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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Proposal of Marbefia, gen. n. and Inermiphonte, gen. n., including updated keys to the species of Pseudonychocamptus Lang, 1944 and Paralaophonte Lang, 1948 (Copepoda, Harpacticoida, Laophontidae)</text>
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                <text>Rony Huys, Wonchoel Lee</text>
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            <description>An account of the resource</description>
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                <text>Both sexes of the enigmatic laophontid species Pseudonychocamptus carthyi Hamond, 1968 (Copepoda, Harpacticoida) are redescribed in detail based on type and other material from Norfolk, England. The species exhibits marked differences with other Pseudonychocamptus species and is consequently fixed as the type of a new genus Marbefia, gen. n., being defined by the following autapomorphies: (1) P2&amp;ndash;P4 enp-2 (except P4 enp-2 in ♂) inflated, with two parallel rows of flimsy setular extensions; (2) P4 with sexually dimorphic setation on enp-2 (outer distal seta reduced in ♀, very long in ♂); and (3) antennule ♀ with spinules along posterior margins of segments 1&amp;ndash;6. Laophonte danversae Hamond, 1969, &amp;ldquo;Laophontid male, ?gen., ?sp.&amp;rdquo; sensu Hamond (1969) [renamed as Inermiphonte hamondi, sp. n.] and Laophonte ?drachi M&amp;eacute;dioni &amp;amp; Soyer, 1966 are collectively placed in a new genus Inermiphonte, gen. n. which shares as sistergroup relationship with Harrietella T. Scott, 1906. Marbefia, gen. n. is considered sister to a clade comprising the genera Pseudonychocamptus Lang, 1944, Pilifera Noodt, 1952, Inermiphonte, gen. n. and Harrietella. Pseudonychocamptus kolarovi Apostolov, 2008 is transferred to Paralaophonte whereas Chislenko&amp;rsquo;s (1967) record of P. koreni Sars, 1908a is considered doubtful. Willey&amp;rsquo;s (1935) variety &amp;ldquo;fissirostris&amp;rdquo; of Paralaophonte brevirostris (Claus, 1863) is rejected pending a thorough analysis of the variability in the P. brevirostris complex of species. P. congenera mediterranea Lang, 1948 appears to be more closely related to P. lacerdai Jakobi, 1953 than to its nominotypical subspecies P. congenera congenera (Sars, 1908b) whereas P. pacifica galapagoensis Mielke, 1981 (here upgraded to full specific rank) is more similar to P. brevirostris than to its nominotypical subspecies P. pacifica pacifica Lang, 1965. A new species, Paralaophonte pallaresae, sp. n. is proposed for P. gracilipes Brady, 1910 sensu Pallares (1968). The potentially paraphyletic status of the genus Paralaophonte is discussed. Dichotomous identification keys are provided for the valid species of Pseudonychocamptus Lang, 1944 and Paralaophonte Lang, 1948.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2009</text>
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            <name>Identifier</name>
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                <text>DOI: 10.3897/zookeys.23.168</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>ZooKeys</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Pensoft Publishers</text>
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                <text>Zoology</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Review of the Capitellidae (Annelida, Polychaeta) from the Eastern Tropical Pacific region, with notes on selected species</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Maria Garcia, Jesus de Leon</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="574">
                <text>The main objective of this work is to contribute to the taxonomic knowledge of the species of Capitellidae reported for the Eastern Tropical Pacific. This catalogue includes the original name of each species, new names, synonymies, type localities, the museum or institution where the type material is deposited, revision of the material reported for the region by different authors, new examined material, previous reports from other regions of the world, and comments on systematics and distributions. The catalogue lists 43 species in 19 genera. Of these, 6 species were erroneously recorded for the region (Decamastus gracilis Hartman, 1963; D. nudus Thomassin, 1970; Mastobranchus variabilis Edwing, 1984; Notomastus aberans Day, 1957; N. americanus Day, 1973; N. latericeus Sars, 1851) and 5 species are found here to be questionable records for the Eastern Tropical Pacific (Capitella capitata (Fabricius, 1780); Dasybranchus glabrus Moore, 1909; D. lumbricoides Grube, 1878; Notomastus lineatus Clapar&amp;egrave;de, 1870 and N. tenuis Moore, 1909).</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2011</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="576">
                <text>DOI: 10.3897/zookeys.151.1964</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>ZooKeys</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="578">
                <text>Pensoft Publishers</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Zoology</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
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            <description>A name given to the resource</description>
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                <text>Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="582">
                <text>Oi-Wing Ng, Choong-Tat Keng, Cynthia Sau-Wai Leung, JS Malik Peiris, Leo Lit-Man Poon, Yee-Joo Tan</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is the etiological agent for the infectious disease, SARS, which first emerged 10 years ago. SARS-CoV is a zoonotic virus that has crossed the species barriers to infect humans. Bats, which harbour a diverse pool of SARS-like CoVs (SL-CoVs), are believed to be the natural reservoir. The SARS-CoV surface Spike (S) protein is a major antigenic determinant in eliciting neutralizing antibody production during SARS-CoV infection. In our previous work, we showed that a panel of murine monoclonal antibodies (mAbs) that target the S2 subunit of the S protein are capable of neutralizing SARS-CoV infection in vitro (Lip KM et al, J Virol. 2006 Jan; 80(2): 941-50). In this study, we report our findings on the characterization of one of these mAbs, known as 1A9, which binds to the S protein at a novel epitope within the S2 subunit at amino acids 1111-1130. MAb 1A9 is a broadly neutralizing mAb that prevents viral entry mediated by the S proteins of human and civet SARS-CoVs as well as bat SL-CoVs. By generating mutant SARS-CoV that escapes the neutralization by mAb 1A9, the residue D1128 in S was found to be crucial for its interaction with mAb 1A9. S protein containing the substitution of D1128 with alanine (D1128A) exhibited a significant decrease in binding capability to mAb 1A9 compared to wild-type S protein. By using a pseudotyped viral entry assay, it was shown that the D1128A substitution in the escape virus allows it to overcome the viral entry blockage by mAb 1A9. In addition, the D1128A mutation was found to exert no effects on the S protein cell surface expression and incorporation into virion particles, suggesting that the escape virus retains the same viral entry property as the wild-type virus.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2014</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="585">
                <text>DOI: 10.1371/journal.pone.0102415</text>
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              <elementText elementTextId="586">
                <text>PLoS ONE</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="587">
                <text>Public Library of Science (PLoS)</text>
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                <text>Science, Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <description>A name given to the resource</description>
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                <text>Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="591">
                <text>Kristina Dietert, Birgitt Gutbier, Sandra M. Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas  C. Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D. Gruber</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="592">
                <text>Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions. Here, we systematically describe and compare the distinctive histopathological features of established models of acute pneumonia in mice induced by Streptococcus (S.) pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Legionella pneumophila, Escherichia coli, Middle East respiratory syndrome (MERS) coronavirus, influenza A virus (IAV) and superinfection of IAV-incuced pneumonia with S. pneumoniae. Systematic comparisons of the models revealed striking differences in the distribution of lesions, the characteristics of pneumonia induced, principal inflammatory cell types, lesions in adjacent tissues, and the detectability of the pathogens in histological sections. We therefore identified core criteria for each model suitable for practical semiquantitative scoring systems that take into account the pathogen- and model-specific patterns of pneumonia. Other critical factors that affect experimental pathologies are discussed, including infectious dose, time kinetics, and the genetic background of the mouse strain. The substantial differences between the model-specific pathologies underscore the necessity of pathogen- and model-adapted criteria for the comparative quantification of experimental outcomes. These criteria also allow for the standardized validation and comparison of treatment strategies in preclinical models.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2017</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.1371/journal.pone.0188251</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="595">
                <text>PLoS ONE</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="596">
                <text>Public Library of Science (PLoS)</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Science, Medicine</text>
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                <text>EN</text>
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                <text>RNA target accessibility is one of the most important factors limiting the efficiency of RNA interference-mediated RNA degradation. However, targeting RNA viruses in their poorly accessible, highly structured regions can be advantageous because these regions are often conserved in sequence and thus less prone to viral escape. We developed an experimental strategy to attack highly structured RNA by means of pairs of specifically designed small interfering RNAs and helper antisense oligonucleotides using the 5' untranslated region (5'UTR) of coxsackievirus B3 as a model target. In the first step, sites accessible to hybridization of complementary oligonucleotides were identified using two mapping methods with random libraries of short DNA oligomers. Subsequently, the accessibility of the mapped regions for hybridization of longer DNA 16-mers was confirmed by an RNase H assay. Using criteria for the design of efficient small interfering RNAs (siRNA) and a secondary structure model of the viral 5'UTR, several DNA 19-mers were designed against partly double-stranded RNA regions. Target sites for DNA 19-mers were located opposite the sites which had been confirmed as accessible for hybridization. Three pairs of DNA 19-mers and the helper 2'-O-methyl-16-mers were able to effectively induce RNase H cleavage in vitro. For cellular assays, the DNA 19-mers were replaced by siRNAs, and the corresponding three pairs of siRNA-helper oligomer tools were found to target 5'UTR efficiently in a reporter construct in HeLa cells. Addition of the helper oligomer improved silencing capacity of the respective siRNA. We assume that the described procedure will generally be useful for designing of nucleic acid-based tools to silence highly structured RNA targets.</text>
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                <text>DOI: 10.1371/journal.pone.0136395</text>
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                <text>MERS epidemiological investigation to detect potential mode of transmission in the 178th MERS confirmed case in Pyeongtaek, Korea</text>
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                <text>Kyujin Chang, Moran Ki, Eun Gyu Lee, Soon Young Lee, Byoungin Yoo, Jong Hyuk Choi</text>
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                <text>Most cases of Middle East Respiratory Syndrome (MERS) infection in Korea (outbreak: May 11-July 4, 2015) occurred in hospital settings, with uncertain transmission modes in some cases. We performed an in-depth investigation epidemiological survey on the 178th case to determine the precise mode of transmission. A 29- year-old man living in Pyeongtaek presented on June 16 with a febrile sensation, chills, and myalgia. Upon confirmatory diagnosis on June 23, he was treated in an isolation room and discharged on July 2 after cure. An epidemiological investigation of all possible infection routes indicated two likely modes of transmission: exposure to MERS in Pyeongtaek St. Mary’s Hospital during a visit to his hospitalized father (May 18-29), and infection through frequent contact with his father between the latter’s referral to Pyeongtaek Good Samaritan Bagae Hospital for treatment without confirmatory diagnosis until his death (May 29-June 6). Although lack of clear proof or evidence to the contrary does not allow a definitive conclusion, all other possibilities could be excluded by epidemiological inferences. While it is impossible to trace back the modes of transmission of all cases in a large-scale outbreak, case-by-case tracking and isolation of infected individuals and those in close contact with them is important in preventing the spread. Efforts should be made to establish a methodology for rapid tracking of all possible contacts and elimination-based identification of the precise modes of transmission.</text>
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                <text>Middle East respiratory syndrome, Epidemiologic investigation, mode of transmission, Outbreak, Korea</text>
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                <text>DOI: 10.4178/epih/e2015036</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Middle East Respiratory Syndrome: MERS</text>
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              <elementText elementTextId="619">
                <text>Emine Parlak</text>
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            <description>An account of the resource</description>
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                <text>Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging respiratory virus. It was first identifiedin Saudi Arabia in 2012. MERS-CoV infection is characterized by a spectrum of illness ranging from mild to acute andfulminant disease. The majority of patients present with fever, fever with chills/rigors, cough, shortness of breath, anddry cough. Cases of human-to-human transmission have been documented. There is currently no specific treatmentand vaccination for MERS-CoV infection. Surveillance and infection-control measures are of vital importance to an efficientpublic health response. J Microbiol Infect Dis 2015;5(2): 93-98</text>
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                <text>2015</text>
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                <text>coronavirus, Middle East respiratory syndrome, MERS-CoV polymerase-chain-reaction</text>
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                <text>DOI: 10.5799/ahinjs.02.2015.02.0184</text>
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            <name>Source</name>
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              <elementText elementTextId="624">
                <text>Journal of Microbiology and Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="625">
                <text>Association of Health Investigations</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Microbiology</text>
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            <description>A language of the resource</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
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                <text>Preventive behaviors by the level of perceived infection sensitivity during the Korea outbreak of Middle East Respiratory Syndrome in 2015</text>
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            <name>Creator</name>
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              <elementText elementTextId="629">
                <text>Soon Young Lee, Hee Jeong Yang, Gawon Kim, Hae Kwan Cheong, Bo Youl Choi</text>
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                <text>OBJECTIVES This study was performed to investigate the relationship between community residents’ infection sensitivity and their levels of preventive behaviors during the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea. METHODS Seven thousands two hundreds eighty one participants from nine areas in Gyeonggi-do including Pyeongtaek, the origin of the outbreak in 2015 agreed to participate in the survey and the data from 6,739 participants were included in the final analysis. The data on the perceived infection sensitivity were subjected to cluster analysis. The levels of stress, reliability/practice of preventive behaviors, hand washing practice and policy credibility during the outbreak period were analyzed for each cluster. RESULTS Cluster analysis of infection sensitivity due to the MERS outbreak resulted in classification of participants into four groups: the non-sensitive group (14.5%), social concern group (17.4%), neutral group (29.1%), and overall sensitive group (39.0%). A logistic regression analysis found that the overall sensitive group with high sensitivity had higher stress levels (17.80; 95% confidence interval [CI], 13.77 to 23.00), higher reliability on preventive behaviors (5.81; 95% CI, 4.84 to 6.98), higher practice of preventive behaviors (4.53; 95% CI, 3.83 to 5.37) and higher practice of hand washing (2.71; 95% CI, 2.13 to 3.43) during the outbreak period, compared to the non-sensitive group. CONCLUSIONS Infection sensitivity of community residents during the MERS outbreak correlated with gender, age, occupation, and health behaviors. When there is an outbreak in the community, there is need to maintain a certain level of sensitivity while reducing excessive stress, as well as promote the practice of preventive behaviors among local residents. In particular, target groups need to be notified and policies need to be established with a consideration of the socio-demographic characteristics of the community.</text>
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              <elementText elementTextId="631">
                <text>2016</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="632">
                <text>Middle East respiratory syndrome coronavirus, epidemics, risk reduction behavior, Cluster analysis</text>
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            <name>Identifier</name>
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              <elementText elementTextId="633">
                <text>DOI: 10.4178/epih.e2016051</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="634">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
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              <elementText elementTextId="635">
                <text>Korean Society of Epidemiology</text>
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                <text>Minyoung Sim</text>
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                <text>DOI: 10.4178/epih.e2016054</text>
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                <text>Epidemiology and Health</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Creator</name>
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                <text>Nikoletta Mavroidi</text>
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                <text>More than 200 of the documented zoonoses represent a high proportion of the infectious diseases that cause cases of morbidity and mortality and almost 75% are emerging infections. Immigration and tourism are human activities that are included in the broader field of human migration and travel. Travel plays a significant role in the emergence and spread of disease. The migration of humans has provided the route of spread for infectious diseases and zoonoses (for example, plague, yellow fever, monkey pox and severe acute respiratory syndrome). Tourism constitutes a small fraction of overall movements of humans but a point worthy of note is the number of international travellers has increased by more than 1 300% over the last 50 years. In addition, over 80 million people, mostly from developing countries, are legal or illegal immigrants. The consequences of travel extend beyond the traveller to the population visited and the ecosystem. Tourism and immigration may constitute an interface for mixing different genetic and ecological profiles, as well as cultural and social aspects, which is of particular interest in regard to zoonoses. Primary prevention, epidemiological surveillance and health education in the framework of intersectoral and international collaboration remain the cornerstone for response to and control of zoonoses in the context of tourism and immigration.</text>
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                <text>2008</text>
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                <text>disease, Health, immigration, Public Health, tourism, travel, zoonosis</text>
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                <text>Veterinaria Italiana</text>
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            <name>Publisher</name>
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                <text>Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale</text>
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                <text>Veterinary medicine, Animal culture</text>
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