103 10 20655 https://www.socictopen.socict.org/files/original/f157b88fd6c7367f96995c9cd3f275f1.pdf c16d773aadf8cbff5c465251188a2203 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Preventive Behavioral Responses to the 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in Korea Creator An entity primarily responsible for making the resource Won Mo Jang, Sang Hyun Cho, Deok Hyun Jang, Un-Na Kim, Hyemin Jung, Jin Yong Lee, Sang Jun Eun Description An account of the resource This study examined the public’s preventive behavioral responses during the 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Korea and the influencing factors. Two cross-sectional telephone surveys were conducted by Gallup Korea using random digit dialing in June 2015 (n = 2004). The main outcome variables were nonpharmaceutical preventive measures (survey (1): Measures for reducing transmission (handwashing, face masks); and survey (2): Measures for avoiding contact with others). Multiple logistic regression was used to identify the factors influencing preventive behaviors. In survey (1), 60.3% of respondents reported more frequent handwashing and 15.5% reported wearing face masks at least once due to the MERS-CoV epidemic. In survey (2), 41−56% of respondents reported practicing avoidance measures. The concerned group was more likely to practice reducing transmission measures (odds ratio (OR) 4.5; 95% confidence interval (CI) 3.3−6.1) and avoidance measures (OR = 9.6; 95% CI, 6.4−14.4). The respondents who had low trust in president or ruling party had a higher practice rate of reducing transmission measures (OR = 1.7; 95% CI, 1.2−2.6) and avoidance measures (OR = 2.1; 95% CI, 1.2−3.5). Cooperative prevention measures need appropriated public concern based on effective risk communication. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Middle East respiratory syndrome coronavirus, disease prevention and control, Disease Outbreaks, health survey Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijerph16122161 Source A related resource from which the described resource is derived International Journal of Environmental Research and Public Health Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/eeb81edd9d957867b1086ed350137cfd.pdf 662e3be13e92909dcab93d136ab53186 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Middle East Respiratory Syndrome Coronavirus and the Upcoming Hajj Creator An entity primarily responsible for making the resource EK Shuman Description An account of the resource [No abstract available] Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource Hajj, Mass gathering, Epidemiology, coronavirus Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived The International Journal of Occupational and Environmental Medicine Publisher An entity responsible for making the resource available National Iranian Oil Company (NIOC) Health Organization Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Industrial medicine. Industrial hygiene Language A language of the resource EN https://www.socictopen.socict.org/files/original/f32a298d37de74a92c6a9199067b0ab8.pdf ea5ceba3d8e9b08410ab50aa4df04a0a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Automated Statistical Methods for Fault Detection in District Heating Customer Installations Creator An entity primarily responsible for making the resource Sara Månsson, Kristin Davidsson, Patrick Lauenburg, Marcus Thern Description An account of the resource In order to develop more sustainable district heating systems, the district heating sector is currently trying to increase the energy efficiency of these systems. One way of doing so is to identify customer installations in the systems that have poor cooling performance. This study aimed to develop an algorithm that was able to detect the poorly performing installations automatically using meter readings from the installations. The algorithm was developed using statistical methods and was tested on a data set consisting of data from 3000 installations located in a district heating system in Sweden. As many as 1273 installations were identified by the algorithm as having poor cooling performance. This clearly shows that it is of major interest to the district heating companies to identify the installations with poor cooling performance rapidly and automatically, in order to rectify them as soon as possible. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource automatic fault detection, district heating, substation performance Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/en12010113 Source A related resource from which the described resource is derived Energies Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Technology Language A language of the resource EN https://www.socictopen.socict.org/files/original/f1115879e879282a29200fc509664b3e.pdf de5f47b31527f24960697360707b0f11 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Profil Leukosit, Diferensial Leukosit, dan Indeks Stres Luwak Jawa (Paradoxurus hermaphroditus) (LEUCOCYTE COUNT, LEUCOCYTE DIFFERENTIATION, AND STRESS INDEX OF COMMON PALM CIVETS (PARADOXURUS HERMAPHRODITUS) Creator An entity primarily responsible for making the resource Aryani Sismin Satyaningtijas, Nastiti Kusumorini, Moh. Mursyid Fachrudin, . Purnomo Description An account of the resource Common palm civets (Paradoxurushermaphroditus) have a potential to be commercial commodityanimal which produce best coffee, parfume, but also as reservoir potential infection desease such as SevereAcute Respiratory Syndrome (SARS). Therefore, their health status is very important. This study wasaimed to discribe the leukocyte profile, and stress index of 4 males Java common pal civets and 4 females.Blood sampling was taken from vena femoralis and done at weeks 1st, 5th, 6th, and 7th. Leukocyte profilewere examined using haemocytometerand blood smear. The average leukocyte count of males and femalescommon palm civets per mm3 were (3.33±0.86)x103 and (2.83±0.70)x103, neutrophil were (1.01±0.47)x103and (0.68±0.30)x103, eosinophil were (0.16±0.18)x103 and (0.04±0.05)x103, lymphocyte were (2.06±0.42)x103and (2.05±0.59)x103, monocyte were (0.09±0.06)x103 and (0.06±0.06)x103. Stress index were (0.49±0.18)for males and (0.37±0.22) for females. Generally, leukocyte count of males Java common palm civet werehigher than those of females. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource Paradoxurushermaphroditus, leukocytes, differentiatial leukocyte, stress index Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Jurnal Veteriner Publisher An entity responsible for making the resource available Universitas Udayana Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN, ID https://www.socictopen.socict.org/files/original/3d2be009c53d2e7c01cb66b501d914ab.pdf 642c8f151b78fa018d925f5bfc87ca9a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evaluating the potential impact of targeted vaccination strategies against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks in the healthcare setting Creator An entity primarily responsible for making the resource Fatima Abdirizak, Rayleen Lewis, Gerardo Chowell Description An account of the resource Abstract Background Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are two coronaviruses with demonstrated potential to generate significant nosocomial outbreaks. In particular, MERS continues to pose a significant threat in the Middle East since 2012. Currently, no licensed vaccine or drug treatment is available to treat patients infected with either coronavirus. However, there are some MERS vaccines in the preclinical stage of development. We sought to evaluate the potential impact of targeted vaccination strategies for mitigating SARS and MERS outbreaks in healthcare settings using simple mathematical models and detailed historic transmission trees describing the progression of past nosocomial outbreaks of SARS and MERS. Results Our findings suggest that vaccination strategies targeting patients and healthcare workers, which have been disproportionately affected during past outbreaks, and assuming two vaccination coverage levels at 50 and 75% have the potential to avert nearly 50% or more of MERS or SARS cases. Conclusion Our modeling results informed by historic outbreak data for SARS and MERS suggest that vaccination strategies targeting patients could be an effective measure to mitigate and prevent outbreaks in the healthcare setting. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS, SARS, coronavirus, nosocomial, Hospital transmission, vaccine Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12976-019-0112-6 Source A related resource from which the described resource is derived Theoretical Biology and Medical Modelling Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Computer applications to medicine. Medical informatics Language A language of the resource EN https://www.socictopen.socict.org/files/original/09f9f45fed544ebc9a155ae1acfeaea6.pdf 3b66778eaff77a1fc52661720c0bae66 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Airflow as a Possible Transmission Route of Middle East Respiratory Syndrome at an Initial Outbreak Hospital in Korea Creator An entity primarily responsible for making the resource Minki Sung, Seongmin Jo, Sang Eun Lee, Moran Ki, Bo Youl Choi, Jin Kwan Hong Description An account of the resource In this study, the results of an airflow investigation conducted on 7 June 2015 as part of a series of epidemiologic investigations at Pyeongtaek St. Mary’s Hospital, South Korea, were investigated. The study involved 38 individuals who were infected directly and indirectly with Middle East Respiratory Syndrome (MERS), by a super-spreader patient. Tracer gas experiments conducted on the eighth floor, where the initial patient was hospitalized, confirmed that the tracer gas spread to adjacent patient rooms and rooms across corridors. In particular, the experiment with an external wind direction and speed similar to those during the hospitalization of the initial patient revealed that the air change rate was 17⁻20 air changes per hour (ACH), with air introduced through the window in the room of the infected patient (room 8104). The tracer gas concentration of room 8110, which was the farthest room, was 7.56% of room 8104, indicating that a high concentration of gas has spread from room 8104 to rooms across the corridor. In contrast, the tracer gas was barely detected in a maternity ward to the south of room 8104, where there was no secondary infected patient. Moreover, MERS is known to spread mainly by droplets through close contact, but long-distance dispersion is probable in certain environments, such as that of a super-spreader patient hospitalized in a room without ventilation, hospitals with a central corridor type, and indoor airflow dispersion due to external wind. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource Middle East respiratory syndrome, infection outbreak, airflow analysis, transmission route, Ventilation, tracer gas Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijerph15122757 Source A related resource from which the described resource is derived International Journal of Environmental Research and Public Health Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/50ed98ea647bd422109788fb52e4f084.pdf a815b90328aa9f25d8b524511801d08b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Cleavage modification did not alter blastomere fates during bryozoan evolution Creator An entity primarily responsible for making the resource Bruno C. Vellutini, José M. Martín-Durán, Andreas Hejnol Description An account of the resource Abstract Background Stereotypic cleavage patterns play a crucial role in cell fate determination by precisely positioning early embryonic blastomeres. Although misplaced cell divisions can alter blastomere fates and cause embryonic defects, cleavage patterns have been modified several times during animal evolution. However, it remains unclear how evolutionary changes in cleavage impact the specification of blastomere fates. Here, we analyze the transition from spiral cleavage – a stereotypic pattern remarkably conserved in many protostomes – to a biradial cleavage pattern, which occurred during the evolution of bryozoans. Results Using 3D-live imaging time-lapse microscopy (4D-microscopy), we characterize the cell lineage, MAPK signaling, and the expression of 16 developmental genes in the bryozoan Membranipora membranacea. We found that the molecular identity and the fates of early bryozoan blastomeres are similar to the putative homologous blastomeres in spiral-cleaving embryos. Conclusions Our work suggests that bryozoans have retained traits of spiral development, such as the early embryonic fate map, despite the evolution of a novel cleavage geometry. These findings provide additional support that stereotypic cleavage patterns can be modified during evolution without major changes to the molecular identity and fate of embryonic blastomeres. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Bryozoa, Cyphonautes, Spiral cleavage, cell lineage, Larva, MAPK Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12915-017-0371-9 Source A related resource from which the described resource is derived BMC Biology Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/469197e26d4ddf9055488bd096005fb4.pdf f6bac082aec89d49e2ea017569e59f84 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits Creator An entity primarily responsible for making the resource W. Widagdo, Nisreen M.A. Okba, Mathilde Richard, Dennis de Meulder, Theo M. Bestebroer, Pascal Lexmond, Elmoubasher A. B. A. Farag, Mohammed Al-Hajri, Koert J. Stittelaar, Leon de Waal, Geert van Amerongen, Judith M.A. van den Brand, Bart L. Haagmans, Sander Herfst Description An account of the resource Middle East respiratory syndrome coronavirus (MERS-CoV) transmission from dromedaries to humans has resulted in major outbreaks in the Middle East. Although some other livestock animal species have been shown to be susceptible to MERS-CoV, it is not fully understood why the spread of the virus in these animal species has not been observed in the field. In this study, we used rabbits to further characterize the transmission potential of MERS-CoV. In line with the presence of MERS-CoV receptor in the rabbit nasal epithelium, high levels of viral RNA were shed from the nose following virus inoculation. However, unlike MERS-CoV-infected dromedaries, these rabbits did not develop clinical manifestations including nasal discharge and did shed only limited amounts of infectious virus from the nose. Consistently, no transmission by contact or airborne routes was observed in rabbits. Our data indicate that despite relatively high viral RNA levels produced, low levels of infectious virus are excreted in the upper respiratory tract of rabbits as compared to dromedary camels, thus resulting in a lack of viral transmission. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS coronavirus, Transmission, rabbits Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11040381 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/48a1f5db27045beecaf113b77bf05798.pdf 872b447328f8e6efb79277e362f69b54 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Presence of Human Bocavirus 1 and other Respiratory Viruses in Children with Lower Respiratory Tract Infection in Latvia Creator An entity primarily responsible for making the resource Vilmane Anda, Ziemele Inga, Rasa Santa, Terentjeva Anna, Murovska Modra, Gardovska Dace, Lin Yung-Cheng, Nora-Krūkle Zaiga Description An account of the resource Lower respiratory tract infection (LRTI) is the major cause of morbidity and mortality of children in the world. In addition to respiratory syncytial virus, influenza virus types A and B, parainfluenza types 1, 2 and 3, and adenoviruses, several new respiratory viruses associated with LRTI were discovered in the 21st century. These are metapneumovirus, coronaviruses NL63 and HKU1, parainfluenza virus type four and human bocavirus one (HBoV1). HBoV1 was discovered in 2005 and is considered as the fourth most prevalent respiratory virus worldwide. However, the high frequency of co-infections detected together with HBoV1 raises doubt about whether HBoV1 is a true pathogen or just a bystander. This is the first study aimed to determine the presence of HBoV1 and 18 other respiratory viruses in nasopharyngeal aspirates (NPA) of children with LRTI in Latvia. Using multiplex real-time polymerase chain reaction method, the HBoV1 genomic sequence was detected in 60.0% of NPA samples, showing that HBoV1 prevalence is high among children with LRTI in Latvia. HBoV1 mono-infection was revealed in 6.67%. The most common co-infections associated with HBoV1 were rhinovirus, adenovirus, respiratory syncytial virus A and B, metapneumovirus, and enterovirus. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource parvovirus, infants, multiplex polymerase chain reaction Identifier An unambiguous reference to the resource within a given context DOI: 10.2478/prolas-2019-0021 Source A related resource from which the described resource is derived Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences Publisher An entity responsible for making the resource available Sciendo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Language A language of the resource EN https://www.socictopen.socict.org/files/original/fda9d04989e4ea5b3912fbf6eabd7829.pdf 8bddff409794c57cc2ee8d395b70856d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombination Creator An entity primarily responsible for making the resource Steven J. van Beurden, Alinda J. Berends, Annika Krämer-Kühl, Dieuwertje Spekreijse, Gilles Chénard, Hans-Christian Philipp, Egbert Mundt, Peter J.M. Rottier, M. Hélène Verheije Description An account of the resource Abstract Background Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens that causes severe economic losses in the poultry industry worldwide. Major advances in the study of the molecular biology of IBV have resulted from the development of reverse genetics systems for the highly attenuated, cell culture-adapted, IBV strain Beaudette. However, most IBV strains, amongst them virulent field isolates, can only be propagated in embryonated chicken eggs, and not in continuous cell lines. Methods We established a reverse genetics system for the IBV strain H52, based on targeted RNA recombination in a two-step process. First, a genomic and a chimeric synthetic, modified IBV RNA were co-transfected into non-susceptible cells to generate a recombinant chimeric murinized (m) IBV intermediate (mIBV). Herein, the genomic part coding for the spike glycoprotein ectodomain was replaced by that of the coronavirus mouse hepatitis virus (MHV), allowing for the selection and propagation of recombinant mIBV in murine cells. In the second step, mIBV was used as the recipient. To this end a recombination with synthetic RNA comprising the 3′-end of the IBV genome was performed by introducing the complete IBV spike gene, allowing for the rescue and selection of candidate recombinants in embryonated chicken eggs. Results Targeted RNA recombination allowed for the modification of the 3′-end of the IBV genome, encoding all structural and accessory genes. A wild-type recombinant IBV was constructed, containing several synonymous marker mutations. The in ovo growth kinetics and in vivo characteristics of the recombinant virus were similar to those of the parental IBV strain H52. Conclusions Targeted RNA recombination allows for the generation of recombinant IBV strains that are not able to infect and propagate in continuous cell lines. The ability to introduce specific mutations holds promise for the development of rationally designed live-attenuated IBV vaccines and for studies into the biology of IBV in general. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource avian coronavirus, infectious bronchitis virus, Mouse hepatitis virus, Targeted RNA recombination, Reverse genetics system, vaccine development Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12985-017-0775-8 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN