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                <text>WITHDRAWN: COVID-19 related acute decline in paediatric admissions in Malta, a population-based study.</text>
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                <text>Sophie Degiorgio, Neil Grech, Yana Marie Dimech, John Xuereb, Victor Grech</text>
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                <text>This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.</text>
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                <text>Early human development</text>
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                <text>Virtual screening of phytoconstituents from miracle herb nigella sativa targeting nucleocapsid protein and papain-like protease of SARS-CoV-2 for COVID-19 treatment.</text>
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                <text>Aditi Srivastava, Sahabjada Siddiqui, Rumana Ahmad, Bilal Ahmad, Shivbrat Upadhyay, Anamika Gupta, Anchal Trivedi, Ishrat Husain, Maqusood Ahamed, Mohsin Ali Khan</text>
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                <text>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel etiological agent of coronavirus disease 2019 (COVID-19). Nigella sativa, commonly known as black seed or black cumin, has been a historical and traditional plant since thousands of years. Based on their therapeutic efficacy, the chief components of terpenoids and flavonoids were selected from N. sativa seeds and seed oil. This study was designed to check the antiviral efficacy of N. sativa main phytoconstituents against five potential targets of SARS-CoV-2 using in silico structure-based virtual screening approach. Out of twenty five phytocomponents, ten components showed best binding affinity against two viral proteins viz. N-terminal RNA binding domain (NRBD; PDB ID: 6M3M) of nucleocapsid protein and papain-like protease (PL-PRO; PDB ID: 6W9C) of SARS-CoV-2 using AutoDock 4.2.6, AutoDock Vina and iGEMDOCK. PASS analyses of all ten phytocomponents using Lipinski's Rule of five showed promising results. Further, druglikeness and toxicity assessment using OSIRIS Data Warrior v5.2.1 software exhibited the feasibility of phytocomponents as drug candidates with no predicted toxicity. Molecular dynamics simulation study of NRBD of SARS-CoV-2 nucleocapsid protein-alpha-spinasterol complex and PL-PRO-cycloeucalenol complex displayed strong stability at 300 K. Both these complexes exhibited constant root mean square deviation (RMSDs) of protein side chains and Cα atoms throughout the simulation run time. Interestingly, PL-PRO and NRBD are key proteins in viral replication, host cell immune evasion and viral assembly. Thus, NRBD and PL-PRO have the potential to serve as therapeutic targets for N. sativa phytoconstituents in drug discovery process against COVID-19.</text>
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                <text>Nucleocapsid protein, SARS-CoV-2, papain-like protease, Nigella sativa, molecular chemoinformatics, phytocomponents</text>
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                <text>10.1080/07391102.2020.1852117</text>
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                <text>Paradoxes and uncertainties of immunomodulatory treatments in the fight against COVID-19.</text>
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                <text>Laurent Kaiser, Diem-Lan Vu-Cantero, Christiane S Eberhardt</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19 and the Kidney: From Epidemiology to Clinical Practice</text>
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                <text>Ida Gagliardi, Gemma Patella, Ashour Michael, Raffaele Serra, Michele Provenzano, Michele Andreucci</text>
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                <text>The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic coronavirus, named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), to date has killed over 630,000 people and infected over 15,000,000 worldwide. Most of the deceased patients had pre-existing comorbidities; over 20% had chronic kidney disease (CKD). Furthermore, although SARS-CoV-2 infection is characterized mainly by diffuse alveolar damage and acute respiratory failure, acute kidney injury (AKI) has developed in a high percentage of cases. As AKI has been shown to be associated with worse prognosis, we believe that the impact of SARS-CoV-2 on the kidney should be investigated. This review sets out to describe the main renal aspects of SARS-CoV-2 infection and the role of the virus in the development and progression of kidney damage. In this article, attention is focused on the epidemiology, etiology and pathophysiological mechanisms of kidney damage, histopathology, clinical features in nephropathic patients (CKD, hemodialysis, peritoneal dialysis, AKI, transplantation) and prevention and containment strategies. Although there remains much more to be learned with regards to this disease, nonetheless it is our hope that this review will aid in the understanding and management of SARS-CoV-2 infection.</text>
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                <text>Pandemic, SARS-CoV-2, acute kidney injury, dialysis, renal transplantation</text>
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                <text>10.3390/jcm9082506</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Telemedicine in India: A tool for transforming health care in the era of COVID-19 pandemic</text>
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                <text>Neema Agarwal, Payal Jain, Rambha Pathak, Rakesh Gupta</text>
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                <text>Although telemedicine has been used spottily in Indian health care so far, the 2020 Covid-19 pandemic provided the nation's health systems an unprecedented opportunity to make a concerted effort to increase access and coverage. Health-care providers can incorporate telemedicine systems to reduce doctor-patient visits and help in breaking the chain of transmission of infections. Anticipating the increased need of telemedicine by health-care providers, the Medical Council of India released practice guidelines in March 2020. In this article, the literature pertinent to telemedicine and its applications with special reference to recently released practice guidelines were reviewed and summarized in a historical and current context. Telemedicine is bound to grow and be adopted by more health-care practitioners and patients in a wide variety of forms due to ease and availability. At the same time, it cannot replace in-person consultation or emergency medicine.</text>
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                <text>10.4103/jehp.jehp_472_20</text>
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                <text>Biotemas</text>
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                <text>Public aspects of medicine, Special aspects of education</text>
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                <text>Introdução: Como parte da Edição Especial de 2020 I, a Revista de Educação Física / Journal of Physical Education (REF/JPE) está trazendo aspectos científicos da prática de atividade física relacionados à pandemia de CoViD-19.  Objetivo: Apresentar e indicar aos leitores da REF/JPE, a leitura da revisão integrativa de Zadow et al., publicado em um periódico internacional, que procurou explorar como pode ser feita uma prescrição de exercício físico de modo que previna a coagulopatia e examinar seu papel na recuperação da CoViD-19.  Conclusão: De acordo a literatura e amplamente discutido pelos autores, o exercício físico pode ser apropriadamente prescrito como terapia coadjuvante a fim de minimizar efeitos adversos medicamentosos e de CoViD-19 no paciente. A intensidade do exercício deve ser de leve a moderada, a fim de contribuir para diminuir o risco de agravamento do quadro de sintomas da doença, bem como para reduzir o risco de coagulopatia, que parece estar associado à mortalidade.</text>
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                <text>Sports</text>
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                <text>Tatiana Aline Carvalho, Matheus Negri Boschiero, Fernando Augusto Lima Marson</text>
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                <text>Brazil is one of the epicenters of the COVID-19 pandemic and has reported 5,113,628 cases and 150,998 deaths by the disease. Comparing the deaths by natural causes expected and the excess mortality rate, there is a 22% increase in deaths mainly of male patients and individuals over 60 years old.</text>
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                <text>10.1016/j.diagmicrobio.2020.115258</text>
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                <text>Cardiomyopathy in Coronavirus Disease Survivors:  Mechanism, Management and Prevention</text>
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                <text>Renan Sukmawan</text>
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                <text>Coronavirus disease (COVID-19) caused by infection of SARS-CoV-2 as of April 2020 has been confirmed  in more than 2.3 million people, with more than 150 thousands deaths across the globe. It has been known that COVID-19 patients with underlying cardiovascular diseases and its risks including: hypertension, diabetes, coronary artery disease, and cerebrovascular diseases may develop more severe respiratory track symptoms requiring intensive care. Some patients may presenting with myocarditis or acute cardiomyopathy, which has high mortality and morbidity. There was also evidence of myocardial Injury with an increase of troponin in one-third of those infected by covid-19.  It is conceivable that among those who recover from COVID-19 infection, there is a risk of developing further cardiomypathy once the pandemic receding in the future. It is important to pay attention to this survivor group since the pandemic may be lasting for longer period. Optimal medical treatment and comprehensive prevention should be taken to manage those high risk patients of developing cardiomyopathy during hospital care as well post discharge. These includes provide best available COVID-19 drugs, cardiovascular medications, and social preventive measures.</text>
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                <text>covid-19, myocarditis, cardiomyopathy</text>
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                <text>10.30701/ijc.1012</text>
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                <text>Majalah Kardiologi Indonesia</text>
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                <text>Indonesian Heart Association</text>
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                <text>Diseases of the circulatory (Cardiovascular) system</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Covid-19: separazione e lutto. È possibile un “tempo nutriente” dell’attesa?</text>
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                <text>Marzia Marsili</text>
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                <text>The  aim  of  this  paper  is  to  reflect  on  sorrow,  grief  and  mourning  following  the Covid-19 pandemic, which globally has caused major effects on population and its physical  and  mental  health.  The  virus  has  caused  a  very  high  number  of  unex-pected  deaths  and  of  separations,  while  lockdown  measures  have  also  affected society  as  a  whole -  such  as  people  being  prevented  from  traditional  grief  rituals like saying farewell; family disposal of the body; etc. The importance of dedicating time  and  space  to  rituals  and  other  symbolic  actions  to  facilitate  grief  work  and deal  with  the  pain  associated  with  it is  well known. The psychological  support  of-fered  by  the  psychologists  of  the  association  Psicologi  per  i  Popoli -  Trentino  has helped  people  in  situations  of  great  fragility  to  navigate  through  a  time  of  suffer-ing, such as that experienced in the uncertain waiting for the fate of family mem-bers or loved ones hospitalised in intensive care units, facilitating the transforma-tion of this painful uncertainty into a “nourishing time of waiting”.</text>
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                <text>covid-19, mourning, Separation, waiting</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Therapeutics. Psychotherapy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Il supporto psicologico telefonico a partire dall’analisi dei bisogni: la creazione dello strumento Analisi dei Bisogni Assistenza Covid-19/ABACO-19</text>
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                <text>Ersilia Cossu, Gianluigi Carta</text>
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                <text>n  this  article,  the  authors  aim  at  describing  the  field  experience  related  to  the telephone  psychological  support  activity  in  Sardinia  during  the  Covid-19  emer-gency.  Specifically,  they  will  illustrate  the  protocols  and  procedures  used  by  psy-chologists according to the psychosocial model of Psicologi per i Popol (PxP).They  also  aim  to describe the  work  of  needs  analysis,  a fundamental  element for intervention planning, which is an essential tool of the emergency and humanitar-ian  assistance  psychologist  in  order  to  promote  effective  listening  and be  able  to enhance the  resources  of  the  people  who call on  the direct  line,  as  well  as  fami-lies,  according  to  an  integrated  psychosocial  approach  that  characterizes  the  in-tervention of PxP.In  line  with  the  psychosocial  approach  as  a theoretical  assumption  applied in  op-erational  interventions  in  emergencies,  they  describe  the  different  organisational and  operational  phases  of  the  service  offered  to  the  population,  the  role  of  the psychologist  and  the  team  of  operators  involved,  the  intervention  methodology and the analysis of the data collected.</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="40245">
                <text>covid-19, perceived stress, Listening, psychological support, needs analysis, personal resources, psycho-social model</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="40246">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="40247">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="40248">
                <text>Therapeutics. Psychotherapy</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
