-term patients at KFMC, 23 health care workers, and 1 who had an indeterminate source of infection. Sequences of full-length MERS coronavirus (MERS-CoV) from 10 patients and a partial sequence of MERS-CoV from another patient, when compared with other MERS-CoV sequences, demonstrated that this outbreak was part of a larger outbreak that affected multiple health care facilities in Riyadh and possibly arose from a single zoonotic transmission event that occurred in December 2013 (95% highest posterior density interval November 8, 2013–February 10, 2014). This finding suggested continued health care–associated transmission for 5 months. Molecular epidemiology documented multiple external introductions in a seemingly contiguous outbreak and helped support or refute transmission pathways suspected through epidemiologic investigation.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2015</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Viruses, coronavirus, MERS-CoV, Middle East respiratory syndrome, MERS, Middle East respiratory syndrome coronavirus</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="27747">
                <text>DOI: 10.3201/eid2111.150944</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="27748">
                <text>Emerging Infectious Diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Centers for Disease Control and Prevention</text>
              </elementText>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="27750">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Detection and Phylogenetic Analysis of Group 1 Coronaviruses in South American Bats</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Christine VF Carrington, Abiodun A Adesiyun, Jinxia Zhang, Gavin JD Smith, Yi Guan, Albert J Auguste, Jerome E Foster, Huachen Zhu, Nadin Thompson, Vernie Ramkissoon</text>
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                <text>Bat coronaviruses (Bt-CoVs) are thought to be the precursors of severe acute respiratory syndrome coronavirus. We detected Bt-CoVs in 2 bat species from Trinidad. Phylogenetic analysis of the RNA-dependent RNA polymerase gene and helicase confirmed them as group 1 coronaviruses.</text>
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                <text>2008</text>
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            <name>Subject</name>
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                <text>South America, coronavirus, dispatch, bat, Trinidad, Bt-CoV</text>
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            <name>Identifier</name>
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                <text>DOI: 10.3201/eid1412.080642</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Viral RNA in Blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection</text>
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                <text>Seung-Jun Lee, Moon-Woo Seong, Sung Sup Park, Jeong-Sun Yang, So-Yeon Kim, Sung Soon Kim, Ga-Yeon Kim, Hyeon-Gun Jee, Sun-Jae Park, Jeesoo Lee, Ran-hui Cha, Yu Mi Jung, Sung Im Cho, Man Jin Kim, Soo Hyun Seo, Yeonjae Kim, Hyoung-Shik Shin, Sook Young Cho</text>
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                <text>We evaluated the diagnostic and clinical usefulness of blood specimens to detect Middle East respiratory syndrome coronavirus infection in 21 patients from the 2015 outbreak in South Korea. Viral RNA was detected in blood from 33% of patients at initial diagnosis, and the detection preceded a worse clinical course.</text>
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                <text>2016</text>
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                <text>Bart L. Haagmans, Marta Muñoz, Judith M.A. van den Brand, Júlia Vergara-Alert, Albert Bensaid, Joaquim Segalés, W. Widagdo, Debby Schipper, David Solanes, Stalin Raj, Ivan Cordón</text>
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                <text>Middle East respiratory syndrome (MERS) cases continue to be reported, predominantly in Saudi Arabia and occasionally other countries. Although dromedaries are the main reservoir, other animal species might be susceptible to MERS coronavirus (MERS-CoV) infection and potentially serve as reservoirs. To determine whether other animals are potential reservoirs, we inoculated MERS-CoV into llamas, pigs, sheep, and horses and collected nasal and rectal swab samples at various times. The presence of MERS-CoV in the nose of pigs and llamas was confirmed by PCR, titration of infectious virus, immunohistochemistry, and in situ hybridization; seroconversion was detected in animals of both species. Conversely, in sheep and horses, virus-specific antibodies did not develop and no evidence of viral replication in the upper respiratory tract was found. These results prove the susceptibility of llamas and pigs to MERS-CoV infection. Thus, the possibility of MERS-CoV circulation in animals other than dromedaries, such as llamas and pigs, is not negligible.</text>
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                <text>DOI: 10.3201/eid2302.161239</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus</text>
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                <text>Paul Kellam, Matthew Cotten, Andrew Rambaut, Oliver G. Pybus, Yi Guan, Eleni Nastouli, Tommy T. Lam, Deenan Pillay, Velislava Petrova, Simon J. Watson, Anne L. Palser, Paul Grant</text>
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                <text>A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from several countries in the Middle East. We report the deep genome sequencing of the virus directly from a patient’s sputum sample. Our high-throughput sequencing yielded a substantial depth of genome sequence assembly and showed the minority viral variants in the specimen. Detailed phylogenetic analysis of the virus genome (England/Qatar/2012) revealed its close relationship to European bat coronaviruses circulating among the bat species of the Vespertilionidae family. Molecular clock analysis showed that the 2 human infections of this betacoronavirus in June 2012 (EMC/2012) and September 2012 (England/Qatar/2012) share a common virus ancestor most likely considerably before early 2012, suggesting the human diversity is the result of multiple zoonotic events.</text>
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                <text>2013</text>
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                <text>evolution, Respiratory tract infections, disease transmission, Molecular, Infectious, coronavirus infections</text>
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            <name>Identifier</name>
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                <text>DOI: 10.3201/eid1905.130057</text>
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                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27785">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases, Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Public Health Lessons from Severe Acute Respiratory Syndrome a Decade Later</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="27788">
                <text>WANG Yu, Jeffrey P. Koplan, Thomas Tsang, David Butler-Jones</text>
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            <description>An account of the resource</description>
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                <text>The outbreak of severe acute respiratory syndrome in 2002–2003 exacted considerable human and economic costs from countries involved. It also exposed major weaknesses in several of these countries in coping with an outbreak of a newly emerged infectious disease. In the 10 years since the outbreak, in addition to the increase in knowledge of the biology and epidemiology of this disease, a major lesson learned is the value of having a national public health institute that is prepared to control disease outbreaks and designed to coordinate a national response and assist localities in their responses.</text>
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                <text>2013</text>
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            <name>Subject</name>
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                <text>Public Health, Viruses, coronavirus, severe acute respiratory syndrome, SARS, disease threats</text>
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            <name>Identifier</name>
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                <text>DOI: 10.3201/eid1906.121426</text>
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              <elementText elementTextId="27793">
                <text>Emerging Infectious Diseases</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="27794">
                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>World Health Organization Global Conference on Severe Acute Respiratory Syndrome</text>
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                <text>Malaysia</text>
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                <text>DOI: 10.3201/eid0909.030559</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Long-term Psychological and Occupational Effects of Providing Hospital Healthcare during SARS Outbreak</text>
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                <text>Thomas E Stewart, Sean B Rourke, Bjug Borgundvaag, Robert G. Maunder, Susan Evans, William J Lancee, Clare Pain, Jocelyn P. Bennett, Linda McGillis Hall, Kenneth E. Balderson, Christopher M.B. Fernandes, David S. Goldbloom, Mona Gupta, Jonathan J. Hunter, Lynn M. Nagle, Sonia S. Peczeniuk, Glenna Raymond, Nancy Read, Rosalie J. Steinberg, Susan VanDeVelde Coke, Georgina G. Veldhorst, Donald A. Wasylenki</text>
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            <description>An account of the resource</description>
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                <text>Healthcare workers (HCWs) found the 2003 outbreak of severe acute respiratory syndrome (SARS) to be stressful, but the long-term impact is not known. From 13 to 26 months after the SARS outbreak, 769 HCWs at 9 Toronto hospitals that treated SARS patients and 4 Hamilton hospitals that did not treat SARS patients completed a survey of several adverse outcomes. Toronto HCWs reported significantly higher levels of burnout (p = 0.019), psychological distress (p</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27807">
                <text>2006</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="27808">
                <text>stress, research, Burnout, Health personnel, professional, severe acute respiratory syndrome</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="27809">
                <text>DOI: 10.3201/eid1212.060584</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="27810">
                <text>Emerging Infectious Diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="27811">
                <text>Centers for Disease Control and Prevention</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="27812">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
