7 10 20655 https://www.socictopen.socict.org/files/original/d90edfbca17d591a3559434d9e0dd21c.pdf d2b5c7967fa06841cd367cc69a1d1835 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Nursing Education Curriculum and Learning Outcomes Creator An entity primarily responsible for making the resource Özlem İbrahimoğlu, Sevinç MERSİN, Hülya SARAY KILIÇ Description An account of the resource The main aim of education in nursing schools is to develop critical thinking skills and psychomotor abilities with universal ethical values so that students can present nursing care to healthy and patient’s individuals and their families. Because of the multidimensional of care, the curriculum should be developed by evaluating learning outcomes so that nurses can improve their individual caregiving capabilities. It seems that the nursing education curriculum has been trying to establish a standard for many years. In this study, nursing education curriculum and learning outcomes were emphasized in order to contribute positively to the nursing education and the graduated student profile. Learning outcomes include knowledge, attitudes, and skills that a student must have at the end of the learning process. These outputs are the skills of the cognitive, affective/psychosocial and psychomotor domains planned for each course at the end of the training. Cognitive learning consists of knowledge, understanding, practice, analysis, synthesis and evaluation steps. Teaching basic concepts in this learning is the first step. Affective/psychosocial learning contains feelings. Positive and negative emotions, attitudes, values, information, personal and social characteristics that the individual possesses are evaluated within this learning. Psychomotor learning focuses on physical skills involving the coordination of brain functions and muscle movements. In order to reach the learning objectives determined during the completion of nursing education, learning outcomes are added to the curriculum. Thus, it is assumed that cognitive, affective/ psychosocial and psychomotor learning outcomes in the curriculum have been achieved. It will be possible to increase the quality of nursing education by evaluating the learning outcomes of the curriculum in addition to the studies aimed at developing the nursing curriculum. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Nursing education, Learning Outcomes, Nursing Curriculum Identifier An unambiguous reference to the resource within a given context DOI: 10.5961/jhes.2019.305 Source A related resource from which the described resource is derived Yükseköğretim ve Bilim Dergisi Publisher An entity responsible for making the resource available Bülent Ecevit University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Education, Education (General) Language A language of the resource EN, TR https://www.socictopen.socict.org/files/original/3437e45691c55349f55511a632f97dba.pdf baf10c426f4261c126c75efd3731ab26 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Nucleocapsid gene analysis from an imported case of Middle East respiratory syndrome coronavirus, Malaysia Creator An entity primarily responsible for making the resource Nor Aziyah Mat-Rahim, Tengku Rogayah Tengku Abdul Rashid, Jeyanthi Suppiah, Ravindran Thayan, Apandi Mohd Yusof, Zainah Sa’at Description An account of the resource Objective: To describe the complete nucleocapsid (N) gene region of Middle East respiratorysyndrome coronavirus (MERS-CoV) from imported case in Malaysia and the relations withhuman- and camel-derived MERS-CoV.Methods: Combination of throat and nasal swab specimens was subjected to viral RNAextraction. For screening, the extracted RNA was subjected to real-time RT-PCR targetingupstream of E gene, open reading frame 1b and open reading frame 1a. For confirmation,the RNA was subjected to RT-PCR targeting partial part of the RNA-dependent RNApolymerase and nucleocapsid, followed by amplification of complete N gene region.Nucleotide sequencing of the first Malaysian case of MERS-CoV was performed following theconfirmation with real-time RT-PCR detection.Results: Initial analysis of partial RNA-dependent RNA polymerase and N gene revealedthat the nucleotides had high similarity to Jeddah_1_2013 strain. Analysis of complete Ngene region (1 242 nucleotides) from the case showed high similarity and yet distinct to thenucleotide sequences of camel-derived MERS-CoV.Conclusions: From the finding, there are possibilities that the patient acquired the infectionfrom zoonotic transmission from dromedary camels. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource Middle East respiratory syndrome, coronavirus, imported case, Malaysia, nucleocapsid gene, Dromedary camels Identifier An unambiguous reference to the resource within a given context DOI: 10.1016/S2222-1808(15)60833-7 Source A related resource from which the described resource is derived Asian Pacific Journal of Tropical Disease Publisher An entity responsible for making the resource available Asian Pacific Journal of Tropical Disease Editorial Office Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Arctic medicine. Tropical medicine, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/5c78ca5b3530cd8658c9b053c3001818.pdf 59f3e044d1d390c3bc9171f737dc30d4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mental health status of people isolated due to Middle East Respiratory Syndrome Creator An entity primarily responsible for making the resource Hyunsuk Jeong, Hyeon Woo Yim, Yeong Jun Song, Moran Ki, Jung Ah Min, Juhee Cho, Jeong-Ho Chae Description An account of the resource OBJECTIVES Isolation due to the management of infectious diseases is thought to affect mental health, but the effects are still unknown. We examined the prevalence of anxiety symptoms and anger in persons isolated during the Middle East Respiratory Syndrome (MERS) epidemic both at isolation period and at four to six months after release from isolation. We also determined risk factors associated with these symptoms at four to six months. METHODS Of 14,992 individuals isolated for 2-week due to having contact with MERS patients in 2015, when MERS was introduced to Korea, 1,692 individuals were included in this study. Anxiety symptoms were evaluated with the Generalized Anxiety Disorder 7-item scale and anger was assessed with the State-Trait Anger Expression Inventory at four to six months after release from isolation for MERS. RESULTS Of 1,692 who came in contact with MERS patients, 1,656 were not diagnosed with MERS. Among 1,656, anxiety symptoms showed 7.6% (95% confidence interval [CI], 6.3 to 8.9%) and feelings of anger were present in 16.6% (95% CI, 14.8 to 18.4%) during the isolation period. At four to six months after release from isolation, anxiety symptoms were observed in 3.0% (95%CI, 2.2 to 3.9%). Feelings of anger were present in 6.4% (95% CI, 5.2 to 7.6%). Risk factors for experiencing anxiety symptoms and anger at four to six months after release included symptoms related to MERS during isolation, inadequate supplies (food, clothes, accommodation), social networking activities (email, text, Internet), history of psychiatric illnesses, and financial loss. CONCLUSIONS Mental health problems at four to six month after release from isolation might be prevented by providing mental health support to individuals with vulnerable mental health, and providing accurate information as well as appropriate supplies, including food, clothes, and accommodation. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Middle East respiratory syndrome coronavirus, isolation, Anxiety, Anger, Korea Identifier An unambiguous reference to the resource within a given context DOI: 10.4178/epih.e2016048 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/d45ff07cd5498382c5760a62e12fbd9a.pdf d8f4bc50f2fe0e80d44a6f69d054afa2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Do Microorganisms Have a Role in Neuropsychiatric Diseases? Creator An entity primarily responsible for making the resource Pelin Yuksel, Bekir Kocazeybek Description An account of the resource The importance of enviromental factors in the development of psychiatric diseases are well known. Accordingly, it is important to investigate the role of infections in neuropsychiatric disorders. The infectious hypothesis, which is particularly strong for schizophrenia, is based more on scientific clinical observations and retrospective cohort seroepidemiological studies rather than specific pathological findings at the molecular level. Research in this field has focused on identifying an infectious etiopathology for three neuropsychiatric diseases. In schizophrenia a strong association has been found between Toxoplasma gondii infection and disease. However, additional infectious agents like Borna disease vırus, herpes simplex virus types 1 and 2, measles, influenza, other respiratory viruses, Coronaviruses, human endogenous retrovırus, West Nile viruses, cytomegalovirus, are also proposed to play a role in the etiopathogenesis in this disease. A similar association between bipolar disorder and viruses/other infectious agents has been reported. This work has mainly concentrated on T. gondii and the members of the Herpesviridae family, herpes simplex virus type 1 and cytomegalovirus. A few reports in the literature have also found a relationship between major depression and human endogenous retroviruses. In conclusion, when investigating the relationship between neuropsychiatric diseases (e.g. schizophrenia, bipolar disorder, major depression) and infection, we suggest that a series of prospective long-term studies with large cohorts are necessary to unravel the etiology of these disorders. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource Schizopherina, Bipolar disorder, major depression, infectious agents Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Publisher An entity responsible for making the resource available Bilimsel Tip Yayinevi Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Microbiology Language A language of the resource EN, TR https://www.socictopen.socict.org/files/original/0aca3c54085b640cf85cbd986a91b552.pdf 420b432e3b3b8ed1b2d2428e4c9aa7d7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epidemiology of Japanese encephalitis in the Philippines: a systematic review. Creator An entity primarily responsible for making the resource Anna Lena Lopez, Josephine G. Aldaba, Vito G Roque, Amado O Tandoc, Ava Kristy Sy, Fe Esperanza Espino, Maricel DeQuiroz-Castro, Youngmee Jee, Maria Joyce Ducusin, Kimberley K Fox Description An account of the resource BACKGROUND:Japanese encephalitis virus (JEV) is an important cause of encephalitis in most of Asia, with high case fatality rates and often significant neurologic sequelae among survivors. The epidemiology of JE in the Philippines is not well defined. To support consideration of JE vaccine for introduction into the national schedule in the Philippines, we conducted a systematic literature review and summarized JE surveillance data from 2011 to 2014. METHODS:We conducted searches on Japanese encephalitis and the Philippines in four databases and one library. Data from acute encephalitis syndrome (AES) and JE surveillance and from the national reference laboratory from January 2011 to March 2014 were tabulated and mapped. RESULTS:We identified 29 published reports and presentations on JE in the Philippines, including 5 serologic surveys, 18 reports of clinical cases, and 8 animal studies (including two with both clinical cases and animal data). The 18 clinical studies reported 257 cases of laboratory-confirmed JE from 1972 to 2013. JE virus (JEV) was the causative agent in 7% to 18% of cases of clinical meningitis and encephalitis combined, and 16% to 40% of clinical encephalitis cases. JE predominantly affected children under 15 years of age and 6% to 7% of cases resulted in death. Surveillance data from January 2011 to March 2014 identified 73 (15%) laboratory-confirmed JE cases out of 497 cases tested. SUMMARY:This comprehensive review demonstrates the endemicity and extensive geographic range of JE in the Philippines, and supports the use of JE vaccine in the country. Continued and improved surveillance with laboratory confirmation is needed to systematically quantify the burden of JE, to provide information that can guide prioritization of high risk areas in the country and determination of appropriate age and schedule of vaccine introduction, and to measure the impact of preventive measures including immunization against this important public health threat. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pntd.0003630 Source A related resource from which the described resource is derived PLoS Neglected Tropical Diseases Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Arctic medicine. Tropical medicine, Public aspects of medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/f20c56ceb32fd91203c0a6c620fc9d2b.pdf cf692d593d937b246a47540963354e15 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Comparative pathogenesis of three human and zoonotic SARS-CoV strains in cynomolgus macaques. Creator An entity primarily responsible for making the resource Barry Rockx, Friederike Feldmann, Douglas Brining, Don Gardner, Rachel LaCasse, Lisa Kercher, Dan Long, Rebecca Rosenke, Kimmo Virtaneva, Daniel E. Sturdevant, Stephen F. Porcella, John Mattoon, Michael Parnell, Ralph S. Baric, Heinz Feldmann Description An account of the resource The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathogen that entered the human population through an intermediate host like the palm civet. To prevent future introductions of zoonotic SARS-CoV strains and subsequent transmission into the human population, heterologous disease models are needed to test the efficacy of vaccines and therapeutics against both late human and zoonotic isolates. Here we show that both human and zoonotic SARS-CoV strains can infect cynomolgus macaques and resulted in radiological as well as histopathological changes similar to those seen in mild human cases. Viral replication was higher in animals infected with a late human phase isolate compared to a zoonotic isolate. While there were significant differences in the number of host genes differentially regulated during the host responses between the three SARS-CoV strains, the top pathways and functions were similar and only apparent early during infection with the majority of genes associated with interferon signaling pathways. This study characterizes critical disease models in the evaluation and licensure of therapeutic strategies against SARS-CoV for human use. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0018558 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/e5a51d09a7089d306f2f885df5c6323b.pdf abbfb0d776766e638b84d50ba2b857e0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource BEST: improved prediction of B-cell epitopes from antigen sequences. Creator An entity primarily responsible for making the resource Jianzhao Gao, Eshel Faraggi, Yaoqi Zhou, Jishou Ruan, Lukasz Kurgan Description An account of the resource Accurate identification of immunogenic regions in a given antigen chain is a difficult and actively pursued problem. Although accurate predictors for T-cell epitopes are already in place, the prediction of the B-cell epitopes requires further research. We overview the available approaches for the prediction of B-cell epitopes and propose a novel and accurate sequence-based solution. Our BEST (B-cell Epitope prediction using Support vector machine Tool) method predicts epitopes from antigen sequences, in contrast to some method that predict only from short sequence fragments, using a new architecture based on averaging selected scores generated from sliding 20-mers by a Support Vector Machine (SVM). The SVM predictor utilizes a comprehensive and custom designed set of inputs generated by combining information derived from the chain, sequence conservation, similarity to known (training) epitopes, and predicted secondary structure and relative solvent accessibility. Empirical evaluation on benchmark datasets demonstrates that BEST outperforms several modern sequence-based B-cell epitope predictors including ABCPred, method by Chen et al. (2007), BCPred, COBEpro, BayesB, and CBTOPE, when considering the predictions from antigen chains and from the chain fragments. Our method obtains a cross-validated area under the receiver operating characteristic curve (AUC) for the fragment-based prediction at 0.81 and 0.85, depending on the dataset. The AUCs of BEST on the benchmark sets of full antigen chains equal 0.57 and 0.6, which is significantly and slightly better than the next best method we tested. We also present case studies to contrast the propensity profiles generated by BEST and several other methods. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0040104 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/38f95c6f9ba048d5b704ed64b310827c.pdf ad40e3cda76d5f01014ab82776b4c957 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A new species of Parategastes Sars, 1904 from the Thale Noi Lake, southern Thailand (Copepoda, Harpacticoida, Tegastidae) Creator An entity primarily responsible for making the resource Thanida Saetang, Supiyanit Maiphae Description An account of the resource Parategastes pholpunthini sp. n. is described and illustrated based on material collected in the Thale Noi Lake, Phatthalung province, southern Thailand. This species can be distinguished from its congeners by the number segments of female antennule, the lengths of rami and basis of P1, the shape of middle inner seta of P4 exp-3, shape of P5, and relative lengths of spine at apically of baseoendopod of P5. The differences among Parategastes species are pointed out and they are compared with the new species. An identification key to species of the genus Parategastes are proposed. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Identifier An unambiguous reference to the resource within a given context DOI: 10.3897/zse.91.5283 Source A related resource from which the described resource is derived Zoosystematics and Evolution Publisher An entity responsible for making the resource available Pensoft Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/dc2e2506e79b8a2c21ed9d8ac03fe039.pdf c6d58b6e84f1e46b9b250b5d6f9aa647 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis Creator An entity primarily responsible for making the resource Jung Sook Yeom, Chung Mo Koo, Ji Sook Park, Ji Hyun Seo, Eun-Sil Park, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn Description An account of the resource We report the case of a 12-year-old girl who had mild encephalopathy with a reversible splenial lesion (MERS) associated with acutepyelonephritis caused by Escherichia coli. The patient was admitted with a high fever, and she was diagnosed with acute pyelonephritis based on pyuria and the results of urine culture, which detected cefotaxime-sensitive E. coli. Although intravenous cefotaxime and tobramycin were administered, her fever persisted and her C-reactive protein level increased to 307 mg/L. On day 3 of admission, she demonstrated abnormal neuropsychiatric symptoms, such as delirium, ataxia, and word salad. Magnetic resonance imaging (MRI) of the brain performed on day 4 showed marked hyperintensities in the bilateral corpus callosum and deep white matter on diffusion-weighted images, with corresponding diffusion restriction on apparent diffusion coefficient mapping. No abnormalities or pathogens were detected in the cerebrospinal fluid; however, lipopolysaccharides (LPS, endotoxin) were detected in plasma (41.6 pg/mL), associated with acute neurological deterioration. Her clinical condition gradually improved, and no neurological abnormalities were observed on day 6. Follow-up brain MRI performed 2 weeks later showed near-disappearance of the previously noted hyperintense lesions. In this patient, we first proved endotoxemia in a setting of MERS. The release of LPS following antibiotic administration might be related to the development of MERS in this patient. The possibility of MERS should be considered in patients who present with acute pyelonephritis and demonstrate delirious behavior. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource encephalopathy, Corpus Callosum, White Matter, Pyelonephritis Identifier An unambiguous reference to the resource within a given context DOI: 10.3345/kjp.2018.61.2.64 Source A related resource from which the described resource is derived Korean Journal of Pediatrics Publisher An entity responsible for making the resource available Korean Pediatric Society Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics Language A language of the resource EN https://www.socictopen.socict.org/files/original/b0cd2e5486b4ffd51c1c1d45370b89cb.pdf bc1d667bea3a199498e3e602089554ea Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus Polyadenylation. Creator An entity primarily responsible for making the resource Yu-Hui Peng, Ching-Houng Lin, Chao-Nan Lin, Chen-Yu Lo, Tsung-Lin Tsai, Hung-Yi Wu Description An account of the resource Similar to eukaryotic mRNA, the positive-strand coronavirus genome of ~30 kilobases is 5'-capped and 3'-polyadenylated. It has been demonstrated that the length of the coronaviral poly(A) tail is not static but regulated during infection; however, little is known regarding the factors involved in coronaviral polyadenylation and its regulation. Here, we show that during infection, the level of coronavirus poly(A) tail lengthening depends on the initial length upon infection and that the minimum length to initiate lengthening may lie between 5 and 9 nucleotides. By mutagenesis analysis, it was found that (i) the hexamer AGUAAA and poly(A) tail are two important elements responsible for synthesis of the coronavirus poly(A) tail and may function in concert to accomplish polyadenylation and (ii) the function of the hexamer AGUAAA in coronaviral polyadenylation is position dependent. Based on these findings, we propose a process for how the coronaviral poly(A) tail is synthesized and undergoes variation. Our results provide the first genetic evidence to gain insight into coronaviral polyadenylation. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0165077 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN