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                <text>DOI: 10.1371/journal.pone.0230183</text>
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                <text>DOI: 10.13181/mji.ed.204615</text>
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                <text>Faculty of Medicine Universitas Indonesia</text>
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                <text>Severe acute respiratory syndrome corona virus 2 (SARS CoV2) is responsible for corona virus disease (COVID-19). Many organizations have given guidelines for the prevention of COVID-19. Other societies have given updates regarding living and deceased donor transplantation during the pandemic. This article reviews the literature available on corona virus and its impact on living and deceased donor transplantation.</text>
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                <text>DOI: 10.4103/ijot.ijot_21_20</text>
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                <text>Aktualʹnaâ Infektologiâ</text>
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                <text>A vision of the use of technology in medical education after the COVID-19 pandemic</text>
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                <text>Poh Sun  Goh, John Sandars</text>
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                <text>Medical education across the world has experienced a major disruptive change as a consequence of the COVID-19 pandemic and technology has been rapidly and innovatively used to maintain teaching and learning. The future of medical education is uncertain after the pandemic resolves but several potential future scenarios are discussed to inform current decision-making about the future provision of teaching and learning.  The use of emergent technology for education, such as artificial intelligence for adaptive learning and virtual reality, are highly likely to be essential components of the transformative change and the future of medical education. The benefits and challenges of the use of technology in medical education are discussed with the intention of informing all providers on how the changes after the pandemic can have a positive impact on both educators and students across the world.</text>
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                <text>technology, Medical Education, transformative change, coronavirus, COVID-19</text>
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                <text>Association for Medical Education in Europe (AMEE)</text>
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                <text>Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.</text>
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                <text>Sarah R. Leist, Kara L Jensen, Ralph S. Baric, Timothy P. Sheahan</text>
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                <text>Newly emerging viral pathogens pose a constant and unpredictable threat to human and animal health. Coronaviruses (CoVs) have a penchant for sudden emergence, as evidenced by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV) and most recently, swine acute diarrhea syndrome coronavirus (SADS-CoV). Small animal models of emerging viral pathogenesis are crucial to better understand the virus and host factors driving disease progression. However, rodent models are often criticized for their limited translatability to humans. The complete blood count is the most ordered clinical test in the United States serving as the cornerstone of clinical medicine and differential diagnosis. We recently generated a mouse model for MERS-CoV pathogenesis through the humanization of the orthologous entry receptor dipeptidyl peptidase 4 (DPP4). To increase the translatability of this model, we validated and established the use of an automated veterinary hematology analyzer (VetScan HM5) at biosafety level 3 for analysis of peripheral blood. MERS-CoV lung titer peaked 2 days post infection concurrent with lymphopenia and neutrophilia in peripheral blood, two phenomena also observed in MERS-CoV infection of humans. The fluctuations in leukocyte populations measured by Vetscan HM5 were corroborated by standard flow cytometry, thus confirming the utility of this approach. Comparing a sublethal and lethal dose of MERS-CoV in mice, analysis of daily blood draws demonstrates a dose dependent modulation of leukocytes. Major leukocyte populations were modulated before weight loss was observed. Importantly, neutrophil counts on 1dpi were predictive of disease severity with a lethal dose of MERS-CoV highlighting the predictive value of hematology in this model. Taken together, the inclusion of hematological measures in mouse models of emerging viral pathogenesis increases their translatability and should elevate the preclinical evaluation of MERS-CoV therapeutics and vaccines to better mirror the complexity of the human condition.</text>
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                <text>DOI: 10.1371/journal.pone.0220126</text>
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                <text>PLoS ONE</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Science, Medicine</text>
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            <description>A language of the resource</description>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <description>A name given to the resource</description>
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                <text>How to risk-stratify elective surgery during the COVID-19 pandemic?</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Philip F. Stahel</text>
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                <text>coronavirus, COVID-19, resource utilization, emergency preparedness, Elective surgery</text>
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            <name>Identifier</name>
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                <text>DOI: 10.1186/s13037-020-00235-9</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Patient Safety in Surgery</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>BMC</text>
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                <text>Surgery</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation.</text>
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            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="14217">
                <text>Máté Pálfy, Gunnar Schulze, Eivind Valen, Nadine L Vastenhouw</text>
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            <description>An account of the resource</description>
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                <text>In many organisms, early embryonic development is driven by maternally provided factors until the controlled onset of transcription during zygotic genome activation. The regulation of chromatin accessibility and its relationship to gene activity during this transition remain poorly understood. Here, we generated chromatin accessibility maps with ATAC-seq from genome activation until the onset of lineage specification. During this period, chromatin accessibility increases at regulatory elements. This increase is independent of RNA polymerase II-mediated transcription, with the exception of the hypertranscribed miR-430 locus. Instead, accessibility often precedes the transcription of associated genes. Loss of the maternal transcription factors Pou5f3, Sox19b, and Nanog, which are known to be required for zebrafish genome activation, results in decreased accessibility at regulatory elements. Importantly, the accessibility of regulatory regions, especially when established by Pou5f3, Sox19b and Nanog, is predictive for future transcription. Our results show that the maternally provided transcription factors Pou5f3, Sox19b, and Nanog open up chromatin and prime genes for activity during zygotic genome activation in zebrafish.</text>
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                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.1371/journal.pgen.1008546</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="14221">
                <text>PLoS Genetics</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="14222">
                <text>Public Library of Science (PLoS)</text>
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                <text>Genetics</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
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                <text>COVID-19: An International Public Health Concern</text>
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                <text>Israel Oluwasegun Ayenigbara</text>
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            <description>An account of the resource</description>
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                <text>This review presents a synopsis on the current COVID-19 pandemic, with focus on preventive measures. COVID-19 is a new viral infection, and is in form of a positive-sense, single-stranded RNA Coronavirus which belongs to an expanded group of viruses which were identified six decades ago. Importantly, the new COVID-19 belongs to the group of SARS-CoV, and it originated in bats but infected humans through smuggled pangolins. At first, the mode of transmission of infection was animal-to-person, but person-to-person and community transmission of the virus has been confirmed in many parts of the world. With an incubation period of between two-fourteen days, signs and symptoms of infection are mild to high respiratory illness; characterized with cough, breathing problems (shortness of breath), high temperature (Fever), tiredness (Fatigue) and nausea. Presently, no vaccines or specific treatment is available for COVID-19, in light of the aforementioned; prevention is the only substantial and less expensive option. With the envisaged explosive community transmission of COVID-19 in the coming weeks in places with limited daily testing, especially in African countries, it is recommended among many that social distancing which includes avoiding any form of contact with people; either through greetings, hugging or shaking of hands and large gatherings, avoid contact with animal items, dead or alive animals, sick and dead people from areas experiencing COVID-19 epidemic, and basic hygienic practices like thorough washing of hands with clean water and antiseptic soap for the duration of at least twenty seconds should be practiced always. However, in the absence of the aforementioned, an alcohol-based hand gel should be used on the hands frequently. Furthermore, health care workers should adhere strictly to the standard preventive measures in areas of heightened COVID-19 epidemic.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>covid-19 infection, Reservoir of infection, mode of transmission, signs and symptoms, preventive measures</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.5195/cajgh.2020.466</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="14231">
                <text>Central Asian Journal of Global Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="14232">
                <text>University Library System, University of Pittsburgh</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Public aspects of medicine</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <name>Title</name>
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                <text>Treatment of COVID-19: old tricks for new challenges</text>
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                <text>Anne Catherine Cunningham, Hui Poh Goh, David Koh</text>
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                <text>DOI: 10.1186/s13054-020-2818-6</text>
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                <text>Critical Care</text>
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                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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            <description>A language of the resource</description>
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