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Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design
The worldwide pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unprecedented and the impact on public health and the global economy continues to be devastating. Although early therapies such as prophylactic…
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Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical…
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Identification of potential antiviral compounds against SARS-CoV-2 structural and non structural protein targets: A pharmacoinformatics study of the CAS COVID-19 dataset.
SARS-CoV-2 is a newly discovered virus which causes COVID-19 (coronavirus disease of 2019), initially documented as a human pathogen in 2019 in the city of Wuhan China, has now quickly spread across the globe with an urgency to develop effective…
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La economía política de la seguridad alimentaria en comunidades mapuche de la Araucanía- Chile
El presente artículo pretende analizar el impacto de las políticas macroeconímocas e indigenas de la Concertación en la seguridad alimentaria familiar en unas comunidades mapuches del sector Ayjarewe de Xuf-Xuf. Con este propósito el autor reseña las…
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Mechanics and Economics of a Negative Pressure Pulmonary Function Lab in the COVID-19 Era.
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SARS-CoV-2 vaccination and phase 1 cancer clinical trials.
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Planejamento de produção através do método de Monte Carlo para agricultura familiar
A agricultura familiar constitui o elo mais fraco da cadeia por não possuir uma profissionalização no que tange aos aspectos gerenciais. O planejamento, o conhecimento do Sistema Produtivo como um todo e a transmissão destes para ferramentas de…
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COVID-19-related collapsing glomerulopathy revealing a rare risk variant of APOL1: lessons for the clinical nephrologist.
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Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
The humoral immune response to SARS-CoV-2 infection is not yet fully understood. Here, Marot et al. monitor the longitudinal profile and neutralizing activity of IgG, IgA, and IgM among 26 healthcare workers and provide evidence for a short-lasting…
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Students under lockdown: Comparisons of students' social networks and mental health before and during the COVID-19 crisis in Switzerland.
This study investigates students' social networks and mental health before and at the time of the COVID-19 pandemic in April 2020, using longitudinal data collected since 2018. We analyze change on multiple dimensions of social networks (interaction,…
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