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A Minimally Replicative Vaccine Protects Vaccinated Piglets Against Challenge With the Porcine Epidemic Diarrhea Virus
Porcine epidemic diarrhea virus (PEDV), is an economically important enteric coronavirus, with over a 90% mortality rate in neonatal piglets. The virus emerged in the US in 2013, resulting in severe production losses. Effective vaccine development…
Position: 4642 (36 views)
Nucleic Acid Sandwich Hybridization Assay with Quantum Dot-Induced Fluorescence Resonance Energy Transfer for Pathogen Detection
This paper reports a nucleic acid sandwich hybridization assay with a quantum dot (QD)-induced fluorescence resonance energy transfer (FRET) reporter system. Two label-free hemagglutinin H5 sequences (60-mer DNA and 630-nt cDNA fragment) of avian…
Position: 9551 (26 views)
Sensitivity and Limitation in Damage Detection for Individual Buildings Using InSAR Coherence—A Case Study in 2016 Kumamoto Earthquakes
In this paper, evaluation results are presented for multi-temporal interferometric coherence analysis using a Synthetic Aperture Radar (SAR) for damage assessment in an urban area. The latest space-borne SARs potentially have a high enough spatial…
Position: 6435 (31 views)
Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
Abstract Background It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the angiotensin converting…
Position: 16140 (19 views)
A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan
Abstract Background The 2002-2003 Severe Acute Respiratory Syndrome (SARS) outbreak infected 8,422 individuals leading to 916 deaths around the world. However, there have been few epidemiological studies of SARS comparing epidemiologic features…
Position: 12165 (23 views)
Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study
Abstract Background Host genetic factors may play a role in susceptibility and resistance to SARS associated coronavirus (SARS-CoV) infection. The study was carried out to investigate the association between the genetic polymorphisms of…
Position: 12165 (23 views)
The immune gene repertoire of an important viral reservoir, the Australian black flying fox
Abstract Background Bats are the natural reservoir host for a range of emerging and re-emerging viruses, including SARS-like coronaviruses, Ebola viruses, henipaviruses and Rabies viruses. However, the mechanisms responsible for the control of viral…
Position: 14151 (21 views)
Molecular patterning during the development of Phoronopsis harmeri reveals similarities to rhynchonelliform brachiopods
Abstract Background Phoronids, rhynchonelliform and linguliform brachiopods show striking similarities in their embryonic fate maps, in particular in their axis specification and regionalization. However, although brachiopod development has been…
Position: 10333 (25 views)
iEnhancer-ECNN: identifying enhancers and their strength using ensembles of convolutional neural networks
Abstract Background Enhancers are non-coding DNA fragments which are crucial in gene regulation (e.g. transcription and translation). Having high locational variation and free scattering in 98% of non-encoding genomes, enhancer identification is,…
Position: 10333 (25 views)
Coronavirus envelope protein: current knowledge
Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to be capable of infecting humans as well. The outbreak of severe acute respiratory syndrome (SARS) in 2003…
Position: 12165 (23 views)