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                  <text>Dominio científico: Coronavirus</text>
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                <text>Cognitive Reappraisal and the Association Between Perceived Stress and Anxiety Symptoms in COVID-19 Isolated People</text>
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                <text>Chen Xu, Yanjun Xu, Song Xu, Qianhui Zhang, Xiaotong Liu, Yifan Shao, Xiaoxiao Xu, Li Peng, Min Li</text>
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                <text>The purpose of this study is to examine how the emotion regulation strategy, cognitive reappraisal, affects the association between perceived stress and anxiety symptoms in COVID-19 isolated people. Data for this cross-sectional study come from a community-based online survey of COVID-19 isolated people (N = 328), who are not infected with the 2019-nCoV virus. We applied correlation and moderating effect for data analysis and found that cognitive reappraisal negatively moderated the relationship between perceived stress and anxiety symptoms. These results give us a new perspective on understanding the relationship between anxiety symptoms and perceived stress by clarifying the protective function of cognitive reappraisal. It buffers the induced negative emotion when COVID-19 isolated people perceive overpressure, and thus instigates future research into targeted clinical interventions, which aim to cultivate cognitive reappraisal skills for those isolated people in the face of stressful events or crisis events.</text>
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                <text>emotion regulation, perceived stress, anxiety symptoms, cognitive reappraisal, COVID-19 isolated people</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Psychiatry</text>
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                <text>Impact of a Brief Educational Intervention on Knowledge, Perceived Knowledge, Perceived Safety, and Resilience of the Public During COVID-19 Crisis</text>
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                <text>Arielle Kaim, Eli Jaffe, Maya Siman-Tov, Ella Khairish, Bruria Adini</text>
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                <text>Extraordinary and unprecedented public health measures have been implemented to contain the ongoing spread of the coronavirus disease 2019 (COVID-19) pandemic. There is paramount importance of cooperation and population engagement in reducing disease infection rates and relieving an outbreak’s burden on society. The civil society’s engagement may be achieved through disaster education interventions. In this cross-sectional study, a pre-post questionnaire was used to investigate the impact of a brief educational intervention on knowledge, perceived knowledge, perceived safety, and the individual resilience of the population relating to the COVID-19 outbreak. The results of the study display the benefits of the educational intervention to include a significant overall increase in all examined variables. The study also reviewed the overall trust of the public concerning the main responding authorities, as well as practices concerning protective measures for COVID-19. This study demonstrates that educational interventions, such as the brief video, provide an easily implementable design and effective means for educating and empowering the public and should, thus, be considered as a component of future outbreak responses.</text>
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                <text>The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV</text>
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                <text>Suneel Kateriya, Mayanka Awasthi, Peeyush Ranjan, Sahil Gulati, Debi  P. Sarkar, Swasti Tiwari, Santosh  Kumar Verma</text>
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                <text>COVID-19 novel coronavirus (CoV) disease caused by severe acquired respiratory syndrome (SARS)-CoV-2 manifests severe lethal respiratory illness in humans and has recently developed into a worldwide pandemic. The lack of effective treatment strategy and vaccines against the SARS-CoV-2 poses a threat to human health. An extremely high infection rate and multi-organ secondary infection within a short period of time makes this virus more deadly and challenging for therapeutic interventions. Despite high sequence similarity and utilization of common host-cell receptor, human angiotensin-converting enzyme-2 (ACE2) for virus entry, SARS-CoV-2 is much more infectious than SARS-CoV. Structure-based sequence comparison of the N-terminal domain (NTD) of the spike protein of Middle East respiratory syndrome (MERS)-CoV, SARS-CoV, and SARS-CoV-2 illustrate three divergent loop regions in SARS-CoV-2, which is reminiscent of MERS-CoV sialoside binding pockets. Comparative binding analysis with host sialosides revealed conformational flexibility of SARS-CoV-2 divergent loop regions to accommodate diverse glycan-rich sialosides. These key differences with SARS-CoV and similarity with MERS-CoV suggest an evolutionary adaptation of SARS-CoV-2 spike glycoprotein reciprocal interaction with host surface sialosides to infect host cells with wide tissue tropism.</text>
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                <text>MERS-CoV, spike glycoprotein, SARS-CoV-2, n-terminal domain</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Microbiology</text>
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                <text>La Divulgación de la información en la encrucijada de la crisis del COVID-19 en Paraguay</text>
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                <text>Olga Elizabeth Moreno Fleitas</text>
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                <text>Desde finales del año 2019, con el surgimiento de la crisis mundial generada por el SARS-CoV-2, se ha elevado considerablemente el porcentaje de la producción y consumo global de noticias e información sobre el tema, acaparando este la mayor parte del espacio en los medios masivos. Por ello, teniendo en cuenta la importancia de la información que se produce, emite y consume en un país, generando posteriormente diferentes tipos de reacciones en una sociedad; en el presente artículo, el objetivo general fue la realización de un análisis reflexivo sobre la situación acontecida durante el primer mes de confinamiento en Paraguay en el marco de la publicación de información referente a la pandemia mundial generada por el virus SARS-CoV-2. Los objetivos específicos se centraron en el análisis de la circulación de noticias falsas e interpretaciones erróneas y la neurosis generada a raíz de ello; la búsqueda y el análisis de las noticias basadas en fuentes científicas primarias; y la participación de investigadores nacionales y profesionales del área de la salud en la difusión de la información. Para la realización del estudio, que se corresponde con el enfoque cualitativo de diseño descriptivo, se analizaron a través del método inductivo las principales fuentes periodísticas tanto impresas, televisivas y principalmente digitales a nivel país, teniendo en cuenta los que poseen la programación de noticiarios de mayor influencia y alcance nacional de acuerdo a los últimos datos estadísticos recogidos por el Ministerio de Tecnologías de la Información y Comunicación de Paraguay. Los resultados obtenidos indican que una gran parte de la colectividad paraguaya ha caído en la diseminación de información falsa incluso ya desde antes del ingreso del virus al país, lo que ha generado una rápida reacción de neurosis en la sociedad, decantando en acciones relacionadas con compras compulsivas, xenofobia, prácticas riesgosas de cuidado sanitario, etc. En el segundo objetivo, se determinó que los principales medios masivos de comunicación contaban con una muy escasa –por no decir nula– producción propia de noticias basadas en fuentes científicas primarias, denotando una redacción basada en la traducción directa de otros periódicos extranjeros. En cuanto al último objetivo, se determinó la existencia de una participación incremental de los investigadores y especialistas como referentes principales al momento de ofrecer explicaciones relacionadas al virus y la pandemia a través de los medios masivos y digitales. Finalmente se realiza una breve recomendación útil para casos futuros, basada en experiencias extranjeras.</text>
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                <text>coronavirus, pandemia, Paraguay, noticia falsa</text>
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                <text>10.32480/rscp.2020-25-1.58-85</text>
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                <text>Revista de la Sociedad Científica del Paraguay</text>
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                <text>Engineering (General). Civil engineering (General), Science (General)</text>
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                <text>Vaccine Candidates Against Coronavirus Infections. Where Does COVID-19 Stand?</text>
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                <text>Seven years after the Middle East respiratory syndrome (MERS) outbreak, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) made its first appearance in a food market in Wuhan, China, drawing an entirely new course to our lives. As the virus belongs to the same genus of MERS and SARS, researchers have been trying to draw lessons from previous outbreaks to find a potential cure. Although there were five Phase I human vaccine trials against SARS and MERS, the lack of data in humans provided us with limited benchmarks that could help us design a new vaccine for Coronavirus disease 2019 (COVID-19). In this review, we showcase the similarities in structures of virus components between SARS-CoV, MERS-CoV, and SARS-CoV-2 in areas relevant to vaccine design. Using the ClinicalTrials.gov and World Health Organization (WHO) databases, we shed light on the 16 current approved clinical trials worldwide in search for a COVID-19 vaccine. The different vaccine platforms being tested are Bacillus Calmette–Guérin (BCG) vaccines, DNA and RNA-based vaccines, inactivated vaccines, protein subunits, and viral vectors. By thoroughly analyzing different trials and platforms, we also discuss the advantages and disadvantages of using each type of vaccine and how they can contribute to the design of an adequate vaccine for COVID-19. Studying past efforts invested in conducting vaccine trials for MERS and SARS will provide vital insights regarding the best approach to designing an effective vaccine against COVID-19.</text>
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                <text>coronavirus, MERS, SARS, vaccine, covid-19, Clinical trials</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity</text>
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              <elementText elementTextId="46130">
                <text>Gyula Batta, Lieve Naesens, Anikó Borbás, Zsolt Szűcs, Annelies Stevaert, Eszter Ostorházi, Pál Herczegh</text>
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                <text>Influenza A and B viruses are a global threat to human health and increasing resistance to the existing antiviral drugs necessitates new concepts to expand the therapeutic options. Glycopeptide derivatives have emerged as a promising new class of antiviral agents. To avoid potential antibiotic resistance, these antiviral glycopeptides are preferably devoid of antibiotic activity. We prepared six vancomycin aglycone hexapeptide derivatives with the aim of obtaining compounds having anti-influenza virus but no antibacterial activity. Two of them exerted strong and selective inhibition of influenza A and B virus replication, while antibacterial activity was successfully eliminated by removing the critical N-terminal moiety. In addition, these two molecules offered protection against several other viruses, such as herpes simplex virus, yellow fever virus, Zika virus, and human coronavirus, classifying these glycopeptides as broad antiviral molecules with a favorable therapeutic index.</text>
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                <text>antiviral, human coronavirus, Influenza Virus, glycopeptide antibiotic, vancomycin aglycone hexapeptide</text>
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                <text>10.3390/ph13070139</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine, Pharmacy and materia medica</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Clinical and CT findings of COVID-19: differences among three age groups</text>
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              <elementText elementTextId="46121">
                <text>Guangzhao Yang, Zhihua Xu, Jian Wang, Xiandi Zhu, Guoqun Mao, Yuzhu Jia, Zongyu Xie, Jing Wang, Weiqun Ao</text>
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                <text>Abstract Background The novel coronavirus pneumonia (coronavirus disease 2019, COVID-19) has spread around the world. We aimed to recapitulate the clinical and CT imaging features of COVID-19 and their differences in three age groups. Methods The clinical and CT data of patients with COVID-19 (n = 307) that had been divided into three groups (Group 1:</text>
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                <text>2020</text>
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                <text>covid-19, Age, X-ray computed tomography, Pulmonary infection</text>
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                <text>10.1186/s12879-020-05154-9</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
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                <text>Korean Society of Epidemiology</text>
              </elementText>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases</text>
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              <name>Title</name>
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              <name>Description</name>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Psoriasis, biological drugs and Coronavirus Disease 2019: Real life experience of two Italian provinces</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Martina Vispi, Teresa Corradin, Camilla Peccianti, Luca Feci, Laura Casini, Chiara Pisani, Susanna Fabbroni, Paola Corsetti, Margherita Croatto, Michele Pellegrino</text>
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            <description>An account of the resource</description>
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                <text>On January 30, 2020, World Health Organization (WHO) stated that a new coronavirus disease outbreak [COronaVIrus Disease - 19 (COVID-19)] was an international public health emergency. Many news, often fake ones, about the derived pandemic rapidly spread along the media, thus leading many dermatological patients to identify as “risk category” and sometimes discontinue treatments by themselves. The Dermatology Units in Grosseto and Pordenone simultaneously carried out a data collection by remote-conducted visits, evaluating the incidence of COVID-19 in psoriatic patients. Only 1 patient (close contact of a case) as part of the psoriasis analyzed group was tested and turned out to be positive for SARS-CoV-2, developing no symptoms during the observation period. The collected information may suggest that psoriasis, biotechnologically treated or not, cannot promote or aggravate the clinical trend of the SARS-CoV-2 infection, hence stopping systemic therapy in negative or clinically free SARS-CoV-2 patients is not recommended in general.</text>
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                <text>2020</text>
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                <text>covid-19, Psoriasis, Biological drugs</text>
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            <name>Identifier</name>
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                <text>10.4081/dr.2020.8642</text>
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                <text>Dermatology Reports</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>PAGEPress Publications</text>
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                <text>Dermatology</text>
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                <text>We Are Not Alone in Trying to Be Alone</text>
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            <name>Creator</name>
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                <text>Patricia C. Lopes</text>
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                <text>disease transmission, covid-19, social behavior, sickness behavior, parasite avoidance, disgust avoidance</text>
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                <text>10.3389/fevo.2020.00172</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Ecology, Evolution</text>
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