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                <text>At the end of the 2019 and the beginning of 2020, an outbreak of viral pneumonia caused by the new coronavirus Coronavirus disease 2019 (Covid-19) began. From the history of outbreaks of severe acute respiratory syndrome in 2002–2003 and the Middle East respiratory syndrome in 2012, it is known that an effective and safe etiotropic treatment of coronavirus infection does not exist. Therefore, the actual challenge today is the fight against coronavirus infection. Potentially effective antiviral agents are antiseptics from the group of surfactants. In particular, decamethoxin, which has a pronounced bactericidal, fungicidal and antiprotistal effect, also has experimentally proven antiviral activity. In vitro, it was shown that decamethoxin exhibits a statistically significant virucidal effect influencing the extracellular virus with possible damage to the viral protease. In experiments on the tissue cultures and experimental animals, the ability of decamethoxin to inhibit the replication of influenza A and B viruses, herpes simplex virus by affecting the stage of virus penetration into the cell and viral nucleic acid replication has been proved. Another mechanism of decamethoxin action can be considered its effect on the early stages of the interaction of the virus with the host cell such as adsorption, penetration and deproteinization of the virus. The use of decamethoxin for the treatment of respiratory tract infections is pathogenetically justified due to the dosage form of a sterile solution for inhalation using a nebulizer — Decasan® single-dose containers. Decamethoxin is successfully used in the treatment of patients with infectious exacerbations of bronchial asthma and chronic bronchitis without negative impact on bronchial obstruction. The proven efficacy of decamethoxin as an effective agent against complex viruses regardless of their antigenic structure gives grounds for its practical use in respiratory tract infections, including coronavirus infection.</text>
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                <text>Aktualʹnaâ Infektologiâ</text>
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                <text>Canine infectious respiratory disease (CIRD) is a syndrome where multiple viral and bacterial pathogens are involved sequentially or synergistically to cause illness. There is limited information regarding the prevalence of pathogens related to CIRD in the United States as well as the role of co-infections in the pathogenesis of the syndrome. We aimed to conduct a comprehensive etiologic and epidemiologic study of multiple CIRD agents in a diverse dog population using molecular methods and statistical modeling analyses. In addition, a novel probe-based multiplex real-time PCR was developed to simultaneously detect and differentiate two species of Mycoplasma (M. canis and M. cynos). Canine adenovirus, canine distemper virus, canine parainfluenza virus, coronavirus, influenza A virus (H3N2 and H3N8), Bordetella bronchiseptica, M. canis, M. cynos and Streptococcus equi subsp. zooepidemicus were investigated in specimens from clinically ill and asymptomatic dogs received at the Athens Veterinary Diagnostic Laboratory. Results showed low occurrence of classical CIRD agents such as B. bronchiseptica, canine adenovirus and distemper virus, while highlighting the potential role of emerging bacteria such as M. canis and M. cynos. Statistical modeling analyses of CIRD pathogens emphasized the impact of co-infections on the severity of clinical presentation, and showed that host factors, such as animal age, are the most important predictors of disease severity. This study provides new insights into the current understanding of the prevalence and role of co-infections with selected viruses and bacteria in the etiology of CIRD, while underscoring the importance of molecular diagnosis and vaccination against this disease.</text>
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                <text>DOI: 10.1371/journal.pone.0215817</text>
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                <text>PLoS ONE</text>
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                <text>The outbreak of an epidemic disease may pose significant treats to human beings and may further lead to a global crisis. In order to control the spread of an epidemic, the effective management of rapidly increased medical waste through establishing a temporary reverse logistics system is of vital importance. However, no research has been conducted with the focus on the design of an epidemic reverse logistics network for dealing with medical waste during epidemic outbreaks, which, if improperly treated, may accelerate disease spread and pose a significant risk for both medical staffs and patients. Therefore, this paper proposes a novel multi-objective multi-period mixed integer program for reverse logistics network design in epidemic outbreaks, which aims at determining the best locations of temporary facilities and the transportation strategies for effective management of the exponentially increased medical waste within a very short period. The application of the model is illustrated with a case study based on the outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Even though the uncertainty of the future COVID-19 spread tendency is very high at the time of this research, several general policy recommendations can still be obtained based on computational experiments and quantitative analyses. Among other insights, the results suggest installing temporary incinerators may be an effective solution for managing the tremendous increase of medical waste during the COVID-19 outbreak in Wuhan, but the location selection of these temporary incinerators is of significant importance. Due to the limitation on available data and knowledge at present stage, more real-world information are needed to assess the effectiveness of the current solution.</text>
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              <elementText elementTextId="13321">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="13322">
                <text>Epidemic outbreak, Medical waste, reverse logistics, epidemic logistics, network design, Operations research</text>
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                <text>DOI: 10.3390/ijerph17051770</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="13324">
                <text>International Journal of Environmental Research and Public Health</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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                <text>Medicine</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>A Meta-Analysis of Multiple Whole Blood Gene Expression Data Unveils a Diagnostic Host-Response Transcript Signature for Respiratory Syncytial Virus</text>
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              <elementText elementTextId="13329">
                <text>Ruth Barral-Arca, Alberto Gómez-Carballa, Miriam Cebey-López, Xabier Bello, Federico Martinón-Torres, Antonio Salas</text>
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            <description>An account of the resource</description>
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                <text>Respiratory syncytial virus (RSV) is one of the major causes of acute lower respiratory tract infection worldwide. The absence of a commercial vaccine and the limited success of current therapeutic strategies against RSV make further research necessary. We used a multi-cohort analysis approach to investigate host transcriptomic biomarkers and shed further light on the molecular mechanism underlying RSV-host interactions. We meta-analyzed seven transcriptome microarray studies from the public Gene Expression Omnibus (GEO) repository containing a total of 922 samples, including RSV, healthy controls, coronaviruses, enteroviruses, influenzas, rhinoviruses, and coinfections, from both adult and pediatric patients. We identified &amp;gt; 1500 genes differentially expressed when comparing the transcriptomes of RSV-infected patients against healthy controls. Functional enrichment analysis showed several pathways significantly altered, including immunologic response mediated by RSV infection, pattern recognition receptors, cell cycle, and olfactory signaling. In addition, we identified a minimal 17-transcript host signature specific for RSV infection by comparing transcriptomic profiles against other respiratory viruses. These multi-genic signatures might help to investigate future drug targets against RSV infection.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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              <elementText elementTextId="13332">
                <text>Meta-analysis, RNA, transcriptomic, RSV, Respiratory Syncytial Virus, array</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3390/ijms21051831</text>
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="13334">
                <text>International Journal of Molecular Sciences</text>
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            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13335">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="13336">
                <text>Biology (General), Chemistry</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13337">
                <text>EN</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="13338">
                <text>Optimization Method for Forecasting Confirmed Cases of COVID-19 in China</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="13339">
                <text>Mohammed A. A. Al-qaness, Ahmed  A. Ewees, Hong Fan, Mohamed Abdelaziz</text>
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            <description>An account of the resource</description>
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                <text>In December 2019, a novel coronavirus, called COVID-19, was discovered in Wuhan, China, and has spread to different cities in China as well as to 24 other countries. The number of confirmed cases is increasing daily and reached 34,598 on 8 February 2020. In the current study, we present a new forecasting model to estimate and forecast the number of confirmed cases of COVID-19 in the upcoming ten days based on the previously confirmed cases recorded in China. The proposed model is an improved adaptive neuro-fuzzy inference system (ANFIS) using an enhanced flower pollination algorithm (FPA) by using the salp swarm algorithm (SSA). In general, SSA is employed to improve FPA to avoid its drawbacks (i.e., getting trapped at the local optima). The main idea of the proposed model, called FPASSA-ANFIS, is to improve the performance of ANFIS by determining the parameters of ANFIS using FPASSA. The FPASSA-ANFIS model is evaluated using the World Health Organization (WHO) official data of the outbreak of the COVID-19 to forecast the confirmed cases of the upcoming ten days. More so, the FPASSA-ANFIS model is compared to several existing models, and it showed better performance in terms of Mean Absolute Percentage Error (MAPE), Root Mean Squared Relative Error (RMSRE), Root Mean Squared Relative Error (RMSRE), coefficient of determination (    R 2    ), and computing time. Furthermore, we tested the proposed model using two different datasets of weekly influenza confirmed cases in two countries, namely the USA and China. The outcomes also showed good performances.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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              <elementText elementTextId="13342">
                <text>COVID-19, Adaptive neuro-fuzzy inference system (ANFIS), forecasting, Salp Swarm Algorithm (SSA), Flower Pollination Algorithm (FPA)</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="13343">
                <text>DOI: 10.3390/jcm9030674</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="13344">
                <text>Journal of Clinical Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="13345">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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            </elementTextContainer>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease.</text>
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                <text>Anneloes L van Rijn, Sander van Boheemen, Igor Sidorov, Ellen C Carbo, Nikos Pappas, Hailiang Mei, Mariet Feltkamp, Marianne Aanerud, Per Bakke, Eric C. J. Claas, Tomas M. Eagan, Pieter S. Hiemstra, Aloys C. M. Kroes, Jutte J C de Vries</text>
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                <text>INTRODUCTION:Exacerbations are major contributors to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and respiratory bacterial and viral infections are an important trigger. However, using conventional diagnostic techniques, a causative agent is not always found. Metagenomic next-generation sequencing (mNGS) allows analysis of the complete virome, but has not yet been applied in COPD exacerbations. OBJECTIVES:To study the respiratory virome in nasopharyngeal samples during COPD exacerbations using mNGS. STUDY DESIGN:88 nasopharyngeal swabs from 63 patients from the Bergen COPD Exacerbation Study (2006-2010) were analysed by mNGS and in-house qPCR for respiratory viruses. Both DNA and RNA were sequenced simultaneously using an Illumina library preparation protocol with in-house adaptations. RESULTS:By mNGS, 24/88 samples tested positive. Sensitivity and specificity, as compared with PCR, were 96% and 98% for diagnostic targets (23/24 and 1093/1120, respectively). Additional viral pathogens detected by mNGS were herpes simplex virus type 1 and coronavirus OC43. A positive correlation was found between Cq value and mNGS viral normalized species reads (log value) (p = 0.002). Patients with viral pathogens had lower percentages of bacteriophages (p</text>
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                <text>2019</text>
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              <elementText elementTextId="13352">
                <text>DOI: 10.1371/journal.pone.0223952</text>
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              <elementText elementTextId="13353">
                <text>PLoS ONE</text>
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                <text>Public Library of Science (PLoS)</text>
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                <text>Science, Medicine</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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          <element elementId="50">
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                <text>Alltagsleben und Alltagskommunikation im Coronavirus-Kapitalismus</text>
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                <text>Christian Fuchs</text>
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                <text>Im Jahr 2020 führte die Coronavirus-Krise zu einem Bruch in den Gesellschaften der Welt und deren Alltagsleben. Dieser Artikel ist ein Beitrag zur kritischen Theoretisierung der Veränderungen, die die Gesellschaften im Kontext der Coronavirus-Krise durchmachen. Er stellt die folgenden zwei Frage: Wie haben sich Alltagsleben und Alltagskommunikation in der Coronavirus-Krise verändert? Wie beeinflusst der Kapitalismus das Alltagsleben und die Alltagskommunikation in dieser Krise?  Abschnitt 2 beschäftigt sich damit, wie sich der soziale Raum, das Alltagsleben und die Alltagskommunikation durch die Coronavirus-Krise verändert haben. Abschnitt 3 setzt sich mit der Kommunikation von Ideologie im Kontext des Coronavirus auseinander, indem die Kommunikation von Verschwörungstheorien und Falschnachrichten über das Coronavirus analysiert wird.  Die Coronavirus-Krise ist eine Existenzkrise der Menschheit und der Gesellschaft. Sie konfrontiert die Menschen in radikaler Weise mit dem Tod und der Angst vor dem Tod. Diese kollektive Erfahrung kann einerseits zu neuen Formen der Solidarität und des Sozialismus führen. Wenn Ideologie und die extreme Rechte sich durchsetzt, so kann es andererseits aber zum Fortschreiten von Krieg und Faschismus kommen. Politisches Handeln und politische Ökonomie sind in einer derartigen tiefen Krise, die die Gesellschaft und das Alltagsleben erschüttert, entscheidende Faktoren.</text>
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