303 10 20655 https://www.socictopen.socict.org/files/original/a197c5421c9bf48158219c174854f5d9.pdf e17f9693a1157b5ca5046c9adc2ac5e6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Real-Time PCR Assay for Bat SARS-Like Coronavirus Detection and Its Application to Italian Greater Horseshoe Bat Faecal Sample Surveys Creator An entity primarily responsible for making the resource Laura Gallina, Santino Prosperi, Andrea Balboni, Mara Battilani, Alessandra Palladini Description An account of the resource Bats are source of coronaviruses closely related to the severe acute respiratory syndrome (SARS) virus. Numerous studies have been carried out to identify new bat viruses related to SARS-coronavirus (bat-SARS-like CoVs) using a reverse-transcribed-polymerase chain reaction assay. However, a qualitative PCR could underestimate the prevalence of infection, affecting the epidemiological evaluation of bats in viral ecology. In this work an SYBR Green-real time PCR assay was developed for diagnosing infection with SARS-related coronaviruses from bat guano and was applied as screening tool in a survey carried out on 45 greater horseshoe bats (Rhinolophus ferrumequinum) sampled in Italy in 2009. The assay showed high sensitivity and reproducibility. Its application on bats screening resulted in a prevalence of 42%. This method could be suitable as screening tool in epidemiological surveys about the presence of bat-SARS-like CoVs, consequently to obtain a more realistic scenario of the viral prevalence in the population. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.1100/2012/989514 Source A related resource from which the described resource is derived The Scientific World Journal Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology, Science, Medicine https://www.socictopen.socict.org/files/original/71d5bc2e6dec6c0bcf1d266ab3a74c56.pdf 36d6f5a3e5e8bb566ac79800eb87289e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India Creator An entity primarily responsible for making the resource Rakesh Lodha, Sushil Kumar Kabra, Immaculata Xess, Arti Kapil, Urvashi Singh, Guruprasad R Medigeshi, Balaji Arvind Description An account of the resource Background & objectives: Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF). The infection occurs with a unique spectrum of bacterial pathogens that are usually acquired in an age-dependent fashion. The objective of this study was to find out the aetiological agents in respiratory specimens from children with CF during pulmonary exacerbation and relate with demographic variables. Methods: In this observational study, airway secretions from children (n=104) with CF presenting with pulmonary exacerbations were collected and tested for bacteria, fungi, mycobacteria and viral pathogens using appropriate laboratory techniques. The frequencies of isolation of various organisms were calculated and associated with various demographic profiles. Results: Bacteria were isolated in 37 (35.5%) and viral RNA in 27 (29.3%) children. Pseudomonas was the most common bacteria grown in 31 (29.8%) followed by Burkholderia cepacia complex (Bcc) in three (2.8%) patients. Among viruses, Rhinovirus was the most common, identified in 16 (17.4%) samples followed by coronavirus in four (4.3%). Fungi and mycobacteria were isolated from 23 (22.1%) and four (3.8%) children, respectively. Aspergillus flavus was the most common fungus isolated in 13 (12.5%) children. Interpretation & conclusions: Pseudomonas was the most common organism isolated during exacerbation. Non-tuberculous mycobacteria were not isolated, whereas infection with Bcc and Mycobacterium tuberculosis was observed, which could probably have a role in CF morbidity. Polymicrobial infections were associated with severe exacerbations. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource acute exacerbation - children - cystic fibrosis - microbiology - pseudomonas - polymicrobial infection Identifier An unambiguous reference to the resource within a given context DOI: 10.4103/ijmr.IJMR_1275_18 Source A related resource from which the described resource is derived Indian Journal of Medical Research Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/2e32c1443e0c8dbf7391a762f8ebad42.pdf 25b46ef4fa1f4b750af7113bb020510f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Common Cold And Clinical Approaches Creator An entity primarily responsible for making the resource Selim Öncel Description An account of the resource The common cold is what we call “upper respiratory tract infection”, “acute nasopharyngitis”, or “acute rhinopharyngitis” in medicine. There is a chapter titled “Common Cold” in Ebers papyrus (16th century B.C.). Şaban Şifai of Ayaş (18th century B.C.) proposed bloodletting and cold application in children with common cold. İshak bin Murad of Gerede used the term “tumagu” for the common cold with fever, coughing, and expectoration in 1390. According to Hildegard von Bingen (12th century B.C.), rhinitis arises from accumulation of cold and damp substances and their transformation to a toxin in the brain. Benjamin Franklin (18th century B.C.) has observed that common cold spreads more easily when people stay closer to each other.Rhinovirus is the most frequent pathogen of the common cold. Common cold spreads with direct contact rather than with droplets. Adenovirus and influenza viruses almost completely destruct respiratory epithelium whereas rhinovirus and coronavirus cause less cellular damage. The symptomatology of common cold is a hyperinflammation syndrome, and therefore the treatment of common cold should be carried out with an antipyretic/analgesic agent with anti-inflammatory properties.Children less than six years of age experience an average of six to eight bouts of the common cold in a year. Complications include acute otitis media, acute bacterial rhinosinüsitis, asthma exacerbations, and lower respiratory infections.Nasal irrigation with isotonic saline, gargling, honey, and zinc preparations have been shown to have some benefit. Excessive fluid intake, over-the-counter common cold preparations, vitamin C, echinacea, and Chinese herbal medicine are not advisable for treatment. Hand hygiene and some probiotics may be useful for prophylaxis. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource vitamin C, Rinovirus, C vitamini, Rhinovirus, Echinacea, common cold, soğuk algınlığı, ekinezya Identifier An unambiguous reference to the resource within a given context DOI: 10.30934/kusbed.348505 Source A related resource from which the described resource is derived Kocaeli Üniversitesi Sağlık Bilimleri Dergisi Publisher An entity responsible for making the resource available Kocaeli University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General), Medicine https://www.socictopen.socict.org/files/original/23dac968de2e20398e85ae3473e6d101.pdf 876e0370bc3c9451d02f422b920b9e4b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Critical care response to a hospital outbreak of the 2019-nCoV infection in Shenzhen, China Creator An entity primarily responsible for making the resource Yong Liu, Jinxiu Li, Yong-wen FENG Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13054-020-2786-x Source A related resource from which the described resource is derived Critical Care Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical emergencies. Critical care. Intensive care. First aid https://www.socictopen.socict.org/files/original/109b6e8d14708ce805261cdc7bcb78e3.pdf 185059bae11d9481e18fb58300fbb289 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correction: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants. Creator An entity primarily responsible for making the resource Ande West, Mehul Suthar, Boyd Yount, Alan Whitmore, Robert Johnston, Nancy Davis, Amy Sims, Ralph Baric, Damon Deming, Mark Heise, Timothy Sheahan, Jack Harkema, Raymond Pickles, Eric Donaldson, Kristopher Curtis Date A point or period of time associated with an event in the lifecycle of the resource 2007 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pmed.0040080 Source A related resource from which the described resource is derived PLoS Medicine Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/d9d32ab03311ef93c056f03b77940855.pdf 3ade9d2f0686d3add73b520388802f70 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. Creator An entity primarily responsible for making the resource Bruno Coutard, Nicolas Papageorgiou, François Ferron, Bruno Canard, Etienne Decroly, Julien Lescar, Claire Debarnot, Miguel Ortiz-Lombardía, Gérard Bricogne, Mickaël Bouvet, Isabelle Imbert, Laure Gluais, Andrew Sharff Description An account of the resource Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping. The Severe Acute Respiratory Syndrome coronavirus nsp16 protein is a S-adenosylmethionine-dependent (nucleoside-2'-O)-methyltransferase only active in the presence of its activating partner nsp10. We report the nsp10/nsp16 complex structure at 2.0 Å resolution, which shows nsp10 bound to nsp16 through a ∼930 Ų surface area in nsp10. Functional assays identify key residues involved in nsp10/nsp16 association, and in RNA binding or catalysis, the latter likely through a SN2-like mechanism. We present two other crystal structures, the inhibitor Sinefungin bound in the S-adenosylmethionine binding pocket and the tighter complex nsp10(Y96F)/nsp16, providing the first structural insight into the regulation of RNA capping enzymes in +RNA viruses. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1002059 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/1672db6e0b747c52d65da493720bc1d2.pdf 8f6cd6c09fda5b2b98fbed1c555e4130 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Emergence of the Middle East respiratory syndrome coronavirus. Creator An entity primarily responsible for making the resource Matthew B. Frieman, Christopher M Coleman Date A point or period of time associated with an event in the lifecycle of the resource 2013 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1003595 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/992ffa67a592f654eec1c00824ed0780.pdf ead0439d9a9ce1b401475310d1436e3d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication. Creator An entity primarily responsible for making the resource Dan Liu, Luis Enjuanes, Zhilin Li, Yajing Gao, Jian Pan, Xiao-lu Lu, Deyin Guo, Marta L. DeDiego, Xiaoxue Peng, Musarat Ishaq, Yingzhao Chen Description An account of the resource Analyses of viral protein-protein interactions are an important step to understand viral protein functions and their underlying molecular mechanisms. In this study, we adopted a mammalian two-hybrid system to screen the genome-wide intraviral protein-protein interactions of SARS coronavirus (SARS-CoV) and therefrom revealed a number of novel interactions which could be partly confirmed by in vitro biochemical assays. Three pairs of the interactions identified were detected in both directions: non-structural protein (nsp) 10 and nsp14, nsp10 and nsp16, and nsp7 and nsp8. The interactions between the multifunctional nsp10 and nsp14 or nsp16, which are the unique proteins found in the members of Nidovirales with large RNA genomes including coronaviruses and toroviruses, may have important implication for the mechanisms of replication/transcription complex assembly and functions of these viruses. Using a SARS-CoV replicon expressing a luciferase reporter under the control of a transcription regulating sequence, it has been shown that several viral proteins (N, X and SUD domains of nsp3, and nsp12) provided in trans stimulated the replicon reporter activity, indicating that these proteins may regulate coronavirus replication and transcription. Collectively, our findings provide a basis and platform for further characterization of the functions and mechanisms of coronavirus proteins. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0003299 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine https://www.socictopen.socict.org/files/original/f1a4cefe6c194aa39fd8a2205e754442.pdf eaa353bf064ee3a153f9831f308ceb25 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Interaction of the coronavirus infectious bronchitis virus membrane protein with beta-actin and its implication in virion assembly and budding. Creator An entity primarily responsible for making the resource Bo Chen, James P Tam, Han Xiao, Ding Xiang Liu, Shou Guo Fang, Jibin Wang Description An account of the resource Coronavirus M protein is an essential component of virion and plays pivotal roles in virion assembly, budding and maturation. The M protein is integrated into the viral envelope with three transmembrane domains flanked by a short amino-terminal ectodomain and a large carboxy-terminal endodomain. In this study, we showed co-purification of the M protein from coronavirus infectious bronchitis virus (IBV) with actin. To understand the cellular factors that may be involved in virion assembly, budding and maturation processes, IBV M was used as the bait in a yeast two-hybrid screen, resulting in the identification of beta-actin as a potentially interacting partner. This interaction was subsequently confirmed by coimmunoprecipitation and immunofluorescence microscopy in mammalian cells, and mutation of amino acids A159 and K160 on the M protein abolished the interaction. Introduction of the A159-K160 mutation into an infectious IBV clone system blocks the infectivity of the clone, although viral RNA replication and subgenomic mRNA transcription were actively detected. Disruption of actin filaments with cell-permeable agent cytochalasin D at early stages of the infection cycle led to the detection of viral protein synthesis in infected cells but not release of virus particles to the cultured media. However, the same treatment at late stages of the infection cycle did not affect the release of virus particles to the media, suggesting that disruption of the actin filaments might block virion assembly and budding, but not release of the virus particles. This study reveals an essential function of actin in the replication cycle of coronavirus. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0004908 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine https://www.socictopen.socict.org/files/original/7283588ece8311a51fe3f52697bce98a.pdf 61e4488757c28cb98d37163cc10d1ad9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. Creator An entity primarily responsible for making the resource Zhu Chen, Qi Zhao, Haitao Yang, Mark Bartlam, Dawei Ma, Kai-Lin Yang, Jing Ma, Duanqing Pei, Zhe Zhou, Xiaoyu Xue, Kwok-yung Yuen, Sai-Juan Chen, Zihe Rao, Rolf Hilgenfeld, Wen-Xue Liang, John Ziebuhr, Guangxia Gao, Wei-Qing Xie, Luet Wong Date A point or period of time associated with an event in the lifecycle of the resource 2005 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pbio.0030428 Source A related resource from which the described resource is derived PLoS Biology Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General)