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                <text>COVID-19 and smoking: A systematic review of the evidence</text>
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                <text>Constantine I. Vardavas, Katerina Nikitara</text>
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                <text>2020</text>
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                <text>smoking, tobacco, coronavirus, COVID-19</text>
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                <text>DOI: 10.18332/tid/119324</text>
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                <text>Tobacco Induced Diseases</text>
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                <text>European Publishing</text>
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                <text>Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Diseases of the respiratory system</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Feline infeksiyöz peritonitisli kedilerde bazı hematolojik ve biyokimyasal Parametrelerin Araştırılması</text>
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                <text>Halil İbrahim  GÖKCE, Hasan Barış  CENGİZ</text>
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                <text>Araştırmanın amacı felin infeksiyöz peritonitisli (FİP) kedilerde bazı biyokimyasal ve hematolojik parametrelerin araştırılmasıdır. Ayrıca kuru form ve yaş from FİP’li kediler arasında analiz edilen bu parameterlerde farlılıkların belirlenmesi de hedeflenmiştir. Çalışmada klinik belirtiler gösteren, sadece Feline Coronavirus (FCoV) Ag veya FCoV Ab pozitif olan 20 adet (çalışma grubu) ve klinik olarak sağlıklı tüm testlerden negatif olan 10 adet (kontrol grubu) kedi kullanıldı. Ayrıca, klinik ve nekropsi bulguları ışığında 20 FİP’li kedi eşit olarak kuru ve yaş from FİP’li olarak iki gruba ayrıldı. Bu hayvanların klinik muayeneleri, hematolojik ve biyokimyasal analizleri yapılarak elde edilen değerler kayıt altına alındı. Çalışmada, yapılan klinik muayenede FİP’li kedilerin sadece solunum sayılarının kontrol grubuna göre daha yüksek olduğu (p&amp;lt;0,01), kalp frekansı ve rektal derecelerinde ise önemli farklılıkların olmadığı belirlenmiştir. Yapılan hematolojik analizler sonucunda FİP’li kedilerin total lökosit (WBC) (p&amp;lt;0,01), granulosit (p&amp;lt;0,01) ve monosit (p&amp;lt;0,01) sayılarında kontrol grubuna göre önemli düzeyde artışların olduğu buna karşın total eritrosit (p&amp;lt;0,01) ve lenfosit sayıları (p&amp;lt;0,05) ile hemoglobin (HGB) konsantasyonlarının (p&amp;lt;0,05) ise kontrol grubuna göre anlamlı düzeyde düşük olduğu saptanmıştır. Biyokimyasal analizler sonucunda FİP’li kedilerin alanin aminotransferaz (ALT) (p&amp;lt;0,01), laktat dehidrojenaz (LDH) (p&amp;lt;0,05), alkalen fosfotaz (ALP) (p&amp;lt;0,05), total bilirubin (TB) (p&amp;lt;0,01), total protein (TP) (p&amp;lt;0,05) ve globülin (G) (p&amp;lt;0,001) değerlerinin kontrol grubuna göre istatistiksel olarak anlamlı düzeyde yüksek, albumin (A) (p&amp;lt;0,05) ve A/G (p&amp;lt;0,001) oranının ise daha düşük olduğu saptandı. Kuru formda bulunan kedilerin BUN, TP, A, G değerlerinin yaş formda bulunan kedilerin değerlerine göre daha yüksek, A/G oranının ise daha düşük olduğu belirlendi. Sonuç olarak, bu çalışmada elde edilen bulgular FİP’li kedilerin hematopoetik sistemi yanında karaciğer ve böbrek fonksiyonlarınında bu infeksiyondan negatif yönde etkilendiğini ortaya koymaktadır.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2019</text>
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            <description>The topic of the resource</description>
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                <text>Hematoloji, biyokimya, feline infeksiyöz peritonitis (fi̇p)</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.24880/maeuvfd.615750</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Mehmet Akif Ersoy University</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Veterinary medicine</text>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="28512">
                <text>Hong Tang, Gang Wang, Gang Chen, Gen-hong Cheng, Dahai Zheng</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>BACKGROUND:Coronaviruses such as severe acute respiratory syndrome (SARS) coronavirus (SCoV) and mouse hepatitis virus A59 (MHV-A59) have evolved strategies to disable the innate immune system for productive replication and spread of infection. We have previously shown that papain-like protease domain 2 (PLP2), a catalytic domain of the nonstructural protein 3 (nsp3) of MHV-A59, encodes a deubiquitinase (DUB) and inactivates IFN regulatory factor 3 (IRF3) thereby the type I interferon (IFN) response. PRINCIPAL FINDINGS:Here we provide further evidence that PLP2 may also target TANK-binding kinase-1 (TBK1), the upstream kinase of IRF3 in the IFN signaling pathway. Overexpression experiments showed that PLP2 deubiquitinated TBK1 and reduced its kinase activity, hence inhibited IFN-β reporter activity. Albeit promiscuous in deubiquitinating cellular proteins, PLP2 inactivated TBK1 and IFN-β response in TNF receptor associated factor 3 (TRAF3) deficient cells, suggesting that targeting TBK1 would be sufficient for PLP2 to inhibit IRF3 activation. This notion was further supported by in vitro kinase assays, in which prior treatment of TBK1 with PLP2 inhibited its kinase activity to phosphorylate IRF3. Intriguing enough, results of PLP2 overexpression system and MHV-A59 infection system proved that PLP2 formed an inactive complex with TBK1 and IRF3 in the cytoplasm and the presence of PLP2 stabilized the hypo-phosphorylated IRF3-TBK1 complex in a dose-dependent manner. CONCLUSIONS:These results suggest that PLP2 not only inactivates TBK1, but also prevents IRF3 nuclear translocation hence inhibits IFN transcription activation. Identification of the conserved DUB activity of PLP2 in suppression of IFN signaling would provide a useful clue to the development of therapeutics against coronaviruses infection.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="28514">
                <text>2011</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="28515">
                <text>DOI: 10.1371/journal.pone.0017192</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="28516">
                <text>PLoS ONE</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Public Library of Science (PLoS)</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Science, Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="28519">
                <text>Further COVID-19 Infection Control and Management Recommendations for the ICU</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="28520">
                <text>Raschke RA</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>No abstract available. Article truncated after 150 words. An ad hoc committee of intensivists from the Phoenix area has been meeting via Zoom. They are sharing some of their thoughts and recommendations. Like the previous ICU recommendations published in SWJPCC (1), these are not necessarily evidence-based but based on recent experience and published experience with previous coronavirus outbreaks such as SARS. They are meant to supplement CDC recommendations, not to conflict or restate them. Infection control outside the rooms of suspected/confirmed COVID-19 patients.1.	All healthcare workers should be allowed to exercise droplet precautions at all times while at work. 2.	All staff should wear a single surgical mask per day to see all non-COVID patients and for rounds. The mask mitigates droplet spread bidirectionally between patients and HCWs and also helps prevent inadvertent touching of the nose and mouth.3.	Treat all code patients with airborne / standard / contact precautions4.	Use MDIs in preference to …</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="28522">
                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="28523">
                <text>prevention, control, Intubation, aerosol, coronavirus, ICU, recommendations, HEPA, COVID-19, air purifying respirators</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="28524">
                <text>DOI: 10.13175/swjpcc020-20</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="28525">
                <text>Southwest Journal of Pulmonary and Critical Care</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="28526">
                <text>Arizona Thoracic Society</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="28527">
                <text>Medical emergencies. Critical care. Intensive care. First aid, General works</text>
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                <text>Dear Colleagues, Europe is severely hit by the virus SARS-CoV-2 and most countries report                     increasing numbers of people affected by COVID-19. WHO has declared it a                     pandemic, many countries have introduced severe restrictions on travelling and                     thousands of people around Europe are in quarantine. Currently, the most                     severely affected European country is Italy, which also experienced some of the                     first European cases.</text>
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                <text>In Italy, for some time there has been a constant shortage of specialized medical staff, in particular in emergency areas such as anaesthesia and intensive care. Specialization schools do not have enough places to allow access to all qualified doctors. The dramatic coronavirus pandemic has highlighted this situation. Specializing “on field” non-specialist doctors can be a way of overcoming what is called the training funnel.</text>
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            <name>Title</name>
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                <text>COVID-19 in intensive care. Some necessary steps for health care workers</text>
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            <name>Creator</name>
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                <text>Pranav Ish, Nitesh Gupta, Nipun Malhotra, Somya Ish</text>
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                <text>Due to the nature of their profession, health care personnel (HCP) have always been easy targets for transmission of communicable diseases like COVID-19. Shielding HCPs is of consequential significance in ensuring continued health care for the whole population in addition to reducing further spread. Close contact, repeated contact and prolonged contact are unavoidable in the intensive care (IC) environment. It is not uncommon for IC-HCPs to get carried away during an emergent situation, such as that posed by a suddenly deteriorating patient, and forgo the protective barriers that protect them from contracting a communicable infection. Some notable precautionary measures are mentioned below. This is by no means an exhaustive list.</text>
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                <text>protection, coronavirus, ICU</text>
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                <text>DOI: 10.4081/monaldi.2020.1284</text>
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                <text>Monaldi Archives for Chest Disease</text>
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                <text>PAGEPress Publications</text>
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                <text>Medicine</text>
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