1549 10 20655 https://www.socictopen.socict.org/files/original/0ebfdc2b025c9c061aab2e4eb44a924c.pdf beeed70e6c7c30b4b75bd42070cedce2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) Creator An entity primarily responsible for making the resource Paul E Marik, Ruben Manuel Luciano Colunga Biancatelli, John D Catravas, Max Berrill Description An account of the resource Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Flavonoids, vitamin C, quercetin, antiviral, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2020.01451 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/b70d43d8f145a9aa1ea11c4448284481.pdf 1c4a60520d27b068e16ca562df4d32ef Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Membrane–initiated estradiol signaling regulating sexual receptivity Creator An entity primarily responsible for making the resource Paul E. Micevych, Phoebe eDewing Description An account of the resource Estradiol has profound actions on the structure and function of the nervous system. In addition to nuclear actions that directly modulate gene expression, the idea that estradiol can rapidly activate cell signaling by binding to membrane estrogen receptors (mERs) has emerged. Even the regulation of sexual receptivity, an action previously thought to be completely regulated by nuclear ERs, has been shown to have a membrane-initiated estradiol signaling (MIES) component. This highlighted the question of the nature of mERs. Several candidates have been proposed, ERα, ERβ, ER-X, GPR30 (G protein coupled estrogen receptor; GPER), and a receptor activated by a diphenylacrylamide compound, STX. Although each of these receptors has been shown to be active in specific assays, we present evidence for and against their participation in sexual receptivity by acting in the lordosis-regulating circuit. The initial MIES that activates the circuit is in the arcuate nucleus of the hypothalamus (ARH). Using both activation of μ-opioid receptors (MOR) in the medial preoptic nucleus and lordosis behavior, we document that both ERα and the STX receptor participate in the required MIES. ERα and the STX receptor activation of cell signaling are dependent on the transactivation of type 1 metabotropic glutamate receptors (mGluR1a) that augment progesterone synthesis in astrocytes and protein kinase C (PKC) in ARH neurons. While estradiol-induced sexual receptivity does not depend on neuroprogesterone, proceptive behaviors do. Moreover, the ERα and the STX receptor activation of medial preoptic MORs and augmentation of lordosis were sensitive to mGluR1a blockade. These observations suggest a common mechanism through which mERs are coupled to intracellular signaling cascades, not just in regulating reproduction, but in actions throughout the neuraxis including the cortex, hippocampus, striatum and DRGs. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource Cell Signaling, estrogen receptor, Neurosteroids, Lordosis behavior, neuroprogesterone, STX Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fendo.2011.00026 Source A related resource from which the described resource is derived Frontiers in Endocrinology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the endocrine glands. Clinical endocrinology Language A language of the resource EN https://www.socictopen.socict.org/files/original/51121cdfdff82f32099aa467d5d5e133.pdf 72e183cad07027a59487ac865b6449b5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Paediatric research in the times of COVID-19. Creator An entity primarily responsible for making the resource Paul F Fleming, Chris Gale, Eleanor J Molloy, Saul N Faust, Kate Costeloe, Edmund Juszczak, Charles C Roehr Description An account of the resource The COVID-19 pandemic poses many direct and indirect consequences for children's health and associated research. Direct consequences include participation of children in COVID-19 research trials, pausing other research in children and the potential implications of a global economic downturn on future research funding. Collaborative and networked research together with streamlined research processes and use of remote technology have been central to efforts by clinicians and scientists around the world and have proved essential for reducing COVID-19 morbidity and mortality. IMPACT: Maintain streamlined and efficient approaches to research governance and data sharing to facilitate high-quality collaborative research. Ensure early inclusion of children in trials of therapies for diseases that affect all age groups. Paediatric Research Societies should co-ordinate effective processes to define key research questions and develop multinational clinical trials for diagnostics, therapeutics and preventative strategies for infants, children and young people. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1038/s41390-021-01479-6 Source A related resource from which the described resource is derived Pediatric research https://www.socictopen.socict.org/files/original/7ef314902f9a6f48cd3788570f8c32cf.pdf 651530f038fe94a05b2e5c5c437d861a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Varcare la soglia: il digitale nel catalogo, alcune riflessioni Creator An entity primarily responsible for making the resource Paul Gabriele Weston, Agnese Galeffi Description An account of the resource L'esperienza vissuta dalle biblioteche, specie di pubblica lettura, nel periodo del Covid-19 e la lettura di tre libri sul catalogo e la catalogazione hanno messo in luce alcuni limiti nel modo in cui il digitale viene trattato all'interno dei cataloghi. In particolare, appaiono particolarmente contraddittori e causa di disorientamento da parte dei lettori i criteri adottati per segnalare e descrivere le riproduzioni digitali di edizioni cartacee e le edizioni digitali nel pubblico dominio. Fino a oggi ha prevalso il presupposto che una riproduzione digitale abbia le medesime caratteristiche di una fotocopia, di un microfilm o di una microfiche. Nuovi dispositivi software, unitamente alla manipolabilità del digitale, fanno sì che tra la riproduzione analogica e quella elettronica esistano differenze tali da richiedere che quest'ultima venga trattata a fini catalografici in modo assai diverso. Le caratteristiche dell'oggetto digitale meritano di essere descritte allo stesso modo di quelle dell'originale cartaceo, in primo luogo perché hanno conseguenze non banali sul modo in cui il lettore ne può fruire e in secondo luogo perché possono essere esse stesse oggetto di ricerca, eventualmente come elemento filtro nell'impostazione dell'interrogazione. Ulteriore elemento di riflessione sono le conseguenze derivanti dall'evoluzione di dispositivi di rappresentazione volti a favorire la convergenza nel catalogo di risorse di nature anche molto differenti da quella bibliografica con l’obiettivo di fare del catalogo stesso uno degli strumenti per l'organizzazione semantica de web. Non essere partiti da una preventiva riflessione sui principi della catalogazione e sulla funzione del catalogo, ma aver seguito un approccio sostanzialmente pragmatico rischia di svuotare il catalogo delle sue prerogative e di favorire la sostituzione del servizio offerto dalle biblioteche con quello di soggetti che non hanno le medesime finalità culturali e sociali.  Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource cataloguing practice, digital objects cataloguing, cataloguing principles and functions Identifier An unambiguous reference to the resource within a given context 10.2426/aibstudi-12260 Source A related resource from which the described resource is derived AIB Studi Publisher An entity responsible for making the resource available Associazione italiana biblioteche Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bibliography. Library science. Information resources https://www.socictopen.socict.org/files/original/40b2935711a926673b689aa8c313c17c.pdf 28f9f4d431ffef8d7bc6b2a797586309 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Fourth Ageism: Real and Imaginary Old Age Creator An entity primarily responsible for making the resource Paul Higgs, Chris Gilleard Description An account of the resource This paper is concerned with the issue of ageism and its salience in current debates about the COVID-19 pandemic. In it, we address the question of how best to interpret the impact that the pandemic has had on the older population. While many feel angry at what they see as discriminatory lock-down practices confining older people to their homes, others are equally concerned by the failure of state responses to protect and preserve the health of older people, especially those receiving long-term care. This contrast in framing ageist responses to the pandemic, we suggest, arises from differing social representations of later life, reflecting the selective foregrounding of third versus fourth age imaginaries. Recognising the tension between social and biological parameters of ageing and its social categorisations, we suggest, may offer a more measured, as well as a less discriminatory, approach to addressing the selective use of chronological age as a line of demarcation within society. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, ageism, nursing homes, Third age, fourth age Identifier An unambiguous reference to the resource within a given context 10.3390/soc11010012 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social sciences (General) https://www.socictopen.socict.org/files/original/98cad9d3520e91f9e547f00437d0ba52.pdf 46596d3ba7293b7d30dde096e292dd9a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Re: Links between air pollution and COVID-19 in England. Creator An entity primarily responsible for making the resource Paul J Villeneuve, Mark S Goldberg Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1016/j.envpol.2021.116576 Source A related resource from which the described resource is derived Environmental pollution (Barking, Essex : 1987) https://www.socictopen.socict.org/files/original/0c025f5523ba062d7e254487e07552a1.pdf 18ada824a3112f612368cf7d19e1f504 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Human Metapneumovirus-associated Atypical Pneumonia and SARS Creator An entity primarily responsible for making the resource Paul K. S. Chan, Ka-Fai To, Alan Wu, Gary MK Tse, Kui-Fat Chan, Siu-Fai Lui, Joseph J. Y. Sung, John S. Tam, Brian Tomlinson Description An account of the resource Acute pneumonia developed in a previously healthy man during the outbreak of severe acute respiratory syndrome (SARS) in southern China in March 2003. Antibiotic treatment was ineffective, and he died 8 days after illness onset. Human metapneumovirus was isolated from lung tissue. No other pathogen was found. Other etiologic agents should thus be sought in apparent SARS cases when coronavirus infection cannot be confirmed. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource human metapneumovirus, respiratory tract infection, post mortem, SARS, Hong Kong Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1003.030513 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/ffb8b82ef12f50a2e7a65965580f2165.pdf a315811e0ad9e1484d78ad66f7cc0d53 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Immunofluorescence Assay for Serologic Diagnosis of SARS Creator An entity primarily responsible for making the resource Paul K. S. Chan, King-Cheung Ng, Rickjason C. W. Chan, Rebecca K. Y. Lam, Viola C. Y. Chow, Mamie Hui, Alan Wu, Nelson Lee, Florence H.Y. Yap, Frankie W. T. Cheng, Joseph J. Y. Sung, John S. Tam Description An account of the resource We evaluated a virus-infected cell-based indirect immunofluorescence assay for detecting anti–severe acute respiratory syndrome-associated coronavirus (SARS-CoV) immunoglobulin (Ig) G antibody. All confirmed SARS cases demonstrated seroconversion or fourfold rise in IgG antibody titer; no control was positive. Sensitivity and specificity of this assay were both 100%. Immunofluorescence assay can ascertain the status of SARS-CoV infection. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource coronavirus, diagnosis, serology, Sensitivity, specificity, severe acute respiratory syndrome Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1003.030493 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/4a22521e995cd3f292f909c9311f29bd.pdf 57d18250889661f0a297837e45f3c9bb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Severe Acute Respiratory Syndrome–associated Coronavirus Infection Creator An entity primarily responsible for making the resource Paul K. S. Chan, Margaret Ip, K.C. Ng, Rickjason C. W. Chan, Alan Wu, Nelson Lee, Timothy H. Rainer, Gavin M. Joynt, Joseph J. Y. Sung, John S. Tam Description An account of the resource Whether severe acute respiratory syndrome–associated coronavirus (SARS-CoV) infection can be asymptomatic is unclear. We examined the seroprevalence of SARS-CoV among 674 healthcare workers from a hospital in which a SARS outbreak had occurred. A total of 353 (52%) experienced mild self-limiting illnesses, and 321 (48%) were asymptomatic throughout the course of these observations. None of these healthcare workers had antibody to SARS CoV, indicating that subclinical or mild infection attributable to SARS CoV in adults is rare. Date A point or period of time associated with an event in the lifecycle of the resource 2003 Subject The topic of the resource coronavirus, healthcare worker, hospital, Prevalence, SARS, severe acute respiratory syndrome Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid0911.030421 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/fa82a76b996219f92430193a0d082f60.pdf c7b521843c7348539be05ffb46c71859 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Laboratory Diagnosis of SARS Creator An entity primarily responsible for making the resource Paul K. S. Chan, Wing-Kin To, King-Cheung Ng, Rebecca K. Y. Lam, Tak-Keung Ng, Rickjason C. W. Chan, Alan Wu, Wai-Cho Yu, Nelson Lee, David S.C. Hui, Sik To Lai, Ellis K. L. Hon, Chi-kong Li, Joseph J. Y. Sung, John S. Tam Description An account of the resource The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription–polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%–40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource coronavirus, diagnosis, Reverse transcription–polymerase chain reaction, SARS, virus isolation, viral shedding Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1005.030682 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN