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RNase L mediated protection from virus induced demyelination.
IFN-alpha/beta plays a critical role in limiting viral spread, restricting viral tropism and protecting mice from neurotropic coronavirus infection. However, the IFN-alpha/beta dependent mechanisms underlying innate anti-viral functions within the…
Position: 10210 (25 views)
A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations.
Human Endogenous Retrovirus type K (HERV-K) is the only HERV known to be insertionally polymorphic; not all individuals have a retrovirus at a specific genomic location. It is possible that HERV-Ks contribute to human disease because people differ in…
Position: 7999 (28 views)
Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.
For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived…
Position: 6306 (31 views)
Systematics and molecular phylogeny of the family oscarellidae (homoscleromorpha) with description of two new oscarella species.
The family Oscarellidae is one of the two families in the class Homoscleromorpha (phylum Porifera) and is characterized by the absence of a skeleton and the presence of a specific mitochondrial gene, tatC. This family currently encompasses sponges in…
Position: 15127 (20 views)
Prevalence and genetic diversity analysis of human coronavirus OC43 among adult patients with acute respiratory infections in Beijing, 2012.
To determine the prevalence, epidemiology and genetic diversity of human coronavirus OC43 (HCoV-OC43) among adult patients with acute respiratory infections (ARI) in Beijing,five hundred and fifty-nine nasopharyngeal swab samples were collected from…
Position: 16982 (18 views)
Species-area relationships are controlled by species traits.
The species-area relationship (SAR) is one of the most thoroughly investigated empirical relationships in ecology. Two theories have been proposed to explain SARs: classical island biogeography theory and niche theory. Classical island biogeography…
Position: 13022 (22 views)
A leaderless genome identified during persistent bovine coronavirus infection is associated with attenuation of gene expression.
The establishment of persistent viral infection is often associated with the selection of one or more mutant viruses. For example, it has been found that an intraleader open reading frame (ORF) in genomic and subgenomic mRNA (sgmRNA) molecules is…
Position: 8690 (27 views)
Viral etiology of acute respiratory infection in Gansu Province, China, 2011.
BACKGROUND: Acute respiratory infections (ARIs) are the leading cause of children and their leading killer. ARIs are responsible for at least six percent of the world's disability and death. Viruses are one of the most common agents causing ARIs. Few…
Position: 7346 (29 views)
Comparative in vivo analysis of recombinant type II feline coronaviruses with truncated and completed ORF3 region.
Our previous in vitro comparative study on a feline coronavirus (FCoV) pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II…
Position: 2260 (48 views)
ARCHAEOLOGICAL SURVEYS ON THE GERMAN NORTH SEA COAST USING HIGH-RESOLUTION SYNTHETIC APERTURE RADAR DATA
We show that high-resolution space-borne Synthetic Aperture Radar (SAR) imagery with pixel sizes well below 1 m2 can be used to complement archaeological surveys in areas that are difficult to access. After major storm surges in the 14th and…
Position: 10210 (25 views)