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Elicitation of broadly neutralizing antibodies against HIV-1 – the germline/maturation hypothesis
We have previously observed that all known broadly neutralizing antibodies (bnAbs) against HIV-1 are highly divergent from their putative germline predecessors in contrast to bnAbs against henipaviruses and SARS coronavirus, which are much less…
Position: 9241 (17 views)
The Coronavirus Nucleocapsid Is a Multifunctional Protein
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and…
Position: 6583 (19 views)
Synthesis and Antiviral Activity of Novel 1,4-Pentadien-3-one Derivatives Containing a 1,3,4-Thiadiazole Moiety
1,4-Pentadien-3-one derivatives derived from curcumin possess excellent inhibitory activity against plant viruses. On the basis of this finding, a series of novel 1,4-pentadien-3-one derivatives containing a 1,3,4-thiadiazole moiety were designed and…
Position: 4628 (21 views)
MERS may not be SARS; but India is still vulnerable
Position: 5530 (20 views)
Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution…
Position: 2755 (24 views)
Aptamers in Diagnostics and Treatment of Viral Infections
Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have been conducted through the process known as SELEX (Systematic…
Position: 7825 (18 views)
Slopes of Avian Species-Area Relationships, Human Population Density, and Environmental Factors
There is increasing interest in how humans influence spatial patterns in biodiversity. One of the most frequently noted and marked of these patterns is the increase in species richness with area, the species-area relationship (SAR). SARs are used for…
Position: 5530 (20 views)
The CD8 T Cell Response to Respiratory Virus Infections
Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and parainfluenza virus. While some viruses simply cause symptoms of the…
Position: 635 (36 views)
Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test
Meng-Yuan Dai,1 Jin-Ping Qiao,2 Yuan-Hong Xu,2 Guang-He Fei1 1Pulmonary Department, 2Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic ofChina Purpose: To investigate the…
Position: 9241 (17 views)
A Conceptual Framework to use Remediation of Errors Based on Multiple External Remediation Applied to Learning Objects
This paper presents the application of some concepts of Intelligent Tutoring Systems (ITS) to elaborate a conceptual framework that uses the remediation of errors with Multiple External Representations (MERs) in Learning Objects (LO). To this is…
Position: 6583 (19 views)