Navegar por los elementos (20655 total)
Ordenar por:
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated development of antiviral nucleosides due to its proofreading activity. We recently reported…
Position: 10260 (25 views)
Coronavirus spike protein inhibits host cell translation by interaction with eIF3f.
In response to viral infection, the expression of numerous host genes, including predominantly a number of proinflammatory cytokines and chemokines, is usually up-regulated at both transcriptional and translational levels. It was noted that in cells…
Position: 2063 (50 views)
Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.
Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of sensors and signaling molecules that make up the host innate immune response. Here we show that human coronavirus (HCoV) NL63 and severe acute respiratory syndrome…
Position: 14098 (21 views)
Coronavirus Pandemic—Therapy and Vaccines
The current coronavirus COVID-19 pandemic, which originated in Wuhan, China, has raised significant social, psychological and economic concerns in addition to direct medical issues. The rapid spread of severe acute respiratory syndrome-coronavirus…
Position: 13075 (22 views)
Coronavirus pandemic challenges migrants worldwide and in Russia
The paper deals with the situation of one of the most vulnerable social groups under COVID-19, namely migrants and refugees. The author classifies pandemic-related challenges faced by migrants into several groups: (1) economic, (2) medical, or…
Position: 14098 (21 views)
Coronavirus Pandemic a Factor in Delayed Mourning in Survivors: A Letter to The Editor
This article has no abstract.
Position: 12106 (23 views)
Coronavirus Pandemic (SARS-COV-2): Pre-Exercise Screening Questionnaire (PESQ) for Telepresential Exercise
Position: 16101 (19 views)
Coronavirus Outbreak in Italy: Physiological Benefits of Home-Based Exercise During Pandemic
The Coronavirus Disease 2019 (COVID-19) pandemic has forced the hardest-hit populations, like Italians, to radically change their daily habits, starting with social distancing, strict preventive measures, and self-isolation. These precautions also…
Position: 19230 (15 views)
Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers
Abstract Coronaviruses (CoV) are enveloped viruses and rely on their nucleocapsid N protein to incorporate the positive-stranded genomic RNA into the virions. CoV N proteins form oligomers but the mechanism and relevance underlying their…
Position: 19230 (15 views)
Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines.
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1…
Position: 7393 (29 views)