1605 10 20655 https://www.socictopen.socict.org/files/original/e0fbce95deeb8d16b4c14f97970ee3e9.pdf 8b42bdeccea39f77f15d81ba12b4d06e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource HORTA ORGÂNICA NA ESCOLA: UMA PROPOSTA DE MANEJO SUSTENTÁVEL Creator An entity primarily responsible for making the resource Queiti Nunes Pinto, Tarcisio Barcellos Cardoso, Danusia de Oliveira Trecha Description An account of the resource A agricultura convencional destaca-se como uma das atividades mais impactantes ao meio ambiente. O presente trabalho conta com pesquisa bibliográfica de campo sobre técnicas sustentáveis utilizadas na produção de hortaliças, com a intenção de aplicá-las na Horta da Escola Estadual Deputado Adão Pretto. Iniciou-se com a análise, adubação e manejo do solo, em seguida plantio de hortaliças, através do estudo da época de plantio, das especificidades e com a valorização da cultura e do saber da comunidade local. A partir da interação com a comunidade, resgatou-se técnicas milenares e de princípios ecológicos: calendário lunar, armadilhas construídas em materiais recicláveis, utilização de plantas com função de controle biológico e estudo sobre plantas companheiras, antagônicas e indicadoras. Realizou-se o plantio e a colheita de hortaliças, sendo acrescentadas à merenda da escola. Todo o projeto foca na produção orgânica e na aproximação com a ecologia, com respeito ao conhecimento e à vida. Durante a V Feira Regional de Ciências, Matemática e Mais Saberes, os alunos utilizarão, para a apresentação, cartazes, banners, amostras do solo da horta da escola (com destaque para os horizontes), amostra das armadilhas ecológicas desenvolvidas e relatório com fotografia do trabalho realizado pelos autores do projeto com crianças das escolas municipais que integram a comunidade escolar, visando difundir os princípios da agricultura orgânica e de base ecológica. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Identifier An unambiguous reference to the resource within a given context 10.15536/reducarmais.0.2015.%p.714 Source A related resource from which the described resource is derived Revista Educar + Publisher An entity responsible for making the resource available Instituto Federal Sul-Rio-Grandense (IFSul) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Education Relation A related resource <a href="https://periodicos.ifsul.edu.br/index.php/educarmais/article/view/714" target="_blank" rel="noreferrer noopener">https://periodicos.ifsul.edu.br/index.php/educarmais/article/view/714</a> https://www.socictopen.socict.org/files/original/475c71a422a6a30a30d400deb26d7d57.pdf 47430288bef068d8d85621dbcd46a28c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Covid-19 COVID-19 Pandemic: An Unseen’s Evolution War Creator An entity primarily responsible for making the resource Quek Yek Song, Michelle Jia Ni Ling Description An account of the resource This is a new beginning. It started just like a fiction movie. In December 2019, a new cluster of pneumonia caused by the 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan, China. Without any mercy, it became a pandemic and left no time for grief. It was not only life-threatening but also challenged our healthcare system, economy, culture, lifestyle and belief. It forced us to make changes. We need to evolve, and we must evolve. Malaysia, a multi-ethnicity and multireligious country which is located in Southeast Asia, has a population of 32 million with a median age of 28.9 years in 2019. According to the Observatory of Economic Complexity, Malaysia has experienced rapid globalization and is the 19th leading exporter in the world. It is an upper-middle-income country with a gross domestic product (GDP) of 370 billion USD in 2019, of which 4.5% is funded to the healthcare system. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Malaysia, social distancing, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22502/jlmc.v8i1.354 Source A related resource from which the described resource is derived Journal of Lumbini Medical College Publisher An entity responsible for making the resource available Lumbini Medical College Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/7634027ff06358fd724836694ee8c228.pdf f3afcb6d88207cc355b3938689b3da06 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mental Health Status of Canadian Funeral Service Workers at the Beginning of the COVID-19 Pandemic. Creator An entity primarily responsible for making the resource Quentin Durand-Moreau, Jean-Michel Galarneau Description An account of the resource To describe the mental health situation and job stress levels of Funeral Service Workers (FSW) during the first months of the pandemic. We conducted a cross-sectional study in Canada between May and July 2020. Funeral service professional organizations were asked to spread a questionnaire to their members including job description, assessment of anxiety (GAD-7), depression (PHQ-8), and job stress (effort-reward imbalance questionnaire). Fifty-eight FSW completed a questionnaire, 32% reported anxiety symptoms (GAD-7 > 10), 29% reported depressive symptoms (PHQ-8 > 10), 31% reported job stress. Women were more likely to report overcommitment (66.7% vs. 31.8%, P = 0.015). Levels of anxiety and depression identified in Canadian FSW were higher than those identified in other occupational groups during the first few months of the pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1097/JOM.0000000000002204 Source A related resource from which the described resource is derived Journal of occupational and environmental medicine https://www.socictopen.socict.org/files/original/6155294a34da43aa6c0b4bcc3b301e73.pdf 743afbc88517b18126a647f386615a93 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH) Creator An entity primarily responsible for making the resource Quentin Spillier, Severine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick Description An account of the resource For many years now, targeting deregulation within cancer cells&#8217; metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments. Recently, numerous reports highlighted the crucial role of the serine synthetic pathway, and particularly of the phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, to sustain cancer progression. Yet, because of very weak potencies usually in cell-based settings, the inhibitors reported so far failed to lay ground on the potential of this approach. In this paper, we report a structure&#8722;activity relationship study of a series of &#945;-ketothioamides that we have recently identified. Interestingly, this study led to a deeper understanding of the structure&#8722;activity relationship (SAR) in this series and to the identification of new PHGDH inhibitors. The activity of the more potent compounds was confirmed by cellular thermal shift assays and in cell-based experiments. We hope that this research will eventually provide a new entry point, based on this promising chemical scaffold, for the development of therapeutic agents targeting PHGDH. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource PHGDH, α-ketothioamides, serine synthesis pathway inhibitors Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ph13020020 Source A related resource from which the described resource is derived Pharmaceuticals Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica Language A language of the resource EN https://www.socictopen.socict.org/files/original/9ef4b62728f4294e3ba3007aeee12fa2.pdf 2862fa01cf122708725bbc9de958d23f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epigenética, conceptualización y alcance epistémico Creator An entity primarily responsible for making the resource Quintero, Fabián Description An account of the resource La epigenética, concepción frecuentemente atribuida a Corad Waddington (1905-1975), ha estado estrechamente relacionada a una lucha en el campo intelectual por más de dos mil años. Postulada por Aristóteles bajo la denominación de epigénesis, en oposición a la concepción biológica preformacionista de Demócrito, ha ido variando en sus contenidos y alcances en consonancia con el desarrollo del conocimiento científico. En la actualidad la epigenética se presenta en la literatura científica como un concepto con rasgos polisémicos y escasa integración conceptual. Sin embargo, la gran amplitud de fenómenos biológicos que abarca y la magnitud de la producción científica involucrada hacen necesario un nuevo acercamiento que integre ecología, evolución y desarrollo (eco-evo-devo). Se propone en este sentido conceptualizar la epigenética desde una perspectiva adaptativa, que implica la inclusión de mecanismos epigenéticos transgeneracionales o darwinianos, dependiendo del nivel de integración que se analice. Esto permitiría integrar conceptos y resolver contradicciones en áreas de la biología funcional y evolutiva. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource Antropologia, Ciencias Naturales Source A related resource from which the described resource is derived Revista Argentina de Antropología Biológica Publisher An entity responsible for making the resource available Asociación de Antropología Biológica Argentina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Anthropology, Physical anthropology. Somatology Relation A related resource <a href="http://sedici.unlp.edu.ar/handle/10915/6046" target="_blank" rel="noreferrer noopener">http://sedici.unlp.edu.ar/handle/10915/6046</a> https://www.socictopen.socict.org/files/original/4437e3b568a4ca5a8a2258863704a55a.pdf a20733ed4175b330a9f274b95e783a28 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells Creator An entity primarily responsible for making the resource Qutayba Hamid, Azzam A. Maghazachi, Abiola C. Senok, Rabih Halwani, Saba Al Heialy, Mahmood Yaseen Hachim, Ibrahim Yaseen Hachim Description An account of the resource Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward the development of a vaccine against SARS-CoV-2, such a vaccine will not be available in time to contribute to the containment of the ongoing pandemic. Therefore, there is an urgent need to develop a framework for the rapid identification of novel targets for diagnostic and therapeutic interventions. We analyzed publicly available transcriptomic datasets of SARS-CoV infected humans and mammals to identify consistent differentially expressed genes then validated in SARS-CoV-2 infected epithelial cells transcriptomic datasets. Comprehensive toxicogenomic analysis of the identified genes to identify possible interactions with clinically proven drugs was carried out. We identified IFITM3 as an early upregulated gene, and valproic acid was found to enhance its mRNA expression as well as induce its antiviral action. These findings indicate that analysis of publicly available transcriptomic and toxicogenomic data represents a rapid approach for the identification of novel targets and molecules that can modify the action of such targets during the early phases of emerging infections like COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Valproic acid, antiviral immunity, interferon-induced transmembrane proteins, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2020.01372 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/c3ef7b4b8a45a2d0902df8349e16cfac.pdf cd28e4c5b9c2d2bc79b45c01e8ad6803 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression Creator An entity primarily responsible for making the resource Qutayba Hamid, Rabih Halwani, Bassam Mahboub, Qutayba Hamid, Rifat Hamoudi, Rabih Halwani, Swati Goel, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif Askari, Bushra Madkhana, Ahmad Munzer Alwaa, Bassam Mahboub, Adel M Zakeri, Elaref Ratemi, Rifat Hamoudi, Qutayba Hamid, Rabih Halwani Description An account of the resource Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many cellular processes and are essential for immune cells function. Their activity is controlled by dual-specificity phosphatases (DUSPs). A comprehensive analysis of publicly available gene expression data sets of human airway epithelial cells (AECs) infected with SARS-CoV-2 identified DUSP1 and DUSP5 among the lowest induced transcripts within these pathways. These proteins are known to downregulate MAPK and NF-κB pathways; and their lower expression was associated with increased activity of MAPK and NF-κB signaling and enhanced expression of proinflammatory cytokines such as TNF-α. Infection with other coronaviruses did not have a similar effect on these genes. Interestingly, treatment with chloroquine and/or non-steroidal anti-inflammatory drugs counteracted the SARS-CoV-2 induced reduction of DUSP1 and DUSP5 genes expression. Therapeutically, impeding this evasion mechanism of SARS-CoV-2 may help control the exaggerated activation of these immune regulatory pathways during a COVID-19 infection. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, MAPK, NFƙB, DUSP5, DUSP1 Identifier An unambiguous reference to the resource within a given context 10.3389/fphar.2021.631879 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology https://www.socictopen.socict.org/files/original/bdb0515d25afcd4425cdf2e58cfb618d.pdf e6a0ccd621191fe9e0d4b8ad2591862e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource [Thrombus in transit in patient with COVID-19 pneumonia]. Creator An entity primarily responsible for making the resource R Chalela, M P Gracia-Arnillas, R Olivero-Soldevila, A Izquierdo-Marquisa, M Acer-Puig, D A Rodríguez-Chiaradía Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1016/j.medin.2020.06.002 Source A related resource from which the described resource is derived Medicina intensiva https://www.socictopen.socict.org/files/original/58b9a6989efff9d15463e1a60867fa56.pdf 5b991bfef42790ba2c8e2a1ec7fbf07a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource [Can we talk about triage of patients and with whom?] Creator An entity primarily responsible for making the resource R Cremer, P Valette Description An account of the resource During the first wave of the Covid-19 epidemic that hit France in the spring of 2020 sparked controversy over the triage of patients in the emergency room. From this controversy, this text will seek to clarify this notion of triage and, and to shed light on the ethical position of bedside physicians who find themselves summited to public health strategies, scientific data, regulatory injunctions and ethical duties. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, ethics, public health strategies, Triage of patients Identifier An unambiguous reference to the resource within a given context 10.1016/j.etiqe.2020.11.002 Source A related resource from which the described resource is derived Ethique & sante https://www.socictopen.socict.org/files/original/8d0d6e1b36b5dc2aad1a6c90d1f61664.pdf f571dc75ccac1c210d37c603346ac8b0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19: Socio-Cultural Influences And Adherence To Governmental Strategies For Social Isolation In Peru Creator An entity primarily responsible for making the resource R Dammert-Elejalde Description An account of the resource On March 15, Peruvian President Martín Vizcarra, in a message to the nation, announced that, with 71 positive cases, he was declaring a state of emergency, just 9 days after announcing on national television the presence of the first positive case, a worker of a well-known airline. In hindsight, we all forget that it was considered at the time a very drastic decision, even a hasty one; but the Head of the Nation was definitely already completely soaked in the world's reality, just four days away from the late declaration by the WHO, on March 11, 2020, of COVID-19, as a Pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.25176/RFMH.v20i4.3044 Source A related resource from which the described resource is derived Revista de la Facultad de Medicina Humana Publisher An entity responsible for making the resource available Universidad Ricardo Palma Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medicine (General)